• Transcriptional regulation plays an important role in establishing gene expression profiles during development or in response to (a)biotic stimuli. (plantcell.org)
  • The major aim of Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back is to illustrate key advances in the field - specifically how signals are transmitted to the nucleus in response to neuronal activity, what genes are activated and how this is achieved, and how these changes in gene expression alter neuronal function. (springer.com)
  • This volume aims to provide the most recent advances in techniques for studying gene expression regulation at the post-transcriptional level. (springer.com)
  • Transcriptional cofactors (COFs) communicate regulatory cues from enhancers to promoters and are central effectors of transcription activation and gene expression 1 . (nature.com)
  • Tetracycline-Controlled Transcriptional Activation is a method of inducible gene expression where transcription is reversibly turned on or off in the presence of the antibiotic tetracycline or one of its derivatives (e.g. doxycycline). (dbpedia.org)
  • The 5th Symposium on Post-Transcriptional Regulation of Plant Gene Expression (PTRoPGE) will be held June 8-12, 2005 at The University of Texas at Austin. (bio.net)
  • Despite the existence of multiple myometrial gene expression studies, the transcriptional programs that initiate labor are not known. (frontiersin.org)
  • Through many recent remarkable developments, perhaps the most significant advancements in the study of transcriptional regulation are the development of genome-wide approaches for measuring gene expression, exemplified by gene chips (chip), and chromatin immunoprecipitation assays (ChIP) for measuring in vivo protein-DNA interactions at any genomic loci. (foyles.co.uk)
  • The Mizgerd, Viglianti, Denis and Henderson labs are investigating the transcriptional mechanisms that lead to dysregulated gene expression of inflammatory mediators and how this contributes to diseases such as asthma, diabetes and AIDS. (bu.edu)
  • More recently, Walhout has expanded her focus to include the post-transcriptional regulation of gene expression, exploring how micro-RNAs (miRNAs) function on a genome-wide scale ( 7 ). (rupress.org)
  • The highly specialized intrinsic membrane and firing properties that allow cortical FS interneurons to perform these functions are attributable to equally specialized gene expression, which is ultimately coordinated by cell-type-specific transcriptional regulation. (jneurosci.org)
  • Modeling transcriptional networks has recently been made tractable by next-generation sequencingbased technologies that can comprehensively catalog gene expression and transcription factor-binding genome-wide, but has not yet been extensively applied to undomesticated tree species or woody growth. (usda.gov)
  • 1998) Mammalian mediator of transcriptional regulation and its possible role as an end‐point of signal transduction pathways. (els.net)
  • Transcriptional signatures thus identified can be readily validated in real cancers and more easily reverse-engineered into signaling pathways, given preexisting molecular knowledge. (jci.org)
  • Using a network-analysis algorithm based on coexpression with multiple pathway members (pathway-level coexpression), we identified and prioritized novel candidate pathway members, regulators, and cross pathway transcriptional control points for over 140 metabolic pathways. (rti.org)
  • The hypothesis was tested that differential, coregulated transcriptional adaptations of various cellular pathways would occur early with increased mechanical loading of atrophied skeletal muscle and relate to concurrent damage of muscle fibers. (biomedsearch.com)
  • Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. (broadinstitute.org)
  • Coregulators, which function as both metabolic sensors and transcriptional effectors, are ideally positioned to synchronize metabolic pathways to environmental stimuli. (epfl.ch)
  • When analyzed in terms of the genomic and transcriptional data presented here, it is apparent that these mutations result from RNA processing or transcriptional defects. (genetics.org)
  • When comparing the genomic and transcriptomic data, 1,809 sites of transcriptional base modifications were detected, where the transcriptional landscape is different from the corresponding genomic sequences. (news-medical.net)
  • Chapters detail next-generation sequencing technologies, data analysis, protocols on analysis and visualization of single-cell RNA-Seq data, analysis of 3D chromatin architecture, interpretation of large-scale interaction networks, transcriptional networks in embryonic and adult stem cells, derivation of stem cells, and transcriptional programs that promote reprogramming, transdifferentiation, and cancer formation. (worldcat.org)
  • Although embryonic transcriptional events govern the initial steps of cell-type specification in most cortical interneurons, including FS cells, the electrophysiological properties that distinguish adult cortical cell types emerge relatively late in postnatal development, and the transcriptional events that drive this maturational process are not known. (jneurosci.org)
  • Our recent analysis of the transcriptional controls affecting expression of the Drosophila insulin receptor gene indicates that a remarkable amount of DNA is dedicated to encoding sophisticated feedback and feed forward signals. (mdpi.com)
