Transcriptional transcription genetic. Medical search. Frequent questions

These regions primarily function in the regulation of gene transcription. (wikipedia.org)
Polymorphisms in this region can lead to changes in the regulation of transcription. (wikipedia.org)
Scholars@Duke publication: Transcriptional down-regulation of tumor necrosis factor-alpha gene expression by a synthetic peptide homologous to retroviral envelope protein. (duke.edu)
MicroRNAs perform important roles in the post-transcriptional regulation of gene expression. (researchsquare.com)
Insertions of TEs influence the transcriptional regulation of some genes as well as the termination of transcription. (ecancer.org)
To identify elements other than Tup1 that are involved in regulation of the Mac1 regulon, we screened a C. albicans transcription factor mutant library with this FRE7 promoter fused to a lacZ reporter. (canada.ca)
From endocrine-mimics that modulate nuclear receptor driven gene expression to indirectly altering homeostatic regulation of lipoprotein metabolism, transcription factor pharmacotherapy is a current reality and will increasingly contribute to the treatment of human disease. (eurekaselect.com)
Patterns of transcriptional regulation from resting to induced levels varied among populations for both treatments. (datadryad.org)
Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)
Adult Drosophila acquire rapid functional tolerance to ethanol after a single sedation due in part to a transcriptional up-regulation of the slowpoke message. (utexas.edu)
Regulation of gene expression involves post-translational modifications to histones which cause chromatin decondensation and recruit transcription factors at the promoter to initiate transcription. (utexas.edu)
Increased acetylation at conserved control elements in the promoter is responsible for the transcriptional up-regulation of the gene following ethanol sedation. (utexas.edu)
The result of this investigation is the distributed control of transcriptional gene regulation: depending on the genotypic conditions, regulation is mediated either by dedicated transcription factors (digital) of by the change of DNA conformation (analog), that is, DNA supercoiling. (tu-darmstadt.de)
Transcriptional regulation is an important mechanism underlying gene expression and has played a crucial role in evolution. (upm.es)
A role of this interaction in transcriptional regulation was confirmed in planta. (upm.es)
Transcriptional co-regulation of physical clusters of adaptive genes may provide a way for the parasite to readily adapt to its highly heterogeneous and strongly selective environment. (ox.ac.uk)
Although the current generation of dCas9-based transcription activators is able to achieve up-regulation of some endogenous loci, the magnitude of transcriptional up-regulation achieved by individual single-guide RNAs (sgRNAs) 12 typically ranges from low to ineffective 8 - 11 . (cdc.gov)
We found that the regulation of TE transcription during brain development is essential for the establishment of long-term transcriptional repression carried to adulthood (Paper I and IV). (lu.se)
More so, our results show that the epigenetic regulation of TE transcription is dynamically regulated throughout life (Paper II), upon the beginning of neuroinflammation (Paper III), and in a disease-driving polymorphic TE insertion (Paper IV). (lu.se)

