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RetinoblastomaRetinoblastoma ProteinRetinal NeoplasmsGenes, RetinoblastomaEye NeoplasmsMolecular Sequence DataRetinoblastoma-Like Protein p107Amino Acid SequenceRetinoblastoma-Like Protein p130E2F Transcription FactorsEye EnucleationTumor Suppressor Protein p53Cell CycleTranscription Factor DP1Base SequenceProtein BindingDNA-Binding ProteinsCyclin-Dependent KinasesRetinoblastoma-Binding Protein 1E2F1 Transcription FactorSequence Homology, Amino AcidCell Cycle ProteinsNuclear ProteinsTranscription FactorsCell LineCarrier ProteinsCyclinsPhosphorylationTumor Cells, CulturedG1 PhaseCyclin-Dependent Kinase 4MutationCloning, MolecularSequence AlignmentTranscription, GeneticAdenovirus E1A ProteinsBacillus PhagesPromoter Regions, GeneticCell DivisionCyclin D1Cyclin-Dependent Kinase Inhibitor p16TransfectionApoptosisBinding SitesChromosomes, Human, Pair 13Blotting, WesternPhosphoproteinsRecombinant Fusion ProteinsCyclin-Dependent Kinase 2Protein Structure, TertiaryGene Expression RegulationRNA, MessengerViral ProteinsCyclin-Dependent Kinase 6Cyclin-Dependent Kinase Inhibitor p21Cell NucleusProteinsPapillomavirus E7 ProteinsS PhaseCDC2-CDC28 KinasesHeLa CellsCells, CulturedRecombinant ProteinsCyclin-Dependent Kinase Inhibitor p27Antigens, Polyomavirus TransformingE2F3 Transcription FactorRepressor ProteinsE2F4 Transcription FactorCell ProliferationSignal TransductionDNA, ComplementaryCyclin EProtein-Serine-Threonine KinasesDNA PrimersDNACell Line, TumorPrecipitin TestsArabidopsis ProteinsProto-Oncogene ProteinsOncogene Proteins, ViralMembrane ProteinsArabidopsisTwo-Hybrid System TechniquesGene ExpressionPlant ProteinsCell DifferentiationImmunohistochemistryBacteriophage PRD1ImmunoblottingCyclin ATumor Suppressor ProteinsFibroblastsChromosomal Proteins, Non-HistoneMicrotubule-Associated ProteinsPlasmidsPhylogenyHistonesRetinoblastoma-Binding Protein 2Models, BiologicalCyclin D
Nuclear ProteinsP130GenesPost-transcriptionalProto-OncogeneMRNAs and proteinsOncogenicRegulatesTranscriptionCoregulatorInhibitoryTumorRepressionRegulatorsGeneCyclinFamilialChromatinRegulatoryMammalianRegulationIncreased risk ofComplexesPhosphorylationMultifunctionalBRCA1DifferentiationNucleusAbnormalDistinctCellularMotifMeSHCellPocketFunctionRegulateCancerSpecificControlCells
Nuclear Proteins2
  • Nuclear Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
  • Below are the most recent publications written about "Nuclear Proteins" by people in Profiles over the past ten years. (uams.edu)
P1306
  • The members of the retinoblastoma family of pocket proteins, pRb, p107 and p130, are negative regulators of the cell cycle with tumor suppressor activity and with roles in differentiation. (oncotarget.com)
  • Pocket proteins Rb, p107 and p130 play central roles in cell cycle progression and differentiation. (eu.org)
  • The LxSxE motif is specific for p107/p130 and is present in LIN52, a component of the DREAM complex. (eu.org)
  • A phosphorylation downstream to the core motif acts as a switch that binds to a positively charged pocket only present in p107/p130. (eu.org)
  • The LxDLFD motif ( LIG_RB_pABgroove_1 ) mediates binding to a highly conserved deep groove formed in the interface between the A and B subdomains of the Rb, p107 and p130 pocket domains. (eu.org)
  • Pro-proliferative focus on genes cyclinD1 (CCND1) and E2F1 aswell as anti-proliferative goals CDKN1A (p21) PTEN RB1 RBL1 (p107) RBL2 (p130) had been proven as common goals for miR-17 -20 and -106b. (techblessing.com)
Genes6
  • Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
  • Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
  • In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)
  • Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
  • A substantial portion of the regulatory interactions in the higher eukaryotic cell are mediated by simple sequence motifs in the regulatory segments of genes and (pre-)mRNAs, and in the intrinsically disordered regions of proteins. (biomedcentral.com)
  • Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). (bvsalud.org)
Post-transcriptional2
  • Background MicroRNAs are brief (～22 nt) non-coding regulatory RNAs that control gene appearance on the post-transcriptional level. (techblessing.com)
  • Consequently, motifs are indispensable for temporal, spatial, conditional and basal regulation at the transcriptional, post-transcriptional and post-translational level. (biomedcentral.com)
Proto-Oncogene1
