Transformations ligands. Medical search. Frequent questions

These are in fact ideal precursors for the development of novel chiral ligands to be used in radiopharmaceuticals and asymmetric catalysis. (ncl.ac.uk)
In ideal scenario of developing asymmetric C-H activation reactions, the reaction should only proceed when chiral ligands are present. (nyu.edu)
Further development of chiral ligands has enabled the enantioselective C-H activation reactions of methylene C-H bonds for the first time. (nyu.edu)
But a large majority of these transformations make use of expensive and toxic 4d transition metals in combination with sophisticated chiral ligands, which constitutes a considerable limitation. (thieme.de)

The additional redox equivalents provided by redox non-innocent ligands are also used as controlling factors to steer homogeneous catalysis. (wikipedia.org)
and to catalysis, especially involving non-innocent ligands. (tamu.edu)
N-heterocyclic carbenes (NHCs) are commonly used ligands in transition-metal catalysis. (chemistryviews.org)
Highly fluorinated benzenes (HFB) are useful , but underused, solvents and ligands in organic synthesis and catalysis. (chemistryviews.org)
The team found that the complexes are useful in catalysis-even with weakly binding substrates-due to the weakly binding HFB ligand. (chemistryviews.org)
In this regard, enantioselective catalysis has proven to be a powerful tool and continuous efforts have been devoted to design novel asymmetric transformations and apply them for practical usage. (thieme.de)
I am very impressed by this study,' comments Manuel van Gemmeren , a catalysis and ligand design researcher at Kiel University in Germany. (chemistryworld.com)
The ligands are robust, versatile and easy to access synthetically,' says Allegra Franchino , a catalysis and ligand design researcher at the University of Durham, UK. (chemistryworld.com)
The seemingly matured field of ligand discovery still holds significant potential and will steer the field of homogeneous catalysis. (bvsalud.org)

Typically, complexes containing non-innocent ligands are redox active at mild potentials. (wikipedia.org)
The concept assumes that redox reactions in metal complexes are either metal or ligand localized, which is a simplification, albeit a useful one. (wikipedia.org)
The simplest case of a suspect ligand is NO..." Conventionally, redox reactions of coordination complexes are assumed to be metal-centered. (wikipedia.org)
This leads to the formation of ligand radical complexes. (wikipedia.org)
Another example is higher oxidation states of copper complexes of diamido phenyl ligands that are stabilized by intramolecular multi center hydrogen bonding Nitrosyl (NO) binds to metals in one of two extreme geometries - bent where NO is treated as a pseudohalide (NO−), and linear, where NO is treated as NO+. (wikipedia.org)
The Fout research program focuses on the synthesis of ligand architectures that can support transition metal complexes capable of mediating unusual transformations for biological, environmental and energy problems. (tamu.edu)
SPO ,N-ligands bearing a PHOX type backbone were inactive in this transformation as they tend to form inactive palladium-bis-ligand complexes. (cuvillier.de)
Insight into the Scope and Mechanism for Transmetalation of Hydrocarbyl Ligands on Complexes Relevant to C-H Activation , Chan, N.H. (msu.edu)

We have identified the hydrogenation of the bridging ligand, which inhibits the light-driven electron transfer between the photocentre and catalytic centre, as the deactivation mechanism. (nature.com)
They were prepared from precursors with norbornadiene ligands by hydrogenation. (chemistryviews.org)
In the second part new PHOX -type ligands were tested in the iridium-catalyzed asymmetric hydrogenation of different unsaturated compounds. (cuvillier.de)
Although low activities and selectivities were found in most cases, one ligand showed promising results in the hydrogenation of allylic alcohols and imines. (cuvillier.de)
Among several types of ligands, chiral bidentate phosphine ligands have played a pivotal role in developing asymmetric hydrogenation. (bvsalud.org)
This review evaluates the possibility of the use of C1-symmetric diphosphorus ligands in asymmetric hydrogenation to produce chiral compounds. (bvsalud.org)
The recent strategies and advances in the application of C1-symmetric diphosphorus ligands in the metal-catalyzed asymmetric hydrogenation of a variety of Cî C bonds have been summarized. (bvsalud.org)
The potential of diphosphorus ligands in asymmetric hydrogenation to produce pharmaceutical intermediates, bioactive molecules, drug molecules, agrochemicals, and fragrances is discussed. (bvsalud.org)
Metal-catalyzed hydroformylation and hydrogenation heavily rely on ligands, among which phosphorous ligands play a pivotal role. (bvsalud.org)
The synthesis of these ligands, isolation, characterization, and their performance in transition metal-catalyzed hydroformylation, isomerizing hydroformylation, and asymmetric hydrogenation of olefins is summarized. (bvsalud.org)
Thus, this account demonstrates the central role of phosphorus ligands in industrially relevant transformations such as hydrogenation and hydroformylation. (bvsalud.org)

