• Inhibitors of anti-apoptotic BCL-2 family proteins in combination with chemotherapy and hypomethylating agents (HMAs) are promising therapeutic approaches in acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS). (haematologica.org)
  • Many laboratories have focused on the functions of the clock genes and proteins that are involved in cellular activities, including cell survival, cell cycle regulation, proliferation, apoptosis, DNA damage repair, and tumor promotion or suppression [ 5 , 6 ]. (explorationpub.com)
  • Transcription factors (like all proteins) are transcribed from a gene on a chromosome into RNA, and then the RNA is translated into protein. (sg-bio.com)
  • Helix-turn-helix ,helix-loop-helix ,zinc finger (e.g. glucocorticoid receptors, GATA proteins),basic protein-leucine zipper ,activator protein-1,β-sheet motifs are different families of transcription factors. (sg-bio.com)
  • The highly divergent C-terminal half of MEF2 proteins has been suggested to modulate their transcriptional activity17 18 The spectrum of targets activated by MEF2 transcription factors in different cell types is dependent on association with specific co-repressors and co-activators in response to multiple signaling pathways17. (researchassistantresume.com)
  • The secretory pathway has two main functions: 1) performing proper folding and post-translational modifications (PTMs) of proteins e.g. glycosylation and sulfation, and 2) sorting proteins to their final cellular or extracellular destination. (biomedcentral.com)
  • The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in epigenetics and chromatin-mediated transcriptional regulation. (embl-heidelberg.de)
  • BEX proteins have been reported to be involved in transcriptional regulation and signaling pathways in neurodegeneration, cell cycle and tumor growth [ 5 - 8 ]. (ijbs.com)
  • Structural genes encode proteins that are not involved in gene regulation. (p450inhibitors.com)
  • In LPS/D-GalN hepatitis a dose titration of twice, a quarter and a twentieth of the human equivalent dose resulted in improvement of liver hemorrhage and necrosis, reduction in liver HIF-1 α and Pro-IL-1 β transcripts as well as the proteins of IL-1 β, HIF-1 α, pro-IL-1 β and cleaved (P10) caspase-1. (p450inhibitors.com)
  • In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. (neobiotechnologies.com)
  • Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. (lookformedical.com)
  • Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)
  • The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)
  • A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
  • Conversely, early developmental stage ZF1 did not affect cell viability or apoptosis, albeit increasing Bax/Bcl-2 mRNA ratio. (livingroom.health)
  • Cell cycle analysis showed an accumulation of tumor cells predominantly in 511296-88-1 manufacture G0/G1 phase with an increase in concentration of TD-MSCs, which was confirmed by increased mRNA expression of cell cycle negative regulator p21. (immune-source.com)
  • Melatonin has oncostatic properties that are mediated by induction of apoptosis, arresting the cell cycle, regulation of metabolic activity, and the inhibition of hypoxia-inducible factor 1α (HIF-1α) activity [ 9 ]. (explorationpub.com)
  • MicroRNAs, a key class of gene expression regulators, have emerged as crucial players in various biological processes such as cellular proliferation and differentia-tion, development and apoptosis. (123dok.net)
  • Colorectal cancer Core tip: MicroRNAs (miRNAs), a key class of gene ex-pression regulators, have emerged as crucial players in various biological processes such as cellular prolifera-tion and differentiaprolifera-tion, development and apoptosis. (123dok.net)
  • These data indicate that the inhibition of autophagy promotes apoptosis as described for herpes simplex computer virus 1 and mouse herpesvirus 68 [41]. (immune-source.com)
  • CONCLUSION: Our findings indicate that miR2911, an active component present in Lonicera japonica exosomes, inhibits proliferation and induces apoptosis of cervical cancer cells by targeting the E6/E7 genes of HPV16/18. (bvsalud.org)
  • Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases. (lookformedical.com)
  • Also, since BCL6 interacts with several co-repressor complexes to inhibit transcription, and its gene is frequently trans-located and hyper-mutated in diffuse large B cell lymphoma (DLBCL), miR-155 acts to enhance transcription and contribute to the pathogenesis of DLBCL. (biomedcentral.com)
  • Ets-2 interacts with co-repressor BS69 to repress target gene expression. (musc.edu)
  • In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)
  • Anaplastic Thyroid Cancer (ATC), accounting for 1-2% of all thyroid cancers, is the most aggressive form of thyroid cancer, with a median survival of 5 months, and is characterized by the accumulation of several oncogenic alterations [ 1 ]. (oncotarget.com)
  • Although genetics have played a dominant role in cancer research, epigenetics (heritable changes in gene function that do not involve alterations in DNA sequence) has become equally important in this field. (aacrjournals.org)
  • Furthermore, we discuss recent findings on EBV associated gastric carcinogenesis by focusing on the roles of latent genes, epigenetic abnormalities, genomic alterations, and post-transcriptional regulation by cellular and viral microRNAs (miRNAs). (spandidos-publications.com)
  • One step in this direction is thus to understand exactly which downstream genes and cellular processes become affected in the outcome of driver alterations. (biomedcentral.com)
  • The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. (wikipedia.org)
  • The assay utilizes the observation that the BCL-6 binds to the same DNA sequence motif as STAT transactivators. (ncri.org.uk)
  • They are important post-transcriptional regulators of gene expression in plants, metazoans, and mammals, and are predicted to control the activity of 30% of all protein-coding genes [ 2 ]. (biomedcentral.com)
  • In addition, expression of the apoptotic regulators bcl -2 and bax was analyzed. (aacrjournals.org)
  • The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ inter- actions and is common to transcriptional regulators involved in chromatin modeling. (neobiotechnologies.com)
  • Previous studies have shown that some EBV latent genes have oncogenic properties. (spandidos-publications.com)
  • Four latency types (0, I, II, III) are defined depending on the expression pattern of EBV latent genes, and at the same time are linked to a particular tumor type [ 6 , 7 ]. (ijbs.com)
  • If they bind to the enhancers they activate the gene expression and are known as activators. (sg-bio.com)
  • This gene encodes a member of the trithorax group of transcriptional activators. (cancerindex.org)
  • Recent advances in understanding the role that epigenetics plays in cancer pathogenesis and understanding the mechanisms through which these processes regulate gene expression have stimulated considerable interest in developing clinically viable antineoplastic agents that target enzymatic components of transcriptional regulatory complexes responsible for the establishment of pathologic epigenetic modifications that lead to deregulated gene expression in cancer. (aacrjournals.org)
  • The function of this domain is not yet known but in analogy with the LIM domain it could be involved in protein-protein interaction and be important for the assembly or activity of multicomponent complexes involved in transcriptional activation or repression. (embl-heidelberg.de)
  • RISC-loading complex subunit TARBP2 is a protein that in humans is encoded by the TARBP2 gene. (wikipedia.org)
  • The precise functions of melatonin are mediated by guanosine triphosphate (GTP)-binding protein (G-protein) coupled melatonin receptor 1 (MT1) and MT2 receptors. (explorationpub.com)
  • What does this gene/protein do? (cancerindex.org)
  • Tumor-infiltrated macrophages were isolated from human GC tissues using magnetic beads, gene transcription was determined by real-time PCR, protein expression was monitored using western blots, metabolites were determined using HPLC, and transcriptional regulation was analyzed by the luciferase-based reporter gene system. (cancerindex.org)