  • Below are the most recent publications written about "Proto-Oncogene Proteins c-mdm2" by people in Profiles. (umassmed.edu)
MRNAs and proteins1
  • This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
Oncogenic1
  • Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomavirus, bind and inactivate pRb, this can lead to cancer. (wikipedia.org)
Regulates2
  • Therefore, EBF3 regulates a transcriptional program underlying a putative tumor suppression pathway. (aacrjournals.org)
  • In budding yeast, these substrates include the transcriptional inhibitor Whi5 that regulates the G1/S transition. (bvsalud.org)
Transcription10
  • RB/E2F-family proteins repress transcription. (wikipedia.org)
  • pRb binds and inhibits E2 promoter-binding-protein-dimerization partner (E2F-DP) dimers, which are transcription factors of the E2F family that push the cell into S phase. (wikipedia.org)
  • The pRb-E2F/DP complex also attracts a histone deacetylase (HDAC) protein to the chromatin, reducing transcription of S phase promoting factors, further suppressing DNA synthesis. (wikipedia.org)
  • The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)
  • this family of proteins is hereafter called EBF) are a group of DNA-binding transcription factors with the basic helix-loop-helix (bHLH) domain. (aacrjournals.org)
  • Many strikingly miR-17 -20 and -106b had been found to market cell proliferation by raising the intracellular activity of E2F transcription elements even though miR-17 -20 and -106b straight focus on the transcripts that encode because of this proteins family members. (techblessing.com)
  • In budding yeast, the G1 cyclin Cln3-Cdk1 complex is thought to directly phosphorylate the Whi5 protein, thereby releasing the transcription factor SBF and committing cells to division. (bvsalud.org)
  • We observe that each gene and its products have a unique set of DNA, RNA or protein motifs that encode a regulatory program to define the logical circuitry that guides the life cycle of these biomolecules, from transcription to degradation. (biomedcentral.com)
  • Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. (childrensmercy.org)
  • Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
Coregulator1
  • Deleterious, protein-altering variants in the transcriptional coregulator ZMYM3 in 27 individuals with a neurodevelopmental delay phenotype. (uams.edu)
Inhibitory1
  • The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)
Tumor2
Repression1
Regulators1
Gene8
  • In humans, the protein is encoded by the RB1 gene located on chromosome 13-more specifically, 13q14.1-q14.2. (wikipedia.org)
  • This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • Note that by convention gene names are italicized and the proteins they make are not. (cancerquest.org)
  • As an example TP 53 refers to the gene and p53 refers to the protein. (cancerquest.org)
  • The retinoblastoma susceptibility gene RB1 was the first tumour suppressor gene to be identified and characterised. (eu.org)
  • The other project involves the study of a single nucleotide polymorphism (SNP) in the human p53 gene that results in either arginine (R) or proline (P) at position 72 of the p53 protein. (mdanderson.org)
  • Members of this family of proteins are often found associated with histone-modifying enzymes and protein complexes that regulate gene expression. (bvsalud.org)
Cyclin2
Familial2
  • Two forms of retinoblastoma were noticed: a bilateral, familial form and a unilateral, sporadic form. (wikipedia.org)
  • Inactivation of Rb may contribute to many human malignancies including familial retinoblastoma, small-cell lung carcinomas, cervical carcinomas, prostate carcinomas, breast carcinomas, and some forms of leukaemias ( Burkhart,2008 ). (eu.org)
Chromatin1
  • These findings indicate that E2F1 stimulates DNA repair through a non-transcriptional mechanism that functions in the context of chromatin. (mdanderson.org)
Regulatory4
  • It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. (jefferson.edu)
  • Finally, we contrast the regulatory properties of protein motifs and the regulatory elements of DNA and (pre-)mRNAs, advocating that co-regulation, co-operativity, and motif-driven regulatory programs are common mechanisms that emerge from the use of simple, evolutionarily plastic regulatory modules. (biomedcentral.com)
  • It undergoes tyrosine phosphorylation by C-SRC PROTEIN PP60 and plays a regulatory role in CAVEOLAE formation. (nih.gov)
