Transfusion of platelets. Medical search. Frequent questions

Despite prophylactic platelet transfusions, people with blood cancers often bleed, and other risk factors for bleeding such as inflammation and duration of thrombocytopenia should be considered. (wikipedia.org)
Several studies have now assessed the benefit of using preventive platelet transfusions in adults with dengue who have profound thrombocytopenia (platelet count (wikipedia.org)
The [original] guideline recognized the important role of platelet transfusion in the prevention and treatment of bleeding in patients with treatment-related thrombocytopenia but also sought to avoid the overuse of platelet transfusions by identifying patients who are most likely to benefit," guideline panel chair Charles A. Schiffer, MD, of Wayne State University in Detroit, and co-authors said in the introduction to the updated guideline. (medpagetoday.com)
Thrombocytopenia, bleeding, and use of platelet transfusions in sick neonates. (ox.ac.uk)
Platelet transfusions are used commonly as prophylaxis in premature neonates with thrombocytopenia. (ox.ac.uk)
Immune thrombocytopenia (ITP) is a type of platelet disorder . (nih.gov)
Platelet transfusion is commonly used to prevent or treat bleeding in people with thrombocytopenia or platelet dysfunction. (atlasofscience.org)
We concluded that thrombocytopenia was common after ECC, maximum drop of the platelet counts after ECC was usually seen on the second day after ECC, and platelet counts started to recover on the fifth day after ECC. (nature.com)
This study is investigating the safety and efficacy of platelet transfusion as a treatment for infants with thrombocytopenia. (nih.gov)
This study investigates immature platelet counts as a marker for bleeding risk in newborns with thrombocytopenia, compared with platelet counts alone. (nih.gov)
Platelet transfusion, as the primary treatment for severely low platelet count (thrombocytopenia) or disorders of platelet function, is used extensively in patients with blood system diseases or active hemorrhaging. (blood-genomics.com)
We suggest that the anti-HIV-1gp120 antiidiotype-like complex contributes to the markedly elevated platelet Ig and C3 level of HIV-1-ITP patients and propose that this may contribute to their thrombocytopenia. (jci.org)
A low platelet count is called thrombocytopenia. (healthline.com)
Whether or not you experience symptoms of thrombocytopenia may depend on how low your platelet count is. (healthline.com)
Platelets live about 7-10 days in people without thrombocytopenia. (healthline.com)
Although parturients, a cohort of patients that often receives neuraxial anesthesia, are generally in a hypercoagulable state, certain conditions of pregnancy (eg, gestational thrombocytopenia, HELLP [hemolysis, elevated liver enzymes, low platelets] syndrome, and complications of preeclampsia) can increase the incidence of epidural hematoma. (medscape.com)

Patient A. In October 2004, a man aged 74 years in Ohio with leukemia received a transfusion consisting of a pool of five platelet unit concentrates. (cdc.gov)
Fresh whole blood has long been thought of as the criterion standard for transfusion, but the advent of whole blood fractionation techniques subsequent to World War II provided a means of more efficient use of the various components (i.e., packed red blood cells [PRBCs], fresh frozen plasma [FFP], individual factor concentrates, platelet concentrates, cryoprecipitate). (medscape.com)
Among transfusable blood products, however, platelet concentrates (PCs), which also contain plasma, have a higher frequency of transfusion reactions than red blood cells or fresh frozen plasma. (atlasofscience.org)
Platelet concentrates were divided equally into CSP (stored at 4°C ± 2°C) and RTP (stored at 22°C ± 2°C) fractions. (bvsalud.org)
Platelet concentrates (PCs) are blood components transfused in thrombocytopenic patients, including patients with blood malignancies. (phcogj.com)
1 recently published in Haematologica, evaluating the structural and functional consequences induced by Amotosalen/UVA treatment using the Intercept Blood System (IBS) on platelets from apheresis platelet concentrates (PCs) during storage. (haematologica.org)

Higher platelet transfusion thresholds have been used in premature neonates, but this has been based on limited evidence. (wikipedia.org)
However, there is widespread variation in the pretransfusion thresholds for platelet count and evidence of marked disparities in platelet transfusion practice between hospitals and countries. (ox.ac.uk)
Unlike other patient groups, specifically patients with hematological malignancies, there have been no recent clinical trials undertaken comparing different thresholds for platelet transfusion in premature neonates. (ox.ac.uk)
This project exists within a greater evidenced based initiative in which guidelines detailing thresholds to transfuse platelets will be implemented into practice. (hope.edu)
Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in patients with haematological disorders after chemotherapy or stem cell transplantation. (ox.ac.uk)
The objectives are as follows: To determine whether different platelet transfusion thresholds for administration of prophylactic platelet transfusions (platelet transfusions given to prevent bleeding) affect the efficacy and safety of prophylactic platelet transfusions in preventing bleeding in patients with haematological disorders after chemotherapy with or without stem cell transplantation. (ox.ac.uk)

A review in people with blood cancers compared different platelet transfusion doses. (wikipedia.org)
this review compares different platelet transfusion doses. (ox.ac.uk)

