- This gene encodes a transcriptional repressor which represses neuronal genes in non-neuronal tissues. (wikipedia.org)
- The protein is also found in undifferentiated neuronal progenitor cells, and it is thought that this repressor may act as a master negative regulator of neurogenesis. (wikipedia.org)
- Activation of GABA neurons suppressed neuronal responses in the neocortex to a forthcoming auditory stimulus in mice of both sexes. (bvsalud.org)
- Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. (kb.se)
- Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. (kb.se)
- Cytotactin, an extracellular matrix protein of neural and non-neural tissues that mediates glia-neuron interaction. (academicinfluence.com)
- RE1-Silencing Transcription factor (REST), also known as Neuron-Restrictive Silencer Factor (NRSF), is a protein which in humans is encoded by the REST gene, and acts as a transcriptional repressor. (wikipedia.org)
- It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element (NRSE, also known as RE1). (wikipedia.org)
- Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule. (academicinfluence.com)
- Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. (academicinfluence.com)
- Additionally, an in-depth analysis of IL21R region revealed that GTF2I might bind to the IL21R promoter to regulate the expression of the IL21R, with four peaks of GTF2I binding sites, including three increased binding sites in upstream, one increased binding site in 5' UTR. (bvsalud.org)
- RE1-Silencing Transcription factor (REST), also known as Neuron-Restrictive Silencer Factor (NRSF), is a protein which in humans is encoded by the REST gene, and acts as a transcriptional repressor. (wikipedia.org)
- NRSF bound to DNA and cofactors on each of its two cofactor binding domains. (wikipedia.org)
- This gene encodes a transcriptional repressor which represses neuronal genes in non-neuronal tissues. (wikipedia.org)
- Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. (nih.gov)
- It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element (NRSE, also known as RE1). (wikipedia.org)
- represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). (nih.gov)
- Compared with regular silencers, these dual-function REs are evolving under stronger purifying selection and are enriched for mutations associated with disease phenotypes and altered gene expression. (nih.gov)
- 13. Characterization of gene regulatory elements for selective gene expression in human melanoma cells. (nih.gov)
- Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. (nih.gov)
- 6. A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: a potential role in derepression of neuroendocrine genes and a useful clinical marker. (nih.gov)
- HN - 2018 FX - ATPases Associated with Diverse Cellular Activities MH - AAA Proteins UI - D000074582 MN - D8.811.277.40.13 MN - D12.776.157.25 MS - A large, highly conserved and functionally diverse superfamily of NTPases and nucleotide-binding proteins that are characterized by a conserved 200 to 250 amino acid nucleotide-binding and catalytic domain, the AAA+ module. (nih.gov)
- Moreover, REST potently protects neurons from oxidative stress and amyloid β-protein toxicity. (wikipedia.org)
- We then focus on evidence that supports a role for transcriptional dysfunction and impaired protein folding and degradation as early events in disease pathogenesis. (nih.gov)
- 17. Transcriptional targeting in ovarian cancer cells using the human epididymis protein 4 promoter. (nih.gov)
- Developmentally regulated expression of the cold-inducible RNA-binding motif protein 3 in euthermic rat brain. (neurotree.org)
- We show that evolutionary conservation and coding consequence are key determinants of the strength of purifying selection, that rare-variant load varies substantially across biological pathways, and that each individual contains hundreds of rare non-coding variants at conserved sites, such as motif-disrupting changes in transcription-factor-binding sites. (nature.com)
- 8. Neuron specific enolase promoter for suicide gene therapy in small cell lung carcinoma. (nih.gov)
- Temporal sequence learning in winner-take-all networks of spiking neurons demonstrated in a brain-based device. (neurotree.org)
- 16. The expression of DNA methyltransferases and methyl-CpG-binding proteins is not associated with the methylation status of p14(ARF), p16(INK4a) and RASSF1A in human lung cancer cell lines. (nih.gov)
- Focusing on enhancer-silencer transitions specific to the development of T cells, we built an accurate deep learning classifier of REs and identified about 12,000 silencers active in primary peripheral blood T cells that act as enhancers in embryonic stem cells. (nih.gov)
- The medial prefrontal cortex (mPFC) is essential in the execution of cognitive tasks, however very little is known on how these neurons are modulated during specific tasks and which subtype of neurons are responsible for so. (bvsalud.org)
- A successful protocol validation was followed by our preliminary results, which showed that both glutamatergic and gabaergic neurons presented significant change in activation intensity and number of events in specific contexts throughout the task days. (bvsalud.org)
- Dual-function REs consist of two intertwined but largely distinct sets of binding sites bound by either activating or repressing TFs, depending on the type of RE function in a given cell line. (nih.gov)
- However, at the onset of differentiation, REST expression diminishes, and cells differentiate to become neurons (left hand side). (mdanderson.org)
- However, the role of CCK-GABA neurons in the cortical microcircuits is still unclear. (bvsalud.org)