Furthermore air- and moisture-stable secondary phosphine oxide ( SPO ) containing bidentate ligands were tested in the palladium-catalyzed asymmetric allylic alkylation reaction. (cuvillier.de)
Using an arylation reaction as a model, they began by systematically screening bidentate ligands containing both a hydrogen-bond acceptor and an internal base. (chemistryworld.com)

In the enzymes chloroperoxidase and cytochrome P450, the porphyrin ligand sustains oxidation during the catalytic cycle, notably in the formation of Compound I. In other heme proteins, such as myoglobin, ligand-centered redox does not occur and the porphyrin is innocent. (wikipedia.org)
The catalytic cycle of galactose oxidase (GOase) illustrates the involvement of non-innocent ligands. (wikipedia.org)
In the key steps of the catalytic cycle, a cooperative Brønsted-basic ligand-site deprotonates the alcohol, and subsequently the oxygen atom of the tyrosinyl radical abstracts a hydrogen atom from the alpha-CH functionality of the coordinated alkoxide substrate. (wikipedia.org)
However, bioinspired molecular devices designed for artificial photosynthesis, consisting of a photocentre, a bridging ligand and a catalytic centre, can become unstable and break down when their individual modules are structurally compromised, halting their overall functionality and operation. (nature.com)
For asymmetric catalytic hydrogenations and other transformations. (strem.com)
Catalytic Behavior of Mono-N-Protected Amino Acid Ligands in Ligand-Accelerated C-H Activation by Palladium(II) , Salazar, C.A. (msu.edu)

For enantioselective transformations, chiral NHCs can be used. (chemistryviews.org)
The final project area aims to engineer hydrogen-bond acceptors on ligands of hydrogen-atom transfer catalysts to achieve enantioselective C-H functionalization. (msu.edu)

The team also demonstrated that the HFB ligands can be readily substituted by other weakly binding ligands such as isobutene, opening up new opportunities in synthesis. (chemistryviews.org)
His research focuses on the design and synthesis of amino alcohol ligands with tunable steric and electronic properties in order to develop better organometallic catalysts for interesting organic transformations. (hmc.edu)
The Trost group at Stanford University has pioneered the use of C-2 symmetric diaminocyclohexyl (DACH) ligands in AAA, allowing for the rapid synthesis of a diverse range of chiral products with a limited number of chemical transformations. (sigmaaldrich.com)
C-H functionalisation is one of the most versatile reactions in organic synthesis but the ubiquity and inertness of these bonds make selective transformations incredibly challenging. (chemistryworld.com)

Cationic rhodium diphosphines, for example, are pre-catalysts for a variety of important transformations. (chemistryviews.org)
Thus, it could be possible to develop new, more active catalysts that incorporate the very weakly binding HFB ligands. (chemistryviews.org)
By studying the relationship between catalyst structure, rate, and selectivity in these transformations, we aim to decode the nature of attractive interactions between catalysts and open-shell transition states. (msu.edu)

Although C2-symmetric chiral bidentate phosphine ligands have dominated the field, it has been found that several C1-symmetric ligands are equally effective and, in many cases, have outperformed their C2-symmetric counterparts. (bvsalud.org)