We report here that in tumor cells expressing high levels of c-Myc the transcription factor accumulates in the promoter regions of active genes and causes transcriptional amplification, producing increased levels of transcripts within the cell's gene expression program. (nih.gov)
Enhancers are DNA sequences found in 5′ flanking regions of eukaryotic genes that affect transcription. (wikipedia.org)
This protein is a transcription factor, which means it helps regulate the activity of other genes. (medlineplus.gov)
Specifically, the forkhead box G1 protein acts as a transcriptional repressor, turning off (repressing) the activity of certain genes when they are not needed. (medlineplus.gov)
The condition can also result from a deletion of genetic material from a region of the long (q) arm of chromosome 14 that includes the FOXG1 gene and several neighboring genes. (medlineplus.gov)
This synthetic genetic interaction is seen at the level of single genes and acts downstream of promoter nucleosome reorganization. (sdbonline.org)
However, the existence of specific transcriptional repressors responsible for the silencing of lineage inappropriate genes remains elusive. (eur.nl)
We found that HDAC7 specifically interacted with the transcription factor MEF2C in pre-B cells and was recruited to MEF2 binding sites located at the promoters of genes critical for macrophage function. (eur.nl)
Thus, in B cells HDAC7 is a transcriptional repressor of undesirable genes. (eur.nl)
Transcriptional analysis of C. albicans treated with PGE2 indicated differential expression of genes involved in alternative carbon source catabolism, and showed repression of genes encoding components of both the translational machinery and the homolog of Saccharomyces cerevisiae Mac1 regulon needed for iron uptake. (canada.ca)
Advances in molecular genetic tools and an increased understanding of the functional roles of specific genes allow us to test hypotheses concerning the role of variable environments in shaping transcription at known-function candidate loci. (datadryad.org)
Genes can be regulated at multiple levels, for instance, at the level of transcription, level of mRNA splicing, mRNA editing, post-translational modifications to the protein and protein localization. (utexas.edu)
This suggests a local-acting regulatory role for CNVs in transcription of neighboring genes and helps explain the chromosomal clustering that we observed here. (ox.ac.uk)
These include genes involved in energy production, intermediary metabolism and cell signaling/transcription factors (0.4 - 0.7 -fold down regulated). (cdc.gov)
We use these engineered Cas9 activation complexes to investigate sgRNA targeting rules for effective transcriptional activation, demonstrate multiplexed activation of 10 genes simultaneously, and upregulate long intergenic non-coding RNA (lincRNA) transcripts. (cdc.gov)
These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)

Mutations in the major core histones relieve transcriptional repression and bypass the requirement for SNF/SWI and SAGA. (sdbonline.org)
Prostaglandin-mediated repression of the Mac1 regulon required the Tup1p transcriptional regulator, and did not occur in hyphal cells. (canada.ca)
FOXL2 is a transcriptional regulator that is essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. (nih.gov)
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. (fhcrc.org)
Transcriptional repression by nuclear receptors has been correlated to binding of the putative co-repressor, N-CoR. (fhcrc.org)
A complex has been identified that contains N-CoR, the Mad presumptive co-repressor mSin3, and the histone deacetylase mRPD3, and which is required for both nuclear receptor- and Mad-dependent repression, but not for repression by transcription factors of the ets-domain family. (fhcrc.org)
We found that although different types of E2 proteins all exhibited transactivation and repression activities, depending on the sequence context of the E2-binding sites, HPV-16 E2 shows stronger transcription activity and greater DNA-binding affinity than those displayed by the other E2 proteins. (providence.org)

A number of post-transcriptional mechanisms fine-tune the gene expression landscape. (researchsquare.com)
We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)
Taken together, our results suggest that post-transcriptional mechanisms play an important role in the brain both during development and in the adult brain. (lu.se)

Our long-term goal with this project is to achieve a precise understanding of the genetic and transcriptional mechanisms underlying early heart development. (seattlechildrens.org)
Transcriptional control mechanisms influence these genetic networks and some success has been attained by manipulating the action of transcription factors toward a more favorable therapeutic profile. (eurekaselect.com)
When it comes to genetic editing for humans and other species however, "cells have defence mechanisms - a process called gene silencing - that actually resist the genetic manipulation or the activation of a new programmed state," Kotter states, before going on to explain that "gene silencing has emerged as a mechanism that specifically constrains our ability to program human cells. (ddw-online.com)
The molecular genetic mechanisms facilitating local adaptation in salmonids continue to be poorly characterized. (datadryad.org)
Smooth muscle cell (SMC) phenotypic transition, which leads to the formation of various cell types in atherosclerotic plaques, is regulated by a network of genetic and epigenetic mechanisms and governs the risk of disease. (stanford.edu)
To better understand the epigenetic and transcriptional mechanisms that mediate these cell state changes, and how they relate to risk for coronary artery disease (CAD), we have investigated the causality and function of transcription factors (TFs) at genome wide associated loci. (stanford.edu)
To understand the molecular mechanisms that coordinate these processes we are using genetic, genomic, biochemical and proteomic tools. (csic.es)
Furthermore, since a number of genetic disorders or human diseases (including cancer or neurodegenerative diseases) relate to abnormalities in RNA processing and proper ribonucleoprotein assembly, we anticipate that the detailed knowledge of mechanisms regulating the co-transcriptional processing will be of clinical value in the long term. (muni.cz)
Despite extensive genetic and biological research, significant controversy surrounds our understanding of the specific mechanisms of their pathogenesis. (mdpi.com)