Genotyping confirmed HEV in a transfused platelet pool and the donor. (cdc.gov)
TA-GVHD is a condition in which donor T-cells mount an immune response against the transfusion recipient's lymphoid tissue. (businesswire.com)
The requisite documentation for platelet product reservation or donor recruitment is then autogenerated using institutional form templates. (posit.co)
Consequently, patients can be unnecessarily exposed to foreign antigens or infection, the donor platelet supply could be depleted, and organizations may experience unnecessary costs. (hope.edu)
Key Message: In the near future, high-throughput testing of donor genomes via precision transfusion medicine arrays and metabolomics of all donated products will be able to inform the development and implementation of machine learning strategies. (karger.com)
Schedule an appointment to donate blood or platelets using the Red Cross Blood Donor App , visiting redcrossblood.org , or calling 1-800-RED CROSS (1-800-733-2767). (redcross.org)
We report a successful ABO-incompatible living donor liver transplantation in a patient with hepatitis B virus-related liver cirrhosis and hepatocellular carcinoma who had a history of platelet transfusion-related anaphylaxis. (peertechzpublications.org)
Ensure that regulatory agencies and blood transfusion services have clear guidelines and standards for donor screening, testing, and quality control. (researchgate.net)

Researchers are looking at the positive effects of platelet transfusion against the negative effects, such as the release of inflammatory molecules and the formation of blood clots. (nih.gov)

The role of platelet transfusions in neonates is more controversial. (ox.ac.uk)

Data from randomized, controlled trials showed that initiating platelet transfusion at the first sign of bleeding showed similar rates of bleeding with reduced platelet usage, as compared with prophylactic platelet transfusion, authors of the updated guideline wrote in the Journal of Clinical Oncology . (medpagetoday.com)
Development of a web-based clinical decision support application for platelet transfusion management using R and the Tidyverse Blood product transfusion is a high risk and costly medical procedure. (posit.co)
Proper management of platelet transfusions is essential to clinical care, particularly for patients who have developed antibodies against specific platelet types due to pregnancy or past transfusions. (posit.co)
The team has recently participated in two clinical trials, under the Transfusion Medicine/Hemastasis Clinical Trial Network sponsored by NHLBI, identifying and recruiting eligible patients. (jhu.edu)
Plasma is considered to be candidates for the cause of transfusion reactions and removal of plasma in PCs by washing (Fig. 1) effectively reduces transfusion reactions by some clinical studies. (atlasofscience.org)
Clinical preventative effects by WPCs were achieved in 99.8% of the transfusions, and the recurrent transfusion reactions by WPCs were confirmed in only 2 of 1,206 transfusions. (atlasofscience.org)
this was considered to be a high value compared with the transfusion threshold of clinical guidelines. (atlasofscience.org)
Platelet aggregometry is a standard clinical technique that measures the in vitro aggregability of platelets in response to agonists by using the amount of light transmitted through platelet-rich plasma (PRP) ( Holmsen, 1987 ). (nature.com)
BACKGROUND: Platelet transfusions are used in modern clinical practice to prevent and treat bleeding in people who are thrombocytopenic due to bone marrow failure. (ox.ac.uk)
In the clinical application of platelet transfusion, there are large differences between the treatment's effects on different patients. (blood-genomics.com)
Platelets used in clinical therapy include platelets made from whole blood and hemapheresis platelets, and the latter is the main application type used in China. (blood-genomics.com)
STUDY DESIGN AND METHODS: From April 1999 to December 2009, we retrospectively reviewed the clinical and transfusion records of all D- patients who received PLT transfusions from D+ donors at our hospital. (notifylibrary.org)

Different doses of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation. (ox.ac.uk)

PLTVXM queries information on available/pending platelet inventory (and eligible donors) from reports that run in our institutional reporting tool Tableau® via a Tableau Server REST API. (posit.co)
The retrieved data is processed by a published algorithm implemented in R and incorporates user input to present sortable tables of patient-specific compatible platelet inventory (and donors) for consideration. (posit.co)
COVID-19 has had major implications for patients who need blood transfusions, blood donors, and the transfusion services and hospitals that manage transfusions. (blood.ca)
During Trauma Awareness Month in May, the Red Cross urges eligible blood and platelet donors to roll up a sleeve on behalf of those in need. (redcross.org)
The Red Cross salutes the heroes who donate blood or platelets on a regular basis to ensure a readily available supply, including donors like 19-year-old Felix Lilly of Portland, Ore. (redcross.org)
Platelets must be transfused within just five days after donation - so there is a constant, often critical, need for new and current donors to give to keep up with hospital demand. (redcross.org)
Blood donors and their donated blood are rigorously screened, and so the frequency of disease transmission through transfusion is low, although tragically marred by recent scandals in the 1980s when strict screening and testing for infectious agents was less common. (nhsbt.nhs.uk)
Platelet transfusions from D+ donors to D- patients: a 10-year follow-up study of 1014 patients. (notifylibrary.org)
BACKGROUND: Current guidelines recommend that platelets (PLTs) from D- donors should be given to D- patients. (notifylibrary.org)
We thus decided to extend these findings by examining anti-D alloimmunization at our institution, where PLT transfusions from D+ donors are transfused to D- patients because of logistic constraints. (notifylibrary.org)
RhIG was not administered after the transfusion of PCs from D+ donors. (notifylibrary.org)
RESULTS: Our series comprises 1014 D- patients who received 5128 PLT transfusions from D+ donors (89% were pooled PCs). (notifylibrary.org)
Avoiding and monitoring transfusion-transmissible diseases (TTDs) is crucial to ensure the safety of blood transfusions and protect both donors and recipients. (researchgate.net)
With this, why is transfusion transmissible infection (TTI) such as Cytomegalovirus not routinely tested among blood donors in several countries like Nigeria? (researchgate.net)
As part of his job, he processed platelets pooled from individual donors for transfusion. (cdc.gov)
It is not known whether any of the individual platelet donors or the patient with leukemia had HTLV-III infection. (cdc.gov)
In IgA-immunized patients, blood collected from IgA-deficient donors may be preferable for transfusion. (msdmanuals.com)

