• We assessed the effect of allelic deletions in the GSTM1 and GSTT1 genotypes on lung cancer overall survival through a systematic review of the scientific literature after applying predefined inclusion and exclusion criteria. (nih.gov)
  • The GSTM1-0 ( GSTM1 null) and GSTT1-0 ( GSTT1 null) alleles represent deletions of GSTM1 and GSTT1 genes, respectively. (molvis.org)
  • Combined Genotype Analysis of GSTM1 and GSTT1 Polymorphisms in a Polish Population " by Christos Kargas, Renata Krupa et al. (wayne.edu)
  • The prevalence of the "null" genotype of the GSTM1 and GSTT1 genes was determined by using a multiplex polymerase chain reaction methodology in a group of 233 healthy individuals. (wayne.edu)
  • Glutathione S-transferases GSTM1 and GSTT1 polymorphisms and asbestosis. (cdc.gov)
  • A recent clinical study has focused on: 1- the interaction between genetic variants of glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) and smoking on the risk of cardiovascular diseases, 2- the potential capacity of GSTM1 and T1 genotypes in modifying the effect of smoking on inflammation and endothelial function. (tu-dortmund.de)
  • GSTM1 and GSTT1 Null Genotype Polymorphisms and Susceptibility to Arsenic Poisoning: a Meta-analysis. (cdc.gov)
  • Genotyping and analysis was carried out in 152 members (69 affected and 83 unaffected) of 13 families with NBCCS for seven polymorphisms in five metabolic genes including CYP1A1, CYP2D6, GSTM1, GSTP1, and GSTT1. (bmj.com)
  • However, little is known about the effect of gas cooking on bronchial responsiveness and on how this relationship may be modified by variants in the genes GSTM1 , GSTT1 and GSTP1 , which influence antioxidant defences. (bmj.com)
  • Methods The study was performed in subjects with forced expiratory volume in one second at least 70% of predicted who took part in the multicentre European Community Respiratory Health Survey, had bronchial responsiveness assessed by methacholine challenge and had been genotyped for GSTM1 , GSTT1 and GSTP1 -rs1695. (bmj.com)
  • No effect modification by GSTT1 or GSTP1 -rs1695 genotypes was observed. (bmj.com)
  • Functional polymorphisms exist in at least three genes that encode GSTs, including GSTM1, GSTT1, and GSTP1. (qxmd.com)
  • To this end, we have examined 89 cases of t-AML, 420 cases of de novo AML, and 1,022 controls for polymorphisms in GSTM1, GSTT1, and GSTP1. (qxmd.com)
  • The role of the glutathione S-transferase genes GSTT1, GSTM1, and GSTP1 in acetaminophen-poisoned patients. (cdc.gov)
  • The GSTM1 null/GSTT1 null genotype was associated with response to primary chemotherapy ( P = 0.007) but p53 expression was not. (bmj.com)
  • Are individuals with glutathione S-transferase GSTT1 null genotype more susceptible to in vitro oxidative damage. (florence.com.tr)
  • Significant differences occurred between men and women in some age groups, which could suggest that sex differences in susceptibility to diseases may be caused by genotype differences in detoxifying enzymes such as glutathione S-transferase. (wayne.edu)
  • In summary, this meta-analysis suggested that the null genotype of GSTM1 rather than GSTT1 may be involved in the etiology of prostate cancer in Asian population. (oncotarget.com)
  • Although our data suggest some individual differences according to the GSTT1 genotype in the outcome of the comet assay, a large number of individuals should be studied in further investigations to obtain reliable conclusions. (uab.cat)
  • Previous studies have shown that polymorphisms of some metabolic genes encoding the cytochrome p450 (CYP) and glutathione-S-transferase (GST) enzymes influenced the numbers of BCCs in sporadic BCC cases. (bmj.com)
  • Concomitance of Polymorphisms in Glutathione Transferase Omega Genes Is Associated with Risk of Clear Cell Renal Cell Carcinoma. (cancerindex.org)
  • The risks are greater if you the glutathione S-transferase M1, or GSTM1 genes, so it appears we need to find out if we have that gene as females to see how risky talcum powder would be. (blogspot.com)
