Transforming growth factor alpha. Medical search. Frequent questions

In this patient, the lesions of the cutaneous paraneoplastic syndrome were stimulated by the epidermal growth factor receptor. (medscape.com)
[ 12 ] Increased epidermal staining for the epidermal growth factor receptor was initially noted in skin specimens of acanthosis nigricans, seborrheic keratoses, and cutaneous papillomas. (medscape.com)
This process occurs through negative regulation of epidermal growth factor receptor (EGFR) signaling in mammary stroma. (muni.cz)
MA5-14485 targets Epidermal Growth Factor Receptor in IHC (P) applications and shows reactivity with Human samples. (thermofisher.com)
EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. (thermofisher.com)

ProTGF-alpha cleavage is activated in response to tumor-promoting phorbol ester or to calcium ionophore. (nih.gov)
The author examined expression of tumor-related antigens, such as p53 tumor supressor protein, c-myc, TGF-alpha, and TGF-beta proteins in 75 cases of surgically resected epithelial ovarian tumors. (koreamed.org)
These 3 paraneoplastic syndromes are probably directly induced by their underlying neoplasms, most likely by means of a tumor-secreted growth factor. (medscape.com)
Florid cutaneous papillomatosis may be due to a tumor-secreted growth factor, although, to the author's knowledge, none has been identified (see Pathophysiology in Overview ). (medscape.com)
A 45-kilodalton protein heregulin-alpha (HRG-alpha) that specifically induced phosphorylation of p185erbB2 was purified from the conditioned medium of a human breast tumor cell line. (embl.de)
Cytokines secreted by adipocytes, such as tumor necrosis factor-α, transforming growth factor-β, and interleukin-6, are implicated in NAFLD. (wjgnet.com)
Cancer is a complex genetic disease caused by abnormal alteration (mutations) in DNA sequences that leads to dyregulation of normal cellular processes thereby driving tumor growth. (intechopen.com)
Meta-analysis of association of tumor necrosis factor alpha and transforming growth factor beta gene polymorphisms with pneumoconiosis]. (cdc.gov)
Association between tumor necrosis factor-a 308G/A gene polymorphism and silicosis susceptibility: a meta-analysis. (cdc.gov)
Among the growth regulators are cytokines and hepatic growth factors (eg, epithelial growth factor, hepatocyte growth factor, transforming growth factor-alpha, tumor necrosis factor). (msdmanuals.com)

Heparin is a potent modulator of receptor binding of growth factors such as fibroblast growth factor (FGF), vascular endothelial growth factor, and heparin-binding epidermal growth factor (HB-EGF), that play a role in wound repair. (rhumbarlv.com)
Among these factors are epidermal growth factor, transforming growth factor alpha, heparin-binding epidermal growth factor, and keratinocyte growth factor. (dentistryiq.com)

Small amounts of C3b are constantly being formed in the circulation, which are inactivated by factors H and I. The binding of C3b to a foreign antigen decreases its affinity for factor H and allows for the formation of increasing amounts of the alternate pathway convertase. (medscape.com)
CIGB-247 is a cancer therapeutic vaccine that uses as antigen a variant of human vascular endothelial growth factor (VEGF) mixed with the bacterial-derived adjuvant VSSP. (researchsquare.com)

Other cytokines including tumour necrosis factor alpha, transforming growth factor beta 1, interleukin 1 and interleukin 6 have no inhibitory effect. (microbiologyresearch.org)
Among the important functions of the clot are its role as a reservoir of growth factors and cytokines that are released by the degranulation of activated platelets. (dentistryiq.com)
The growth factors and cytokines present in the fibrin clot provide some of the start signals for wound repair. (dentistryiq.com)
Macrophages continue cleansing the wound and releasing cytokines and growth factors. (dentistryiq.com)
It is a reservoir of cytokines and growth factors, as well as signaling molecules, mitogens, and chemotactic factors. (dentistryiq.com)
Proteases and in particular neutrophil elastase could act as regulatory factors in the generation of soluble cytokines with mitogenic activity for mesenchymal cells resulting either in emphysema or in fibrosis or both. (biomedcentral.com)

MIP-1 alpha enhances interleukin-3 (IL-3)/and granulocyte-macrophage colony-stimulating factor (GM-CSF)/induced colony formation of normal bone marrow progenitor cells (BMC) and lineage-negative (Lin-) progenitors, but has no effect on G-CSF or CSF-1/induced colony formation. (ox.ac.uk)
Park, B.H. Interleukin-1 alpha mediates the growth proliferative effects of transforming growth factor-beta in p21 null MCF-10A human mammary epithelial cells. (hopkinsmedicine.org)
The synthesis of specific extracellular matrix molecules by fibroblasts in the wound is regulated by transforming growth factor-b1 and other factors such as insulin-like growth factor, interleukin 1a and 1b, interleukin-4, and vascular endothelial growth factor. (dentistryiq.com)