We also show that EphA2 overexpression is sufficient to confer malignant transformation and tumorigenic potential on nontransformed (MCF-10A) mammary epithelial cells. (aacrjournals.org)
Our studies have shown that chronic exposure to single-walled carbon nanotube s (SWCNT) induces apoptosis resistance and malignant transformation of human lung epithelial cells. (cdc.gov)
The constitutive translocation of NF-κB to the nucleus of Hodgkin lymphoma RSCs is essential for the malignant transformation of the RSCs. (medscape.com)

In chemistry, a (redox) non-innocent ligand is a ligand in a metal complex where the oxidation state is not clear. (wikipedia.org)
C.K. Jørgensen first described ligands as "innocent" and "suspect": "Ligands are innocent when they allow oxidation states of the central atoms to be defined. (wikipedia.org)
If the ligands are always considered to be dianionic (as is done in formal oxidation state counting), then z = 0 requires that that nickel has a formal oxidation state of +IV. (wikipedia.org)
The formal oxidation state of the central nickel atom therefore ranges from +II to +IV in the above transformations (see Figure). (wikipedia.org)
The stilbene-1,2-dithiolate behaves as a redox non-innocent ligand, and the oxidation processes actually take place at the ligands rather than the metal. (wikipedia.org)
On the other hand, one-electron oxidation of [Ru(2,2'-bipyridine)3]2+ is localized on Ru and the bipyridine is behaving as a normal, innocent ligand in this case. (wikipedia.org)
ligands containing ferrocene can have oxidation events centered on the ferrocene iron center rather than the catalytically active metal center. (wikipedia.org)

We have recently discovered a number of ligand scaffolds that can enable C-H activation reactions of weakly coordinating substrates that are otherwise unreactive. (nyu.edu)
We are targeting transformations that fine-tune the shape of lead scaffolds without perturbing the functional groups that engender function. (msu.edu)

RÉSUMÉ L'objectif de l'étude était d'évaler l'importance clinique du ligand de CD40 soluble (sCD40L) chez des patients atteints d'un carcinome hépatocellulaire (CHC) associé au virus de l'hépatite C (VHC). (who.int)

Drosophila melanogaster presents a simpler model system in which to study FGF signaling, with only three ligands and two FGF receptors (FGFRs) identified. (biologists.com)
Direct regulation of T cell function by microbial ligands through Toll-like receptors (TLR) is an emerging part of T cell biology. (mingsheng88.org)
The production of the ligand for these receptors is responsible for the phosphorylation and translocation to the nucleus of NF-κB. (medscape.com)

Our new modules enable ligand-programmable multi-channel CID systems for plant and eukaryotic synthetic biology that can empower new plant-based and microbe-based sensing modalities. (nature.com)
Starting with the Escherichia coli lac operon in the 1970s, many synthetic ligand-regulated circuits have been built by rewiring natural systems for new functions 1 . (nature.com)
Alkoxylation, hydrosilylative-alkoxylation, and dehydrogenative-polymerization are some of the most widely used transformations in synthetic chemistry. (bvsalud.org)

The use of weak coordination from substrates to direct metal insertion opens up possibility of designing ligand to significantly accelerate C-H activation reactions. (nyu.edu)
Strassfeld and Chen quickly identified promising ligand candidates for a range of benzylic and cyclobutyl substrates and next sought to validate the hydrogen-bonding mechanism using a combination of crystallographic, reactivity and computational studies. (chemistryworld.com)

The absolute temperature dependency of human AhR transformation mimics that observed in vivo and provides a useful system to study the mechanism of AhR transformation in detail. (aspetjournals.org)
Although the origin of the gene segments in pandemic (H1N1) 2009 virus has been determined ( 2 , 3 ), the mechanism of transformation of the host-specific amino acid signatures is unclear, because the new viral genes evolved after they were introduced into the swine population some years ago. (cdc.gov)

Removal of hydrogen-bond acceptor or donor groups in either the ligand or substrate resulted in no reaction whilst DFT modelling confirmed the strongly stabilising influence of the hydrogen-bonding interactions. (chemistryworld.com)

