Transcriptional activation transcription factor 7 like 1 protein. Medical search. Frequent questions

1, 2, 3] Approximately 20% of the genes expressed in human leukocytes are regulated positively or negatively by glucocorticoids. (medscape.com)
At the cellular level, the actions of glucocorticoids are mediated by a 94-kd protein, the glucocorticoid receptor (GR). The human (h) GR belongs to the steroid/thyroid/retinoic acid superfamily of nuclear receptors and functions as a ligand-dependent transcription factor that regulates the expression of glucocorticoid-responsive genes positively or negatively. (medscape.com)
(A) FoxO1 regulates autophagy through two mechanisms involving the transcriptional control of autophagy-related genes and the activation of ATG7 in the cytosol associated with the acetylation (Ac) of FoxO1 by the dissociation from SIRT2. (nature.com)
We will mainly focus on the roles of the mouse Hes genes, but also compare them with the zebrafish Hes genes (called the her family of genes)( Table 1 ). (biologists.com)
The AU-rich element RNA-binding protein 1 (AUF1) is an RNA-binding protein, which can both stabilize and destabilize the transcripts of several cancer-related genes. (nature.com)
The lactylation of CENPA at K124 promotes CENPA activation, leading to enhanced expression of its target genes. (bvsalud.org)
YY1 is known to regulate transcriptional activation and repression of various genes associated with different cellular processes such as DNA repair, autophagy, cell survival and apoptosis, and cell division. (bvsalud.org)
The C(2)H(2) zinc finger-containing transcription factors have been implicated as critical regulators of multiple cardiac-expressed genes and are important for human heart development and diseases. (anthropogeny.org)
In studying the parameter dependence of the binding strengths of the protein complexes on the three genes, we use the fact that the nature of the regulation on OCT4 and SOX2 is similar. (lu.se)
The regulatory genes primarily the transcription factors that exert their activity by binding to certain cis DNA elements and consequently either up regulated or down regulate to target expression. (scielo.br)
These ATG genes are highly conserved in mammalian cells, allowing to study their functions also in higher eukaryotes [ 1 - 4 ]. (hindawi.com)
p53 affects the transcription of many target genes and interacts with key cellular proteins. (molvis.org)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
Conserved transcription factor-binding sites within promoter regions of human RON genes were then searched. (spandidos-publications.com)
NF-κB is a transcription factor that plays a pivotal role in the highly specific pattern of gene expression observed for immune, inflammatory and acute phase response genes, including interleukin 1, interleukin 8, tumor necrosis factor and certain cell adhesion molecules. (justia.com)
Rhombotin 1 (RBTN1 or TTG-1) and rhombotin-2 (RBTN2 or TTG-2) are proteins of about 160 amino acids whose genes are disrupted by chromosomal translocations in T-cell leukemia. (embl.de)
[7] Removing DNA methylation marks allows the activation of downstream genes. (wikipedia.org)
however, further transcriptional target genes and cofactors of intranuclear MMP3 have not been uncovered. (elsevierpure.com)
In this paper, we used transcriptomics analysis in order to examine novel transcriptional target genes regulated by intracellular MMP3. (elsevierpure.com)
Taken together, this study newly clarified that intracellular MMP3 cooperate with CBXs/HP1s in transcriptional promotion of HSP genes. (elsevierpure.com)
100 genes ( 1 ). (cdc.gov)
The aim of the present work is to review cumulative evidence regarding the participation of PI3K pathways in neuronal function, focusing on their role in neuronal metabolism and transcriptional regulation of genes involved in neuronal maintenance and plasticity or on the expression of pathological hallmarks associated with neurodegeneration. (mdpi.com)
STE12 is also required for transcription of alpha-specific genes, but there is no evidence that it binds directly to these genes. (embl-heidelberg.de)
To explore the role of STE12 in the pheromone induction of alpha-specific genes, we cloned STE12 and MAT alpha 1 homologs from the related yeast Kluyveromyces lactis. (embl-heidelberg.de)
Transcriptional activator Islet-Brain 1 (IB1) is disclosed which is involved in the control of the GLUT2 and insulin genes by interacting with homologous cis-regulatory elements of the GLUT2 and insulin promoters, and to materials and methods deriving from this work. (justia.com)
The present invention is based on successful expression cloning of a transcription factor that binds to the GTII element of the GLUT2 and insulin genes from a differentiated insulin-secreting cDNA library. (justia.com)
The emphasis of these studies has been to model the relationships between transcription factors and their target genes. (biomedcentral.com)
Using chromatin immunoprecipitation in conjunction with microarrays, it is now possible to measure the binding of many transcription factors to the promoters of most genes, thus elucidating the underlying structure of the transcriptional regulatory network. (biomedcentral.com)
The simplest models identify transcription factor binding sites (or cis regulatory motifs) that are over-represented in the promoters of differentially-expressed genes [ 9 ]. (biomedcentral.com)
Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY. (broadinstitute.org)
A) Luciferase reporter genes were determined in ZR75-1 and MDA-MB-231 breast cancer cells co-transfected with Glutaminase-IN-1 different concentrations of reporter and myc-ZKSCAN5. (bms-911543.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
We use these engineered Cas9 activation complexes to investigate sgRNA targeting rules for effective transcriptional activation, demonstrate multiplexed activation of 10 genes simultaneously, and upregulate long intergenic non-coding RNA (lincRNA) transcripts. (cdc.gov)
We also synthesize a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes which, upon activation, confer resistance to a BRAF inhibitor. (cdc.gov)
These dCas9-activator fusions targeted to the promoter region of endogenous genes can then modulate gene expression 7 - 11 . (cdc.gov)

