Transfer RNA (tRNA) molecules contain various post-transcriptional modifications that are crucial for tRNA stability, translation efficiency, and fidelity. (mdpi.com)
Many cellular processes, including ribosome biogenesis, are regulated through post-transcriptional RNA modifications. (nature.com)
Genes5
From the transcriptome analysis we found increased expression of siderophore synthesis genes and multiple known virulence genes. (biomedcentral.com)
The aim of this study was to compare the in vivo expression of virulence and metabolic genes of S. aureus in a prosthetic joint infection in a human subject with growth in vitro as reference using RNA sequencing (RNA-seq). (biomedcentral.com)
The mitogenome is 16,401 bp in length and consisted of 13 protein-coding genes, 2 ribosomal RNAgenes, 22 transfer RNAgenes, and a control region. (pensoft.net)
Depending on the organism and availability, mt-tRNA Val or mt-tRNA Phe are incorporated, most likely due to their genomic proximity to mt-rRNA genes and consequent near stoichiometric presence of their transcripts 4 , 8 . (nature.com)
As of the July 2013, the total number of genes (including pseudogenes and non-coding RNAgenes) is around 58,000 with the total number of transcripts reaching almost 200,000 ( Gencode ). (tripod.com)
Polymerase2
Such intricacy in tRNA expression regulation cannot be exclusively explained by the global modulation of the RNA polymerase III (RNAPIII) transcriptional activity. (biomedcentral.com)
RNA dependent RNA polymerase (RdRp) sequence of RaTG13 shows that it is 100% similar to that of bat corona virus BtCoV/4991 and 98.7-98.9% similar to SARS-CoV-2 RdRp 2 . (preprints.org)
Genome5
To identify DNAmethylation defects in tDNA, we retrieved the Infinium HumanMethylation450 (HM450) methylation microarray probes' identity that mapped into the loci corresponding to the 416 high confidence tDNA that are found in the human nuclear genome [ 1 ]. (biomedcentral.com)
DENV is an enveloped virus with a positive stranded RNA genome of approximately 11 kb in length that encodes a single polypeptide. (biomedcentral.com)
Expression of this genome entails several, highly regulated processes, with newly synthesised transcripts being cleaved, chemically modified, polyadenylated and further matured in neighbouring structures known as mitochondrial RNA granules (MRGs). (nature.com)
While the RNA components of the mitoribosome are mitochondrially-encoded, all MRPs and assembly factors are encoded in the nuclear genome, thus requiring coordination between two genomes for the assembly of these macromolecular complexes. (nature.com)
The genome of RaTG13 (MN996532.1) was sequenced from the RNA of a bat faecal swab collected in 2013 from Yunnan, China, however the exact location is not mentioned. (preprints.org)
Nucleotide1
MT-TV is a small 69 nucleotide RNA (human mitochondrial map position 1602-1670) that transfers the amino acid valine to a growing polypeptide chain at the ribosome site of protein synthesis during translation. (wikipedia.org)
Peptide1
Treatment with the Ltc 1 peptide reduced the viral RNA in a dose-dependent manner with EC 50 values of 8.3 ± 1.2, 7.6 ± 2.7 and 6.8 ± 2.5 μM at 24, 48 and 72 h, respectively. (biomedcentral.com)
Viral4
The latest detec- tion of viral RNA was 84, 44, and 44 days postinfection in excreta ( 4 ). (cdc.gov)
5 of 6 animals contained viral RNA at day 133 postinfec- bank voles ( 5 ), and excreted PUUV is infectious for up tion, suggesting that bank voles secrete virus only during to 12-15 days outside the host ( 6 ). (cdc.gov)
PCR (RT-PCR) to measure levels of shed viral RNA in Hantavirus , a genus within the family Bunyaviridae , saliva, urine, and feces of subcutaneously inoculated bank contains rodent-borne viruses that cause 2 severe dis- voles until they were killed at day 133 postinfection (PI). (cdc.gov)
HFRS causes 150,000-200,000 hos- subset of viral RNA-positive saliva, urine, and feces sam- pitalizations each year throughout the world ( 1 ). (cdc.gov)
Mitochondrial2
Mitochondrially encoded tRNA valine also known as MT-TV is a transfer RNA which in humans is encoded by the mitochondrial MT-TV gene. (wikipedia.org)
While RNA makes up most of the composition of bacterial and cytosolic eukaryotic ribosomes, mammalian mitochondrial ribosomes present a more elaborate protein shell, which aids coping with the oxidative microenvironment. (nature.com)
TRNAs2
Besides their canonical roles in translation, tRNAs also originate tRNA-derived small RNAs (tsRNAs), a class of small non-coding RNAs with regulatory functions ranging from translation regulation to gene expression control and cellular stress response. (mdpi.com)
In fact, tRNAs actively engage in protein synthesis regulation and in additional molecular processes that are unrelated to translation, like apoptosis prevention and the generation of small derivative non-coding RNAs that perform further cellular functions [ 2 ]. (biomedcentral.com)