  • In this review, we discuss the transcriptional effects of the most widely used epigenetic inhibitors in pancreatic cancer focusing on Bromodomain and Extraterminal domain (BET) and Histone Deacetylase (HDAC) inhibitors, which are currently highly promising therapeutic options. (mdpi.com)
  • NF1-X consists of two functionally distinct domains: a conserved N-terminal DNA-binding domain and a C-terminal transcriptional regulatory domain. (ebi.ac.uk)
  • Thus, COF-promoter compatibilities may underlie distinct transcriptional programs in species as divergent as flies and humans. (nature.com)
  • M. L. Goodson, O.-K. Park-Sarge, and K. D. Sarge, "Tissue-dependent expression of heat shock factor 2 isoforms with distinct transcriptional activities," Molecular and Cellular Biology , vol. 15, no. 10, pp. 5288-5293, 1995. (hindawi.com)
  • However, we did find enhanced transcriptional similarity between clonally related B cells, as well as distinct transcriptional signatures ascribed by BCR vaccine recognition. (jci.org)
  • Our findings support a model where MN-intrinsic transcriptional programs shape the pattern of motor output by orchestrating distinct aspects of MN connectivity. (mdc-berlin.de)
  • Microarray expression analyses revealed that haploid yeast strains carrying an additional chromosome (henceforth disomes) exhibit a common transcriptional signature, dubbed the environmental stress response (ESR). (pnas.org)
  • We detected a conserved transcriptional response that was associated with stress and decreased cell proliferation that was apparent in aneuploid yeast, plants, mice, and humans. (pnas.org)
  • Malik S and Roeder RG (2000) Transcriptional regulation through mediator‐like coactivators in yeast and metazoan cells. (els.net)
  • Post-Transcriptional Gene Regulation, Second Edition is organized in six sections describing bioinformatics approaches for studying post-transcriptional regulation, various expression profiling approaches, protein-RNA interaction and non-coding RNA investigation techniques, methods for profiling RNA modifications, and other techniques such as alternative translation initiation or polyadenylation sites determination. (springer.com)
  • The molecular anatomy of cancer cells is being explored through unbiased approaches aimed at the identification of cancer-specific transcriptional signatures. (jci.org)
  • Here we discuss basic features of transcriptional networks, approaches for modeling biological networks, and examples of biological network models developed for forest trees to date. (usda.gov)
  • Members of this family of transcriptional regulators, which preferentially bind single-stranded DNA, include PBF-2 from plants, the mammalian nuclear factor 1-X (NF1-X), and positive cofactor 4 (PC4). (ebi.ac.uk)
  • Here, we present the first application of the Spec-seq framework, which we applied to human plasmablasts after influenza vaccination in order to characterize transcriptional differences governed by B cell receptor (BCR) isotype and vaccine reactivity. (jci.org)
  • Deletion of the 2.4kb p21 Cip1 promoter to 660bp (still containing the STAT3 site) is responsive to ErbB2-mediated transcriptional upregulation. (aacrjournals.org)
  • Promoters provide the obligatory transcriptional start sites necessary for RNA synthesis and are often sites of signal-dependent regulation ( Figure 1 ). (jci.org)
  • Bioinformatic analysis suggested that decreased activity of cyclic AMP response element binding protein and nuclear factor Y and increased nuclear factor κB transcriptional signalling mediated these effects. (bmj.com)
  • We are performing both gain-of-function and loss-of-function experiments designed to place O/E-1 and other O/E isoforms in the transcriptional cascade leading to adipogenesis. (bidmc.org)
  • We further revealed that the regulation of TAp73 transcriptional activity occurs as a synergistic effect of MDM2 and E2F1, most probably through their physical interaction in the nuclei. (sigmaaldrich.com)
  • Transcriptional network models for forest tree secondary growth and wood formation could ultimately provide new predictive models to accelerate hypothesis-driven research and develop new breeding applications. (usda.gov)
  • Further elucidation of transcriptional controls of INSR will provide the basis for understanding human genetic variation that underlies population-level physiological differences and disease. (mdpi.com)
  • Genetic and transcriptional evolution alters cancer cell line drug response. (broadinstitute.org)
  • A proposed source of transcriptional noise is transcriptional bursting although other sources of heterogeneity, such as unequal separation of cell contents at mitosis are also likely to contribute considerably. (wikipedia.org)
  • I thought you might be interested in this item at http://www.worldcat.org/oclc/1139743191 Title: Stem cell transcriptional Networks : methods and protocols Author: Benjamin L Kidder Publisher: New York, NY : Humana Press, 2020. (worldcat.org)
  • Authoritative and cutting-edge, Stem Cell Transcriptional Network: Methods and Protocols, Second Edition aims to provide a key resource for biologists seeking to interrogate these vital networks. (worldcat.org)
  • Transcriptional Regulation: Methods and Protocols takes this progress and builds upon it with a collection of key protocols used in expert laboratories around the world. (foyles.co.uk)
  • Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2," Biochemical and Biophysical Research Communications , vol. 303, no. 2, pp. 700-706, 2003. (hindawi.com)