We combined synchrotron small angle X-ray scattering, X-ray fluorescence and extended X-ray absorption fine structure spectroscopy to probe the structure of chemically synthesized CoPt 3 nanoparticles (NPs) after ligand removal via the commonly accepted solvent/nonsolvent approach. (osti.gov)
Also, we demonstrated that drastic compositional and structural transformation of water transferred CoPt 3 NPs was rather a result of extensive removal of native ligands via a solvent/nonsolvent approach than leaching of cobalt atoms in aqueous media. (osti.gov)

Redox non-innocent behavior of ligands is illustrated by nickel bis(stilbenedithiolate) ([Ni(S2C2Ph2)2]z). (wikipedia.org)

A copper-catalyzed asymmetric conjugate borylation (ACB) reaction was used to investigate the applicability of the Cholest CAAC as a stereo-directing chiral ligand. (chemistryviews.org)
SPO ,P ligands however, were able to promote the desired reaction in a highly selective fashion although only low activities were found. (cuvillier.de)
An intensive screening of both the organo-catalyst and the palladium-ligand led to reaction conditions which allowed for the selective mono-allylation of ketones in high yields. (cuvillier.de)

In addition IMACS-CD4+ but not IMACS/FACS-CD4+ reactions were upregulated from the TLR-4 ligand lipopolysaccharide (LPS). (mingsheng88.org)
Altogether these results indicate that small variations in cell purity can significantly alter T cell reactions to TLR ligands. (mingsheng88.org)
Our strategy is to develop new reactions that engage heterocycles and amines because these motifs are abundant across several important classes of functional molecules including medicines, biological probes, organocatalysts, and ligands. (msu.edu)

During recent years, the biotic ligand model (BLM) has been proposed as a tool to evaluate quantitatively the manner in which water chemistry affects the speciation and biological availability of metals in aquatic systems. (researchgate.net)

Their thorough and rational ligand design exploits H-bonding to supplement the weak interactions in the pre-reactive complex and transition state and is validated by well-designed computations. (chemistryworld.com)
However, these transformations are traditionally catalyzed by precious, and rare late-transition metals. (bvsalud.org)

Here we analyze the specificity of FGFR [Heartless (Htl) and Breathless (Btl)]activation by each of the FGF ligands [Pyramus (Pyr), Thisbe (Ths) and Branchless (Bnl)] in Drosophila . (biologists.com)
To examine the role of each ligand in supporting activation of the Htl FGFR, we utilize genetic approaches that focus on the earliest stages of embryonic development. (biologists.com)
Designer ligands have promoted what the team behind the work believes is the first alcohol-directed activation of unreactive sp 3 C-H bonds. (chemistryworld.com)
Directed C-H activation attempts to overcome this by employing existing functionality within the substrate to anchor the metal catalyst close to a particular bond and carefully designed ligands allow chemists to use carbonyl and nitrogen-containing groups to direct the initial metal association interaction. (chemistryworld.com)

Currently the functional group tolerance is limited and we can only obtain high yields with tertiary alcohols but we anticipate that these limitations will be addressed by further improvements in ligand design,' comments Strassfeld. (chemistryworld.com)

Filter your compounds for relevant parameters, calculate ADME properties, and gain full control over ligand-target interactions. (biosolveit.de)
If the complex contains ions or co-factors, or if the ligand itself needs additional parameters, the following steps need to be executed. (lu.se)

The coordination chemistry of these metals in the presence of chelating, mono-anionic ligands will be studied. (europa.eu)

This personal account presents a selection of three distinct classes of phosphorous ligands, namely, monodentate meta-substituted phosphinites, bis-phosphites, and P-chiral supramolecular phosphines, developed in our group. (bvsalud.org)

As compared to passage-matched control cells, SWCNT-transformed BEAS-2B cells exhibited resistance to apoptosis induced by death ligands, e.g., tumor necrosis factor-a and Fas ligand, but not by inducers of mitochondria-mediated apoptosis, e.g., antimycin A and cisplatin, suggesting death receptor pathway as the primary pathway of defective apoptosis in SWCNT-transformed cells. (cdc.gov)
Overexpression of FLIP increased apoptosis resistance of the cells, whereas RNAi knockdown of FLIP reversed the apoptosis resistance of cells in response to death ligands. (cdc.gov)