Reporter gene assays show that ZNF322 is a transcriptional activator. (anthropogeny.org)
This TF induction was dependent on signal transducer and activator of transcription-6 signaling and poly ADP ribose polymerase activity. (haematologica.org)
Transactivation assay in yeast cells revealed that CmNAC1 functions as a transcription activator, and its transactivation domain is located in the C-terminus. (frontiersin.org)
GmNAC11 is a transcriptional activator, whereas GmNAC20 is a mild transcriptional repressor. (frontiersin.org)
Further investigation indicated that the transcriptional activator IRF-1 and the closely related IRF-2, a repressor of interferon-induced gene expression, are both capable of activating Qp. (psu.edu)
The objective of specific aim #1 is to determine whether constitutive production of this plasminogen activator in some colon cancers is a consequence of stimulation by autocrine TGF-a. (grantome.com)
Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)

GLI1, a novel target of the ER stress regulator p97/VCP, promotes ATF6f-mediated activation of XBP1. (mayo.edu)
In summary, CENPA function as a transcriptional regulator to promote HCC via cooperating with YY1. (bvsalud.org)
Together, these results suggest that ZNF322 is a member of the zinc-finger transcription factor family and may act as a positive regulator in gene transcription mediated by the MAPK signaling pathways. (anthropogeny.org)
Furthermore, we identified PU.1 as positive transcriptional regulator of ATG3, ATG4D, and ATG5. (hindawi.com)
p53 E3 ubiquitin protein ligase homolog (Mdm2) is an important negative regulator of p53. (molvis.org)
It is a nuclear protein and functions as a transcriptional regulator. (wikipedia.org)

The EZH2 gene encodes for an enzyme that is involved in histone methylation and transcriptional repression. (bvsalud.org)
Expression of the suppressor of cytokine signaling-1 (SOCS1) is inactivated in hematopoietic and solid cancers by promoter methylation, miRNA-mediated silencing, and mutations. (aacrjournals.org)
EGR-1, together with TET1, is employed in programming the distribution of methylation sites on brain DNA during brain development, in learning and in long-term neuronal plasticity . (wikipedia.org)

Upon Wnt signaling, ß-catenin binds and activates nuclear TCFs by providing a trans-activation domain. (hubrecht.eu)
The tumor suppressor protein APC forms the core of a cytoplasmic complex which binds ß-catenin and targets it for degradation in the proteasome. (hubrecht.eu)
Mdm2 binds directly to the transcriptional activation domain of p53 and blocks p53-dependent transcription. (molvis.org)
Isl-1 binds to one of the two cis-acting protein-binding domains of the insulin gene. (embl.de)

In the absence of Wnt signaling, we found that Tcf factors associate with proteins of the Groucho family of transcriptional repressors to repress target gene transcription (9). (hubrecht.eu)
Like other members of the Rel family of transcriptional activators, NF-κB is sequestered in an inactive form in the cytoplasm of most cell types. (justia.com)

The centromere proteins (CENPs), a critical mitosis-related protein complexes, are involved in the kinetochore assembly and chromosome segregation. (bvsalud.org)
The gene contains four exons and spans 23.2kb in chromosome 6p22.1 region, and transcribes a 2.7kb mRNA that encodes a protein with 402 amino acid residues. (anthropogeny.org)
It contains 20 exons and 19 introns and is located on chromosome 3p21 ( 1 - 3 ), a region frequently altered in certain cancer types ( 4 ). (spandidos-publications.com)
The human EGR-1 protein contains (in its unprocessed form) 543 amino acids with a molecular weight of 57.5 kDa , and the gene is located on the chromosome 5 . (wikipedia.org)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)

