Transcriptionally activates. Medical search. Frequent questions

Background: Bivalent chromatin domains consisting of the activating histone 3 lysine 4 trimethylation (H3K4me3) and repressive histone 3 lysine 27 trimethylation (H3K27me3) histone modifications are enriched at developmental genes that are repressed in embryonic stem cells but active during differentiation. (researchgate.net)
Although epigenetically silenced, endogenous retroviral (ERV) genes become activated in tumors and function to ignite immune responses. (frontiersin.org)
Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple biological processes, including in DNA damage repair, cell cycle arrest, apoptosis and senescence. (nih.gov)
In the context of DNA damage, p53 is thought to be a decision-making transcription factor that selectively activates genes as part of specific gene expression programmes to determine cellular outcomes. (nih.gov)
Its most important function may be to sequester the growth stimulatory effects of b-catenin, a protein that transcriptionally activates growth-associated genes in conjunction with tissue-coding factors. (medscape.com)
Although the Hsp70 synthesis started only after 1 hour of recovery, the hsp70 genes were transcriptionally activated immediately after HS and they continued to transcribe till at least 4 hours after the HS. (bioone.org)
One way genes can be controlled is by adding small chemical tags that mark them out to be activated or deactivated, known as epigenetic control. (elifesciences.org)
Antioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element (ARE), to which nuclear factor-E2-related factor 2 (Nrf2) binds and activates transcription. (embl.de)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)

The induction of ATF-3 expression was mediated by mitogen-activated protein kinase (MAPK) signaling pathways in GS-002-treated cells. (hindawi.com)
Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse sex determination. (plos.org)
The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)
This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)

Inhibition of cell viability was assessed with focus on apoptosis transcriptionally and translationally. (hindawi.com)
Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress conditions and plays an important role in inducing cancer cell apoptosis. (hindawi.com)

Many promoters in embryonic stem (ES) cells harbor a distinctive histone modification signature that combines the activating histone H3 Lys 4 trimethylation (H3K4me3) mark an. (researchgate.net)
This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. (thermofisher.com)

It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. (cancerindex.org)
Using this CasIP assay, we identified FECR1, a FLI1 exonic circular RNA that binds to the FLI1 promoter and epigenetically activates FLI1 in breast cancer cells. (biomedcentral.com)

It transcriptionally activates interleukin-3, and is implicated in apoptotic pathways. (wikipedia.org)
This expression was dependent on activation of either NF-κB, JAK1/JAK2 or BTK pathways since these pathways were activated in tumor B-cells and ex vivo treatment with the inhibitory molecules PHA-408, ruxolitinib and ibrutinib led to decrease of its expression. (springer.com)

Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. (genscript.com)

High levels of CLK/CYC activate the transcription of Vrille mRNA to increase protein production, leading to transcriptional repression of clk which ultimately reduces the concentration of CLK/CYC complexes. (wikipedia.org)
The data showed that adenine activated AMP-activated protein kinase (AMPK) signaling contributing to autophagic cell death through mTOR in both colon cancer cell lines. (hindawi.com)
Involvement of AMP-activated protein kinase (AMPK) in anticancer property of adenine was also investigated. (hindawi.com)
A small molecular weight G-protein essential for Nox2 activation, Rac1, is also transcriptionally activated via active DNA methylation-hydroxymethylation. (nature.com)
We show that ionizing radiation specifically enhances the motility and invasiveness of human GSCs through the stabilization and nuclear accumulation of the hypoxia-inducible factor 1α (HIF1α), which in turn transcriptionally activates the Junction-mediating and regulatory protein (JMY). (nature.com)
a protein component of a ubiquitin ligase complex) and hypoxia-inducible factors (a family of transcription factors activated by hypoxia). (lww.com)
Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. (thermofisher.com)
The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)

Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)

FoxM1 transcriptionally activates the PSMB4 expression level in cervical cancer cells. (nih.gov)
We have previously shown that the inflammatory transcription factor nuclear factor of activated T-cells 2 (NFATC1) is overexpressed in FLT3ITD-positive AML, yet its role in the transformation and AML development is unknown. (uni-marburg.de)
Tumors from mice given anti-PD1 had larger numbers of memory CD8+ T cells (CD44+CD62L-KLRG1int) and T cells that expressed PD1, lymphocyte activating 3 (LAG3), and TIGIT compared with mice not given the antibody. (stanford.edu)
It was then demonstrated that both ROS and TRPA1 are required in a subset of anterior enteroendocrine cells for the release of the DH31 neuropeptide which activates its receptor in the neighboring visceral muscles. (sdbonline.org)
No difference was found in how often the UPF1 gene is activated in FSHD cells and normal cells. (elifesciences.org)