In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)
B) When AHL presents and binds to transcriptional regulator, the transcription regulator binds its DNA binding site, thus to reduce the accessibility of RNA polymerase to promoter, repressing the transcription initiation. (igem.org)
Together, this study shows that the PSC is dispensable for blood cell progenitor maintenance and reveals the key role of the conserved transcription factor Col as an intrinsic regulator of hematopoietic progenitor fate. (sdbonline.org)

We expect that this project will identify genetic and epigenetic regulators of muscle fiber-type identities that confer susceptibility or resistance to muscular dystrophy. (seattlechildrens.org)
Studies have focused on the genetic and epigenetic status of CAFs, since they are critical in tumor progression and differ phenotypically and functionally from normal fibroblasts. (spandidos-publications.com)
A total of 7 possible genetic alterations and epigenetic changes in CAFs are discussed, including gene differential expression, karyotype analysis, gene copy number variation, loss of heterozygosis, allelic imbalance, microsatellite instability, post‑transcriptional control and DNA methylation. (spandidos-publications.com)
These genetic and epigenetic characteristics are hypothesized to provide a deep understanding of CAFs and a perspective on their clinical significance. (spandidos-publications.com)
Epigenetic alterations, represented by post-transcriptional control and DNA methylation, have been the focus of recent studies. (spandidos-publications.com)
Therefore, it has been demonstrated that genetic or epigenetic alterations may be responsible for the special features of CAFs ( Fig. 1 ) ( 10 ). (spandidos-publications.com)
The present review summarizes the current knowledge regarding 7 possible genetic and epigenetic alterations in CAFs. (spandidos-publications.com)
Genetic alterations and epigenetic changes in CAFs. (spandidos-publications.com)
Compared to NFs, CAFs possess numerous types of potential genetic alterations and epigenetic changes. (spandidos-publications.com)
e.g. inflammation, genotoxicity, and This chapter focuses on issues as- ellers, growth factors, growth factor epigenetic alterations) and can have sociated with the understanding and receptors, signal transducers, and both genetic and epigenetic origins. (who.int)

As a way to demonstrate the utility of cell-free TX-TL, we illustrate the characterization of two genetic networks: an RNA transcriptional cascade and a protein regulated incoherent feed-forward loop. (biorxiv.org)
Due to the critical role of CAFs during cancer progression, the genetic characterization of CAFs aids in the investigation of cancer therapy. (spandidos-publications.com)
Genetic, structural, and functional characterization of a multi-donor class of 'public' antibodies revealed an NTD epitope that is recurrently mutated among emerging SARS-CoV-2 variants of concern. (cdc.gov)

H2A.Z is preferentially crosslinked in vivo to intergenic DNA at the PH05 and GAL1 loci, and this association changes with transcriptional activation. (sdbonline.org)
We assayed gene transcription at candidate loci that play a role in the molecular genetic response to these stresses, and correlated transcription with temperature data from the streams and the abundance and diversity of bacteria as characterized by massively parallel pyrosequencing. (datadryad.org)
Genomic location of these long noncoding RNA is disproportionately enriched near CAD-related TFs (transcription factors), genetic loci, and gene regulators of SMC identity, suggesting the importance of their function in disease. (stanford.edu)
We describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. (cdc.gov)

