• If some rare clinical hazards manifest as acute inflammation symptoms of various origin, most of them linked with conflicting and undesirable biological material accompanying the therapeutic component (infectious pathogen, pathogenic antibody, unwanted antigen, or allergen), the general feature is subtler and less visible, and essentially consists of alloimmunization or febrile non-hemolytic transfusion reaction. (frontiersin.org)
  • Cerus Corporation is a biomedical products company focused in the field of blood transfusion safety. (pharmiweb.com)
  • She has published over 100 scientific papers, given over 100 national and international presentations, and currently holds significant funding for research in the field of blood transfusion. (traqprogram.ca)
  • In January, the EFS was informed of the Ministry of Health's decision that the INTERCEPT Platelet system should be deployed for the control of bacterial infections transmitted by transfusion, in accordance with a prior December 2016 recommendation by France's regulatory authority, ANSM, the French National Agency for Medicines and Health Products Safety. (pharmiweb.com)
  • A more definitive answer on whether this practice improves outcomes in patients with cardiovascular disease was gleaned from the results of a large prospective trial (the FOCUS trial) that looked at functional capacity at 60 days and postoperative myocardial infarction and death in patients with a history of or at high risk for cardiovascular disease who were anemic after surgical hip fracture repair and who were treated with different transfusion thresholds. (renalandurologynews.com)
  • Interestingly, more recent passive reporting studies of bacterially contaminated red cells from the United States, France, and the United Kingdom that caused symptoms of infection show a relative paucity of Yersinia cases (Table 1 ) ( 35 , 51 , 57 ). (asm.org)
  • The indolent nature of the organism results in cases typically associated with a relatively long history with minimal clinical signs of infection at initial presentation. (medscape.com)
  • C acnes cardiovascular device-related infections typically have a subtle presentation that can include low-grade fever, weight loss, malaise, and myalgias. (medscape.com)
  • They typically are only recommended when a persons hemoglobin fall below 70-80 mg/dL.One may consider transfusion for people with symptoms of cardiovascular disease such as chest pain or shortness of breath. (blogspot.com)
  • Haemovigilance (HV) comprises surveillance procedures covering the whole transfusion chain from collection of blood (components) to follow-up of its recipients. (isbtweb.org)
  • Use of hemovigilance data to evaluate the effectiveness of diversion and bacterial detection. (nih.gov)
  • Bacterial detection was implemented in March 2003 for apheresis PLTs and February 2005 for whole blood-derived PLTs (WBDPs). (nih.gov)
  • Incidence of bloodstream infections and predictive value of qualitative and quantitative skin cultures of patients with overlap syndrome or toxic epidermal necrolysis: A retrospective observational cohort study of 98 cases. (nih.gov)
  • Platelet transfusion practices among neonatologists in the United States and Canada: results of a survey. (jamanetwork.com)
  • Platelet transfusions in neonates: practices in the United States vary significantly from those in Austria, Germany, and Switzerland. (jamanetwork.com)
  • The research group is also involved in a major Quality Management Project funded through the Ontario Ministry of Health and Long Term Care to develop quality essential tools that can be used to ensure standardization and optimal transfusion practices within the hospital setting. (traqprogram.ca)
  • This group combines both quantitative and qualitative methodological techniques to address a wide variety of transfusion-related questions to provide a bench-to-bedside evidence-based approach to transfusion medicine practice. (traqprogram.ca)
  • Patients frequently develop high fever (temperatures as high as 109°F have been observed) and chills during or immediately following transfusion. (asm.org)
  • While this experiment proved an interesting physiologic principle, a study looking at a more diverse group of patients who underwent surgical procedures but refused transfusion support due to religious reasons began to show an increase in 30-day mortality in patients whose hemoglobin nadir was less than 7 g/dL. (renalandurologynews.com)
  • Patients in the liberal transfusion strategy group were transfused when their hemoglobin fell below 10 g/dL. (renalandurologynews.com)
  • Outside of the perioperative setting, good data from a multicenter randomized controlled trial (Transfusion Requirements in Critical Care or the TRICC trial) exists that critically ill patients transfused when their hemoglobin drops below 10 have no better outcomes than patients transfused only when their hemoglobin levels drops below 7 g/dL. (renalandurologynews.com)
  • The numbers of days on which a transfusion was ordered among the days on which patients had PCTs within that range are given in the Platelet Transfusions subsection of the Results section of the text. (jamanetwork.com)
  • Platelet transfusions in the neonatal intensive care unit: factors predicting which patients will require multiple transfusions. (jamanetwork.com)
  • Garcia MG, Duenas E, Sola MC, Hutson AD, Theriaque D, Christensen RD. Epidemiologic and outcome studies of patients who received platelet transfusions in the neonatal intensive care unit. (jamanetwork.com)
  • [ 1 ] In a review performed by Millett et al on 10 patients presenting with pain (average age, 57 y) with C acnes following shoulder surgery, it was found that at the time of confirmation of the diagnosis, clinical signs of infection were absent. (medscape.com)
  • C acnes has been implicated in infections following rotator cuff repair, as well as an outbreak of postoperative shoulder infections linked to a ventilation system. (medscape.com)
  • However, a number of transfusion safety measures have been implemented to achieve this level of safety, despite relatively poor cost-effectiveness, in order to assuage the public's fears ( 32 ). (asm.org)
  • For many years she was the Manager of the Transfusion Service at McMaster Medical Centre Medical Centre in Hamilton and in 1999 was appointed as the Manager of Transfusion Medicine for the Hamilton Regional Laboratory Medicine Program.In 2001, Nancy took on a new challenge as the Director of the Transfusion Research Program at McMaster University. (traqprogram.ca)