  • Background: Bladder cancer has been linked with long-term exposure to disinfection by-products (DBPs) in drinking water.Objectives: In this study we investigated the combined influence of DBP exposure and polymorphisms in glutathione S-transferase (GSTT1, GSTZ1) and cytochrome P450 (CYP2E1) genes in the metabolic pathways of selected by-products on bladder cancer in a hospital-based case-control study in Spain. (upf.edu)
  • Based on that published data on the association of prostate cancer susceptibility with polymorphisms in genes encoding Glutathione S-transferases (GSTs) were inconclusive, the aim of this study was to more precisely address the role of GSTs polymorphisms (especially, GSTT1 and GSTM1 deletions) on prostate cancer risk in Asian descent. (oncotarget.com)
  • Antes de tudo, este genótipo revela mutação do gene GSTM1 e/ou GSTT1, sendo que, ambos os genes, em outras palavras, tendem a gerar maior atraso do sistema de detoxificação e níveis menores da vitamina C. (dglab.com.br)
  • Mas os genes GSTM1 e GSTT1 também estão ligados à quantidade de vitamina C no organismo. (dglab.com.br)
  • O mecanismo pelo qual isso acontece não está explicado, mas se sabe que as glutationas transferases feitos a partir desses genes, conseguem melhores níveis desta vitamina. (dglab.com.br)
  • In eukaryotes, glutathione S-transferases (GSTs) participate in the detoxification of reactive electrophilic compounds by catalysing their conjugation to glutathione. (wikipedia.org)
  • The human glutathione S-transferases (GSTs) have been associated with an increased risk of lung cancer. (nih.gov)
  • Glutathione S-transferases (GSTs), a superfamily of multifunctional enzymes, play an important role in the onset and progression of renal cell carcinoma (RCC). (cancerindex.org)
  • Glutathione S - transferases ( GSTs ) involve a superfamily of multifunctional and ubiquitous phase II metabolic enzymes. (springeropen.com)
  • Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human carcinogens. (qxmd.com)
  • Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia. (qxmd.com)
  • A deletion polymorphism in GSTT1 leads to lack of enzyme activity and has 2 alleles: GSTT1*0 (nonfunctional) and GSTT1*1(functional). (geneinformed.com)
  • Additionally, we investigated whether the polymorphism of glutathione S-transferase T1 (GSTT1) gene may affect the individual level of BT-induced DNA damage in vitro. (uab.cat)
  • Glutathione-S-transferase polymorphism and clinical features of acute drug poisoning in children. (cdc.gov)
  • Gene deletion of GSTM1 or GSTT1 was not specifically associated with susceptibility to t-AML. (qxmd.com)
  • First, the investigators will use induced pluripotent stem cell (iPSC) cell lines exposed to toxins such as paraquat and permethrin to determine whether glutathione S‐transferase theta-1 (GSTT1) deletion increases susceptibility. (health.mil)
  • The role of CYP1A1 , GSTM1 , GSTT1 , EPHX1 , and NAT2 genotypes in susceptibility to malignant mesothelioma (MM) was compared in two case-control studies, previously conducted in two countries where different types of asbestos fibers have been used [Hirvonen et al. (mesothelioma-line.com)
  • Genetic polymorphisms of NQO1, GSTT1, GSTM1 and susceptibility to chronic benzene poisoning]. (cdc.gov)
  • Glutathione S-transferase gene deletions and their effect on iron status in HbE/beta thalassemia patients. (cdc.gov)
  • Prevalence of glutathione S-transferase gene deletions and their effect on sickle cell patients. (cdc.gov)
  • The risk of developing prostate cancer in Algeria does not appear to be associated with CYP1A1 T3801C genotypes and GSTM1 - null , but GSTT1 - null and GSTM1/GSTT1 -double null genotypes increased the risk of prostate cancer. (springeropen.com)
  • To investigate whether genetic polymorphisms of glutathione S-transferases ( GSTM1 , GSTT1 , and GSTO2 ) in relation to the work place contribute to the development of cataract. (molvis.org)
  • Glutathione S-transferase M1 gene polymorphisms are associated with cardiac iron deposition in patients with beta-thalassemia major. (cdc.gov)
  • Status of Catalase, Glutathione Peroxidase, Glutathione S-Transferase, and Myeloperoxidase Gene Polymorphisms in Beta-Thalassemia Major Patients to Assess Oxidative Injury and Its Association with Enzyme Activities. (cdc.gov)
  • 0.0001) glutathione-(GSH), GSH-peroxidase/S-transferase, and catalase erythrocyte activities. (avaate.org)