He underwent an immediate splenectomy with massive transfusion: 9 packed red blood cells units, 7 fresh frozen plasma units, and 1 whole blood platelet pool. (cdc.gov)
To reduce morbidity and mortality as a result of uncontrolled hemorrhage, patients needing a massive transfusion, specifically addressed in detail later in this chapter, must be quickly identified so that immediate interventions can prevent the development of the lethal triad of coagulopathy, hypothermia, and acidosis. (medscape.com)
[ 1 ] Massive transfusion protocols (MTPs) should be institutionally monitored by a blood utilization committee that can track initiation, cessation, component wastage, storage of blood products outside of the blood bank, transport standards, and compliance with applicable Food and Drug Administration (FDA) standards. (medscape.com)
The most common situations are for patients receiving chemotherapy, requiring surgery (especially cardiac surgery) or having experienced severe haemorrhage (e.g. from pregnancy or childbirth, trauma, largely from road traffic accidents, or severe anaemia in the young, often caused by malaria), often being combined with other blood products such as fresh frozen plasma (FFP) and red blood cells (RBCs) in a massive transfusion protocol. (nhsbt.nhs.uk)

The evidence is very uncertain about the effect of platelet transfusions prior to surgery for people with a low platelet count on the all-cause mortality, the number of participants with bleeding events after surgery, serious surgery-related or transfusion-related adverse events. (wikipedia.org)
Researches on the molecular basis or the curative effect of platelet transfusion are increasing, such as the relationship between platelet-activating factors, tissue factors, thrombopoietin, membrane glycoprotein and platelet activation, and their influence on the curative effect of platelet transfusion, the inhibition of antiplatelet therapy in platelet activation, and platelet signal transduction pathways and their significance in the curative effect of platelet transfusion. (blood-genomics.com)
This article aims to review the research progress on the curative effect of platelet transfusion and its molecular mechanisms. (blood-genomics.com)

One of the review's included studies reported on transfusion reactions. (wikipedia.org)
Transfusion reactions can lead to discomfort for the patient and can even be fatal, albeit rarely. (atlasofscience.org)
WPCs were transfused to 86 patients (94.5%) due to recurrent PC-related transfusion reactions that could not be prevented by premedication with antihistamine and hydrocortisone. (atlasofscience.org)
Subgroup analysis revealed that the preventative effect was not affected by sex, disease, type, or severity of transfusion reactions. (atlasofscience.org)
WPCs were therefore safely transfused into patients with a history of severe transfusion reactions such as anaphylaxis and respiratory distress. (atlasofscience.org)
WPCs were effective for recurrent transfusion reactions in almost all transfusions. (atlasofscience.org)
Transfusion reactions were analyzed as a secondary outcome. (ox.ac.uk)
CONCLUSIONS: No differences were seen in the incremental change in platelet count nor in transfusion reactions when comparing major ABO incompatible platelet transfusions with ABO compatible transfusions in a large study of critically ill children. (ox.ac.uk)
What are transfusion reactions? (healthline.com)
Blood transfusion reactions may occur while you're receiving blood or immediately after. (healthline.com)
Transfusion reactions may range in severity from minor to life threatening. (healthline.com)
The following are the different types of transfusion reactions and what can cause them. (healthline.com)
This is one of the most common types of transfusion reactions. (healthline.com)
Anaphylaxis and severe allergic transfusion reactions (ATR) are uncommon complications after blood transfusion. (peertechzpublications.org)
Febrile nonhemolytic transfusion reaction The most common complications of transfusion are Febrile nonhemolytic reactions Chill-rigor reactions The most serious complications, which have very high mortality rates, are Acute hemolytic. (msdmanuals.com)
Decrease transfusion-related complications by using leukocyte-depleted blood products, which have been shown to decrease nonhemolytic febrile reactions, prevent alloimmunization and platelet refractoriness, and prevent cytomegalovirus transmission. (medscape.com)
Transfusion-related adverse reactions declined slightly between 2019 and 2021, although the rate of transfusion-transmitted bacterial infections remained unchanged. (cdc.gov)

As a disadvantage of WPCs, about 10%-20% of platelet loss was reported in the washing process, and this may be the cause of platelet transfusion refractoriness. (atlasofscience.org)
However, platelet values at 24 hours could be evaluated in only 36 patients, and 11 patients had risk factors for platelet transfusion refractoriness such as bleeding and infections. (atlasofscience.org)
for exchange transfusions, for patients who require cytomegalovirus-negative blood that is unavailable, and possibly for the prevention of human leukocyte antigen (HLA) alloimmunization to help prevent refractoriness to platelet transfusion (failure to achieve the target level of blood platelets after platelet transfusion). (msdmanuals.com)

There is now evidence that using a high platelet count threshold (50 x 109/L) increases the risk of death or bleeding compared to a lower platelet count threshold (25 x 109/L) in premature neonates. (wikipedia.org)
To present the recommendations and consensus statements with supporting literature for plasma and platelet transfusions in critically ill neonates and children undergoing cardiac surgery with cardiopulmonary bypass or supported by extracorporeal membrane oxygenation from the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. (nih.gov)
A panel of nine experts developed evidence-based and, when evidence was insufficient, expert-based statements for plasma and platelet transfusions in critically ill neonates and children following cardiopulmonary bypass or supported by extracorporeal membrane oxygenation. (nih.gov)
There is a need for randomized controlled trials to define the optimal use of platelet transfusions in premature neonates, who at present are transfused heavily with platelets. (ox.ac.uk)