Modifications2
A wide variety of tRNA modifications are found in the tRNA anticodon, which are crucial for precise codon recognition and reading frame maintenance, thereby ensuring accurate and efficient protein synthesis. (nature.com)
Helm, M. & Alfonzo, J. D. Posttranscriptional RNA modifications: playing metabolic games in a cell's chemical Legoland. (nature.com)
Sequence2
Taxonomic classification of those E. ictaluri specific phages must rely on a synthesis of morphological and genomic details, taking into consideration that phage evolution continues to be profoundly directed by lateral gene transfer, and that a rational hierarchical technique of phage classification really should be based within the degree of DNA and protein sequence identity for several genetic loci. (hivprotease-signal.com)
What sequence of amino acids would the following RNA sequence code for if it were to be translated by the ribosome? (migzmediagroup.com)
Proteins2
These findings culminated in the central dogma of molecular biology, that proteins are translated from RNA, which is transcribed from DNA. (addgene.org)
The genetic information of life on Earth have been conserved in natural nucleotides-A, G, C, T(U) forming two exclusive sets of base pairs A-T(U) & G-C, that complementing to the fundamental processes of DNA replication & RNA transcription by several polymerases and translation to functional proteins via ribosomal reactions. (fortuneonline.org)
Functions1
Suzuki, T. in Fine-Tuning of RNA Functions by Modification and Editing , Vol. 12 (ed. (nature.com)
Amino acids1
The review also outlines the vast applications of UBPs as novel information storage components as well as in creation of semi-synthetic organisms expressing non canonical amino acids, high affinity aptamer generation, PCR based diagnostics and sitespecific labelling of RNAs. (fortuneonline.org)
Humans1
The only cathelicidin found in humans is LL-37, this is produced in epithelial cells, by proteolytic cleavage from the C-terminal of the hCAP-18 protein. (bestbiochem.com)
Small1
When a genetic association is found, it is very tempting to speculate that the associated variant may be a good biomarker (usually because of the small P value accompanying the association). (tripod.com)
Fluid2
Here, we characterized the staphylococcal transcriptome in vivo and the joint fluid metabolome in a prosthetic joint infection with an acute presentation using deep RNA sequencing and nuclear magnetic resonance spectroscopy, respectively. (biomedcentral.com)
Amplicon sequencing was used for detection of bacteria in fluid obtained by sonication of prosthesis components (all joint fluid was used for RNA-seq). (biomedcentral.com)
Mutation2
Using PCR/single-strand conformation polymorphism analysis of the gene encoding GDH in 12 Japanese patients with persistent hyperinsulinemic hypoglycemia of infancy (PHHI), we found a mutation (Y266C) in one PHHI patient. (diabetesjournals.org)
Must confirm there is no difference in splicing using RNA data. (genome.network)
Specific3
Two specific mutations of 1642G>A and 1644G>A have been found to result in the disease. (wikipedia.org)
Find support for a specific problem in the support section of our website. (mdpi.com)
Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its corresponding amino acid during protein synthesis. (nature.com)
Parallel1
Moreover, Qu and Mudawar [4] GDC-0449 investigated convective boiling heat transfer, flow patterns, and pressure drop of water in parallel microchannels. (interleukin-receptor.com)
System1
We find that a PT invariant system can be pictured as a complex conjugation followed by an inversion in a circle. (preprints.org)
Method1
The main goal of this study was to look for the different micro-organisms carried and potentially transmitted by horseflies, using real time qPCR, which is a direct diagnostic method amplifying the DNA or RNA of the micro-organisms sought. (fortuneonline.org)
Disease1
We hypothesized that the non-coding RNAs transcript may serve as susceptibility to disease biomarkers by smoking and vaping. (researchsquare.com)
Liu and Garimella [5] conducted experiments on boiling heat transfer of deionized water in copper microchannels. (interleukin-receptor.com)
Cell1
z-VAD-fmk ( N -benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone) is a powerful, irreversible and cell permeable inhibitor of caspases, and has been demonstrated to directly block the activity of caspases ( 13 ). (spandidos-publications.com)
Type1
Although they can be found in archaea and eukaryotes, they play the most significant biological role in bacteria where they can be passed from one bacterium to another by a type of horizontal gene transfer (conjugation), usually providing a benefit to the host, such as antibiotic resistance. (addgene.org)