Similar patterning during embryological development can be observed in "basal chordates or ascidians," in which organization of the central nervous system in ascidian larvae are also controlled by fibroblast growth factor genes. (wikipedia.org)
Genes that are significantly altered between FTSECs and HGSOCs are enriched near PAX8 binding sites. (nih.gov)
SMARCB1 inactivation led to large-scale loss of kidney-specific epigenetic programs and restoration of proliferative capacity through the adoption of new dependencies on factors that represent rare essential genes across different cancers. (bvsalud.org)
Furthermore, Notch is responsible for the regulation of known stem cell factor genes. (nature.com)
The current data support previous findings and recapitulate transcriptional regulatory alterations in genes involved in sleep, auditory function, and pain. (frontiersin.org)
Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. (cusabio.com)
Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator of genes regulating oxygen homeostasis. (biomedcentral.com)
While a plethora of PAX8-regulated genes in different contexts have been proposed, we still lack a mechanistic understanding of how PAX8 engages molecular complexes to drive disease-relevant oncogenic transcriptional programs. (physiciansweekly.com)
In the cell, T3 binds to a nuclear receptor, resulting in transcription of specific thyroid hormone response genes. (pharmaceuticalintelligence.com)
Maternal THs acted upstream of pax2a, pax7 and pax8 genes but downstream of shha and fgf8a signalling. (pharmaceuticalintelligence.com)
Se caracterizan por poseer un dominio de unión al ADN emparejado altamente conservado que se identificó por vez primera en genes de segmentación de DROSOPHILA. (bvsalud.org)
They are characterized by a highly conserved paired DNA-binding domain that was first identified in DROSOPHILA segmentation genes. (bvsalud.org)
Transcription factors8
Pax2 along with other transcription factors Pax5, Pax8, En1, and En 2 are expressed across the Otx2-Gbx2 boundary in the mid-hindbrain region. (wikipedia.org)
Regulation of lineage-restricted transcription factors has been shown to influence malignant transformation in several types of cancer. (nih.gov)
These data suggest that transcriptional changes after transformation in ovarian cancer are closely related to epigenetic remodeling in lineage-specific transcription factors. (nih.gov)
Here, we have used CRISPR-Cas9-based genetic screening to demonstrate that loss of SMARCB1, a member of the SWI/SNF chromatin remodeling complex, can confer an advantage to clear cell renal cell carcinoma (ccRCC) cells upon inhibition of the renal lineage factor PAX8. (bvsalud.org)
The following product was used in this experiment: PAX8 (Renal Cell Marker) Recombinant Rabbit Monoclonal Antibody (ZR-1) from Thermo Fisher Scientific, catalog # 7849-RBM9-P1ABX. (thermofisher.com)
In addition, the authors also review future strategies in DN treatment such as transcriptional reprogramming of mature adult kidney cells into uncommitted induced pluripotent stem cells for renal repair and therapeutics. (emjreviews.com)
Comprehensive genomic screens furthermore indicate an additional oncogenic role for PAX8 in renal and ovarian cancers. (physiciansweekly.com)
Regulates2
Epigenetic remodeling regulates transcriptional changes between ovarian cancer and benign precursors. (nih.gov)
At a subset of these, PAX8 together with PRDM3 regulates a specific gene expression module involved in adhesion and extracellular matrix. (physiciansweekly.com)
Thyroid6
The transcription factor PAX8 is critical for the development of the thyroid and urogenital system. (physiciansweekly.com)
thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. (zju.edu.cn)
Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonarry neuroendocrine tumors. (zju.edu.cn)
Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. (zju.edu.cn)
The Neutrophil Gelatinase-Associated Lipocalin (NGAL), a NF-kB-regulated gene, is a survival factor for thyroid neoplastic cells. (uniud.it)
Free T4 measurements were primarily used for assessing thyroid function despite the technical difficulties in free thyroid hormone measurements owing to abnormal binding proteins, changes in binding protein concentrations, and the effects of drugs and illness on thyroid hormone binding. (pharmaceuticalintelligence.com)
Nuclear2
PAX8 is a nuclear transcription factor that controls the embryologic development of the Müllerian system, including the fallopian tubes. (nih.gov)
The immunosuppressive effect of CsA is mainly attributed to inhibition of calcineurin phosphatase activity, consequently favoring the inactive phosphorylated form of nuclear factor of activated T-cells (NFAT). (charite.de)
Genomic1
We show that PAX8 binds a large number of genomic sites and forms transcriptional hubs. (physiciansweekly.com)
Repressor2