Hypolipidemic drugs, such as bezafibrate, known activators of the peroxisome proliferator-activated receptor α (PPAR α ), induce both the PANK1 gene and miR107 (∼2.5-fold) in primary human hepatocytes. (aspetjournals.org)
Data suggest that, unlike the weak mitogen 2-OHE, 16α-OHE 1 stimulates cellular proliferation by constitutively activating the oestrogen receptor. (ersjournals.com)

Thus, H3K9me3 at Rac1 promoter assists in active DNA methylation-hydroxymethylation, activating Rac1 transcription. (nature.com)
Notably, FECR1 utilizes a positive feedback mechanism to activate FLI1 by inducing DNA hypomethylation in CpG islands of the promoter. (biomedcentral.com)

These results highlight the interest of therapies targeting the PD-1/PD-L1 axis in activated lymphomas with PD-L1 expression, with possible synergies with tyrosine kinase inhibitors. (springer.com)
In cholangiocytes, CCN1 activated NF-κB through integrin α v β 5 /α v β 3 , leading to Jag1 expression, JAG1/NOTCH signaling, and cholangiocyte proliferation. (jci.org)
The results of the present study revealed that ketamine treatment induced NF‑κB p65 translocation to nuclei and activated COX‑2 expression and prostaglandin (PGE)2 production in bladder tissue, whereas COX‑2 inhibitor suppressed the inflammatory effect. (spandidos-publications.com)

Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. (avivasysbio.com)

NF-κB constitutive activation is found either in aggressive diffuse large B-cell lymphomas (DLBCL) with an activated phenotype (ABC-DLBCL), or in indolent B-cell lymphomas such as chronic lymphocytic leukemia, Waldenström Macroglobulinemia, marginal zone B-cell lymphomas (MZL) [ 4 ]. (springer.com)

Bivalent promoters are defined by the presence of both activating (H3K4me3) and repressive (H3K27me3) chromatin marks. (researchgate.net)

Vrille is activated by the CLK/CYC complex and encodes a repressor of CLK transcription. (wikipedia.org)
The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. (avivasysbio.com)

Thus, we show for the first time that CYP2C8 is transcriptionally regulated by PPAR α , suggesting the potential for drug-drug interactions due to upregulation of CYP2C8 by PPAR activators. (aspetjournals.org)
show that when DUX4 is activated following the failure of epigenetic control in FSHD patients, the effectiveness of nonsense-mediated decay is also reduced. (elifesciences.org)

Among the ETS family members, Friend leukemia virus integration 1 ( FLI1 ) was first identified as a proto-oncogene activated by proviral integration in F-MuLV-induced erythroleukemias [ 4 ]. (biomedcentral.com)

Overall 5-year survival is approximately 50%, and treatment consists of en bloc surgical resection followed by high-dose conformal radiation therapy (RT) such as proton beam radiation. (medscape.com)
Surgical en bloc resection with negative margins is the only curative treatment for chordoma. (medscape.com)

In this study, we demonstrated that several other translation inhibitors also activate ER stress and the extrinsic apoptotic pathway. (oncotarget.com)
This study reports the identification of Drosophila Activated cdc42 kinase as a growth promoter and a novel Hippo signaling pathway regulator. (sdbonline.org)
Thus, this study identifies Drosophila Activated cdc42 kinase as a Hippo pathway regulator. (sdbonline.org)
A pathway crosstalk network analysis of these significantly high expressed proteins revealed that phagocytes were highly activated in a number of antimicrobial-related biological processes, including oxidation-reduction and lysosomal proteolysis processes. (figshare.com)
NLRP2, an inhibitor of the NF-kappaB pathway, is transcriptionally activated by NF-kappaB and exhibits a nonfunctional allelic variant. (cdc.gov)

Fibrates are a unique hypolipidemic drugs that lower plasma triglyceride and cholesterol levels through their action as peroxisome proliferator-activated receptor alpha (PPARα) agonists. (biomedcentral.com)
They function as agonists for peroxisome proliferator-activated receptor alpha (PPARα). (biomedcentral.com)
The peroxisome proliferator-activated receptors (PPARs) are transcriptional regulators of glucose and lipid metabolism. (rcsb.org)

It transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. (nih.gov)

Mechanistically, they found that ESE3/EHF transcriptionally represses Lin28A and Lin28B while it activates transcription and promotes maturation of let-7 microRNAs in normal cells. (urotoday.com)

A model is proposed that activated cdc42 kinase negatively regulates Expanded by changing its phosphorylation status to promote tissue growth. (sdbonline.org)

Therefore we hypothesized that ZNF322A in lung cancer may contribute to lung cancer stem cell-like (CSC-like) reprogramming through transcriptionally regulating stemness transcription factors, such as Oct4, Nanog, Sox2 and c-Myc. (nature.com)

