Transcriptional processes. Medical search. Frequent questions

Here we present a computational approach called exon-intron split analysis (EISA) that measures changes in mature RNA and pre-mRNA reads across different experimental conditions to quantify transcriptional and post-transcriptional regulation of gene expression. (nature.com)
Furthermore, changes in post-transcriptional regulation can be predicted from differences between exonic and intronic changes. (nature.com)
Small nuclear RNA analysis revealed that the regulation of tissue regeneration, including hair growth were based on the miRNA-mediated transcriptional control of the pluripotency of stem cells. (fortunejournals.com)
Finally, we established 3 groups of transcriptional models to describe Ly6C high to Ly6C low MC subset differentiation, immune checkpoint regulation, Ly6C high MC to MΦ subset differentiation and Ly6C low MC to lymphocyte functional adaptation. (frontiersin.org)
It was discovered that S. pyogenes also shared an rgg/ropB gene located directly next to the subject of its transcriptional regulation, in this case speB protease, with intergenic inverted repeats. (wikipedia.org)
The location of the ropB gene is directly and sequentially proximal to the subject of its transcriptional regulation (speB) which lies downstream of a 941 bp intergenic region between the two. (wikipedia.org)
Mapping transcriptional regulation of biofilm-related genes promoters in Pseudomonas. (usp.br)
Many processes in parasite biology involve changes at the chromatin level, including regulation of transcription along a complex life cycle, delimitation of functional elements in the genome, and antigenic variation. (plos.org)
Post-transcriptional regulation occurs in eukaryotes, stabilizing mRNA for translation. (khanacademy.org)
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (nih.gov)
MicroRNAs perform important roles in the post-transcriptional regulation of gene expression. (researchsquare.com)
Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)
Transcriptional regulation of endogenous retroviruses by chromatin and RNA processing. (uni-muenchen.de)
The ASXL1 protein may have an additional role in gene regulation by signaling to molecules to add a methyl group (a process called methylation) to an area near a gene called the promoter region, which controls gene activity. (medlineplus.gov)
Systematic approach for dissecting the molecular mechanisms of transcriptional regulation in bacteria. (bvsalud.org)
Gene regulation is one of the most ubiquitous processes in biology . (bvsalud.org)
Gene ontology analysis supports the hypothesis that pair-bond formation involves transcriptional regulation, and changes in neuronal structure. (cdc.gov)
Activation of Btk results in a cascade of signaling events resulting in calcium mobilization and fluxes, cytoskeletal rearrangements, and transcriptional regulation involving nuclear factor-kappaB (NF-kappaB) and nuclear factor of activated T cells (NFAT). (medscape.com)

Significantly differentially expressed (SDE) immunological genes and transcription factor (TF) were selected for functional pathways and transcriptional signaling identification. (frontiersin.org)
Twenty-four potential transcriptional regulatory pathways were identified based on SDE TFs matched with their corresponding SDE immunological genes. (frontiersin.org)
Genes required for degradation of and growth on the carbon source pectin were down-regulated, whereas transcripts involved in redox processes were up-regulated. (frontiersin.org)
In line with this, RBPJL is able to fully reconstitute transcriptional repression at Notch target genes in cells lacking RBPJ. (uni-ulm.de)
Gene ontology analysis was performed using the software PANTHER that classified downregulated genes by their molecular functions ( A ) and biological processes ( B ) based on published evidence. (jci.org)
Together, our results expand knowledge of the genes involved in the pair bonding process and open new avenues of research in the molecular mechanisms of bond formation. (cdc.gov)
The significantly upregulated genes encode proteins involved in reactions of the energy-generating phosphotransferase system and transcription processing, which could be related to phage transcription. (lu.se)
Multiple biosynthetic pathways such as sterol synthesis were among the top shared processes, where both unique and shared genes constituted leading-edge subsets. (lu.se)