Represses the transcription of the circadian transcriptional repressor NR1D1. (cusabio.com)
It functions both as a transcriptional activator and repressor to mediate B-cell commitment. (nih.gov)
Chromatin3
We designed the present study in order to understand whether changes in gene expression between FTSECs and HGSOCs relate to alterations in PAX8 binding to chromatin. (nih.gov)
Genome-wide maps of N_NUP98 and NUP98-TOP1 and MLL1 co-bound targets and their chromatin state in NUP98 fusion transformed cells. (nih.gov)
4 Acute hyperglycaemia leads to chronic metabolic and haemodynamic derangements, 5 which trigger chromatin structural changes, transcription factor activation, and gene expression. (emjreviews.com)
Ovarian cancer2
PAX8 and MECOM are interaction partners driving ovarian cancer. (physiciansweekly.com)
PRDM3 is amplified in ovarian cancers and we show that the MECOM locus and PAX8 sustain in vivo tumor growth, further supporting that the identified function of the MECOM locus underlies PAX8-driven oncogenic functions in ovarian cancer. (physiciansweekly.com)
Regulate2
Pax2 and Pax8 regulate the expression of Gata3. (wikipedia.org)
Signaling pathways that are activated by intrinsic or extrinsic stimulation converge on the transcriptional factors and regulate phenotypic changes of cancer cells [ 9 ]. (biomedcentral.com)
Pax51
The activation of Pax2, Pax5, and Pax8 is a conserved feature of all vertebrates. (wikipedia.org)
Epigenetic1
These data uncovered novel epigenetic and transcriptional regulatory mechanism underlying the etiological basis of these symptoms. (frontiersin.org)
Tumor1
PAX2 is believed to be a target of transcriptional suppression by the tumor suppressor gene WT1. (wikipedia.org)
Vitro1
These include MDS1-EVI1 (also called PRDM3) for which we map its interaction with PAX8 in vitro and in vivo. (physiciansweekly.com)
Adhesion2
Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule. (academicinfluence.com)
Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. (academicinfluence.com)
Interactions1
These sites are also near TEAD binding sites, and these transcriptional changes may be related to PAX8 interactions with the TEAD/YAP1 signaling pathway. (nih.gov)
Molecular1
Lineage factor inhibition-resistant ccRCC cells formed tumors with morphological features, but not molecular markers, of neuroendocrine differentiation. (bvsalud.org)
Kidney1
Pax2 and Pax8 are also necessary for the formation of the pronephros and subsequent kidney structures. (wikipedia.org)
Concentration1
Concentration gradients of fibroblast growth factor 8 (FGF8) and Wingless-Type MMTV Integration Site Family, Member 1 (Wnt1) control expression of Pax-2 during development of the Mesencephalon, or midbrain. (wikipedia.org)
Gene family1
The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. (wikipedia.org)
Cancers1
Pathologically, Pax2 has been demonstrated to activate hepatocyte growth factor (HGF) gene promoter, and both have been indicated as playing a role in human prostate cancers. (wikipedia.org)
Hypoxia1
Hypoxia stabilises HIF-1α protein by relaxing its ubiquitin-proteasome degradation [ 12 ] and affects subcellular localisation, DNA binding capacity and transcriptional activation function of the HIF-1 complex. (biomedcentral.com)
Domain2
Hsp90 C-Domain Inhibitors All medical Hsp90 inhibitors target the N-terminal ATP binding site. (forgetmenotinitiative.org)
These subunits are members of the basic helix-loop-helix (bHLH) transcription factor superfamily containing a PAS [PER (Period Clock) -ARNT-SIM (Single-minded)] domain [ 2 ]. (biomedcentral.com)
This gene module correlates with PAX8 and MECOM expression in large scale profiling of cell lines, patient-derived xenografts (PDXs) and clinical cases and stratifies gynecological cancer cases with worse prognosis. (physiciansweekly.com)
DN is a complex multifactorial disease caused by multiple genetic and environmental factors. (emjreviews.com)
Development3
The transcription factor gene PAX2 is important in the regionalized embryological development of the central nervous system. (wikipedia.org)
An understanding of the rules that govern lineage switching could aid the development of more durable lineage factor-targeted and other cancer therapies. (bvsalud.org)
as a proto-oncogene was recently characterized and the gene is implicated as a contributory factor in lung cancer development. (zju.edu.cn)
Essential1
PAX2 encodes for the transcription factor which appears to be essential in the organization of the midbrain and hindbrain regions, and at the earliest can be detected on either side of the sulcus limitans, which separates motor and sensory nerve nuclei. (wikipedia.org)
Show1
Using whole transcriptome shotgun sequencing (RNA-Seq) after PAX8 knockdown and ChIP-Seq, we show that FTSECs and HGSOCs are distinguished by marked reprogramming of the PAX8 cistrome. (nih.gov)
State1
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)