Requirement of vanadate, an inhibitor for protein phosphatases, for activation of the enzyme in this system suggests that phosphorylation-dephosphorylation probably plays a key role in the regulated cleavage of proTGF-alpha. (nih.gov)
The Anti-Transforming Growth Factor Alpha (TGFa) is a α- or alpha protein sometimes glycoprotein present in blood.This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. (tgf-a.com)
Saliva plays a key role in the homeostasis of the digestive tract, through its inorganic components and its protein growth factors. (bjorl.org)
Distinct and overlapping direct effects of macrophage inflammatory protein-1 alpha and transforming growth factor beta on hematopoietic progenitor/stem cell growth. (ox.ac.uk)
Both transforming growth factor beta (TGF beta) and macrophage inflammatory protein 1 alpha (MIP-1 alpha) have been shown to be multifunctional regulators of hematopoiesis that can either inhibit or enhance the growth of hematopoietic progenitor cells (HPC). (ox.ac.uk)
Transforming growth factor alpha (TGF-α) is a protein that in humans is encoded by the TGFA gene. (rhumbarlv.com)
The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions. (embl.de)

Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells. (uchicago.edu)
Thus, TGF α is a likely autocrine growth factor in breast cancer. (rhumbarlv.com)

Furthermore, MIP-1 alpha has no effect on high proliferative potential colony-forming cells 1 or 2 (HPP-CFC/1 or /2) colony formation in vitro, whereas TGF beta inhibits both HPP-CFC/1 and HPP-CFC/2. (ox.ac.uk)

Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. (tgf-a.com)
Since keratinocyte differentiation inhibits keratinocyte proliferation, factors that promote keratinocyte proliferation should be considered as preventing differentiation. (wikipedia.org)
TGF-α is a member of the epidermal growth factor (EGF) family, and is important in the control of glial and Schwann cell proliferation and survival of differentiated neurons. (rhumbarlv.com)
Transforming growth factors have a wide range of biological activities related to cell proliferation and differentiation. (rhumbarlv.com)
In general TGF-alpha promotes cell proliferation while TGF-beta may stimulate or inhibit proliferation depending on the cell type and growth factor environment. (rhumbarlv.com)
1-5 Accumulated knowledge in the past decade has demonstrated the importance of tear components such as epidermal growth factor (EGF) and vitamin A in the regulation of proliferation, differentiation, and maturation of the ocular surface epithelium. (bmj.com)
Several growth factors seem to be key players in regulating the proliferation of keratinocytes in healing wounds. (dentistryiq.com)
EGFR activation signals multiple downstream signaling cascades such as the Ras - ERK, PI3-K - Akt, Jak - STAT and PKC pathways that help in growth and proliferation of cells. (thermofisher.com)

Freeze thaw will destroy a percentage in every cycle and should be avoided.Antibody for research use.Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. (tgf-a.com)
Factors promoting keratinocyte differentiation are: A calcium gradient, with the lowest concentration in the stratum basale and increasing concentrations until the outer stratum granulosum, where it reaches its maximum. (wikipedia.org)
Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)
EGF-like domains in extracellular matrix proteins: localized signals for growth and differentiation? (embl.de)
Stimulates growth and differentiation of various connective tissue, including bone and cartilage, and is crucial for wound healing, gut healing, as well as DNA synthesis and repair. (heartandsoil.co)
Crucial for thymus gland support (command center for immune defense), growth and differentiation of B lymphocytes, and modulating the immune response. (heartandsoil.co)

pNR-2/pS2 immunohistochemical staining in breast cancer: correlation with prognostic factors and endocrine response. (xenbase.org)
Lungs from each experimental group were used for the immunohistochemical assessment of transforming growth factor-β (TGF-β) and transforming growth factor-α (TGF-α) and for determination of the mean linear intercept as well as the percent volume densities of fibrosis and of emphysematous changes. (biomedcentral.com)

The mouse pS2 gene is highly expressed in the stomach mucosa cells, whereas no pS2 gene expression could be detected in the mouse mammary gland, even during postnatal development processes dependent on growth factors or hormones. (xenbase.org)
The relationship between polymorphisms of epidermal growth factor gene and silicosis]. (cdc.gov)

The effects of MIP-1 alpha and TGF beta on the growth of Lin- progenitors were direct and correlate with colony formation in soft agar. (ox.ac.uk)
Separation of the Lin- cells into Thy-1 and Thy-1lo subsets showed that the growth of Thy-1lo Lin- cells is directly inhibited by MIP-1 alpha and TGF beta regardless of the cytokine used to stimulate growth (IL-3), GM-CSF, or CSF-1). (ox.ac.uk)
In contrast, two other stem cell populations (0% to 15% Höechst 33342/Rhodamine 123 [Hö/Rh123] and Lin-Sca-1+ cells) were markedly inhibited by TGF beta and unaffected by MIP-1 alpha. (ox.ac.uk)
Thus, MIP-1 alpha and TGF beta are direct bidirectional regulators of HPC growth, whose effects are dependent on other growth factors present as well as the maturational state of the HPC assayed. (ox.ac.uk)
What is the difference between TGF alpha and beta? (rhumbarlv.com)