  • The glutathione, glutathione-s-transferase, catalase, superoxide dismutase, lipid peroxidation, lactate dehydrogenase, aspartic acid transaminase, and alanine aminotransaminase levels were estimated in the liver of iron treated mice after 30 days post-iron treatment. (biomedres.us)
  • The feeding of different concentrations of iron for 30 days led to an increase in the oxidative stress as indicated by a decline in the glutathione concentration, and glutathione-s-transferase, catalase, and superoxide dismutase activities accompanied by the rise in the lactate dehydrogenase, aspartic acid transaminase, and alanine aminotransaminase levels. (biomedres.us)
  • Treatment of hesperidin for 5 days before iron overload elevated the activities of glutathione-s-transferase, catalase, and superoxide dismutase and glutathione concentration, whereas the activities of lactate dehydrogenase, aspartic acid transaminase, and alanine aminotransaminase and lipid peroxidation declined significantly. (biomedres.us)
  • Our study demonstrates that pre-treatment of hesperidin for five days reduced the iron induced oxidative stress indicated by the reduction in lipid peroxidation, lactate dehydrogenase, aspartic acid transaminase, and alanine aminotransaminase activities and a rise in the glutathione-s-transferase, catalase, and superoxide dismutase and glutathione contents in the mice liver. (biomedres.us)
  • We estimated effects of THMs and GSTT1, GSTZ1, and CYP2E1 polymorphisms on bladder cancer using adjusted logistic regression models with and without interaction terms. (upf.edu)
  • Associations between THMs and bladder cancer were stronger among subjects who were GSTT1 +/+ or +/- versus GSTT1 null (pinteraction = 0.021), GSTZ1 rs1046428 CT/TT versus CC (pinteraction = 0.018), or CYP2E1 rs2031920 CC versus CT/TT (pinteraction = 0.035). (upf.edu)
  • The consistency of these findings with experimental observations of GSTT1, GSTZ1, and CYP2E1 activity strengthens the hypothesis that DBPs cause bladder cancer and suggests possible mechanisms as well as the classes of compounds likely to be implicated. (upf.edu)
  • Functional genetic variants of glutathione S-transferase protect against serum ascorbic acid deficiency. (dglab.com.br)
  • SNP variants in EHS, and a 9.7-fold increased risk (OR: 95% C.I. = 1.3-74.5) of developing EHS for the haplotype (null)GSTT1 + (null)GSTM1 variants. (avaate.org)
  • We found the following frequencies of individuals with mutated alleles: 47.6% were homozygously deficient for GSTM1 (51.1% males, 42.4% females) and 16.3% for GSTT1 (17.7% males, 15.2% females). (wayne.edu)
  • Among the 195 cases and 192 controls with high-risk forms of GSTT1 and GSTZ1, the ORs for quartiles 2, 3, and 4 of THMs were 1.5 (0.7-3.5), 3.4 (1.4-8.2), and 5.9 (1.8-19.0), respectively. (upf.edu)
  • In 81 women with pure invasive ovarian cancer, GSTM1 null and GSTT1 null genotypes were identified using polymerase chain reaction and p53 expression was assessed using immunohistochemistry. (bmj.com)
  • In a multivariate analysis, the effects of GSTM1 null/GSTT1 null on survival were lost when residual disease and tumor grade were included. (bmj.com)
  • However, significantly lower levels of IL-6 were noticed for non-smokers with GSTT1-0 null allele (p=0.05). (tu-dortmund.de)
  • Individuals with a GSTT1 gene variant tend to have a 40% reduction in vitamin C compared to others, even when dietary intake and all other determinants are equal. (geneinformed.com)
  • The GSTT1*0 variant was associated with lowered absorption of vitamin C. (geneinformed.com)
  • Vitamin C levels in blood are influenced by polymorphisms in glutathione S-transferases. (dglab.com.br)
  • A meta-analysis including 8 articles with 711 cases and 1122 controls for GSTT1 and 1098 cases and 1588 controls for GSTM1 was performed. (oncotarget.com)
  • The study also revealed that the risks were greater still for those with a certain genetic profile - women carrying a gene called glutathione S-transferase M1, or GSTM1, but lacking a gene called glutathione S-transferase T1 ( GSTT1), were nearly three times as likely to develop tumors. (blogspot.com)
  • This study describes the distribution of GSTT1 and GSTM1 polymorphisms in a normal population of central Poland. (wayne.edu)