24(1): 50, 2023 10 12. (bvsalud.org)

Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
The energetic ERK-mediated transcriptional occasions eventually impinge on cell routine components catalytically, like the induction of Adrucil tyrosianse inhibitor cyclinD1 for cell routine progression [6C8]. (ampkpathway.com)
Caveolin-1 and so are indicated generally in most cell types -2, while Adrucil tyrosianse inhibitor caveolin-3 is expressed in muscle tissue cells [19] mainly. (ampkpathway.com)
The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)

ZNF322, a novel human C2H2 Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways. (anthropogeny.org)
6 , 7 Multiple signaling pathways , transcription factors, and neurotrophic factors had been implicated in their differentiation. (edu.pl)
The ULK1 protein complex including ULK1, ATG13, and FIP200 coordinates the autophagy initiation from different upstream signaling pathways to induce autophagy [ 6 , 7 ]. (hindawi.com)
Our results indicated that CmNAC1 is a critical factor in ABA signaling pathways and it can be utilized in transgenic breeding to improve the abiotic stress tolerance of crops. (frontiersin.org)

Disruption of protein homeostasis underlies the etiology of several human diseases, including cancer, diabetes and neurodegenerative diseases, among other pathologies. (nature.com)

YY1 promoted its transcriptional expression by directly binding to the MDR1 promoter. (bvsalud.org)
The objective of this study was to identify transcriptional regulatory proteins that mediate EBNA- 1 expression via the viral promoter Qp, which is active in EBV-associated tumors such as Burkitt lymphoma and nasopharyngeal carcinoma. (psu.edu)
Among these factors, heat shock factor 1 (HSF1) cooperated with the MMP3 to activate the HSP70B′ gene promoter in reporter gene assays, while a dominant negative HSF1 blocked the role for MMP3 in the trans-activation. (elsevierpure.com)
The type I interferon (IFN/) bind to the IFN promoter, and stimulate transcription. (cdc.gov)
While studying the activity of BRCA2 gene promoter in breast cancer cells, we discovered that this promoter has bi-directional activity and the product of the reverse activity (a ZAR1-like protein, we named ZAR2) silences the forward promoter at the G0/G1 phase of the cell. (biomedcentral.com)
Standard techniques like cell synchronization by serum starvation, flow cytometry, N-terminal or C-terminal FLAG epitope-tagged protein expression, immunofluorescence confocal microscopy, dual luciferase assay for promoter evaluation, and chromatin immunoprecipitation assay were employed during this study. (biomedcentral.com)
BRCA2 gene promoter has bi-directional activity, expressing BRCA2 and a novel C4-type zinc finger containing transcription factor ZAR2. (biomedcentral.com)
Important cis-regulatory sequences were identified within this promoter region including a functionally responsive PDX-1 element, a cyclic AMP responsive element, and three cis elements termed GTI, GTII and GTIII (3,36,53). (justia.com)
Does the binding of a specific transcription factor to the promoter of a gene regulate its expression? (biomedcentral.com)
Tiling a given promoter region with several sgRNAs can produce more robust transcriptional activation 9 - 11 , but this requirement presents enormous challenges for scalability, and in particular for establishing pooled, genome-wide GOF screens. (cdc.gov)
Here we describe a different method of transgene regulation by the use of the human glial ®brillary acidic protein (GFAP) promoter. (lu.se)

Snail expression, through AhR activation, is an epithelial-to-mesenchymal transition (EMT) determinant. (oncotarget.com)