  • We have demonstrated the use of these methods to identify potential new and known targets for engineering improved growth and IgG production, as well as the general observation that CHO cells seem to have less strict transcriptional regulation of protein secretion than healthy mouse cells. (biomedcentral.com)
  • As RECONs allow the analysis of gene- or protein-level data in their biological context, they become tools for hypothesis-driven biological discovery [ 34 ]. (biomedcentral.com)
  • also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). (cancerindex.org)
  • The carboxy-terminal catalytic domain of the GTPase-activating protein inhibits nuclear signal transduction and morphological transformation mediated by the CSF-1 receptor. (musc.edu)
  • Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
  • The Bcl-2 homology 3 (BH3) domain is crucial for the death-inducing and dimerization properties of pro-apoptotic members of the Bcl-2 protein family, including Bak, Bax, and Bad. (lookformedical.com)
  • MicroRNAs (miRNAs) are short (about 21 nucleotides long) strands of non-coding RNA that regulate the expression of multiple genes [ 1 ]. (biomedcentral.com)
  • EBVaGC belongs to latency type I or II, in which EBERs, EBNA-1, BARTs, LMP-2A and BART miRNAs are expressed. (spandidos-publications.com)
  • miRNAs are able to post-transcriptionally control gene expression by binding to target mRNAs [ 15 ]. (ijbs.com)
  • Here we present data on the development and application of a high throughput cell-based luciferase reporter assay to screen for small drug-like compounds that inhibit the function of BCL-6. (ncri.org.uk)
  • By using a reporter construct that expresses firefly luciferase under the control of a STAT-activated promoter that is repressed by endogenously highly expressed BCL-6 in a Burkitt's lymphoma cell line (DG75), we are able to screen for compounds that derepress the luciferase expression and thus may inhibit the function of BCL-6. (ncri.org.uk)
  • A part for p53 during the regulation from the G2/M check out stage response continues to be advised by previous studies, as several from the transcriptional targets of p53 can right or indirectly inhibit Cdc2 kinase, which include things like p21Waf1/Cip1, 14 three 3s, and Gadd45. (micrornainhibitors.com)
  • BCL-6 expression is often misregulated in diffuse large B-cell lymphoma, and is abnormally high in other types of non-Hodgkin's lymphoma thus, preventing normal B-cell differentiation. (ncri.org.uk)
  • Using genomic PCR amplification and Sanger sequencing of the coding region we identified 11 sequence variants distributed in 10/134 DLBCL cases and 1/35 FL cases (Supplementary Table 1). (researchassistantresume.com)
  • ZF1 also induced the transcription of TERT , encoding the catalytic subunit of telomerase, as well as the gene expression of Bmi-1 , a chromatin remodeler acting as a major telomerase-independent repressor of senescence. (livingroom.health)
  • Exploiting the aforementioned catalogs of driver genes, for example, we recently revealed the mutational landscape of chromatin regulatory factors (CRFs) in cancer [ 5 ]. (biomedcentral.com)
  • Global CpG island hypermethylation, which induces epigenetic silencing of tumor suppressor genes, is also a unique feature of EBVaGC and is considered to be crucial for its carcinogenesis. (spandidos-publications.com)
  • most common form of non-Hodgkin's lymphoma in adults accounting for approximately 40% of diagnoses and also arising from transformation of follicular lymphoma (FL)1. (researchassistantresume.com)
  • Gene expression profiling studies identified the heterogeneity of this germinal center (GC)-related malignancy by distinguishing three phenotypic subtypes namely germinal center B cell-like (GCB) DLBCL activated B cell-like (ABC) DLBCL and primary mediastinal 24, 25-Dihydroxy VD3 B cell lymphoma (PMBL)2 with a small subset of cases that remain unclassified. (researchassistantresume.com)
  • In search for subgroups of diffuse large B-cell lymphoma (DLBCL) with different histogenetic origin and prognosis, as has been described by gene expression profiling, we examined tumor specimens from 125 patients with DLBCL, uniformly treated by either cyclophosphamideAdriamycin-vincristine-prednisone or methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin in a multicenter trial set by the Nordic Lymphoma Group 1989-1994. (aacrjournals.org)
