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  • endocytosis
  • Here, we show that ATP7B is transported from the trans-Golgi network (TGN) to the bile canaliculus by basolateral sorting and endocytosis, and microtubule-mediated transcytosis through the subapical compartment. (biologists.org)
  • The potential for transcytosis (endocytosisintracellular transport → exocytosis) of protein and membrane events associated with fluid phase and adsorptive endocytic processes within epithelia of the choroid plexus [blood-cerebrospinal fluid (CSF) barrier] were investigated in mice injected intravenously or into the lateral cerebral ventricle with native horseradish peroxidase (HRP) or the lectin wheatgerm agglutinin (WGA) conjugated to HRP. (pcom.edu)
  • The data suggest that CSF-borne protein entering the choroid epithelium by adsorptive endocytosis can undergo rapid transcytosis through the cell. (pcom.edu)
  • mucosal
  • As a result of their inability to transcytose flagellin, apical colonization by SPI-2 mutants induced substantially less epithelial IL-8 secretion than wild-type strains suggesting that such SPI-2 mediated transcytosis of flagellin plays a role in the pathogenesis of the mucosal inflammation characteristic of human Salmonellosis. (biologists.org)
  • vivo
  • Both in vivo (micropuncture) and in vitro (proximal tubule cell line) studies showed that α Klotho traffics from the basal to the apical side of the proximal tubule via transcytosis. (asnjournals.org)
  • mechanisms
  • Mechanisms in endothelium are critically involved in insulin transport from the circulation to skeletal muscle myocytes, with insulin undergoing transcytosis across the endothelium in a process that is rate limiting for peripheral insulin action ( 16 - 20 ). (diabetesjournals.org)
  • FcRn
  • The MHC class I-related receptor, FcRn, is involved in both the transcytosis of serum gamma-globulins (IgGs) and in regulating their serum persistence. (jimmunol.org)
  • In addition, two highly conserved Fc histidines (H435 and H436) have been mutated to alanine, and the resulting mutated Fc hinge fragments were analyzed in both transcytosis and pharmacokinetic studies in mice and in competition binding assays using recombinant, soluble FcRn. (jimmunol.org)
  • Transcytosis of both dIgA and IgG depends on sorting motifs embedded within the protein structures of the pIgR and the FcRn. (asmscience.org)
  • thus
  • Transcytosis through the floor of the subcapsular sinus thus represents what we believe to be a new physiological and targetable mode of lymph filtering. (the-jci.org)
  • show
  • Finally, we show that excitatory neurotransmitters increase Tf receptor transcytosis, whereas inhibitory neurotransmitters reduce it. (jneurosci.org)