Transcriptional corepressor for nuclear receptors. Medical search. Frequent questions

The ability of nuclear receptors to alternate between activation and repression in response to specific molecular cues, is now known to be attributable in large part to a diverse group of cellular factors, collectively termed coregulators and including coactivators and corepressors. (wikipedia.org)
Mammalian Sin3 (mSin3) is a 150 kDa protein closely related to the yeast SIN3 repressor protein involved in the transcriptional repression of many genes. (receptors.org)
The nuclear receptor corepressor (N-CoR) or silencing mediator of retinoid and thyroid receptors (SMRT) proteins bind and mediate repression of transcription by the unliganded receptors. (sigmaaldrich.com)
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. (fhcrc.org)
Transcriptional repression by nuclear receptors has been correlated to binding of the putative co-repressor, N-CoR. (fhcrc.org)
A complex has been identified that contains N-CoR, the Mad presumptive co-repressor mSin3, and the histone deacetylase mRPD3, and which is required for both nuclear receptor- and Mad-dependent repression, but not for repression by transcription factors of the ets-domain family. (fhcrc.org)
Some orphan receptors are known to take action constitutively as transcription-promoting factors and to play tasks in liberating transcriptional repression [25]. (2011globalhealth.org)
The nuclear receptor co-repressor (NCoR) complex mediates transcriptional repression dependent on histone deacetylation by histone deacetylase 3 (HDAC3) as a component of the complex. (bvsalud.org)
2010). Transcriptional repressors, like the Rev-erbs, are regulated oppositely, whereby agonist bindingin this complete case, the organic porphyrin heme or additional artificial Rev-erb agonistsinduces corepressor recruitment and repression (Raghuram et al. (lavoixdesrroms.org)
In the absence of retinoid acid, RARA is bound by nuclear corepressor factor, and this causes transcriptional repression. (medscape.com)
In the liver activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs). (icr.ac.uk)
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. (kpu.ac.jp)

Again, using the yeast two-hybrid screen, two corepressors were isolated in rapid succession, nuclear receptor corepressor, or NCoR, in Geoff Rosenfeld's laboratory, and silencing mediator of retinoid and thyroid receptors, or SMRT, by Ron Evans. (wikipedia.org)
The silencing mediator of retinoic acid and thyroid hormone receptors (SMRT) is an established histone deacetylase 3 (HDAC3)-dependent transcriptional corepressor. (nih.gov)
Depletion of GPS2 and TBL1, components of the SMRT corepressor complex, but not histone deacetylase 3 (HDAC3) decreased p21-luciferase activity. (nih.gov)
Moreover, an HDAC3 binding-deficient SMRT DAD mutant coactivated p53 transcriptional activity. (nih.gov)
Containing 4 paired amphipathic helix domains (PAH domains), mSin3A and mSin3B have been shown to directly interact with several other transcriptional repressor proteins including HDAC1, HDAC2, RbAp46, the methyl CpG binding protein MeCP2, the Mad/Max heterodimer, and the corepressors silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR). (receptors.org)
A cell type-specific expression map of NCoR1 and SMRT transcriptional co-repressors in the mouse brain. (escholarship.org)
Nuclear receptor corepressor 1 (NCoR1) and silencing mediator for retinoid or thyroid-hormone receptors (SMRT) are the best characterized transcriptional co-repressors from a molecular point of view. (escholarship.org)
NCOR2, also known as SMRT, is a transcriptional corepressor that maintains the transcriptional silencing of certain target genes. (senescence.info)
It has also been reported that Sirt-1 indirectly influences the transcriptional activity of the nuclear receptor PPAR-c by docking the NCoR and SMRT to PPAR-c. (adenosine-receptor.com)

Nuclear receptor coregulators are a class of transcription coregulators that have been shown to be involved in any aspect of signaling by any member of the nuclear receptor superfamily. (wikipedia.org)
The activity of these hormones is mediated by proteins belonging to the nuclear receptor superfamily. (igbmc.fr)
Peroxisome proliferator activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. (sigmaaldrich.com)
Because the 1st record of TR-interacting protein (7) many nuclear receptor coregulatory protein Tyrphostin AG 879 (coactivators and corepressors) have already been reported that function to modulate the transcription activity of TR and additional people of receptor superfamily (8). (bioinbrief.com)
Nuclear receptors are believed ligand-regulated transcription elements generally, although no more than one-half from the 48 people in the individual nuclear receptor superfamily possess determined physiologic ligands. (lavoixdesrroms.org)
The androgen receptor (AR) is definitely a member of the nuclear receptor superfamily that regulates ligand-dependent gene transcription [2]. (opioid-receptors.com)