  • EBV was the first virus to be associated with human malignancy, which was discovered from a Burkitt's lymphoma cell line in 1964 ( 1 ). (spandidos-publications.com)
  • Epstein-Barr virus (EBV), a member of the human herpesvirus family, was initially identified in Burkitt's lymphoma (BL) in 1964 [ 1 , 2 ]. (ijbs.com)
  • The gene encodes a transcriptional activator and is found mutated in ~11% of diffuse large B cell lymphomas (DLBCLs) and ~12% of follicular lymphomas. (researchassistantresume.com)
  • The BIC gene is activated by promoter insertion at a retroviral integration site on chromosome 21q21 in B cell lymphomas induced by avian leukosis virus. (biomedcentral.com)
  • Brain-expressed X-linked (BEX) genes belong to a family of genes that reside on the mammalian X chromosome [ 4 ]. (ijbs.com)
  • Biochemical studies expose a basal recruitment of \catenin to the messenger ribonucleoprotein and translational pre\initiation complex, fulfilling a translational repressor function. (informationalwebs.com)
  • Alvocidib, a cyclin-dependent kinase 9 (CDK9) inhibitor and indirect transcriptional repressor of the anti-apoptotic factor MCL-1, has previously shown clinical activity in AML. (haematologica.org)
  • Furthermore, this analyses confirmed the positive roles of CDK9 and Yorkie in regulating Mad-dependent gene expression in vivo. (sdbonline.org)
  • Regulation of the murine TRACP gene promoter. (musc.edu)
  • immune lymphocytes like Bcl-2, Bcl-XL and their cells download signal in all TKIs BH1-4. (familie-vos.de)
  • CDK8 can directly interact with Mad in vitro through the linker region between the DNA-binding MH1 (Mad homology 1) domain and the carboxy terminal MH2 (Mad homology 2) transactivation domain. (sdbonline.org)
  • Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. (wikipedia.org)
  • MicroRNA-30c expression was suppressed by hypoxia-inducible factor-1α activation and related to decreased mTOR activity as well as glycolysis in human GC TAMs. (cancerindex.org)
  • Transcriptional activation of a conserved sequence element by ras requires a nuclear factor distinct from c-fos or c-jun. (musc.edu)
  • synergistically according through EFNB is mediated for diverse gene activation and nonlinearly shortening of pathway damage and synaptic junctional dimers. (familie-vos.de)
  • Kininogen, prekallikrein, and cilium XII referred still blocked as channels controlled for the FRS T-cell of genes when Antigen-Specific muscle is packaged to first followed buildings in activation. (familie-vos.de)
  • IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression. (harvard.edu)
  • The molecular structure of FO is shown in Figure 1 , and the method of synthesizing FO was done according to our previous report. (hindawi.com)
  • Since the first report of molecular cloning of the KLF family gene, the number of KLFs has increased rapidly. (mdpi.com)
  • Metastasis is the leading cause of poor prognosis for CRC [ 3 ], therefore, better understanding of the mechanisms underlying metastasis suppression and identification of genes involved in metastasis suppression could definitely contribute to the treatment of CRC patients. (ijbs.com)
  • An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis. (musc.edu)
  • dashed line histogram) or BD Horizon™ R718 Mouse Anti-Human Bcl-6 antibody (Cat. (bdbiosciences.com)
  • HD-IIV3 recipients had similar postvaccination antibody titers compared with SD-IIV4 recipients, whereas RIV4 recipients had significantly higher 1-month-postvaccination antibody titers against vaccine reference viruses for all outcomes. (cdc.gov)
  • Furthermore, I am able to identify other driver genes that cause tumorigenesis through the alteration of very similar sets of targets. (biomedcentral.com)
  • Their sequences contain a 180 nucleotide sequence designated the homeobox, so called because mutations of these genes often results in homeotic transformations, in which one body structure replaces another. (lookformedical.com)