The binding of the TATA box with TATA binding protein initiates the formation of a transcription factor complex. (wikipedia.org)
A specific transcription factor called CAAT-binding protein binds to this region and aids in transcription in eukaryotes. (wikipedia.org)
Taken together, these results suggest that the synthetic retroviral peptide CKS-17 down-regulates TNF-alpha mRNA expression through inhibition of transcriptional activation of the TNF-alpha gene, which requires de novo synthesis of a transcriptional repressor protein(s). (duke.edu)
For example, engineered RNAs can be used as switches to interface with protein-based transcriptional control via CRISPR/Cas systems. (unm.edu)
We aim to understand how plants respond to beneficial and damaging light stimulus by controlling in a coordinated way protein homeostasis, chromatin dynamics and transcriptional networks. (csic.es)
We are especially interested in the events that lead to coordinated transcriptional changes during light adaptation as changes in chromatin states, transcription factor stability and protein homeostasis. (csic.es)
The full-length E2 protein, encoded by human papillomaviruses (HPVs), is a sequence-specific transcription factor found in all HPVs, including cancer-causing high risk HPV types 16 and 18 and wart-inducing low risk HPV types 6 and 11. (providence.org)
A novel protein call AnkA in A. phagocytophilum is translocated from the bacterium within a host vacuole into the host nucleus, where it forms complexes with heterochromatin and is largely responsible for many host transcriptional changes by directly binding to regulatory regions of the DNA. (cdc.gov)
Different strategies to target hypoxic cancer cells and/or HIFs include hypoxia-activated prodrugs and inhibition of HIF dimerization, mRNA or protein expression, DNA binding capacity, and transcriptional activity. (lu.se)
Cas9 nuclease can be converted into an RNA-guided DNA binding protein (dCas9) via inactivation of its two catalytic domains 12 , 13 and then fused to transcription activation domains. (cdc.gov)
In line with our previous results, we found that there are marked differences between HD patients and controls at the protein level but not at the transcriptional level. (lu.se)
Lewy bodies which are intraneuronal aggregates composed mainly of misfolded alpha synuclein (a-syn) protein is a pathological hallmark seen in both sporadic and genetic forms of PD. (lu.se)

Comparative transcriptional and genomic analysis of Plasmodium falciparum field isolates. (ox.ac.uk)
Professor Ma's long-term goal is to utilize comparative genomics to better understand the relationship between genomic differences and phenotypic diversity across mammalian species, which will in turn help understand the human genome and identify key genetic variants related to diseases. (illinois.edu)
Transposable elements (TEs) are mobile genetic sequences that comprise around 50% of our genomic DNA. (lu.se)

HIFs exert differential effects on tumor growth and affect important cancer hallmarks including cell proliferation, apoptosis, differentiation, vascularization/angiogenesis, genetic instability, tumor metabolism, tumor immune responses, and invasion and metastasis. (lu.se)

These results describe a novel pathway for regulating transcription using variant histones to modulate chromatin structure (Santisteban, 2000). (sdbonline.org)
The lab's focus is transcriptional regulatory network inference, modeling gene expression as a function of transcription factor activities, from gene expression and measurements of chromatin state. (cincinnatichildrens.org)
Chromatin accessibility measurements by ATAC-seq, together with transcription-factor DNA-binding preferences (motifs), can be used to broadly profile potential transcription factor binding events in relatively small populations of cells. (cincinnatichildrens.org)