Whereas viscoelastic testing and transfusion algorithms may be considered, in general, evidence informing indications for plasma and platelet transfusions in neonatal and pediatric patients undergoing cardiac surgery with cardiopulmonary bypass or those requiring extracorporeal membrane oxygenation support is lacking. (nih.gov)
There is no evidence of a relationship between platelet count and occurrence of major hemorrhage, and cardiorespiratory problems are considered the main etiological factors in the development of intraventricular and periventricular hemorrhage in the neonatal period. (ox.ac.uk)
FFP can supplement RBCs when whole blood is unavailable for neonatal exchange transfusion. (msdmanuals.com)

We describe HEV infection in a previously healthy man in France who received massive transfusions of blood, plas- ma, and platelets after a traumatic skiing accident. (cdc.gov)
reported recent travel to HEV endemic areas or intake of This case describes HEV infection acquired by an uncooked or poorly cooked pork or game meat in the 3 immunocompetent patient through transfusion of a con- months before the accident. (cdc.gov)
In 1971, hepatitis B surface antigen testing heralded the advent of screening to minimize infection transmission complicating allogeneic transfusion. (medscape.com)
If your ITP was caused by an infection, treating the infection may help increase your platelet count and lower your risk of bleeding problems. (nih.gov)
Features of SARS-CoV-2 infection that affect patients' needs for transfusion. (blood.ca)
Investigate and analyze any suspected transfusion-transmitted infection cases to identify the source and prevent future occurrences. (researchgate.net)

point to the importance of evidence-based transfusion practice. (medpagetoday.com)
Therefore, there is no evidence base with which to inform safe and effective practice for prophylactic platelet transfusions. (ox.ac.uk)
In spite of widespread use, data supporting specific practice paradigms for whole blood and component therapy transfusion are lacking, the notable exception being in the primary treatment of hemorrhagic shock. (medscape.com)
The objective of this project is to survey providers regarding their current practice in prophylactic, pre-procedural, and therapeutic platelet transfusions. (hope.edu)

Issuance of the interim standard would obviate the need for blood centers and hospitals to request a variance to use the INTERCEPT Blood System for platelets in place of irradiation. (businesswire.com)
The INTERCEPT Blood System is designed to reduce the risk of transfusion-transmitted infections by inactivating a broad range of pathogens such as viruses, bacteria and parasites that may be present in donated blood. (businesswire.com)
Cerus currently markets and sells the INTERCEPT Blood System for both platelets and plasma in the United States, Europe, the Commonwealth of Independent States, the Middle East and selected countries in other regions around the world. (businesswire.com)

Patient B. In December 2004, a man aged 79 years in Utah received a transfusion of pheresis platelets for thromobocytopenia after coronary artery bypass surgery. (cdc.gov)
The American Red Cross is the Institution's primary platelet supplier, providing the majority of the more than 18,000 pheresis platelets transfused each year at a cost of nearly $600 each. (jhu.edu)
Since pheresis platelets expire five days after collection, this leaves roughly three days to transfuse the product. (jhu.edu)

You also may have a blood test to check for the antibodies that attack platelets. (nih.gov)
By providing platelets that avoid a patient's known antibodies, improved patient outcomes and better inventory management of a rare blood product are achieved. (posit.co)
Immune or nonimmune factors, such as platelet-specific antibodies, platelet gene analysis and matches, and auxiliary treatment, may affect the curative effect, and even result in ineffective platelet transfusion. (blood-genomics.com)

Because the initial decrease in light transmission in platelet aggregometry is attributed to platelet shape change, it is widely held that platelet shape change is a prerequisite for platelet aggregation. (nature.com)
These results indicate that platelet shape change is not a prerequisite for aggregation and that the signal widely believed to represent shape change reflects platelet microaggregation instead. (nature.com)
We conclude that platelet aggregation occurs independently of shape change and that shape change is not necessarily followed by aggregation. (nature.com)
This study provides results of early diminished platelet function in IBS-treated PCs as compared to conventional PCs, i.e., reduced aggregation response to collagen or thrombin and adhesion to collagen or vWF under flow, increased platelet apoptosis, MAPK p38 activation, and glycoprotein Ibα (GPIbα) shedding and enhanced clearance from the circulation of mice. (haematologica.org)
We also looked at the reactivity of platelets in their storage milieu and, indeed, found there was already inhibition of platelet aggregation in response to ADP on Day 1.5, and to collagen on Day 6.5, which was, however, similar between the untreated and the IBS-PCs 2 (see Online Supplementary Figure S2B). (haematologica.org)
During the process, increased platelet aggregation and coagulation. (msdmanuals.com)

Karen Bieback Background: Red blood cells (RBCs) stored for transfusions can lyse over the course of the storage period. (karger.com)
Washed RBCs are free of almost all traces of plasma, most white blood cells, and platelets. (msdmanuals.com)
Supportive therapy, including transfusions of the cells that are deficient (ie, red blood cells [RBCs], platelets), and treatment of infections are the main treatments. (medscape.com)
Supportive care includes transfusion of RBCs or platelets. (medscape.com)
Patients with congestive heart failure may not tolerate the same degree of anemia as young patients with normal cardiac function, and slow or small-volume (eg, packed RBCs) transfusions with judicious use of diuretics should be considered. (medscape.com)

OBJECTIVES: To determine whether different doses of prophylactic platelet transfusions (platelet transfusions given to prevent bleeding) affect their efficacy and safety in preventing bleeding in people with haematological disorders undergoing myelosuppressive chemotherapy with or without haematopoietic stem cell transplantation (HSCT). (ox.ac.uk)
Bleeding disorders can also result from a problem with the number or function of platelets. (medlineplus.gov)
Although available in many countries, one third of the patients developed signs of iron overload, such as delayed or absent puberty, growth disorders, hypothyroidism, hypogonadism, bone abnormalities, cirrhosis and heart disease (main cause of death in transfusion dependent patients with TM). (scielo.br)
Bone marrow disorders, such as leukemia and lymphoma , can also affect how many platelets the body can produce. (medicalnewstoday.com)