A recent study described a negative regulation of the transcription factor FoxO1 by XBP1s in pancreatic β cells, mediated by a physical interaction 7 . (nature.com)
S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)
The results of qRT-PCR and Western blotting demonstrated that the expression level of Yin Yang 1 (YY1) and multi-drug resistance-1 (MDR1) in MG-63/ADM cells were remarkably increased compared with those in MG-63 cells. (bvsalud.org)
When overexpressed in COS-7 cells, ZNF322-EGFP fusion protein is detected in the nucleus and cytoplasm. (anthropogeny.org)
Furthermore, overexpression of ZNF322 in COS-7 cells activates the transcriptional activity of SRE and AP-1. (anthropogeny.org)
Notch pathway activation promotes the differentiation of beagle dog periodontal ligament stem cells to Schwann cells. (edu.pl)
1 , 2 Schwann cells are essential in increasing the density of peripheral nerve endings, and in the improvement of osseoperception. (edu.pl)
Schwann cells also produce various growth factors that are involved in phagocytosis and the clearance of myelin fragments. (edu.pl)
In our previous study, we found that periodontal ligament stem cells (PDLSCs) isolated from beagle dogs effectively differentiated into SCs with exposure to a combination of dimethyl sulfoxide (DMSO), basic fibroblast growth factor (bFGF), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and forskolin. (edu.pl)
Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
Recepteur d'origine nantais (RON) is a receptor tyrosine kinase (RTK) normally expressed at low levels mostly in epithelial cells ( 1 , 2 ). (spandidos-publications.com)
a protein required for the asymmetric division of vulval blast cells. (embl.de)
Replication of the Epstein-Barr virus (EBV) genome within latently infected cells is dependent on the EBV EBNA-1 protein. (psu.edu)
However, the major QRE-2-specific binding activity detected within extracts of Burkitt lymphoma cells was attributed to IRF-2, suggesting that interferon-independent activation of Qp is largely mediated by IRF-2 in these cells. (psu.edu)
Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. (cancerindex.org)
We previously reported that human MMP3 could translocate into cellular nuclei and control transcription in human chondrosarcoma-derived cells and in articular cartilage (Eguchi et al. (elsevierpure.com)
Most cells have intracellular sensors of viral za virus and appear partially responsible for the ability of products that, when activated, initiate a signaling cascade influenza viruses to infect multiple animal species, which likely contributes to the generation of new pandemic virus- that results in transcriptional induction of the IFN gene. (cdc.gov)
Deregulation of cell cycle and transcriptional control are general features of tumor cells, highlighting the potential for the use of CDK7 inhibitors as novel cancer therapeutics. (imperial.ac.uk)
The expression of caveolin-1 is significantly reduced in human breast cancer cells [22, 23]. (ampkpathway.com)
The loss of mitogenic signalling in senescent cells is related to their up-regulation of caveolin-1 [27C29]. (ampkpathway.com)
Induction from the caveolin-2 gene was up-regulated in response to insulin as well as the endogenous caveolin-2 improved the G1 to S stage changeover of cell routine whereas caveolin-1 inhibits when cells were expressed with recombinant caveolin-1. (ampkpathway.com)
Thus, we demonstrate a coupling in alpha cells between a protein functioning in cell identity, alpha 1, with a protein responsive to the pheromone-induced signal STE12. (embl-heidelberg.de)
For tumour estimation, nude mice were inoculated subcutaneously with 1 107 ZR75-1 cells with different constructs on the right side. (bms-911543.com)
BALB/c mice were injected with 1 106 MDA-MB-231 cells labelled with luciferase carrying the indicated constructs into the lateral tail vein. (bms-911543.com)
B) Luciferase reporter gene detection in ZR75-1 and MDA-MB-231 breast cancer cells co-transfected with expression in ZR75-1 and MDA-MB-231 cells, which were transfected with ZKSCAN5 shRNA, control shRNA, or ZKSCAN5 shRNA plus shRNA-resistant ZKSCAN5 (ZKSCAN5-R). The representative Western blot further showed the expression of ZKSCAN5. (bms-911543.com)
A, B) Cell proliferation and colony formation assays in HLECs cultured in conditioned medium come from ZR75-1 or MDA-MB-231 cells stably infected with lentivirus carrying ZKSCAN5 shRNA or ZKSCAN5 shRNA plus ZKSCAN5-R. The representative Western blot displays the expression of ZKSCAN5. (bms-911543.com)
p 0.01 versus the control shRNA group (A, B). (C, D) Wound healing assays for HLECs cultured in conditioned medium from ZR75-1 or MDA-MB-231 cells, which were Glutaminase-IN-1 stably infected as in (A). The image shown is one of the representative results (C, D). Scale bar: 100 m. (bms-911543.com)
VEGF-D (E, F) Tube formation assays for HLECs cultured in the conditioned medium from ZR75-1 or MDA-MB-231 cells, which were stably infected as in (A). All values shown are the mean SD of triplicate measurements and were repeated three times with analogous. (bms-911543.com)
Differential IkappaB kinase activation and IkappaBalpha degradation by interleukin-1beta and tumor necrosis factor-alpha in human U937 monocytic cells. (nih.gov)
In animals receiving excitotoxic lesions of the striatum we detected an eightfold increase of green ¯uorescent protein (GFP)-expressing cells. (lu.se)
These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)
Thus, enhanced extracellular matrix or beta-glucan synthesis during biofilm growth might prevent antifungals, such as azoles and polyenes, from reaching biofilm cells, thus limiting their toxicity to these cells and the associated transcriptional responses. (who.int)