Transcriptional activity among high and low risk human papillomavirus E2 proteins correlates with E2 DNA binding. (providence.org)
To investigate whether E2 proteins encoded by high risk HPVs may function differentially from E2 proteins encoded by low risk HPVs and animal papillomaviruses, we conducted comparative DNA-binding and transcription studies using electrophoretic mobility shift assays and cell-free transcription systems reconstituted with purified general transcription factors, cofactor, RNA polymerase II, and with E2 proteins encoded by HPV-16, HPV-18, HPV-11, and bovine papillomavirus type 1 (BPV-1). (providence.org)
When AHL represents and binds to luxR proteins, luxR will bind to its DNA binding site, the lux box, thus to reduce the accessibility of RNA polymerases to this promoter, repressing the transcription initiation. (igem.org)
At the level of gene transcription, gene expression is controlled via transcriptional regulatory proteins that selectively bind to regulatory elements in non-coding regions of the genome. (illinois.edu)
Gene Ontology analysis revealed a strong enrichment in proteins with DNA binding and/or transcription-regulatory properties. (sdbonline.org)
Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)
Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)

Additionally, induced mutations in these -35 and -10 promoter sequences have proven to be deleterious to transcription. (wikipedia.org)
Genetic mutation is one genetic alteration, but not all genetic mutations are harmful. (spandidos-publications.com)
Mutations in the FOXL2 gene cause blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) types I and II, a rare genetic disorder. (nih.gov)
Recent findings on the control of gene expression programs has had an essential impact on our perception of transcriptional misregulation in pathologic conditions, as many different disorders are due to mutations in regulatory sequences and their cognate transcription factors. (tigem.it)
The disease is due to mutations in the transcription factor TBX5 , which is important in the development of both the heart and upper limbs. (medscape.com)
Molecular genetic studies reveal that the disease is caused by mutations that inactivate the transcription factor TBX5 . (medscape.com)

LMX1B encodes a LIM-homeodomain transcription factor. (nih.gov)
Elevated expression of the c-Myc transcription factor occurs frequently in human cancers and is associated with tumor aggression and poor clinical outcome. (nih.gov)
If a transcription factor binds to an enhancer in a 5′ flanking region, the DNA strand bends in a way that the transcription factor that is bound to the enhancer can also bind the promoter of a gene. (wikipedia.org)
This is followed by binding of transcription factor TFIID, which then recruits TFIIB, TFIIF, RNA polymerase II and TFIIH (in that order) to form an initiation complex. (wikipedia.org)
We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
The synthetic biology platform is able to express transcription factor combinations that reprogram human iPSCs into highly defined and mature human cell types. (ddw-online.com)
By promoting COP1 turnover DET1 is essential for its activity, keeping a tight control of HY5 transcription factor levels. (csic.es)
MYRF is a membrane associated transcriptional factor highly expressed in developing diaphragm and is depleted of LGD variants in the general population. (columbia.edu)
Analyzing the transcriptome of patient-derived diaphragm fibroblast cells suggest that disease associated variants abolish the transcription factor activity. (columbia.edu)
The EBF transcription factor Collier directly promotes Drosophila blood cell progenitor maintenance independently of the niche. (sdbonline.org)
In the lymph gland , an hematopoietic organ in Drosophila larva, a group of cells called the Posterior Signaling Centre (PSC), whose specification depends on the EBF transcription factor Collier (Col) and the HOX factor Antennapedia (Antp), has been proposed to form a niche required to maintain the pool of hematopoietic progenitors (prohemocytes). (sdbonline.org)
Collier, the single Drosophila COE (Collier/EBF/Olf-1) transcription factor, is required in several developmental processes, including head patterning and specification of muscle and neuron identity during embryogenesis. (sdbonline.org)
In 838 individuals, of which 372 were afflicted with ADHD, in silico, in vitro, and in vivo methods were used to identify and characterize evolutionarily conserved elements within ADGRL3 that showed transcriptional enhancer activity and transcription factor-binding disruption. (medscape.com)
Transcription factor 7-like 2 ( TCF7L2 ) variants have been associated with type 2 diabetes mellitus (T2DM) in multiple ethnic groups. (medscape.com)

At decreased oxygen tensions, hypoxia-inducible factors (HIFs) 1 and 2 are stabilized and mediate a hypoxic response, primarily by acting as transcription factors. (lu.se)