A biological process that is crucial for gene expression in most animal life, including humans. (genomicglossaries.com)
Given the high number of virulence factors present in these bacteria, and the niche-specific role many of them play during different stages of the infectious process, gene expression must be finely tuned in order to efficiently coordinate their expression, and also continue to preserve energy pools. (biomedcentral.com)
A number of post-transcriptional mechanisms fine-tune the gene expression landscape. (researchsquare.com)

To this end, we overexpressed key transcriptional regulators of astroglial development in human GBM and GBM stem cell lines. (lu.se)
Among these developmental actors are the co-transcriptional regulators Yap and Taz (YT). (lu.se)
Previously, our research team had found that two molecules, or more specifically, co-transcriptional regulators, known as YAP and TAZ, are involved in the damage of the lung epithelial cells. (lu.se)

Pseudomonas Strains Induce Transcriptional and Morphological Changes and Reduce Root Colonization of Verticillium spp. (frontiersin.org)
Researchers found that ERK activity is increased during rest intervals to induce transcriptional cycling between c-Fos and CREB in a subset of mushroom body neurons. (sciencedaily.com)

Enriched GO terms included those related to the ubiquitin-proteosome protein degradation system, chromatin-mediated transcriptional pathways, and the GTPase-related signaling system. (biomedcentral.com)
Further exploration of these GO terms will provide a clearer picture of the processes involved in compensatory recovery of the cercal escape system in the cricket and can be compared and contrasted with the distinct pathways that have been identified upon deafferentation of the auditory system in this same animal. (biomedcentral.com)
To detail the process of protein folding and the intracellular pathways of folding and post-translational modification. (bath.ac.uk)
A and B ) PMAGE demonstrated transcriptional changes in mitochondrial metabolism-related pathways in Txnip-KO hearts. (jci.org)

RopB transcriptional regulator, also known as RopB/Rgg transcriptional regulator is a transcriptional regulator protein that regulates expression of the extracellularly secreted cysteine protease streptococcal pyrogenic exotoxin B (speB) [See Also: erythrogenic toxins] which is an important virulence factor of Streptococcus pyogenes and is responsible for the dissemination of a host of infectious diseases including strep throat, impetigo, streptococcal toxic shock syndrome, necrotizing fasciitis, and scarlet fever. (wikipedia.org)

mRNA half-lives have been determined, for example, by blockage of transcription followed by transcriptional profiling 5 . (nature.com)
In two of these, the read coverage along introns was related to nascent transcription in combination with co-transcriptional splicing events 24 and later was used to fit a detailed transcriptional model within a single sample 25 . (nature.com)
The c-Myc oncogenic transcription factor is known to regulate microRNA (miRNA) expression at the transcriptional level. (johnshopkins.edu)
To introduce the process of transcription in prokaryotes. (bath.ac.uk)
In some processes, chromatin modifications carry heritable regulatory information that is transmitted from mother to daughter cells, whereas in other cases, they are implicated in the execution of the information contained in the DNA sequence, or occur as a consequence of dynamic nuclear processes such as transcription. (plos.org)
We integrated high-resolution maps of transcriptional initiation and transcription to annotate a conservative set of intergenic lncRNAs expressed in mouse erythroblasts. (biomedcentral.com)

A closely related debate around chromatin modifications is about causality: several histone PTMs correlate with specific transcriptional states, but in many cases they are not responsible for a transcriptional outcome but rather are a consequence of it [7] . (plos.org)
Here we will describe our current knowledge of the biological processes and mechanisms that can be considered bona fide epigenetic phenomena in Plasmodium biology, and attempt to distinguish them from those unlikely to involve epigenetic flow of information, even if chromatin changes occur. (plos.org)
We will not judge the use of the term epigenetic in different situations, but will rather attempt to clarify the roles of chromatin-based modifications in the different processes. (plos.org)
We subclassified intergenic lncRNAs according to chromatin status at transcriptional initiation regions, defined by relative levels of histone H3K4 mono- and trimethylation. (biomedcentral.com)
The ASXL1 gene provides instructions for making a protein that is involved in a process known as chromatin remodeling. (medlineplus.gov)

Suppresses transcriptional elongation. (tocris.com)