  • In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), provid- ing a new powerful means for the classification, prediction of survival, and response to treatment of lym- phomas. (lu.se)
  • BCL-6 is a transcriptional repressor that plays an essential role in the development of germinal centers of B-cells. (ncri.org.uk)
  • Screening with RNA-Seq in Huh7 cells treated with FO revealed that 317 genes were modulated, of which 188 genes were upregulated and 129 genes were downregulated. (hindawi.com)
  • Herein, genome-wide transcriptome profiling (RNA-Seq) was used to screen the differentially expressed genes (DEGs) in FO-treated Huh7 cells, with the aim of uncovering the pharmacologic pattern. (hindawi.com)
  • Flow cytometric analysis of Bcl-6 expression in Ramos cells. (bdbiosciences.com)
  • A fluorescence histogram showing Bcl-6 expression (or Ig Isotype control staining) was derived from gated events with the forward and side light-scatter characteristics of intact cells. (bdbiosciences.com)
  • We typically use 1 × 10^6 cells in a 100-µl experimental sample (a test). (bdbiosciences.com)
  • Nonetheless, the outcomes of this report propose that IR induced G2/M cell cycle arrest as well as the regulation selleck chemicals PF299804 of Rac1 on the IR induced G2/M checkpoint response is apparently inde pendent of p53, as among the four breast cancer cell lines applied to the studies, MDA MB 231 and T47D cells express mutant p53, whereas MCF seven and ZR75 1 express wild sort p53. (micrornainhibitors.com)
  • Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1. (musc.edu)
  • Non-nuclear oncogenes and the regulation of gene expression in transformed cells. (musc.edu)
  • Synthetic miR2911 and GFP-E6/E7 plasmids were transfected into HEK293T cells to examine the effect of miR2911 on E6/E7 gene expression. (bvsalud.org)
  • Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)
  • introduced a new concept of CKD-associated secretory phenotype (CASP), which indicates that senescent renal cells could secrete SASP components of various cytokines such as IL-1, IL-6, and TNF- α [ 19 , 20 ]. (hindawi.com)
  • [ 1 ] Most of the neutrophils are contained in the bone marrow, either as mitotically active (one third) or postmitotic mature cells (two thirds). (medscape.com)
  • The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
  • Mitogenic signaling by colony-stimulating factor 1 and ras is suppressed by the ets-2 DNA-binding domain and restored by myc overexpression. (musc.edu)
  • Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. (lookformedical.com)
  • When used, we will repair distribution about our assessment and its oxygenases, sculpting such sulfur DNA, in SH3 artists or with gene processes. (familie-vos.de)
  • Nevertheless, to date, the actual misregulation of genes or processes downstream these cliques has not been systematically proven or exploited with the purpose of identifying them. (biomedcentral.com)
  • These transcriptional responses were restricted to the action of early stage factors, since they were not elicited by late developmental stage ZF5. (livingroom.health)
  • A significant decrease in microRNA (miR)-30c and an increase in regulated in development and DNA damage responses 1 (REDD1) were detected in human GC TAMs, the transcription of miR-30c was negatively correlated with REDD1. (cancerindex.org)
  • Prevaccination and 1-month-postvaccination sera were tested by hemagglutination inhibition (HI) assay against 4 cell culture propagated vaccine reference viruses. (cdc.gov)
  • Inhibiting the function of BCL-6 is therefore an interesting therapeutic target. (ncri.org.uk)
  • The borrowing between delivery( EFN) drugs and cyclin Mutations rights positively all in Once gardening through the EPH domain, but also in' gene' enhancing through the EFN region itself. (familie-vos.de)
  • We identified differentially methylated regions (DMRs) and differentially hydroxymethylated regions (DHMRs) between ILC and NK cell subsets and correlated them with transcriptional signatures. (stanford.edu)
  • The role of HMT gene variants in prostate cancer remains unknown. (cancerindex.org)