Adults undergoing hematopoietic stem-cell transplants (HSCT) may safely delay platelet infusion until the first sign of bleeding, as opposed to prophylactic infusion, according to an updated guideline for platelet transfusion in patients with cancer. (medpagetoday.com)
In addressing a half dozen other issues posed for consideration, the panel made no substantive changes to existing recommendations for platelet transfusion for patients with cancer. (medpagetoday.com)
Platelet services are available to help ensure optimal responses to platelet transfusions in sensitized patients. (actscorp.org)
Hospitals of Karachi were flooded with dengue patients as the incursion of mosquitoes triggered the outbreak of dengue virus in the city, however unnecessary transfusion of platelets in dengue patients has been reported in the city, Geo News reported. (noor.news)
Meanwhile, it is reported that some private hospitals in the city, for the lust of money are transfusing platelets unnecessarily to dengue patients against the direction of the World Health Organisation (WHO). (noor.news)
Dr Darnaz also directed the authorities concerned that platelets be transfused to dengue patients, only if it ranges below 20 thousand or the patient starts bleeding. (noor.news)
The platelet transfusion coordinators order inventory based on projected usage, designate selected products for immunized patients, and monitor the use of all platelet products within the Institution. (jhu.edu)
The platelet transfusion coordinators provide coverage 24/7, screening requests for and assigning platelet products to patients as needed. (jhu.edu)
Approximately 3,000 different patients are transfused platelet products in this institution per year. (jhu.edu)
Patients displayed mostly hematological diseases and had a median of 48 transfusion histories. (atlasofscience.org)
This activity will focus on recommendations for plasma and platelet transfusions in patients with cirrhosis and examine strategies for optimizing platelet inventory in a hospital blood bank. (cap.org)
Patients with cirrhosis are often transfused with platelets and plasma, yet the optimal role of these blood products is often poorly understood by ordering providers. (cap.org)
This activity reviews the variety of plasma and platelet products available for transfusion, explores the role of plasma and platelet transfusion in stable, nonbleeding patients with cirrhosis, and discusses options to maintain a platelet inventory that is adequate to support their patientsâ€™ needs while minimizing wastage of unused units. (cap.org)
Describe the role of plasma and platelet transfusions in stable, nonbleeding patients with cirrhosis. (cap.org)
Our objective was to observe the effects of extracorporeal circulation (ECC) with different time on platelet count in patients undergoing cardiac surgery. (nature.com)
However, there are few studies on the effects of ECC time on platelet count in patients after cardiac surgery, especially the effects of different ECC time on postoperative platelet count has not been reported. (nature.com)
The purpose of this study was to conduct a retrospective study to observe the effects of ECC with different time on platelet count in patients undergoing cardiac surgery, so as to provide reference for improving the prognosis of patients undergoing cardiac surgery. (nature.com)
PATIENTS: Children (3 d to 16 yr old) were enrolled if they received a platelet transfusion during one of the predefined screening weeks. (ox.ac.uk)
When asked why he donates, Lilly said, "The fact that I know I'm helping save the lives of cancer patients, burn victims and anyone else who needs platelets to survive. (redcross.org)
In the absence of an iron chelating agent, patients with beta-thalassemia on regular transfusions present complications of transfusion-related iron overload. (scielo.br)
Currently there are three iron chelating agents available for continuous use in patients with thalassemia on regular transfusions (desferrioxamine, deferiprone, and deferasirox) providing good results in reducing cardiac, hepatic and endocrine toxicity. (scielo.br)
Based on this review, the authors propose an iron chelation protocol for patients with thalassemia under regular transfusions. (scielo.br)
Transfusion-dependent patients with thalassemia major(TM) develop iron overload which leads to damage of the liver, heart, and endocrine organs and related morbidity and mortality ( 1 1. (scielo.br)
Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. (scielo.br)
We had 315 (31.1%) patients who had a blood sample to analyze the presence of anti-D 4 or more weeks after the first D+ PLT transfusion with a median follow-up of 29 weeks (range, 4-718 weeks). (notifylibrary.org)
Medical teams use it in situations when patients need a transfusion but their blood type is unknown. (kidshealth.org)
Oxygen-carrying capacity may be adequate with Hb levels as low as 7 g/dL (70 g/L) in healthy patients, but transfusion may be indicated with higher Hb levels in patients with decreased cardiopulmonary reserve or ongoing bleeding. (msdmanuals.com)
Guidelines for transfusion in patients with MDS and bone marrow failure are as follows. (medscape.com)
Patients with low-risk or intermediate-1-risk MDS typically have long-term survival and may receive multiple RBC transfusions. (medscape.com)
These patients may develop transfusion-induced iron overload and can incur significant damage of the liver, heart, pancreas, and other tissues. (medscape.com)
Platelet transfusion is beneficial to stop active bleeding in thrombocytopenic patients, but the life span for transfused platelets is only 3-7 days. (medscape.com)

The threshold for transfusing platelets in the pediatric hematology/oncology population is not standardized, resulting in potentially inappropriate transfusions. (hope.edu)