A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF) has been shown [ ( PUBMED:2288911 ) ( PUBMED:6334307 ) ( PUBMED:6607417 ) ( PUBMED:3282918 ) ] to be present, in a more or less conserved form, in a large number of other, mostly animal proteins. (embl.de)
Various diverse extracellular proteins possess Ca(2+)-binding epidermal growth factor (EGF)-like domains, the function of which remains uncertain. (embl.de)
Several complementary DNA clones encoding related HRGs were identified, all of which are similar to proteins in the epidermal growth factor family. (embl.de)
Several ECM proteins such as laminin, tenascin and thrombospondin contain domains with homology to epidermal growth factor (EGF) and exhibit growth promoting activity. (embl.de)

The results of this study support the ideas that expression of c-myc and TGF-alpha might be a useful prognostic indicator in human ovarian carcinomas, and expression of p53 could be another indicator of prognosis, as the expression of p53 is characteristic in that the expression is mostly seen in invasive ovarian carcinomas. (koreamed.org)

It is well known that some cancers are caused by mutations in the EGF receptor, making them addicted to EGF, which results in uncontrolled cell growth," Dr. (rhumbarlv.com)
Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
The on-and-off switch is operated by transforming growth factor (TGF) β3 levels, which are undetectable in plasma and high in serum, and by TGFβ receptor (TβR) type II levels, which are low in epidermal cells and high in dermal cells. (rupress.org)
and (3) mechanistic considerations involving the over expression of transforming growth factor-alpha (TGF-a) and the under expression of TGF-BII receptor in the GST-P positive foci. (cdc.gov)
EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. (thermofisher.com)

Ductal morphogenesis in the mouse mammary gland: evidence supporting a role for epidermal growth factor. (xenbase.org)

Biologic features and molecular characterization of hemagglutinin, thymidine kinase, and vaccinia growth factor genes suggested a vaccinia virus infection, which strengthens the idea of the reemergence and circulation of vaccinia virus in Brazil. (cdc.gov)
Loss of SPRY1 resulted in up-regulation of EGFR-extracellular signal-regulated kinase (ERK) signaling in response to amphiregulin and transforming growth factor alpha stimulation. (muni.cz)

IDE hydrolyzes a variety of regulatory peptides, including insulin, glucagon, atrial natriuretic factor, and transforming growth factor-alpha in vitro (1). (rndsystems.com)

The receptors are activated upon binding of specific ligands which include EPIDERMAL GROWTH FACTORS, and NEUREGULINS. (bvsalud.org)

Is TGF alpha a cytokine? (rhumbarlv.com)
Tumour Necrosis Factor alpha (TNF alpha), is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signalling events within cells, leading to necrosis or apoptosis. (rhumbarlv.com)
Silicosis and its progress influenced by genetic variation on TNF-alpha locus- 308, TNF-alpha and IL-10 cytokine on cement factory workers in Indonesia. (cdc.gov)

Alpha interferon inhibits hepatitis C virus replication in primary human hepatocytes infected in vitro. (microbiologyresearch.org)

In particular, neutrophil elastase (NE), and other elastolytic proteases, such as cathepsin G, and macrophage elastase are thought to be the main causative factors of tissue damage in this condition. (biomedcentral.com)

Evidence suggests that obesity and insulin resistance are the major factors that contribute to the development of NAFLD. (wjgnet.com)

A positive correlation was found between expression of p53(P=0.02), c-myc(P=0.03), and TGF-alpha(P=0.001) and histological degrees of malignancy(benign, borderline, or malignant) in epithelial ovarian tumors. (koreamed.org)
Expression of p53 and c-myc was closely correlated with expression of TGF-alpha irrespective of the histological degrees of malignancy and type of epithelial ovarian tumors(0.4 (koreamed.org)
TGFα induces an OA-like phenotype in articular chondrocytes, by inhibiting matrix synthesis and promoting catabolic factor expression. (uwo.ca)

Is there a link between TGF alpha and breast cancer? (rhumbarlv.com)

In response to injury and loss, growth regulators induce hepatocellular hyperplasia (producing regenerating nodules) and arterial growth (angiogenesis). (msdmanuals.com)

Cathepsin E. TALE homeodomain transcription factors. (wikipedia.org)