As far back as the early 1970s, receptor-associated nonhistone proteins were known to support the function of nuclear receptors. (wikipedia.org)
A greater understanding of the mechanism of transcriptional regulation by nuclear receptors has lead to the identification of multiple accessory proteins that bind to the nuclear receptors in a ligand-dependent manner. (sigmaaldrich.com)
Coactivator proteins such as SRC1 and CBP/p300 are recruited by agonist bound receptors and promote initiation of transcription by remodelling the chromatin structure while coactivators such as the PPAR binding protein (PBP) and TRAP220 interact directly with the transcriptional machinery. (sigmaaldrich.com)
One of Chakravarti's major research interests is to determine the mechanisms of steroid hormone and vitamin signaling with special emphasis on the role of the nuclear hormone receptor co-regulatory proteins in gene transcription. (northwestern.edu)
We, in a dogma changing study demonstrated that key cell cycle genes are regulated by HCFC1 cofactor recruitment not by the E2F proteins but by a THAP11-ZNF143 transcriptional complex. (northwestern.edu)
Today's study shows a novel system where TR isoforms immediate their selective features via preferential recruitment of the subset of nuclear coregulatory proteins. (bioinbrief.com)
The expression of many nuclear receptor coregulatory proteins is tissue dependent. (bioinbrief.com)
In view of the critical regulatory role of the widely distributed nuclear receptor coregulatory proteins in TR transcriptional activity we hypothesized that one Tyrphostin AG 879 of the mechanisms by which TR isoforms achieve their selective cellular functions could be mediated by preferential recruitment of a subset of nuclear receptor coregulatory Tyrphostin AG 879 proteins. (bioinbrief.com)
In today's research using tandem-affinity chromatography we demonstrated that TRβ1PV and TRα1PV recruited not merely common nuclear proteins but also a subset of specific nuclear proteins in HeLa cells. (bioinbrief.com)
5 Interestingly.5 more distinct nuclear proteins (33 and six distinct associated proteins for TRα1PV and TRβ1PV respectively) had been preferentially recruited by TRα1PV than by TRβ1PV assisting the hypothesis how the action of TR mutant isoforms could possibly be mediated at least partly with a subset of nuclear regulatory proteins. (bioinbrief.com)
A proteomic characterization of nuclear proteins interacting with RAR regions distinct from the AF-2 revealed unsuspected functional properties of the RAR N-terminus. (pasteur.fr)
The system of actions of nuclear receptor ligands can be complex, as the same ligand can possess different cells-, cell-, and promoter-specific actions, with regards to the manifestation degrees of coregulator proteins frequently, and also screen graded receptor activity (Shang et al. (lavoixdesrroms.org)
Under physiological circumstances co-activators are essential for the forming of a successful transcriptional AR complicated by facilitating DNA occupancy chromatin redecorating and/or AR proteins balance and acetylation [4]. (opioid-receptors.com)
liganded nuclear receptors would recruit RNA polymerase II or linked proteins directly. (biodiversityhotspot.org)
These interactions ended up being elusive, sparking a seek out adapter proteins that could make bridging connections to the overall transcriptional equipment. (biodiversityhotspot.org)
We now know that a very large number of proteins participate in the regulatory complexes recruited to nuclear receptors. (biodiversityhotspot.org)

PPARs regulate gene expression by heterodimeric partnering with retinoid X receptors (RXR) and subsequent binding to specific response elements (PPREs) in the promoter regions of target genes. (sigmaaldrich.com)
리간드가 없을 때 SMILE은 핵수용체 전사활성을 저해하는 보조억제인자로 작용하며, 실제로 constitutive androstane receptors(CAR), retinoid X receptors(RXR), and estrogen-related receptor gamma(ERR γ ) 등 여러 핵수용체의 전사활성을 저해한다[ 10 , 12 ]. (etals.org)

