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  • expression
  • Surprisingly, chronic expression of Cre recombinase from these transgenes ( UAST-cre ) was found to be toxic for proliferating cells. (springer.com)
  • in transgenic mice by a tetracycline Conditional and inducible transgene expression in mice Here we describe a triple transgenic mouse system, which combines the tissue specificity of any Cre- transgenic line with the inducibility of the reverse tetracycline Inducible podocyte-specific gene expression in transgenic Inducible podocyte-specific gene expression in transgenic mice . (nordwest-gamer.de)
  • therapeutic
  • In 2011 partner Roche terminated the 2007 agreement under which Transgene granted Roche exclusive global development and commercialization rights to the therapeutic vaccine. (wikipedia.org)
  • Sung Jin Kim, Chang Ho Lee, and Seong-Wook Lee, Dankook University, Yongin, Republic of Korea, describe the novel gene therapy control system they developed in the article "Targeting the MicroRNA Passenger Strand for Regulating Therapeutic Transgenes" . (eurekalert.org)
  • This clear and convincing paper proposes a new, safe, and effective approach to regulate therapeutic transgenes," says Executive Editor Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit, MI. (eurekalert.org)
  • 1997
  • Post-transcriptional silencing of a neomycin phosphotransferase II transgene correlates with the accumulation of unproductive RNAs and with increase cytosine methylation of 3′-flanking regions, Plant J., 1997, 12(2): 379. (springer.com)
  • gene therapy
  • However, they are completely different in their purposes, as gene therapy aims to cure a defect in cells, and transgenesis seeks to produce a genetically modified organism by incorporating the specific transgene into every cell and changing the genome. (wikipedia.org)
  • plant
  • Epigenetic transcriptional silencing and 5-azacytidine-mediated reactivation of a complex transgene in rice, Plant Physiol. (springer.com)
  • company
  • Transgene S.A. (Euronext: TNG), part of Institut Mérieux, is a publicly traded French biopharmaceutical company focused on designing and developing targeted immunotherapies for the treatment of cancer and infectious diseases. (businesswire.com)
  • foreign
  • Scientist were able to develop other methods to perform the transformations, such as incorporating transgenes into retroviruses and then infecting cells, using electroinfusion which takes advantage of an electric current to pass foreign DNA through the cell wall, biolistics which is the procedure of shooting DNA bullets into cells, and also delivering DNA into the egg that has just been fertilized. (wikipedia.org)
  • useful
  • it also has high bioavailability when taken orally, so it is useful for determining whether the transgene has been taken up effectively. (wikipedia.org)
  • wild
  • Transgene flow from glyphosate-tolerant oilseed rape might be easier than that from glufosinate-tolerant oilseed rape to wild B. juncea. (greenmedinfo.com)