Three recent studies based on RNA-seq provided evidence that intronic reads might correlate with transcriptional activity. (nature.com)

The persistence and transcriptional reactivation of HIV lead to the development of neuropathological complications. (cdc.gov)

Overall, our study reveals a previously unrecognised function of c-Myc in miRNA processing and provides valuable insight into a new aspect of how c-Myc regulates microRNA expression. (johnshopkins.edu)

Post-transcriptional processing generates a diversity of 5'-modified long and short RNAs. (inra.fr)
Here we show that processing of mature mRNAs through an as yet unknown mechanism may generate complex populations of both long and short RNAs whose apparently capped 5' ends coincide. (inra.fr)
Supplying synthetic promoter-associated small RNAs corresponding to the c-MYC transcriptional start site reduced MYC messenger RNA abundance. (inra.fr)
MicroRNAs (miRNAs) are small regulatory non-coding RNAs, resulting from the cleavage of long primary transcripts (pri-miRNAs) in the nucleus by the Microprocessor complex generating precursors (pre-miRNAs) that are then exported to the cytoplasm and processed into mature miRNAs. (mdpi.com)
Post-transcriptional biological modification of messenger, transfer, or ribosomal RNAs or their precursors. (bvsalud.org)

P. protegens CHA0 alters transcriptional profiles of V. longisporum during 2 h liquid media co-cultivation in pectin-rich medium. (frontiersin.org)

YT are known to be responsible for a wide range of biologic processes and targeting YT's profibrotic activity and promoting their pro-regenerative activities may result in beneficial effects for IPF patients. (lu.se)
We review the fundamental relationships between the circadian timing system and biologic processes, considering how common practices, such as shift work and variations in sleep timing on work/school versus work/school-free days (ie, social jetlag), disrupt circadian alignment and predispose individuals to cardiovascular, metabolic, and pulmonary disease. (cdc.gov)

2021. Sexual Dimorphism in Cancer: Insights from Transcriptional Signatures in Kidney Tissue and Renal Cell Carcinoma. (who.int)
2020. Metabolic Signatures of 10 Processed and Non-processed Meat Products after In Vitro Digestion. (who.int)

Evidence continues to accumulate to suggest important roles for inflammation and genetic factors in the process of atherosclerosis and specifically in stroke. (medscape.com)

Thus, global transcriptional analysis and functional analysis revealed previously unknown host responses to filamentous phage infection. (lu.se)

This inhibitory effects seemed to contribute to the prevention of possible complications in the process of cancer recovery, such as recurrence and metastasis. (fortunejournals.com)
In the long process of cancer recovery, it is as much important to recognize the improvement by each individual patient day by day, together with the results obtained by clinical examinations at the hospitals and clinics. (fortunejournals.com)
Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting? (mdpi.com)
Researchers connect a tumor's leading edge transcriptional profile to poor survival outcomes across cancer types. (the-scientist.com)
We take advantage of the similarity between neural developmental processes and cancer hierarchy to mitigate, if not completely abolish, the malignant nature of tumor cells and pave the way for new intervention strategies. (lu.se)

Regardless of what may happen in the future, we may say that already at the present moment the characters are being used for transcriptional purposes (the annotation of the sounds of completely unrelated words) more now than ever before. (upenn.edu)

Individual miRNAs are capable of regulating gene networks by interacting with multiple targets or by suppressing transcriptional controllers [ 6 , 8 ]. (researchsquare.com)

Epigenetic alterations, represented by post-transcriptional control and DNA methylation, have been the focus of recent studies. (spandidos-publications.com)

TNF-alpha, major pro-inflammatory cytokine, is involved in physiological and pathophysiological processes in the skeletal muscle. (cdc.gov)

We show that long-lived CAR-T cells developed a CD4/CD8 double-negative phenotype with an exhausted-like memory state and distinct transcriptional signature. (nature.com)
Oct. 7, 2020 A research team has discovered that during memory consolidation, there are at least two distinct processes taking place in two different brain networks -- the excitatory and inhibitory networks. (sciencedaily.com)