The biological effects of γ-Fe 2 O 3 NP and Gd-DTPA on the kidney were obtained using a biochemical automatic analyzer and multiple proinflammatory factor kit on the serum. (dovepress.com)
13 The rationale for their observation was based upon the fact that vitamins or growth factors present in tears are also present in serum. (bmj.com)

Transforming growth factor-alpha (TGF-alpha) is synthesized and transported to the cell surface as a membrane-anchored precursor (proTGF-alpha) that is converted to the soluble form by proteolytic cleavage. (nih.gov)
Mechanism(s) controlling conversion of the membrane-anchored precursor to the soluble TGF-alpha are unknown, and the responsible protease has not been identified. (nih.gov)

Levels of transforming growth factor alpha (TGF-α) in basal and stimulated saliva samples after chewing parafilm-M in the group of patients with Sjögren's syndrome and confirmed laryngopharyngeal reflux (study group) and the group of healthy volunteers (control group). (bjorl.org)
Decreased salivary transforming growth factor alpha levels were observed in dyspeptic patients, but there have been no studies in patients with Sjögren's syndrome and laryngopharyngeal reflux. (bjorl.org)
To compare the salivary transforming growth factor alpha levels of patients with Sjögren's syndrome and laryngopharyngeal reflux to those of healthy controls. (bjorl.org)
[ 11 ] found high levels of immunoreactive human growth hormone in 2 patients with tylosis, one of whom had the sign of Leser-Trélat. (medscape.com)

These factors include: The transcription factor p63, which prevents epidermal stem cells from differentiating into keratinocytes. (wikipedia.org)

Using the fluorogenic substrate succinyl-Ala-Ala-Ala-4-methylcoumaryl-7-amide (Suc-Ala-Ala-Ala-MCA), containing the sequence similar to the cleavage sites for proTGF-alpha processing, we identified a putative candidate proTGF-alpha-converting enzyme in the membrane fractions of Chinese hamster ovary (CHO) cells. (nih.gov)
Inhibitor profile of the enzyme, including inhibition by serine protease inhibitors and no inhibition by elastatinal, coincides with that previously reported for proTGF-alpha cleavage activity on CHO cells. (nih.gov)
These findings suggest that the enzyme is a processing protease involved in the cleavage of proTGF-alpha and that induction of proTGF-alpha conversion by phorbol ester or by calcium ionophore can be attributed to activation of the processing protease. (nih.gov)

Epidermal growth factor (EGF) is a peptide present in both colostrum and human milk. (rhumbarlv.com)

These conditions develop by means of a common or similar pathogenic pathway due to an underlying malignancy that produces a factor possibly similar to human epidermal growth factor. (medscape.com)
We have determined, at high resolution (1.5 A), the crystal structure of such a domain, from human clotting factor IX, as a complex with Ca2+. (embl.de)

Singularly, SPDEF, a transcription factor associated with mucus metaplasia, was rarely detected in mucus cells in IPF. (bmj.com)
Mucus cells lining abnormal airways from patients with IPF expressed MUC5B and SOX2 but lacked SAM pointed domain containing ETS transcription factor (SPDEF) and forkhead box A3(FOXA3). (bmj.com)
What cells produce TGF alpha? (rhumbarlv.com)
Stimulating the growth of new skin cells, EGF also protects your skin by allowing moisture to absorb faster and deeper, which ultimately makes your skin smoother and softer. (rhumbarlv.com)

To find SCN-secreted factors not previously documented, a hamster SCN cDNA library was screened in a yeast signal sequence trap. (nih.gov)

motif containing cell growth factors. (xenbase.org)
2021 ). They exert multiple biological functions, including limiting excessive inflammatory responses, regulating metabolism and immune cell functions, decreasing the production of pro-inflammatory factors, increasing anti-inflammatory mediators, and promoting tissue repair and homeostasis (Miao et al. (springer.com)

Vascular endothelial growth factor (VEGF) has been broadly studied due to its relevant role in physiological and pathological angiogenesis [1]. (researchsquare.com)

Genetic and environmental factors are important for the development of NAFLD. (wjgnet.com)
Association between Genetic Variants of Transforming Growth Factor-ß1 and Susceptibility of Pneumoconiosis: A Meta-analysis. (cdc.gov)

How is TGF alpha cleaved from its precursor? (rhumbarlv.com)

Obesity is one of several factors implicated in the genesis of diabetic nephropathy (DN). (hindawi.com)
In comparing the factors that contribute to the buildup of excess calories in obesity, an imbalance of energy homeostasis can be considered as the basis. (wjgnet.com)
Sun exposure is a major risk factor for skin cancer, but without physical activity, children are at risk of childhood obesity. (cdc.gov)

Alcohol consumption is an important risk factor for the development of serious toxicological effects following exposure to carbon tetrachloride, since alcohol induces CYP2E1, leading to increased production of reactive metabolites. (cdc.gov)

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