Calcium/calmodulin-dependent protein kinase type II gamma chain is an enzyme that in humans is encoded by the CAMK2G gene. (wikipedia.org)
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. (wikipedia.org)
RON is a 180-kDa heterodimeric protein composed of a 40-kDa α-chain and a 150-kDa transmembrane β-chain with intrinsic tyrosine kinase activity. (spandidos-publications.com)
Maturation occurs in the cell membrane resulting in a 180-kDa heterodimeric protein composed of a 40-kDa α-chain and a 150-kDa transmembrane β-chain with intrinsic tyrosine kinase activity ( 5 , 6 ). (spandidos-publications.com)
Purpose: CDK-activation kinase (CAK) is required for the regulation of the cell-cycle and is a trimeric complex consisting of Cyclin Dependent Kinase 7 (CDK7), Cyclin H and the accessory protein, MAT1. (imperial.ac.uk)
A Candida albicans gene (CPH1) was cloned that encodes a protein homologous to Saccharomyces cerevisiae Ste12p, a transcription factor that is the target of the pheromone response mitogen-activated protein kinase cascade. (embl-heidelberg.de)

We have shown in frogs (4), flies (7) and worms (11) that the TCF proteins constitute the effectors of the canonical Wnt pathway. (hubrecht.eu)
In the MAPK signalling cascades, the ERK proteins are sites where varied indicators converge to elicit specific biological reactions through activation from the ERK effectors. (ampkpathway.com)
Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins. (broadinstitute.org)

The cyclin D1 gene is inhibited during overexpression of caveolin-1 [24]. (ampkpathway.com)
Conversely, hnRNPA1 overexpression reduced NP expression at the mRNA and protein levels and impeded virus replication by (60.70%), suggesting antagonistic function. (cdc.gov)

Vertebrate protein kinases LIMK-1 and LIMK-2. (embl.de)
Recent research claim that caveolins work as scaffolding protein to connect to signalling substances like G-proteins, receptor tyrosine kinases (RTKs), Src-like kinases, eNOS, ERK and Ras [17, 18]. (ampkpathway.com)

The non-processed mRNA encodes a protein that is highly unstable with no transcriptional activity, known as XBP1u (for unspliced XBP1) 2 . (nature.com)
The RON cDNA encodes 1,400 amino acids, which are synthesized first as a single-chain precursor (pro-RON) ( 1 ). (spandidos-publications.com)
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. (cancerindex.org)
The IB1cDNA encodes a 714 amino acid protein with a proline-rich region and a putative basic helix-loop-helix domain (bHLH). (justia.com)
This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)

Upon mitogenic stimulation, ERK was re-localized from cytoplasm to nucleus [7, 12]. (ampkpathway.com)

In this primer, we describe the key features of Hes factors and detail their roles in some representative processes of embryogenesis: namely, in the development of the nervous and digestive systems, two well-characterized processes, where Hes1 (and Hes3 and Hes5 in the nervous system) regulates cell proliferation and differentiation, and in the process of somite segmentation, where Hes7 functions as a biological clock. (biologists.com)
Cardiac differentiation involves a cascade of coordinated gene expression that regulates cell proliferation and matrix protein formation in a defined temporal-spatial manner. (anthropogeny.org)
RON is activated in response to macrophage-stimulating protein (MSP), and then induces an invasive program ( 8 ) consisting of cell proliferation, migration, and invasion, all of which are important at multiple points during tumorigenesis. (spandidos-publications.com)

The process of canonical autophagy follows a hierarchical-ordered recruitment of autophagy-related (ATG) proteins to the phagophore assembly site [ 5 ]. (hindawi.com)

The AF-1 plays an important role in the interaction of the receptor with molecules necessary for the initiation of transcription, such as coactivators, chromatin modulators, and basal transcription factors, including RNA polymerase II, TATA-binding protein (TBP), and a host of TBP-associated proteins (TAFIIs). (medscape.com)
a protein required for the differentiation of the set of six touch receptor neurons in this nematode. (embl.de)
CDK7 also plays a critical role in regulating transcription, primarily by phosphorylating RNA polymerase II, as well as transcription factors such as estrogen receptor-α (ER). (imperial.ac.uk)
A novel pathogenic mutation on the interleukin-7 receptor has been described in a newborn. (medscape.com)