The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)

Transcriptional profiling of TNF-a-induced effects on skeletal myogenic differentiation. (cdc.gov)
YT modulate processes such as proliferation, differentiation, and organ size and are regulated by the Hippo pathway. (lu.se)

Here we address two important, and incompletely answered, questions concerning the origins (transcriptional initiation regions (TIRs)) and classification of intergenic lncRNAs. (biomedcentral.com)

Thus, the secondary metabolite mediated effect of Pseudomonas isolates on Verticillium species results in a complex transcriptional response, leading to decreased growth with precautions for self-protection combined with the initiation of a change in fungal growth direction. (frontiersin.org)

The sst2 somatostatin receptor mediates the inhibitory effects of somatostatin on secretive and proliferative processes. (eurekamag.com)

Both in vitro andin vivo microRNA processing assays demonstrated that c-Myc promotes miRNA processing by upregulating the Drosha expression level. (johnshopkins.edu)
Biofilm formation is a crucial and precisely regulated process at the transcriptional level. (usp.br)
Taken together, our data strongly suggests that the eve - grn transcriptional code controls axon guidance, in part, by regulating the level of unc-5 expression. (biologists.com)

Transcriptional codes within a neuron direct the expression of an array of receptors and adhesion molecules that will eventually determine its guidance and connectivity properties. (biologists.com)

Some lncRNAs originate from intragenic enhancers which, when active, behave as alternative promoters producing transcripts that are processed using the canonical signals of their host gene. (biomedcentral.com)

After a complex process of education and maturation, a circulating lymphocyte can bind to an antigen. (medscape.com)

Biological process ( B ) covers the biological systems to which a protein contributes. (jci.org)

This process requires the involvement of nuclear transport receptors, collectively termed karyopherin-ß (Kap-ß) in yeast, and various regulatory factors. (sinica.edu.tw)

The online software will then guide you through the project setup process, including sequence optimization. (thermofisher.com)
Within the context of host-symbiotic models, the most intriguing challenge requiring optimization is the fixation and permeabilization process. (lu.se)

These two classes of 5′ capped and polyadenylated RNA transcripts are indistinguishable with regard to their length, number of exons or transcriptional orientation relative to their closest neighboring gene. (biomedcentral.com)

To provide students with an integrated and comprehensive view of the key processes controlling the production and turnover of cellular proteins. (bath.ac.uk)
Each group refers to a group of proteins with common function or process. (jci.org)

More recently, another group of researchers reported that they had developed a process for optimizing low- abundance RNA, by combining aRNA amplification with template- switching. (genomicglossaries.com)

These findings raise the possibility that a universal transcriptional signature of clinically effective, persistent CD19 CAR-T cells exists. (nature.com)
Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
Treated cells undergo a remarkable shift in structure, acquiring an astrocyte-like morphology with star-shaped bodies and radial branched processes. (lu.se)

untranslated region, lacked TATA and CCAAT boxes, and had multiple transcriptional start sites. (eurekamag.com)

Hence, the debate about the use of the term epigenetics is a terminology issue that affects our understanding of how cellular processes are ultimately controlled. (plos.org)
Cellular aging or cellular senescence is the critical factor for the process of aging. (hindawi.com)

Chemicals and Drugs2

Phenomena and Processes3

Regulation18

Genes8

Gene expression3

Regulators3

Induce Transcriptional2

Pathways4

Regulator1

Transcription6

Chromatin5

Elongation1

Correlate1

Persistence1

Regulates1

RNAs5

Alters1

Biologic processes2

Signatures2

Genetic1

Functional1

Cancer5

Annotation1

MiRNAs1

Methylation1

Inflammatory1

Distinct2

Generates1

Differentiation2

Intergenic1

Pseudomonas1

Receptor1

Level3

Molecules1

Promoters1

Lymphocyte1

Biological process1

Nuclear1

Optimization2

Transcripts1

Proteins2

Abundance1

Cells3

Start sites1

Cellular2