  • A family of endogenous regulatory proteins that associate with RETINOBLASTOMA PROTEIN via a specific high-affinity binding domain. (bvsalud.org)
Mammalian2
  • Here we show a novel function for Retinoblastoma family member, p107 in controlling stem cell expansion in the mammalian brain. (rupress.org)
  • We subsequently validated 19 of 47 putative BIKE interactors using mammalian cell-based protein-protein interaction assays. (bvsalud.org)
Regulation2
  • In this work we studied the relative contribution of the retinoblastoma family members to the regulation of Sox2 expression. (oncotarget.com)
  • The most studied function of the Rb protein is in the regulation of cell cycle progression at the G1/S boundary ( Giacinti,2006 ). (eu.org)
Increased risk of1
  • This explains why sufferers of sporadic retinoblastoma are not at increased risk of cancers later in life, as both alleles are functional in all their other cells. (wikipedia.org)
Complexes1
  • After translation, where is a protein localised, and what complexes should it join? (biomedcentral.com)
Phosphorylation4
Multifunctional1
  • Although its common function is seen as binding and repressing E2F targets, pRb is likely a multifunctional protein as it binds to at least 100 other proteins. (wikipedia.org)
BRCA13
  • In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (jefferson.edu)
  • This graph shows the total number of publications written about "BRCA1 Protein" by people in this website by year, and whether "BRCA1 Protein" was a major or minor topic of these publications. (jefferson.edu)
  • Below are the most recent publications written about "BRCA1 Protein" by people in Profiles. (jefferson.edu)
Differentiation2
  • Pocket proteins play essential roles in cell cycle progression, quiescence and differentiation, and their functional disruption is associated with human cancer. (eu.org)
  • Additionally utilizing a cocktail of development and differentiation elements (XXL-medium) differentiation of USSC into cells of neuronal lineage (XXL-USSC) expressing neurofilament and Vandetanib trifluoroacetate sodium route proteins was acquired [3]. (techblessing.com)
Nucleus2
  • Proteins found in the nucleus of a cell. (uams.edu)
  • Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (uams.edu)
Abnormal1
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
Distinct1
Cellular1
  • The small protein ubiquitin plays a vital role in virtually all aspects of cellular life. (intechopen.com)
Motif1
  • The adenovirus E1A protein mimics the LxDLFD motif and competes with E2F for binding to Rb, promoting E2F activation and cell proliferation. (eu.org)
MeSH1
  • Immunoglobulin J Recombination Signal Sequence-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Cell2
  • The effects of POP inhibition and knockdown on the proliferation of cultured human estrogen receptor-positive (ER+) MCF7 and T47D, and ER-negative (ER-) MDA-MB-231 breast cancer cell lines and the MCF12A non-tumorigenic epithelial cell line were tested by analyzing their influence on cell proliferation (WST-1 assay), cell viability (trypan blue exclusion assay), and cell cycle arrest (cell cycle analysis, cell cycle regulator proteins expression). (cancerindex.org)
  • We also demonstrate that the transcriptional regulator PRDM16 (PRD1-BF1-RIZ1 homologous domain containing 16) controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells. (bioseek.eu)
Pocket1
  • pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. (wikipedia.org)
Function1
  • PRDM16 stimulates brown adipogenesis by binding to PPAR-gamma (peroxisome-proliferator-activated receptor-gamma) and activating its transcriptional function. (bioseek.eu)
Regulate1
  • The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)
Cancer1
  • Sufferers of the former were over six times more likely to develop other types of cancer later in life, compared to individuals with sporadic retinoblastoma. (wikipedia.org)
Specific1
  • A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
Control3
  • Participan en el control transcripcional relacionado con el crecimiento. (bvsalud.org)
  • They are involved in growth-related transcriptional control. (bvsalud.org)
  • ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
Cells2
  • Adult p107-null mice had elevated numbers of proliferating progenitor cells in their lateral ventricles. (rupress.org)
  • In vitro neurosphere assays revealed striking increases in the number of neurosphere forming cells from p107 −/− brains that exhibited enhanced capacity for self-renewal. (rupress.org)