The yeast two-hybrid protein-protein interaction assay led to the identification of an array of receptor-interacting factors in David Moore's laboratory and RIP140 repressive protein was discovered in Malcolm Parker's laboratory. (wikipedia.org)
Here, we report that the guanine nucleotide-binding protein (G protein)-coupled receptor-activated WD-repeat Gβ interacts with the glucocorticoid receptor (GR), comigrates with it into the nucleus and suppresses GR-induced transactivation of the glucocorticoid-responsive genes. (rupress.org)
For instance, the phosphorylation of nuclear receptors regulates nuclear VTP-27999 2,2,2-trifluoroacetate transcription and translocation, while ubiquitination is important in protein degradation. (2011globalhealth.org)
Furthermore, the binding of chaperones such as for example heat surprise protein 90 (HSP90) and HSP70 handles the nuclear translocation of some receptors [43,44], therefore the chaperones could be goals for testing strategies [45 also,46,47]. (2011globalhealth.org)
transcriptional regulating protein 13. (nig.ac.jp)
B) nuclear receptors bind to particular DNA response components, recruit coregulator protein, which remodel chromatin and handles polymerase binding, which handles the appearance of specific focus on genes. (lavoixdesrroms.org)
The approved system of actions for nuclear receptor transcriptional activators (Fig. 1C) dictates an agonist ligand binds towards the LBD and escalates the recruitment of coactivator protein, which escalates the transcription of focus on genes. (lavoixdesrroms.org)
Nevertheless, many antagonists referred to for nuclear receptors screen inverse agonist activity for receptors with significant basal or constitutive transcriptional activity, where binding from the ligand raises recruitment of corepressor protein and positively represses transcription. (lavoixdesrroms.org)
Nuclear receptors are transcription factors that regulate gene expression through the ligand-controlled recruitment of the different group of protein referred to as coregulators. (biodiversityhotspot.org)
Subsequently, it is becoming apparent that coregulator protein play a central function in mediating transcriptional legislation by nuclear receptors. (biodiversityhotspot.org)

Early cell transfection experiments had shown that discrete regions of certain receptors, such as thyroid hormone receptor, were sufficient to repress, or silence, reporter genes when fused to DNA-binding domains of heterologous transcription factors, suggesting that specific cellular factors - or corepressors - might bind to these regions and silence receptors in cells. (wikipedia.org)
This is an important study demonstrating distinct roles for the nuclear receptor genes COUP-TFI and COUP-TFII in hippocampal development. (elifesciences.org)
The hormone-receptor pair functions as a highly selective lock-and-key system that modulates the expression of many genes and the activities of target cells. (igbmc.fr)
The activity of about two-thirds of the 48 nuclear receptors is controlled by selective ligands (e.g. steroid hormones, retinoids, intracellular lipids), and is fine-tuned by transcriptional coregulators forming macromolecular complexes that activate (coactivators) or repress (corepressors) the expression of target genes by modulating the accessibility of the transcriptional machinery to DNA. (igbmc.fr)
Since the expression of genes defining discrete phenotypes is highly coordinated, application of reverse engineering algorithms to transcriptome datasets allows interpreting transcriptional networks by defining MRs and their associated regulons and gene circuits. (aging-us.com)
Unexpectedly, we found that signaling by the receptor activator of nuclear factor κB (RANK) converts the NCoR/HDAC3 co-repressor complex to a co-activator of AP-1 and NF-κB target genes that are required for mouse osteoclast differentiation. (bvsalud.org)

Mechanistically, RANK signaling promotes RNA-dependent interaction of the transcriptional co-activator PGC1ß with the NCoR/HDAC3 complex, resulting in the activation of PGC1ß and inhibition of HDAC3 activity for acetylated histone H3. (bvsalud.org)
Moreover, we demonstrated that nuclear receptor PPAR-c interacts with the nuclear receptor corepressor NCoR. (adenosine-receptor.com)

Therefore, EBF3 regulates a transcriptional program underlying a putative tumor suppression pathway. (aacrjournals.org)

Nuclear all-trans retinoic acid receptors (RARs) initiate early transcriptional events which engage pluripotent cells to differentiate into specific lineages. (pasteur.fr)
The retinoic acid alpha receptor gene ( RARA ) is encoded by the long arm of chromosome 17. (medscape.com)
The fusion gene product causes the retinoic acid receptor to bind more tightly to the nuclear co-repressor factor. (medscape.com)
The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic acid is elicited through retinoic acid receptor alpha. (kpu.ac.jp)
Retinoic acid receptor gamma 2 gene expression is up-regulated by retinoic acid in 3T3-L1 preadipocytes. (kpu.ac.jp)
Receptor for retinoic acid. (abcam.com)