We therefore introduce the reader to CRISPR-based screens in the related apicomplexan Toxoplasma gondii and discuss how these approaches could be adapted to develop CRISPR/Cas9 based genome-scale genetic screens in malaria parasites. (portlandpress.com)
Although A. baumannii possesses Type I-F CRISPR-Cas systems, they have not yet been used for genetic modifications. (bvsalud.org)
To investigate transcriptional inhibition by the Type I-F CRISPR system, the gene encoding its Cas2-3 nuclease was deleted and the native Type I-F Cascade effector was repurposed to regulate transcription of alcohol dehydrogenase gene adh4. (bvsalud.org)

We also show that the transcriptional initiation of myc mRNA is changed in the RICs. (lu.se)

To illustrate the importance of this concept, we study transcriptional cascades consisting of two inducible synthetic transcription factors connected in series. (researchgate.net)
Furthermore, multi-component transcriptional cascades can result in a significant time delay. (igem.org)

Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
Every differentiation step is characterized by the activation of a new, lineage-specific, genetic program and the extinction of the previous one. (eur.nl)
All of the quorum sensing systems currently exploited in synthetic biology exhibit transcriptional activation, which cannot provide negative feed back loops during cell-cell communication. (igem.org)
Tiling a given promoter region with several sgRNAs can produce more robust transcriptional activation 9 - 11 , but this requirement presents enormous challenges for scalability, and in particular for establishing pooled, genome-wide GOF screens. (cdc.gov)

This leads to RNA polymerase recruitment and interaction with transcription factors and the promoter, and an overall higher transcription rate than the basal level. (wikipedia.org)
Bacterial RNA polymerase binds to these regions to align itself and begin transcription. (wikipedia.org)
The concept of the CTD code that specifies the position of RNA polymerase II in the transcriptional cycle and thus recruits specific processing factors, was suggested almost a decade ago. (muni.cz)
However, how the C-terminal domain (CTD) of RNA polymerase II recruits, activates, and displaces appropriate processing factors in coordination with the transcription cycle, remains obscure. (muni.cz)

Harper said the traditional thinking is that cells don't control cell death following transcriptional inhibition-that cell death is accidental. (umassmed.edu)

These results provide an explanation for the diverse effects of oncogenic c-Myc on gene expression in different tumor cells and suggest that transcriptional amplification reduces rate-limiting constraints for tumor cell growth and proliferation. (nih.gov)
A Gradual Transition Toward Anaplasia in Wilms Tumor Through Tolerance to Genetic Damage. (lu.se)

Thus, we have used ATAC-seq with RNA-seq to enable de novo inference of transcriptional regulatory networks in physiological settings where sample material is limiting (e.g., intestinal immune cells in response to microbial/genetic perturbations). (cincinnatichildrens.org)
Indeed, numerous mendelian diseases are attributable to alterations in transcription factors acting at the node of gene regulatory networks, often responsible for subtle changes at critical moments of cell fate decisions. (tigem.it)

These new models, which we term Multi-Functional Human Tissue Genetics, allow up to 10 alleles or more to be altered simultaneously, permitting genetic experiments with an unprecedented degree of rapidity and complexity. (stanford.edu)

Here, we review the arrival of genetic screens in malaria parasites to analyse parasite gene function at a genome-scale and their impact on understanding parasite biology. (portlandpress.com)

Eight additional individuals with de novo LGD or missense variants were identified from our other genetic studies or from the literature. (columbia.edu)

Nucleosomes impose a block to transcription that can be overcome in vivo by remodeling complexes such as SNF/SWI and histone modification complexes such as SAGA. (sdbonline.org)
The variant histone H2A.Z regulates gene transcription, and deletion of the gene encoding H2A.Z strongly increases the requirement for SNF/SWI and SAGA. (sdbonline.org)

