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  • VP16
  • It is also human codon optimized and composed of 3 minimal VP16 activation domains. (wikipedia.org)
  • If the in vivo concentration is much higher than the equilibrium binding constant, then the activation binding site should be fully occupied regardless of whether the TFIIIA-VP16 is mutated or not. (umsystem.edu)
  • This suggests that the activation binding site absolutely should be full regardless of whether the TFIIIA-VP16 is mutated or not, which means activation isn't based solely on an equilibrium binding parameter. (umsystem.edu)
  • targets
  • Consequently, identification of the transcriptional targets of p53 is a potential key to understanding functions of p53 and its signaling pathways in tumorigenesis, and to exploiting their potential use as molecular targets for cancer chemotherapeutic drugs. (aacrjournals.org)
  • phosphorylation
  • CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic cell line. (wikipedia.org)
  • demonstrate
  • Together, these findings demonstrate that ATF2 and c-Jun mutually regulate each other by altering the dynamics of subcellular localization and by positively impacting transcriptional activity. (nih.gov)
  • molecular
  • Upon moving to Cornell University, Dr. August initiated work on his PhD thesis, to understand the molecular basis of activation of T cells. (wikipedia.org)
  • activity
  • Src induced activation of Inducible T cell Kinase (ITK) requires PI3 kinase activity and the Pleckstrin Homology domain of inducible T cell kinase. (wikipedia.org)
  • epigenetic
  • In C. elegans, Argonaute CSR-1 interacts with 22G small RNAs derived from RNA-dependent RNA polymerase and antisense to germline-expressed transcripts to protect these mRNAs from Piwi-piRNA mediated silencing via promoting epigenetic activation. (wikipedia.org)
  • levels
  • TFEB increases the pool of lysosomes in the proximity of the PM and promotes their fusion with PM by raising intracellular Ca²⁺ levels through the activation of the lysosomal Ca²⁺ channel MCOLN1. (nih.gov)
  • genes involved
  • Using high-density DNA microarrays and Northern analyses, we demonstrated that the activation of a nutrient-sensing pathway, the hexosamine biosynthesis pathway (HBP), rapidly decreased the expression of a cluster of nuclear-encoded mitochondrial genes involved in skeletal muscle oxidative phosphorylation. (jci.org)
  • Mutations of the GLI2 gene are associated with several phenotypes including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. In human keratinocytes Gli2 activation upregulates a number of genes involved in cell cycle progression including E2F1, CCND1, CDC2 and CDC45L. (wikipedia.org)
  • leads
  • Since the activation of c-Src leads to the promotion of survival, angiogenesis, proliferation and invasion pathways, the aberrant growth of tumors in cancers is observed. (wikipedia.org)