July 2020) that helps address the challenge of information overload by synthesizing expert opinion on the supply and use of blood for transfusion during the pandemic. (blood.ca)
Transfusion;60 Suppl 3: S119-S123, 2020 06. (bvsalud.org)
Title : Impact of the COVID-19 pandemic on blood donation and transfusions in the United States in 2020 Personal Author(s) : Basavaraju, Sridhar V.;Free, Rebecca J.;Chavez Ortiz, Joel L.;Stewart, Phylicia;Berger, James;Sapiano, Mathew R. P. (cdc.gov)

an estimated one in 1,000--3,000 platelet units are contaminated with bacteria, resulting in transfusion-associated sepsis in many recipients ( 2 ). (cdc.gov)
This report summarizes two fatal cases of transfusion-associated sepsis in platelet recipients in 2004 and describes results of a 2004 survey of infectious-disease consultants regarding their knowledge of transfusion-associated bacterial infections and the new AABB standard. (cdc.gov)
The occurrence of the acquired immunodeficiency syndrome (AIDS) in intravenous (IV) drug users, blood transfusion recipients, and persons with hemophilia indicates that parenteral transmission of human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) occurs via infectious blood or blood products (1). (cdc.gov)
Currently available practices have nearly eliminated these risks for transfusion recipients and persons with hemophilia (2,3). (cdc.gov)

Systematic review and consensus conference of international, multidisciplinary experts in platelet and plasma transfusion management of critically ill children. (nih.gov)
Compare and contrast the various types of plasma that are available for transfusion. (cap.org)
Normal blood clotting involves blood particles, called platelets, and as many as 20 different plasma proteins that layer over the platelets. (medlineplus.gov)
Type O negative red blood cells, type AB plasma and platelets play a critical role in hospitals. (redcross.org)
This analytic observational study with a cross-sectional design was carried out on PCs obtained from platelet-rich plasma (PRP-PC). (phcogj.com)
Blood transfusions are most commonly done for blood components, such as red blood cells , platelets , or plasma . (healthline.com)
Factors affecting transfusion of fresh frozen plasma, platelets, and red blood cells during elective coronary artery bypass graft surgery. (nataonline.com)
Blood contains four main components: plasma, red blood cells, white blood cells, and platelets. (medicalnewstoday.com)
Fresh frozen plasma (FFP) is an unconcentrated source of all clotting factors without platelets. (msdmanuals.com)
From 2019 to 2021, the median price hospitals paid per unit of leukoreduced red blood cells, leukoreduced and pathogen-reduced apheresis platelets, and fresh frozen plasma increased. (cdc.gov)

Platelet transfusion, also known as platelet concentrate, is used to prevent or treat bleeding in people with either a low platelet count or poor platelet function. (wikipedia.org)

To reduce this risk, AABB (formerly the American Association of Blood Banks) adopted a new standard on March 1, 2004, that requires member blood banks and transfusion services to implement measures to detect and limit bacterial contamination in all platelet components ( 3 ). (cdc.gov)
Before transfusion, the pooled platelet unit had been tested for bacterial contamination with a reagent strip test (Multistix ® , Bayer Diagnostics, Tarrytown, New York) to determine the pH level, a means for detecting the presence of bacteria. (cdc.gov)
Before transfusion, platelets from the unit bag were tested for bacterial contamination with liquid culture media (BacT/Alert ® , BioMerieux Inc., Durham, North Carolina) by using 4 mL in a standard aerobic blood culture bottle and were found to be negative after 5 days' incubation. (cdc.gov)
A total of 143 (36%) respondents reported they were aware that bacterial contamination of platelets is one of the most common infectious risks of transfusion therapy. (cdc.gov)
We have also participated in national meetings and have authored a paper related to bacterial contamination of platelet products that will be published in December 2009. (jhu.edu)

Effects of ABO Matching of Platelet Transfusions in Critically Ill Children. (ox.ac.uk)
OBJECTIVES: To determine if transfusing ABO compatible platelets has a greater effect on incremental change in platelet count as compared to ABO incompatible platelets in critically ill children. (ox.ac.uk)
Studies in larger, prospectively enrolled cohorts should be performed to validate whether ABO matching for platelet transfusions in critically ill children is necessary. (ox.ac.uk)

With the extension of ECC time, the drop in platelet counts is more pronounced, the volume of perioperative blood loss and blood products transfusion are more, and the recovery level and speed of platelet counts is lower. (nature.com)

isolates from the patient's blood and the platelet bag were indistinguishable by pulsed-field gel electrophoresis (PFGE). (cdc.gov)
A primary responsibility of the Service is to monitor correct use of platelet products in order to keep outdating to a minimum, while maintaining an inventory that can support patient's needs yet respond to unexpected emergencies. (jhu.edu)

Some versions of platelets have had the white blood cells partially removed or been gamma irradiated which have specific benefits for certain populations. (wikipedia.org)
Opinions are embraced and defended, but transfusion of red blood cells has not reliably demonstrated increased survival, other than in 2 specific populations, as follows: (1) those with active hemorrhage, and (2) those with active cardiac ischemia. (medscape.com)
Platelets are tiny blood cells that are made in the bone marrow. (nih.gov)
This test measures your platelet count and the number of other blood cells in your blood. (nih.gov)
Platelets (blood cells that initiate clotting) are a rare and expensive blood product with a short shelf life. (posit.co)
There have been no major advances to improve the storage of platelets beyond 7 days, compared with 35-40 days for red blood cells, making these a comparatively perishable blood product. (nhsbt.nhs.uk)
Platelets , the smallest blood cells, help to clot the blood and control bleeding. (kidshealth.org)
So some people getting treatment for cancer might need a transfusion of red blood cells or platelets. (kidshealth.org)

Platelet increase 24 hours after WPC transfusion was observed at a median of 3.5 (range, −13 to 53.6) × 10 9 /L, lower than those reported in previous studies. (atlasofscience.org)
the median (interquartile range) change for ABO-identical transfusions was 28 × 10 cells/L (8-68 × 10 cells/L), for transfusions with major incompatibility 26 × 10 cells/L (7-74 × 10 cells/L), and for transfusions with minor incompatibility 54 × 10 cells/L (14-81 × 10 cells/L) (p = 0.37). (ox.ac.uk)