It is widely recognized that the accumulation of various harmful genetic alterations in normal cells may induce malignant cancer cells ( 1 ). (spandidos-publications.com)
Genetic alterations include genetic mutation, gene copy number variation (CNV), loss of heterozygosity (LOH), allelic imbalance (AI) and microsatellite instability (MSI). (spandidos-publications.com)
The dynamic changes in expression of these lncRNAs correspond to alterations in transcriptional programs that are relevant to CAD, suggesting a critical role for lncRNAs in SMC phenotypic transition and human atherosclerotic disease. (stanford.edu)

Also, the precise dynamics through which transcription factors regulate cell fate decisions and to what extent associated DNA sequence variants can determine pathogenic effects are still largely unknown. (tigem.it)
Autosomal genetic variance is enriched for common variants and regions of lower linkage disequilibrium. (nature.com)
This makes TCF7L2 variants the strongest known genetic risk factors for T2DM. (medscape.com)
[ 11 ] Subsequent studies have shown that several noncoding genetic variants of TCF7L2 are associated with T2DM risk in populations of diverse ancestries in the United Kingdom, the Netherlands, Finland, Sweden, France, India, and Japan. (medscape.com)
[ 29 ] These data suggest that genetic susceptibility to T2DM as determined by TCF7L2 variants might prove an actionable indicator for early intervention and disease prevention. (medscape.com)

We identified several LMX1B binding sites in the putative regulatory regions of both CD2AP and NPHS2 (podocin) and demonstrated that LMX1B binds to these sequences in vitro and can activate transcription through them in cotransfection assays. (nih.gov)

We are using zebrafish and mouse models to study the functions of factors such as Pbx homeodomain transcription factors and how they control muscle fiber-type development. (seattlechildrens.org)
Treatments are contained in separate tabs where "C" under the treatment column reflects control or resting state transcription and "T" or "P" indicates response to temperature or vaccine challenge. (datadryad.org)
These data brought new evidence that Col direct control of the expression of the transcription regulators apterous and eyes-absent (eya) is critical to specifying neuronal identities. (sdbonline.org)
The level of adh4 transcription was inhibited by up to 900-fold compared with the control. (bvsalud.org)

We have used transcript profiling to explore the early transcriptional responses of mature C. albicans biofilms exposed to various antifungal agents. (who.int)
Thus, enhanced extracellular matrix or beta-glucan synthesis during biofilm growth might prevent antifungals, such as azoles and polyenes, from reaching biofilm cells, thus limiting their toxicity to these cells and the associated transcriptional responses. (who.int)

Here we describe transcriptional variation among culture-adapted field isolates of Plasmodium falciparum, the species responsible for most malarial disease. (ox.ac.uk)
The researchers found a variation in ECR47 associated with ADHD that disrupts its ability to function normally and interferes with gene transcription, specifically in the thalamus. (medscape.com)
More so, TEs are a rich source of genetic variation, which makes them an intriguing research avenue to investigate humanspecific traits, including their impact on human brain evolution and their relevance in disease. (lu.se)

Dr. Lakin has previously worked on a number of biological modeling languages, including Visual DSD , Genetic Engineering of Cells , and the Stochastic Pi Machine . (unm.edu)
There are built-in signaling pathways that cells use to sense transcriptional fidelity. (umassmed.edu)
Perhaps they're sensing their transcriptional fidelity in different ways as well, and we just aren't targeting them in a rational way because we don't know how these drugs are causing cells to die," Harper said. (umassmed.edu)
Cell-free transcription-translation (TX-TL) systems offer a simple and fast alternative to performing these characterizations in cells. (biorxiv.org)
The company's proprietary opti-ox (optimised inducible overexpression) technology is what bit.bio uses to execute these genetic programs in human stem cells. (ddw-online.com)
Some transcription factors with dominant roles in controlling cell fate decisions are also capable of reprogramming cell states when ectopically expressed, turning somatic cells into stem cells or new cell identities and thus stimulating new research directions into human regenerative medicine. (tigem.it)

Nuclear run-on transcription assays further reveal that CKS-17 suppresses the TNF-alpha mRNA transcription rate. (duke.edu)