Activation and nuclear translocation of NF-κB occurs following signal-induced phosphorylation of IκB, which leads to proteolysis via the ubiquitin pathway. (justia.com)
Moreover, CDK7 expression was positively associated with ER expression and in particular with phosphorylation of ER at serine 118, a site important for ER transcriptional activity. (imperial.ac.uk)

Comparison of the kinetics of ERK activation and nuclear translocation revealed that it is the active phosphorylated form of ERK that re-localizes into the nucleus [13]. (ampkpathway.com)

β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
We describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. (cdc.gov)

Alternative splicing of the primary transcript gives rise to the 2 mRNA and protein isoforms, hGR-alpha and hGR-beta. (medscape.com)
Experimental Design: mRNA and protein expression of CDK7 and its essential co-factors cyclinH and MAT1, were evaluated in breast cancer samples to determine if their levels are altered in cancer. (imperial.ac.uk)
Results: We show that expression of CDK7, cyclinH and MAT1 are all closely linked at the mRNA and protein level and their expression is elevated in breast cancer compared with the normal breast tissue. (imperial.ac.uk)

The GLUT2 facilitated glucose transporter isoform is a membrane protein present in the pancreatic .beta. (justia.com)
This factor is abundantly expressed in the pancreatic islets and in the brain and has been named IB-1 for Islet-Brain 1. (justia.com)

Since expression of IRF-1 and IRF-2 is increased in response to interferons, the Qp activity observed in the presence of interferon likely represented an equilibrium between IRF factors that activate and those that repress gene expression in response to interferon. (psu.edu)

In doing so, the UPR controls several cellular processes to decrease the unfolded protein load, highlighting the ER-associated degradation pathway and autophagy. (nature.com)
Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
Journal of Cellular Biochemistry , 118 (1), 43-51. (elsevierpure.com)
A major dsRNA by these proteins may result in initiation of heli- component of this system is the innate immune response, case activity, concomitant with a conformational change which includes all the host barriers and responses with that leads to recruiting additional cellular factors, includ- broad specificity against pathogens. (cdc.gov)
Activated IRF3, the subsequent adaptive cellular and humoral immune together with NF-B and AP-1, accumulate in the nucleus, responses to develop. (cdc.gov)
β-Catenin is a fascinating protein with many important cellular and developmental functions. (chemdiv.com)

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. (oncotarget.com)

As a largest plant-specific transcription factor family, NAC domain proteins play an important role in plant development and regulation of abiotic stress tolerance. (frontiersin.org)
GmNAC11 and GmNAC20 from soybean are induced by phytohormones and abiotic stress with different transcriptional activities. (frontiersin.org)

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. (cancerindex.org)
The predicted protein contains 9 tandem C(2)H(2)-type zinc-finger motifs. (anthropogeny.org)
Some LIM domains bind protein partners via tyrosine-containing motifs. (embl.de)
Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl.de)
The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. (cancerindex.org)
The proportion of CqbZIPs was different in each subfamily, and members within the same subgroup shared conserved exon-intron structures and protein motifs. (biomedcentral.com)

The protein encoded by this gene belongs to the EGR family of Cys 2 His 2 -type zinc finger proteins. (wikipedia.org)

2021;30(7):721-726. (edu.pl)
2021) Principles of mRNA targeting and regulation via the Arabidopsis m6A-binding proteins ECT2 and ECT3. (oeaw.ac.at)
2021) The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation. (oeaw.ac.at)
2021) Cdc4 phospho-degrons allow differential regulation of Ame1CENP-U protein stability across the cell cycle. (oeaw.ac.at)
2021) Epigenetic reprogramming rewires transcription during the alternation of generations in Arabidopsis. (oeaw.ac.at)
Brodersen P, Arribas-Hernández L, ..., Nodine MD (2021) The Arabidopsis m6A-binding proteins ECT2 and ECT3 bind largely overlapping mRNA target sets and influence target mRNA abundance, not alternative polyadenylation. (oeaw.ac.at)

Cell 75:495, 1993), and a series of unique E6-AP homologous proteins have been identified (Huibregtse et al. (justia.com)

Of interest, the MAPK-mediated sign cascade can be negatively regulated by the relative abundance of caveolin-1 [22C27]. (ampkpathway.com)
Caveolin-1, thus, affects the regulatory mechanism of cell growth negatively and reduces not only cell growth but also tumourigenecity. (ampkpathway.com)

Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
The basic leucine zipper (bZIP) transcription factor represents exclusively in eukaryotes and can be related to many biological processes. (biomedcentral.com)