For example, ZNF322A and c-Jun cooperatively bind to AP-1 elements on the cyclin D1 and alpha-adducin promoters to transcriptionally upregulate their expression to enhance tumor growth and tumor metastasis [ 2 ]. (nature.com)

Zfp322a promotes OKSM (Oct4, Klf4, Sox2, c-Myc)-induced mouse embryonic fibroblast reprogramming to mES cells by transcriptionally activating Oct4 and Nanog expression. (nature.com)
Activated cdc42 kinase promotes tissue growth through modulating Yorkie activity. (sdbonline.org)

RSKs are downstream effectors of the Ras-extra mobile signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signalling cascade. (ncbcs.org)
Non-receptor tyrosine kinase Activated cdc42 kinase (see Drosophila Ack ) was reported to participate in several types of cancers in mammals. (sdbonline.org)
Furthermore, Activated cdc42 kinase interacts with Expanded and induces tyrosine phosphorylation of Expanded on multiple sites. (sdbonline.org)

The importance of the p53/MDM2 relationship is underscored by the existence of an autoregulatory feedback loop whereby activated p53 transcriptionally upregulates the expression of its own inhibitor, MDM2. (rndsystems.com)

Strikingly, concurrent demethylation of both lysine residues resulted in a rapid and profound expansion of EHMT1's chromatin binding capacity, enabling EHMT1 to reprogram the transcription networks in prostate cancer cells and activate oncogenic signaling pathways. (bvsalud.org)

The first tier is primarily governed by pattern recognition receptors that are activated by recognition of evolutionarily conserved pathogen or microbial-associated molecular patterns (PAMPs or MAMPs). (wikipedia.org)
ETI is typically activated by the presence of specific pathogen "effectors" and then triggers strong antimicrobial responses (see R gene section below). (wikipedia.org)

POX1 has been shown to be transcriptionally activated in the presence of unsaturated fatty acids. (umn.edu)
They are activated by natural ligands, such as fatty acids, and are also targets of synthetic antidiabetic and hypolipidemic drugs. (rcsb.org)

Compared to aCO2 distinct parts of the community were transcriptionally activated. (uni-marburg.de)
On scRNA-seq, TG (but not WT) kidneys contained transcriptionally distinct, cdkn1a+ epithelia, recruited leukocytes and increased activated myofibroblasts. (asn-online.org)

As(III) transcriptionally activates the gadd45a gene via the formation of H2O2. (cdc.gov)
Our hypothesis is that KZFP gene expansion and diversification has been driven primarily by the constant onslaught of ERVs and other transposable elements (TEs) to the genomes of our ancestors, as a means to transcriptionally repress them. (nih.gov)
These activated STAT molecules form heterodimers that translocate to the nucleus and associate with an additional factor, IFN regulatory factor-9 (IRF-9), forming the complex termed IFN-stimulated gene factor-3 (ISGF3). (jci.org)

We show that these lnc-eRNAs are broadly activated in MLL -rearranged leukemia ( MLL leukemia), an aggressive leukemia caused by a chromosomal translocation, through a mechanism by which the HOXA cluster initiates enhancer activity, and the epigenetic reader BRD4 cooperates with the coregulator MLL fusion oncoprotein to induce transcriptional activation. (biomedcentral.com)
This study shows that lnc-eRNAs are epigenetically activated by cancer-initiating oncoproteins and uncovers a cis-activating mechanism of oncogene transcription control based on lnc-eRNA-mediated epigenetic regulation of enhancer activity, providing insights into the critical roles of lnc-eRNAs in cancer initiation and progression. (biomedcentral.com)

Mutants from two of the complementation groups, frm1 and frm3, were also defective in their ability to activate a reporter construct containing the 5'-upstream region of POX1. (umn.edu)

Significance: In this study, we demonstrate that EHMT1 and EHMT2 proteins drive prostate cancer development by transcriptionally activating multiple oncogenic pathways. (bvsalud.org)

In addition, the rifampicin-responsive constructs were strongly activated by a range of CYP3A inducers. (aspetjournals.org)

In some cases, defense-activating signals spread to the rest of the plant or even to neighboring plants. (wikipedia.org)

Anatomy2

Chemicals and Drugs4

Disciplines and Occupations1

Genes9

Mitogen-activa4

Apoptosis2

Histone2

Binds2

Pathways2

Tumor1

Protein8

MAPK1

Cells5

Receptor2

Promoter2

Expression3

Active1

Cell1

Presence1

Complex2

Show2

Family1

Treatment2

Pathway5

Peroxisome3

Skeletal muscle1

Mechanistically1

Regulates1

Stemness1

Promoters1

Promotes2

Kinase3

Inhibitor1

Chromatin1

Pathogen2

Fatty acids2

Distinct2

Gene3

Mechanism2

Ability to activate1

Proteins1

Addition1

Plant1