This is due to a paucity of functional annotation from sequence homology, which is compounded by low genetic tractability compared with many model organisms. (portlandpress.com)

In this paper we describe the effect of the translocation on myc transcription in the RIC system. (lu.se)

Their mutagenic potential and gene regulatory effect have shaped the evolution of transcriptional networks involved in development, pluripotency, and inflammation. (lu.se)

Unluckily, both AHS and CHS challenge the genetic, nutritional, pharmaceutical, and management developments made by the animal farming industries that cause a considerable drop in production, proving to be one of the major hurdles to achieve efficient livestock farming in many regions of the world ( 9 , 10 ). (frontiersin.org)

To date, the central role of specific transcription factors in positively regulating these distinct differentiation processes to acquire a B cell-specific genetic program is well established. (eur.nl)
In contrast with this model, this study shows that genetic ablation of the PSC does not cause an increase in blood cell differentiation or a loss of blood cell progenitors. (sdbonline.org)

Combining transcriptional data and in silico modeling along with in vitro validation, we identified CAD gene ZEB2 as a target through which these lncRNAs exert their function in SMC phenotypic transition.Expression of a large and diverse set of lncRNAs in human coronary artery SMC are highly dynamic in response to CAD-related stimuli. (stanford.edu)

Experiments in Arabidopsis thaliana and Saccharomyces cerevisiae demonstrate the sensitive detection of banned organophosphate contaminants using living biosensors and the construction of multi-input/output genetic circuits. (nature.com)

One transcription enhancer called ECR47 showed the highest association with ADHD. (medscape.com)

Researchers from the National Human Genome Research Institute in Bethesda, Maryland, have further characterized a genetic risk for attention-deficit/hyperactivity disorder ( ADHD ). (medscape.com)

The Cascade transcriptional module was also successfully applied in a clinical Klebsiella pneumoniae isolate. (bvsalud.org)
CONCLUSION: This study proposed a tool for future exploration of the genetic characteristics of A. baumannii or other clinical strains. (bvsalud.org)
Clinical and genetic analyses of a Swedish patient series diagnosed with ataxia. (lu.se)

This property of the regulatory apparatus explains the genetic adaptability of bacteria to changing environmental conditions. (tu-darmstadt.de)

Individual miRNAs are capable of regulating gene networks by interacting with multiple targets or by suppressing transcriptional controllers [ 6 , 8 ]. (researchsquare.com)
We also provide guidelines for designing TX-TL experiments to characterize new genetic networks. (biorxiv.org)

Here, we used mice with a genetic deletion of miR-22 to extend these insights. (researchsquare.com)

Although the mechanism is unclear, researchers believe that the extra genetic material leads to these developmental problems by altering early brain development. (medlineplus.gov)
Gene transcription is a highly regulated step in the expression of a phenotype and it has been shown to respond to selection and thus may be one mechanism that facilitates the development of local adaptation. (datadryad.org)
This suggests that slowpoke mediated rapid tolerance to ethanol involves a transcription-independent mechanism. (utexas.edu)

Anatomy15

Organisms9

Chemicals and Drugs124

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes84

Disciplines and Occupations1

Information Science3

Regulation19

Genes16

Repression7

Post-transcriptional mechanisms3

Mechanisms9

Regulator3

Epigenetic10

Characterization3

Loci4

Protein12

Genomic3

Metabolism1

Chromatin3

Proteins7

Mutations6

Factor14

Mediate1

CRISPR3

Initiation1

Cascades2

Activation4

Polymerase4

Inhibition1

Tumor2

Regulatory Networks2

Genetics1

Malaria parasites1

Novo1

Histone2

Alterations3

Variants5

Binds1

Control4

Responses2

Variation3

Cells6

Assays1

Sequence homology1

Describe1

Inflammation1

Regions1

Differentiation2

Silico1

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Enhancer1

Human genome1

Clinical3

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Networks2

Deletion1

Mechanism3