RAR-controlled transactivation depends mostly on agonist-induced structural transitions in RAR C-terminus (AF-2), thus bridging coactivators or corepressors to chromatin, hence controlling preinitiation complex assembly. (pasteur.fr)
During the past few years, our understanding of nuclear receptor action has dramatically improved as a result of the identification and functional analysis of co-regulators such as factors involved in chromatin remodeling, transcription intermediary factors (co-repressors and co-activators), and direct interactions with the basal transcriptional machinery. (elsevierpure.com)
The p300/CBP-associated aspect (PCAF) has been proven to act being a co-activator to modify gene transcription possibly including AR-regulated transcriptional activity in PCa cells [6 7 PCAF possesses histone acetyltransferase (Head wear) activity where it makes the chromatin environment easier available for the transcriptional equipment. (opioid-receptors.com)

A comprehensive database of coregulators for nuclear receptors and other transcription factors was previously maintained at the Nuclear Receptor Signaling Atlas website which has since been replaced by the Signaling Pathways Project website. (wikipedia.org)
These nuclear receptor coregulators exhibit varied regulatory roles to affect transcriptional initiation elongation translation and splicing. (bioinbrief.com)
Indeed more than 350 nuclear coregulators have been identified (http://www.NURSA.org). (biodiversityhotspot.org)

Extracellular stimuli that activate cell surface receptors modulate glucocorticoid actions via as yet unclear mechanisms. (rupress.org)
Additional ligands can modulate post-translational changes from the receptor, impacting function 3rd party of transcriptional agonism (Choi et al. (lavoixdesrroms.org)
It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcriptional activity (By similarity). (icr.ac.uk)

While this article refers to the historical terms "coactivator" and "corepressor," this distinction is less clear than was at first thought, and it is now known that cell type, cell signaling state and promoter identity can influence the direction of action of any given coregulator. (wikipedia.org)
The first authentic, common nuclear receptor coactivator was steroid receptor coactivator 1, or SRC-1 (NCOA1), first cloned in Bert O'Malley's laboratory. (wikipedia.org)
핵수용체는 표적유전자의 프로모터 전사조절부위에 직접 결합하여, 보조활성인자(coactivator) 혹은 보조억제인자(corepressor)와의 상호작용을 통해 유전자 발현을 조절하는 리간드 의존성 전사조절인자이다[ 11 ]. (etals.org)

Our extensive molecular and genome wide studies as well as analysis of human cancer samples suggest that WDR5-H3T11P interaction integrates epigenetic cross talk in driving androgen receptor target gene expression, prostate cancer cell proliferation and disease progression. (northwestern.edu)
Steroid receptors such as the estrogen receptor (ER) (ER: NR3A1, ER: NR3A2) and androgen receptor (AR: NR3C4) bind to DNA as homodimers. (2011globalhealth.org)

The ligand-binding site is the main target of many screenings, as ligand binding causes transcriptional activity. (2011globalhealth.org)

The tissue specific expression of these cofactors may be responsible for the differential transcriptional regulation and responses observed in different cell types in vivo . (sigmaaldrich.com)
Nuclear receptor and epigenomic regulation of Uterine Fibroids (Mol. (northwestern.edu)
An orphan nuclear receptor that is implicated in regulation of steroidogenic pathways. (nih.gov)
Barrett, TJ & Spelsberg, TC 1998, ' Steroid receptors at the nexus of transcriptional regulation ', Journal of cellular biochemistry , no. (elsevierpure.com)
Overexpression and ribozyme-mediated targeting of transcriptional coactivators, CBP and p300, revealed their indispensable roles in adipocyte differentiation through the regulation of PPAR-gamma. (kpu.ac.jp)

PPARs have a highly conserved DNA binding domain (region C) and a diverse ligand-independent activation domain (region A/B) which can confer constitutive activity on the receptor. (sigmaaldrich.com)
C) ligands that bind towards the nuclear receptor LBDs elicit a number of pharmacological replies, including activation VU 0364439 (agonists), inactivation (antagonists or non-agonists), and, for receptors that are energetic constitutively, ligands can downregulate the constitutive response (inverse agonists). (lavoixdesrroms.org)

SR1001 binds specifically to the ligand-binding domains of RORα and RORγt, inducing a conformational change within the ligand-binding domain that encompasses the repositioning of helix 12 and leads to diminished affinity for co-activators and increased affinity for co-repressors, resulting in suppression of the receptors' transcriptional activity. (nature.com)
Nuclear receptors could be split into two classes generally, transcriptional repressors and VU 0364439 activators. (lavoixdesrroms.org)