When your skin is injured or broken , your platelets clump together and form clots to stop the bleeding . (healthline.com)
Platelets are small cells that clump together and help blood clot. (medicalnewstoday.com)

There is little evidence for the use of preventive platelet transfusions in people with chronic bone marrow failure, such as myelodysplasia or aplastic anemia. (wikipedia.org)

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation-bringing clarity and insight to an increasingly complex healthcare future. (blood.ca)

Platelets can be produced either from whole blood or by apheresis. (wikipedia.org)
The aim of this study was to confirm the effects of short-term refrigeration in platelets from apheresis-derived. (karger.com)
The largest increase in price per unit of blood component in 2021 was for leukoreduced apheresis platelets, which increased by ~$51. (cdc.gov)

Bacterial infections are relatively more common with platelets as they are stored at warmer temperatures. (wikipedia.org)
However, health-care providers also should be able to diagnose transfusion-associated infections, because even when testing complies with the new standard, false negatives can occur and fatal bacterial sepsis can result. (cdc.gov)
To assess clinician experience with transfusion-associated bacterial infections and knowledge of the new AABB standard, the Infectious Diseases Society of America (ISDA) conducted a survey of infectious-disease consultants in the United States. (cdc.gov)
Report all cases of transfusion-transmitted infections promptly to the relevant public health authorities. (researchgate.net)
In accordance with the research titled 'Transfusion Services in Tropical Africa: Challenges and Prospects from the Nigerian Perspective' conducted by Sagir Gumel Ahmed in 2022, unlike other routinely tested transfusion transmissible infections such as HIV, & hepatitis B and C viruses, Cytomegalovirus is said to be highly contagious and prevalent especially in developing countries such as Nigeria. (researchgate.net)
Conversely, comparable levels of availability, safety and quality do not yet exist in most developing countries, which still face serious blood shortages and the fact that the risk associated with transfusion-transmissible infections has not yet been eliminated, particularly in countries where the prevalence and incidence of those infections are high. (who.int)

CONCORD, Calif.--( BUSINESS WIRE )--Cerus Corporation (NASDAQ:CERS) announced today that AABB has granted the first requests of U.S. blood centers and hospitals to use INTERCEPT pathogen reduction in place of irradiation to satisfy AABB's requirement to reduce the risk of transfusion-associated graft versus host disease (TA-GVHD). (businesswire.com)
Director Sindh Blood Transfusion Authority, Dr Darnaz Jamal reacted to the situation and said, "Private hospitals are transfusing platelets unnecessary just for money. (noor.news)
By sharing experience and developing expert consensus, their study can help transfusion services and hospitals in Canada and around the world as they grapple with local and national challenges at different stages of the pandemic. (blood.ca)
The prices hospitals paid for most blood products increased, as did the use of pathogen-reduced platelets. (cdc.gov)

Does your infant have a low platelet count? (nih.gov)

The preserved reactivity of IBS-platelets was further confirmed in perfusion studies over adhesive protein-coated surfaces under relevant shear rates, in accordance with previously reported results. (haematologica.org)

Active hemorrhage resulting in shock is one of the few evidence-based established indications for transfusion. (medscape.com)
Further studies are needed to evaluate both transfusion efficacy and healthcare cost of WPCs, and preparation of guidelines for WPC indications and contraindications is desirable. (atlasofscience.org)

International guidelines recommend that platelets transfusions are given to people with reversible bone marrow failure to reduce the risk of spontaneous bleeding when the platelet count is less than 10 x 109/L. If the person is well using a higher platelet count threshold does not reduce the risk of bleeding further. (wikipedia.org)
Multiple guidelines recommend prophylactic platelet transfusions are not used routinely in people with chronic bone marrow failure, and instead an individualised approach should be taken. (wikipedia.org)

Some people have low platelet counts due to genetic factors. (medicalnewstoday.com)
Low platelet counts affect close to 10% of pregnant people at the time of birth. (medicalnewstoday.com)

Platelet transfusions are biological agents and as such are associated with risks. (ox.ac.uk)
A doctor or nurse will explain any risks of blood transfusions and closely monitor you while receiving the blood. (healthline.com)
Are There Any Risks to Blood Transfusions? (kidshealth.org)

Other modes of transmission for dengue virus are less common but include vertical transmission from a mother to a baby, blood transfusion or organ transplantation, needle stick, mucocutaneous exposure, or hospital or laboratory accidents, breast milk, and rarely, sexual transmission. (cdc.gov)

It is often given at the same time as the RBC transfusion, which is ineffective. (medscape.com)

