• adenine (A) - A nitrogenous base that occurs in DNA and RNA nucleotides and pairs with thymine (in DNA) or uracil (in RNA) through two hydrogen bonds. (rcsb.org)
  • The m 6 A modification is recognized by the reader proteins, such as YTH-domain family proteins and specific RNA binding proteins (RBPs), which mediate the downstream effects of m 6 A methylation [ 4 ]. (biomedcentral.com)
  • Although some successful computational tools have been reported to recognize RNA binding sites in proteins, the problem of specificity remains poorly investigated. (biomedcentral.com)
  • After the nucleotide base composition, the dinucleotide is the smallest unit of RNA sequence information and many RNA-binding proteins simply bind to regions enriched in one dinucleotide. (biomedcentral.com)
  • Dinucleotide-specific contact predictions have also been extended to the prediction of interacting protein and RNA fragment pairs, which shows the applicability of this method to predict targets of RNA-binding proteins. (biomedcentral.com)
  • Most of these biological functions involve an accurate identification of specific recognition sites in proteins and RNA. (biomedcentral.com)
  • Several computational approaches have been developed to identify RNA-binding proteins and RNA-binding sites. (biomedcentral.com)
  • As a natural extension of this approach to RNA-binding proteins, and also because some RNA-binding proteins are shown to bind regions largely characterized by enrichment in one dinucleotide [ 17 ], we explored the possibility of predicting amino acid dinucleotide contacts. (biomedcentral.com)
  • Following the release, exosomes will transfer to specific targets such as immune cells or the central nervous system (CNS) to exert pleiotropic effects [ 8 , 9 ]. (hindawi.com)
  • The analysis of selected reporters by mass spectrometry and RNA-seq showed that not only translation but also transcription errors contribute to stop codon miscoding. (biorxiv.org)
  • However, stop codon miscoding (SCM) may occur either by a transcription error, when the RNA polymerase misincorporates a nucleotide and eliminates the stop codon, or by a translation error when the ribosome misincorporates a tRNA at the stop codon (also called stop codon readthrough and nonsense suppression 5 , 6 ). (biorxiv.org)
  • Regulation of gene expression, protein synthesis, replication and assembly of many viruses involve RNA-protein interactions. (biomedcentral.com)
  • RNA helicase VAS encoded by the gene vasa (8). (nih.gov)
  • However, none of these methods addresses the crucial issue of specific interactions i.e. the same protein interacts with some RNA sequences and not others. (biomedcentral.com)