Here we report that antidiabetic thiazolidinediones (TZDs) and other ligands for the nuclear receptor PPARγ dramatically upregulate oxidized LDL receptor 1 (OLR1) in adipocytes by facilitating the exchange of coactivators for corepressors on the OLR1 gene in cultured mouse adipocytes. (jci.org)
Forty-eight types of nuclear receptors have been found in humans, and 25 of these are orphan receptors with unfamiliar endogenous ligands [22]. (2011globalhealth.org)
Agonists may also induce corepressor recruitment to nuclear receptor transcriptional activators (Fernandes and White colored, 2003), whereas some ligands become agonists using antagonists and cells in others, in part with regards to the degree of coregulator manifestation in the cells (Shang and Brownish, 2002). (lavoixdesrroms.org)
The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. (icr.ac.uk)

However, the contribution of other domains of RAR to its overall transcriptional activity remains poorly defined. (pasteur.fr)

NCOR2 expression and its occupancy on peroxisome proliferator-activated receptor (PPAR) target gene promoters are increased with age in major metabolic tissues. (senescence.info)
Click links below to explore KE 228, peroxisome proliferator activated receptor promoter demethylation in tools offered by third parties. (aopwiki.org)

The knockdown of Rev-erbα in osteoclast precursor cells enhanced receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation, as well as expression of nuclear factor of activated T cells 1 (NFATc1), osteoclast-associated receptor (OSCAR), and tartrate-resistant acid phosphatase (TRAP). (molcells.org)

These data predict that the ligand-induced switch of heterodimeric nuclear receptors from repressor to activator functions involves the exchange of complexes containing histone deacetylases with those that have histone acetylase activity. (fhcrc.org)

PPAR-RXR heterodimers can also be activated by ligand binding to either receptor partner independently. (sigmaaldrich.com)
Our co-immunoprecipitation data indicate that Sirt-1 interacts with the nuclear receptor PPAR-c and this interaction was downregulated by nicotinamide. (adenosine-receptor.com)

Coregulator complexes that repress transcription are recruited to unliganded receptors or receptors bound to inverse agonists generally. (biodiversityhotspot.org)

Gβ2 was associated with GR/glucocorticoid response elements (GREs) in vivo and suppressed activation function-2-directed transcriptional activity of the GR. We conclude that the Gβγ complex interacts with the GR and suppresses its transcriptional activity by associating with the transcriptional complex formed on GR-responsive promoters. (rupress.org)
SMILE acts as a corepressor for nuclear receptors related transcriptional activity and other transcription factors. (etals.org)
Shifting its repressive activity towards PPARs, by selectively disabling one of its two major receptor-interacting domains, resulted in premature ageing in mice and related metabolic diseases accompanied by reduced mitochondrial function and antioxidant gene expression. (senescence.info)
Mouse monoclonal to CD4.CD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection (CD4 is primary receptor for HIV-1 surface glycoprotein gp120). (bioinbrief.com)
In a negative feedback loop, PER and CRY interact with the BMAL1/CLOCK heterodimer and interfere with its transcriptional activity. (molcells.org)
Focusing on of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells. (opioid-receptors.com)
Focusing on of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells. (opioid-receptors.com)
In addition to the acetylation of FR 180204 histones HATs have already been shown to acetylate AR advertising AR transcriptional activity [5]. (opioid-receptors.com)
Nevertheless, recruitment to nuclear receptors and additional sequence-specific transcription elements implies that coregulator activity can be directed to particular genomic loci resulting in particular adjustments in gene rules. (biodiversityhotspot.org)

Our data thereby extends the previously known RAR interactome from classical transcriptional modulators to components of the elongation machinery, and unravel a functional role of RAR in transcriptional elongation. (pasteur.fr)

In the traditional feeling, an antagonist would stop the binding from the agonist towards the LBD and stop the agonist from inducing a conformational modification in the receptor. (lavoixdesrroms.org)

Moreover, due to their effects on metabolism, proliferation and inflammation, their receptors are therapeutic targets for pathologies refractory to current treatments such as various autoimmune and rare diseases, as well as cancers. (igbmc.fr)

Furthermore, the elucidation of the crystal structures of the empty ligand-binding domains of the nuclear receptor and of complexes formed by the nuclear receptor's ligand-binding domain bound to agonists and antagonists has contributed significantly to our understanding of the early events of nuclear receptor action. (elsevierpure.com)