In contrast, here we focus on reverse-engineering the network of relationships among transcription factors that regulate the cell cycle in S. cerevisiae . (biomedcentral.com)
We have developed a technique to reverse-engineer networks of the time-dependent activities of transcription factors that regulate the cell cycle in S. cerevisiae . (biomedcentral.com)

Mammalian and avian cysteine-rich protein (CRP), a 192 amino-acid protein of unknown function. (embl.de)
The reverse activity transcribes the ZAR2 mRNA with 966 nt coding sequence which codes for a 321 amino acid protein. (biomedcentral.com)

A variety of extracellular stimuli including mitogens, cytokines, antigens, stress inducing agents, UV light and viral proteins initiate a signal transduction pathway that ultimately leads to NF-κB release and activation. (justia.com)

Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)

Classical polarization is usually associated with a proinflammatory response, including the increased production of tumor necrosis factor (TNF)-α, IL-1, and IL-6. (haematologica.org)
Exposure of isolated human adipocytes to tumor necrosis factor-α (TNF-α) produced a marked and specific decrease in the mRNA encoding the SREBP1c isoform and completely blocked the insulin-induced cleavage of SREBP1 protein. (diabetesjournals.org)

The well-known function of AUF1 is the destabilization of mRNAs by forming complexes with other proteins. (nature.com)
We therefore consider binding strengths a3 and a2 which determine how strongly OCT4-SOX2-NANOG and OCT4-SOX2 bind to OCT4, respectively, and e2 and e1, the binding strengths of the OCT4-SOX2-NANOG and OCT4-SOX2 complexes on the NANOG gene respectively (see Eq. (1) in the main text. (lu.se)
This is intuitively obvious, since the stronger that these complexes bind to OCT4, SOX2 and NANOG, the higher the transcription rate, and hence a smaller threshold of the environmental factor is required to turn the switch on. (lu.se)

Meanwhile, EZH2 is a histone-lysine N-methyltransferase enzyme encoded by gene 7 in humans. (bvsalud.org)

Sterol regulatory element binding protein (SREBP)-1 is a transcription factor with important roles in the control of fatty acid metabolism and adipogenesis. (diabetesjournals.org)
Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. (broadinstitute.org)

The CmNAC1-GFP fusion protein was transiently expressed in tobacco leaves for subcellular localization analysis, and we found that CmNAC1 is localized in the nucleus. (frontiersin.org)
Numerous transcription factors, including Elk-1, Egr-1, and c-Jun, are modulated by ERK in the nucleus for regulation of gene transcription [8C11, 14, 15]. (ampkpathway.com)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)

We validate our approach in two ways: by demonstrating that it accurately models expression data and by demonstrating that our reconstructed model is similar to previously-published models of transcriptional regulation of the cell cycle. (biomedcentral.com)

Matrix metalloproteinases (MMPs) are crucial factors in tumor progression, inflammatory/immune responses and tissue development/regeneration. (elsevierpure.com)
We have used transcript profiling to explore the early transcriptional responses of mature C. albicans biofilms exposed to various antifungal agents. (who.int)

The Notch signaling pathway positively regulated the process of PDLSC differentiation into SCs, and the activation of this signaling was impor tant in maintaining the differentiation of PDLSCs to SCs, and then SC myelination. (edu.pl)
Degradation of a protein via the ubiquitin pathway proceeds by two discrete and successive steps: (a) covalent attachment of multiple ubiquitin molecules to the protein substrate, and (b) degradation of the targeted protein by the 26S proteasome complex. (justia.com)
EGR-1 recruits the TET1 protein that initiates a pathway of DNA demethylation . (wikipedia.org)
Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)

Although the current generation of dCas9-based transcription activators is able to achieve up-regulation of some endogenous loci, the magnitude of transcriptional up-regulation achieved by individual single-guide RNAs (sgRNAs) 12 typically ranges from low to ineffective 8 - 11 . (cdc.gov)

