In cultured human aortic smooth muscle cells, pharmacologic or genetic activation of AMPK inhibited the signal transducer and activator of transcription-1 (STAT1), while inhibition of AMPK had opposite effects. (diabetesjournals.org)
The metabolic abnormalities of type 2 diabetes, including hyperglycemia, dyslipidemia, and insulin resistance, activate the Janus kinases/signal transducer and activator of transcription (JAK/STAT) signaling pathway, a major intracellular inflammatory cascade that transmits the intracellular signaling to the nucleus ( 2 ), promoting inflammatory response, inducing insulin resistance ( 3 ), and accelerating the development of cardiovascular complications ( 4 ). (diabetesjournals.org)
Interleukin (IL)-12, which is secreted by antigen-presenting cells, acts via signal transducer and activator of transcription (STAT)4 to promote the differentiation of naïve T cells into Th1 cells ( 9 - 11 ). (frontiersin.org)
Description: A sandwich quantitative ELISA assay kit for detection of Human Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (unicoupi.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Signal Transducer And Activator Of Transcription 3 (STAT3) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (unicoupi.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (unicoupi.com)
Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene. (wikipedia.org)
Background Both phosphorylated signal transducer and activator of transcription 3(pStat-3) and integrin v6 can play vital role in the advancement and progression of cancer. (researchhunt.com)
Recent studies have demonstrated the importance of members of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signalling pathway in the granulosa cell population of mouse and horse ovaries, with perturbation of JAK1 signalling in the mouse shown to impair oocyte maintenance and accelerate primordial follicle activation. (edu.au)
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) intracellular signaling pathway is implicated in the pathogenesis of a number of inflammatory dermatoses. (nih.gov)
A high-throughput assay for signal transducer and activator of transcription 5b based on fluorescence polarization. (mpg.de)
Prevention was associated with the downregulation of signal transducer and activator of transcription 3 (STAT3)-activating and Foxp3-counteracting interleukin-6 (IL-6), lower numbers of phospho-STAT3-containing lymphocytes, and higher Foxp3 + T-cell counts in the colon. (nature.com)
Apratoxin A is a potent cytotoxic marine natural product that rapidly inhibits signal transducer and activator of transcription (STAT) 3 phosphorylation by an undefined mechanism. (aspetjournals.org)
STAT5 is a member of the signal transducer and activator of transcription factors (STAT) family, mediating growth and cytokine signaling. (biolegend.com)
In a PCR array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of signal transducer and activator of transcription 3 (STAT3). (cdc.gov)
In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. (wikipedia.org)
Binding of Prolactin to its receptor leads to the phosphorylation and activation of STAT (signal transducers and activators of transcription) proteins. (nih.gov)
Apratoxin A inhibits Janus kinase (JAK)/STAT signaling through rapid down-regulation of interleukin 6 signal transducer (gp130). (aspetjournals.org)
Discovery of chromone-based inhibitors of the transcription factor STAT5. (mpg.de)
Protein3
The STAT4 gene provides instructions for a protein that acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. (medlineplus.gov)
Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. (abnova.com)
Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. (lu.se)
STAT12
Moreover, AMPK activation attenuated the proinflammatory actions induced by STAT1 activators such as interferon-γ and angiotensin II (AngII). (diabetesjournals.org)
Phosphorylation of STAT1 at Y701 leads to dimerization and translocation to the nucleus to activate gene transcription. (rndsystems.com)
Discovery1
Another line of research development centers on the establishment of novel chemical libraries aiming at mechanism-based or lead compound-based drug discovery for cancer/inflammation, particularly by targeting Bcl-2 family proteins and apoptosis pathways, transcription factors as well as epigenetic therapy with the aid of molecular docking and chemical synthesis. (utmb.edu)
Factor1
Aims: The STAT4 gene encodes a transcription factor which plays an important role in the development of inflammation of many immune-mediated diseases. (ewha.ac.kr)
Cytokines1
Given the importance of CD4 + Th cells in the disease process, this review will focus on how Th cells differentiate in the inflamed intestinal tract during IBD and how the Th lineage-specific cytokines and transcription factors (TFs) contribute to disease. (frontiersin.org)