The circadian clock mechanism includes an interconnected transcriptional and translational feedback loop, in which the most well-known positive regulator is a heterodimer of BMAL1 and CLOCK. (molcells.org)

There are also some receptors that bind to DNA as monomers, including some orphan receptors [28,29]. (2011globalhealth.org)
Our data demonstrate the feasibility of targeting the orphan receptors RORα and RORγt to inhibit specifically T H 17 cell differentiation and function, and indicate that this novel class of compound has potential utility in the treatment of autoimmune diseases. (nature.com)

Crystal constructions of ligand-receptor complexes offer an atomic snapshot in to the molecular system of action from the receptor. (lavoixdesrroms.org)
Taken together, this implies the specificity of actions of coregulator complexes depends upon an elaborate, but particular network of recruitment to different transcriptional regulators. (biodiversityhotspot.org)
In the Zanamivir entire case of nuclear receptors, the absence or presence of the bound ligand decides which nuclear receptor coregulator complexes are recruited. (biodiversityhotspot.org)

this review, we cover the chemical testing methods for nuclear receptor modulators, focusing on assay methods and chemical libraries for screening. (2011globalhealth.org)
We include some recent examples of the finding of nuclear receptor modulators. (2011globalhealth.org)
The development of specific modulators of nuclear receptors is definitely important not only to provide tools for fundamental practical studies, but also for study into human being disease. (2011globalhealth.org)

A CBP Integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. (kpu.ac.jp)

Rev-erbs lack the carboxy-terminal tail of the ligand-binding domain that is required for ligand-dependent transcriptional activation by other nuclear receptors. (molcells.org)
Upregulation of PCAF advertised AR transcriptional activation and cell growth in cultured PCa cells. (opioid-receptors.com)

Over the last two decades, studies based on genome-wide gene expression and functional profiling have revealed the great diversity of transcriptional alterations occurring in liver carcinogenesis. (aging-us.com)
Corepressors are molecules that function to repress gene expression mainly through the interaction with unliganded TR (10). (bioinbrief.com)
Vitamin D receptor gene expression is up-regulated by 1, 25-dihydroxyvitamin D3 in 3T3-L1 preadipocytes. (kpu.ac.jp)

Thyroid hormone receptors (TR) are ligand-dependent transcription elements that regulate development differentiation and maintenance of metabolic homeostasis. (bioinbrief.com)
The two AF areas regulate transcription by directly interacting with transcription cofactors, such as corepressors and coactivators [30,31,32]. (2011globalhealth.org)

The retinoid X receptor (RXR) (RXR: NR2B1, RXR: NR2B2, RXR: NR2B3) forms heterodimers with numerous receptors as partners to bind to their specific DNA sites. (2011globalhealth.org)

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. (kpu.ac.jp)

Moreover, corepressors themselves recruit ancillary enzyme activities which help to establish or maintain the repressive state at their target promoters. (wikipedia.org)

2008 known as selective nuclear receptor modulation )also. (lavoixdesrroms.org)

Growing evidence shows that co-regulators elements recruited by transcription elements to activate or repress transcription are essential the different parts of transcriptional gene legislation [5]. (opioid-receptors.com)

The binding of ligand triggers a series of events which result in conformational changes involving recruitment of coactivators and dissociation of corepressors. (sigmaaldrich.com)
Experimental and theoretical studies on ligandCreceptor relationships and the conformational changes induced in the receptors provide a wealth of info for developing screening strategies and assay methods. (2011globalhealth.org)

Anatomy16

Organisms8

Diseases3

Chemicals and Drugs143

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes62

Information Science3

Repression12

SMRT9

Superfamily6

Proteins16

Retinoid X recepto2

Protein10

Genes6

NCoR2

Regulates1

Retinoic6

Chromatin3

Coregulators3

Modulate3

Coactivator3

Androgen receptor2

Causes transcriptional1

Regulation5

Constitutive2

Repressors2

Ligands4

Overall transcriptional1

Peroxisome prolifer2

Activator of nuclear1

Histone1

PPAR2

Inverse agonists1

Activity9

Machinery1

Agonist1

Metabolism1

Antagonists1

Mechanism1

Orphan receptors2

Complexes3

Modulators3

Complex1

Activation2

Gene expression3

Regulate2

Bind1

Binds1

Recruit1

Modulation1

Repress transcription1

Conformational2