Evaluate ligand-target interactions by intuitive color codes and gorgeous visualization. (biosolveit.de)

K. Uemura, "Crystal Structure of cis -[PtCl 2 (PyCN) 2 ] (PyCN = 4-Cyanopyridine) Showing Temperature Dependent Single-Crystal-to-Single-Crystal Transformation," Advances in Materials Physics and Chemistry , Vol. 3 No. 1A, 2013, pp. 36-40. (scirp.org)

This study stresses the importance of a stringent purification method when investigating the part of microbial ligands in T cell function. (mingsheng88.org)

His work-in the Aarhus University Research on the Anthropocene project and in an emergent creative research studio in Amsterdam-focuses on biogeochemical articulations of the planetary, through a research practice that attends to contemporary shifts in sociotechnical assemblages and their historical flows, paying attention to the reciprocal transformations of the context and the content of scientific work. (hmc.edu)

C. Hu and U. Englert, "Crystal-to-Crystal Transformation from a Chain Polymer to a Two-Dimensional Network at Low Temperatures," Angewandte Chemie International Edition, Vol. 44, No. 15, 2005, pp. 2281-2283. (scirp.org)

We contend that inherent properties of FGF ligands make them suitable to support specific FGF-dependent processes, and that FGF ligands are not always interchangeable. (biologists.com)

The PMAO-induced transformation of Cs 4 PbBr 6 NCs opens up a strategy for the chemical modification of metal halide NCs initially passivated with nucleophilic amines. (rsc.org)

The interaction between neutral hydroxyls and palladium is known to be weak due to a mismatch between the soft metal centre and the hard ligand. (chemistryworld.com)

The fully-transformed CsPbBr 3 NCs have high photoluminescence quantum yield and enhanced colloidal stability, which we attribute to the adhesion of polysuccinamic acid to the NC surface through its multiple functional groups in place of oleate and alkylammonium ligands. (rsc.org)

After binding of TCDD to the cytoplasmic AhR there occurs a poorly understood "transformation" step, wherein the TCDD-AhR complex is converted to a form that can bind to DNA with high affinity. (aspetjournals.org)
The transformation occurs through the formation of Cs 4 PbBr 6 -CsPbBr 3 heterostructures as intermediates, which are captured because of the mild reactivity of PMAO and are investigated by high-resolution electron microscopy. (rsc.org)

For the analysis of data from multiple donors, the data underwent logarithmic transformation due to the non-normal distribution of ideals. (mingsheng88.org)

The diamagnetism of this complex arises from anti-ferromagnetic coupling between the unpaired electrons of the two ligand radicals. (wikipedia.org)
The complex Cr(2,2'-bipyridine)3 is a derivative of Cr(III) bound to three bipyridine1− ligands. (wikipedia.org)
In vertebrates, FGF signaling is complex, with over 100 predicted FGF ligand-receptor combinations. (biologists.com)

The first described CID systems involve microbe-derived dimerizing ligands, such as rapamycin, that direct protein neo-associations that rewire eukaryotic cell signaling 5 . (nature.com)
The transforming capacity of EphA2 is related to the failure of EphA2 to interact with its cell-attached ligands. (aacrjournals.org)
Primary myelofibrosis results from neoplastic transformation of a pluripotent hematopoietic stem cell. (msdmanuals.com)

SeeSAR automatically detects the binding site of a ligand for you. (biosolveit.de)

It is important the first ligand in a pair have more or equal number of atoms than the second ligand, and that the atoms that should not be perturbed have the same name in both ligands. (lu.se)

This system is unique because of the relative ease with which ligand recognition can be reprogrammed. (nature.com)

Transformation of this pharmacophore representation into a correlation vector results in a vector of feature probabilities which can be utilized for rapid virtual screening of compound databases or virtual libraries. (unboundmedicine.com)

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