A review in people with blood cancers receiving intensive chemotherapy or a stem cell transplant found that overall giving platelet transfusions when the platelet count is less than 10 x 109/L reduced the number of bleeding events and days with significant bleeding. (wikipedia.org)
Two reviews in people with blood cancers receiving intensive chemotherapy or a stem cell transplant found that overall giving platelet transfusions when the platelet count is less than 10 x 109/L compared to giving platelet transfusions when the platelet count is less than 20 or 30 x 109/L had no effect on the risk of bleeding. (wikipedia.org)
In people with a low platelet count, prophylactic platelet transfusions do not need to be given prior to procedures that have a low risk of causing bleeding. (wikipedia.org)
Guidelines recommend that it is safe to perform central venous catheter insertion when the platelet count is 20 x 109/L or above. (wikipedia.org)
The evidence for this is based on observational studies in which bleeding occurred due to procedure error rather than due to the platelet count. (wikipedia.org)
In ITP, your blood does not clot as it should, because you have a low platelet count. (nih.gov)
When you have a low platelet count, you may have trouble stopping bleeding. (nih.gov)
Most people who have chronic ITP can stop treatment at some point and maintain a safe platelet count. (nih.gov)
Treatment depends on your platelet count and whether you have any symptoms. (nih.gov)
In mild cases, you may not need any treatment, and your provider will monitor your condition to make sure that your platelet count does not become too low. (nih.gov)
Primary outcome was the platelet count before operation (T 1 ), at the end of operation (T 2 ), on the first day (T 3 ), the second day (T 4 ) and the fifth day after operation (T 5 ). (nature.com)
To participate in this study, your child must be younger than 6 months old and have a low platelet count (less than 100 × 109/L). This study takes place in Boston, Massachusetts. (nih.gov)
To participate in this study, you must have a newborn who is less than 32 weeks' gestational age, has a birth weight greater than 500 grams, and has a platelet count less than 100 × 109/L. This study takes place in multiple locations in the United States, the Netherlands, and Sweden. (nih.gov)
The primary outcome was the incremental change in platelet count. (ox.ac.uk)
Having a low platelet count can affect your blood's ability to clot. (healthline.com)
What is a low platelet count? (healthline.com)
What are the symptoms of a low platelet count? (healthline.com)
Talk to a healthcare professional if you have a low platelet count and experience headaches or neurological problems. (healthline.com)
What are the causes of a low platelet count? (healthline.com)
A low platelet count can be a result of the body destroying too many platelets too quickly. (healthline.com)
If you think you may be experiencing symptoms of low platelet count, talk to a healthcare professional - especially if you're experiencing serious symptoms, such as wounds or cuts that won't stop bleeding, or blood in your stools or urine. (healthline.com)
How is a low platelet count diagnosed? (healthline.com)
If your doctor suspects a low platelet count, they will first do a physical exam. (healthline.com)
Your doctor will check your body for unusual bruising or evidence of petechiae (small red and purple dots), which is a sign of capillary bleeding that often accompanies a low platelet count. (healthline.com)
If you are diagnosed with low platelet count, this information can help your healthcare professional treat your condition effectively. (healthline.com)
A doctor can diagnose thin blood by looking at platelet numbers in a complete blood count or CBC. (medicalnewstoday.com)
However, sometimes treating the underlying cause may not change the platelet count, and the blood will remain thin. (medicalnewstoday.com)

Within the Johns Hopkins Hemapheresis and Transfusion Service (commonly referred to as "HATS"), a specialized team of nine people, known as the Platelet Transfusion Service, manages the Institution's pheresis platelet inventory and relevant patient data. (jhu.edu)

They maintain transfusion reaction files, transfusion protocols, and transfusion histories for each patient being followed by the Service. (jhu.edu)
There were also no differences observed between the groups for any transfusion reaction (p = 0.07). (ox.ac.uk)
If the blood type is not a match, you can experience a transfusion reaction. (healthline.com)
You can also have a transfusion reaction if you receive blood containing infectious microbes, if you experience an allergic reaction, or if you receive too much blood. (healthline.com)
This article will discuss the various transfusion reaction types, symptoms, and treatments. (healthline.com)
Also known as a hemolytic transfusion reaction, this routine procedure adds donated blood to your own as long as it's accurately matched to your blood type . (healthline.com)
This is called a delayed transfusion reaction. (healthline.com)
As always, the first step in managing a transfusion reaction is to stop the transfusion. (healthline.com)
The prevalence of an acute hemolytic reaction from a blood transfusion is approximately 1 in 70,000 transfusions . (healthline.com)
You can have an allergic reaction to a blood transfusion as well. (healthline.com)
This type of transfusion reaction could also progress into a more severe allergic reaction known as anaphylaxis . (healthline.com)

A blood transfusion is when a donor's blood is given to a patient. (kidshealth.org)

The review added to evidence from two systematic reviews conducted in 2015 by the AABB (formerly the American Association of Blood Banks ) and the International Collaboration for Transfusion Medicine Guidelines . (medpagetoday.com)
However, it is anticipated that results will be used to direct the development of evidenced-based guidelines focused on platelet transfusion practices. (hope.edu)

This study's authors suggested that a high-dose platelet transfusion strategy may lead to a higher rate of transfusion-related adverse events. (wikipedia.org)

Anatomy12

Organisms5

Diseases49

Chemicals and Drugs86

Analytical, Diagnostic and Therapeutic Techniques and Equipment68

Phenomena and Processes36

Disciplines and Occupations1

Technology, Industry, Agriculture1

Humanities1

Information Science2

Named Groups4

Health Care19

Thrombocytopenia16

Concentrates6

Thresholds6

Different platelet transfusion doses2

Donor8

Effects of platelet transfusion1

Role of platelet1

Clinical12

Prophylactic platelet transfusion1

Donors17

Massive transfusion4

Effect of platelet3

Reactions17

Refractoriness3

Neonates4

Neonatal3

Infection6

Practice4

INTERCEPT Blood System3

Pheresis platelets3

Antibodies3

Aggregation6

RBCs5

Disorders4

Patients31

Hematology1

20203

Recipients4

Plasma10

Poor platelet1

Bacterial contamination5

Critically ill children3

Perioperative blood loss1

Patient's2

Blood cells8

Median2

Clump together2

Aplastic anemia1

Therapy1

Apheresis3

Infections6

Hospitals4

Infant1

Reactivity1

Indications2

Bone marrow failure2

Counts2

Risks3

Dengue virus1

Ineffective1

Count27

Commonly1

Reaction11

Donor's blood1

Guidelines2

Adverse1