Upon activation IRE1α catalyzes the splicing of the mRNA encoding the transcription factor XBP1, leading to the expression of a potent transcription factor termed XBP1s. (nature.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Aberrant expression of the tight junction protein claudin 6 (CLDN6) is a hallmark of gastric cancer progression. (bvsalud.org)
Its expression is regulated by the cAMP response element-binding protein (CREB). (bvsalud.org)
Low PU.1 expression in AML may account for low ATG gene expression in this disease. (hindawi.com)
In contrast to monocytes, human macrophages did not show increased tissue factor expression upon stimulation with lipopolysaccharide and interferon-γ. (haematologica.org)
7 In contrast, alternatively activated macrophages are characterized by increased expression of IL-10 and of scavenger receptors. (haematologica.org)
Thus, by usurping both IRF-1 and its transcriptional antagonist IRF-2 to activate Qp, EBV has evolved not only a mechanism to constitutively express EBNA-1 but also one which may sustain EBNA-1 expression in the face of the antiviral effects of interferon. (psu.edu)
EGR-1 has also been found to regulate the expression of VAMP2 (a protein important for synaptic exocytosis ). (wikipedia.org)
Like ERα , CDK7 expression is inversely proportional to poor prognostic factors and survival. (imperial.ac.uk)
Instead, the MAT alpha-encoded protein alpha 1 and the MCM1 product bind to the DNA element that is responsible for alpha-specific and a-factor-inducible expression. (embl-heidelberg.de)
Many techniques have been developed to accomplish this by utilizing transcription factor binding data in conjunction with expression data. (biomedcentral.com)
The model utilizes linear regression to first estimate the activities of transcription factors from expression time series and genome-wide transcription factor binding data. (biomedcentral.com)
In the future, we plan to apply our technique to reverse-engineer other systems where both genome-wide time series expression data and transcription factor binding data are available. (biomedcentral.com)
To answer these questions, one must analyze the transcription factor binding data in conjunction with expression data collected from multiple conditions. (biomedcentral.com)
Expression data is typically obtained using microarrays that allow monitoring of changes in the transcription of all mRNAs between samples. (biomedcentral.com)
A variety of methods have been developed that utilize both expression data and transcription factor binding data to model transcriptional regulation. (biomedcentral.com)
However, it is likely that transcription factor binding affects gene expression in a nonlinear fashion, e.g., below some level it has no effect and above some higher level the effect might saturate. (biomedcentral.com)
As a transcription factor whose expression is increased by DNA damage, p53 blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)
Using toxin-induced lesions we investigated to what extent transgene expression could be regulated in accordance with the activation of the endogenous GFAP gene. (lu.se)
2000). We of glial cell line-derived neurotrophic factor (GDNF) in models of have recently reported that this vector directs transgene expression to Parkinson's disease (Georgievska et al. (lu.se)
Efforts have therefore, designed a study to compare the expression of green ¯uor- been made to develop systems based on different drugs or hormones escent protein (GFP) and GDNF under the control of the hGFAP including tetracycline, rapamycine and progestrone (Clackson, 2000). (lu.se)

Protein homeostasis in higher eukaryotes is balanced by a dynamic network of adaptive mechanisms, including the unfolded protein response (UPR) and autophagy. (nature.com)
These data reveal an imprecise relationship between IKK activation, IkappaBalpha degradation, and NF-kappaB DNA binding, suggesting the existence of additional mechanisms that regulate NF-kappaB activation. (nih.gov)
These results suggested that the resistance of C. albicans biofilms to azoles or polyenes was due not to the activation of specific mechanisms in response to exposure to these antifungals but rather to the intrinsic properties of the mature biofilms. (who.int)

Both systems rely on ATG7, an E1-like enzyme, for activation. (hindawi.com)
One such component, a single E1 enzyme, carries out activation of ubiquitin. (justia.com)
88:7351, 1991) and it appears that each E2 enzyme can act with one or more E3 proteins (Nuber et al. (justia.com)

EGR-1 (Early growth response protein 1) also known as ZNF268 (zinc finger protein 268) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene . (wikipedia.org)

Anatomy2

Organisms1

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes12

Information Science3

Genes38

Activator7

Regulator6

Methylation3

Binds4

Family of transcriptional2

Chromosome5

20231

Inhibitor4

Pathways4

Including cancer1

Promoter11

Epithelial-to-mesenchymal transition1

Cells32

Kinase6

Effectors3

Overexpression2

Kinases2

Encodes5

Cytoplasm1

Cell Proliferation3

Autophagy-related1

Receptor4

Phosphorylation2

Nuclear translocation1

Mediate2

MRNA and protein3

Pancreatic2

Repress1

Cellular7

20221

Abiotic stress2

Motifs7

Zinc finger p1

20216

19931

Negatively2

Leucine zipper2

Regulate the cell cycle2

Amino-acid protein2

Viral proteins1

Keap11

Tumor necros2

Complexes3

Histone1

Metabolism2

Nucleus3

Regulation of the cell-cycle1

Responses2

Pathway4

Activators1

Expression23

Mechanisms3

Enzyme3

Humans1