• Regulation of gene transcription is controlled in part by nuclear receptors that function coordinately with coregulator proteins. (aspetjournals.org)
  • also p21SNFT) is a 20 kDa nuclear member of the bZIP family of proteins. (rndsystems.com)
  • ACVR2 transmits the growth effects of activin via phosphorylation of SMAD proteins to affect gene transcription. (nih.gov)
  • The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. (elifesciences.org)
  • This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. (nih.gov)
  • These characteristics correlate with a distinct nuclear architecture, epigenetic signatures enriched for active chromatin marks and hyperdynamic binding of structural chromatin proteins. (biomedcentral.com)
  • This process is carried out by the human spliceosome machinery, in which over 300 proteins sequentially assemble with uridine-rich small nuclear RNA molecules (U snRNAs) to form distinct small nuclear ribonucleoprotein complexes (snRNPs). (biomedcentral.com)
  • The HNF-1β protein is one of a large group of transcription factors called homeodomain proteins. (medlineplus.gov)
  • 200 nucleotides with no or little protein-coding capacity 15 . (nature.com)
  • Transcription factor IIIB 50 kDa subunit (TFIIIB50) also known as b-related factor 2 (BRF-2) is a protein that in humans is encoded by the BRF2 gene. (wikipedia.org)
  • The product of this gene, a TFIIB-like factor, is directly recruited to the TATA box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. (wikipedia.org)
  • Complemented ACVR2 protein complexed with ACVR1 with activin treatment, generating nuclear phosphoSMAD2 and activin-specific gene transcription. (nih.gov)
  • GADD153 is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP alpha and beta. (thermofisher.com)
  • Protein synthesis mechanism with reference of Translation and Transcription d. (slideshare.net)
  • Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
  • The value was acquired by the intensity percentage between the target protein and histone H3 band for nuclear fractionation in each lane. (techblessing.com)
  • Activation of the transcription factor nuclear factor KB (NF-KB) requires the NEMO protein. (medscape.com)
  • Activator protein-1 (AP-1) and nuclear factor-kB (NF-kB) have been shown to play pivotal roles in tumor initiation, promotion, and progression. (cdc.gov)
  • Here, I will describe our recent progress in characterizing the structure and interactions of c-Myc focusing on MB0-II by nuclear magnetic resonance (NMR), small-angle x-ray scattering (SAXS) and protein crystallography. (lu.se)
  • The HNF1B gene provides instructions for making a protein called hepatocyte nuclear factor-1 beta (HNF-1β). (medlineplus.gov)
  • Based on this role, the protein is called a transcription factor. (medlineplus.gov)
  • RNA polymerase (Pol) III transcribes small untranslated RNAs such as 5S ribosomal RNA, transfer RNAs, and U6 small nuclear RNA. (nih.gov)
  • Because of the functions of these RNAs, Pol III transcription is best known for its essential contribution to RNA maturation and translation. (nih.gov)
  • Differential sensitivities of all three transcription events, synthesizing the rRNAs, mRNAs, and light-strand RNAs, was shown to exist to a small molecular weight factor(s) present in the cytoplasm, and the availability of energetic substrates. (caltech.edu)
  • POLR3C is a specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (thermofisher.com)
  • Competition for PRPF8 availability alters the transcription-coupled splicing of RNAs in which weak 5′ splice sites predominate, enabling diversification of human gene expression during biological processes like mitosis. (biomedcentral.com)
  • Small RNAs have proven to be essential regulatory molecules encoded within eukaryotic genomes. (biomedcentral.com)
  • As part of the genome sequencing initiative for the tammar, we have explored the evolution of each of the major classes of mammalian small RNAs in an Australian marsupial for the first time, including the first genome-scale analysis of the newest class of small RNAs, centromere repeat associated short interacting RNAs (crasiRNAs). (biomedcentral.com)
  • Using next generation sequencing, we have characterized the major classes of small RNAs, micro (mi) RNAs, piwi interacting (pi) RNAs, and the centromere repeat associated short interacting (crasi) RNAs in the tammar. (biomedcentral.com)
  • A survey of the tammar gonadal piRNAs shows that these small RNAs are enriched in retroelements and carry members from both marsupial and tammar-specific repeat classes. (biomedcentral.com)
  • These small RNAs are derived largely from centromere-enriched retroelements, including a novel SINE. (biomedcentral.com)
  • This study encompasses the first analyses of the major classes of small RNAs for the newly completed tammar genome, validates preliminary annotations using deep sequencing and computational approaches, and provides a foundation for future work on tammar-specific as well as conserved, but previously unknown small RNA progenitors and targets identified herein. (biomedcentral.com)
  • Small RNAs play important roles in many aspects of pre- and post-transcriptional gene regulation, epigenetic modifications, chromosome segregation and genome structure. (biomedcentral.com)
  • Each class of small RNAs is synthesized by a distinct mechanism and each has discrete biological functions. (biomedcentral.com)
  • The first class of small RNAs identified were the micro RNAs (miRNAs), which are small (~22 nt) non-coding RNAs that regulate gene expression by base pairing to mRNAs where they direct either mRNA cleavage or repress translation [ 8 ]. (biomedcentral.com)
  • Another class of important small RNAs is the piRNAs. (biomedcentral.com)
  • David J. Mangelsdorf (Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas): "Nuclear hormone receptors are a family of related transcription factors that are activated by binding small hydrophobic hormones like the steroids, thyroxin, vitamin D3, and all-trans retinoic acid. (the-scientist.com)
  • Transcription factors 3: nuclear receptors. (embl.de)
  • TACI can bind to both APRIL and BAFF, stimulate the activation of transcription factors NF-κB and AP-1, and can mediate the calcineurin-dependent activation of NF-AT (nuclear-factor of activated T cells). (peprotech.com)
  • Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
  • The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
  • Located within the intrinsically disordered N-terminus part of c-Myc are the highly conserved so-called Myc boxes (MB0-IV), which are crucial for Myc function and interaction with other transcription factors. (lu.se)
  • We will present first molecular data showing how these boxes interact with critical transcription factors as well as with each other in a highly specific but also highly dynamic manner, and how these interactions can be interrupted. (lu.se)
  • OBJECTIVE: There is little information about the epidemiology and factors associated with opioid therapy in systemic lupus erythematosus (SLE). (cdc.gov)
  • To understand how the B 1 and B 2 regions influenced the transcriptional functions of nuclear HER3, we performed cyclin D1 promoter-luciferase assays in which HER3 deleted of the B 1 and B 2 regions was severely hindered in regulating this promoter. (plos.org)
  • Basic principle of transcription, organization of transcriptional units in pr. (slideshare.net)
  • This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. (wikipedia.org)
  • Furthermore, other rare diseases are also associated with mutations in genes encoding subunits of Pol III (POLR3H, POLR3GL) and the BRF1 component of the TFIIIB transcription initiation factor. (nih.gov)
  • Whithout mutations we would know very little about inheritance and the existence of genes. (intechopen.com)
  • The receptors function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. (embl.de)
  • These response elements position the receptors, and the complexes recruited by them, close to the genes of which transcription is affected. (embl.de)
  • A shortage of this transcription factor disrupts the activity of genes that direct the development and function of certain tissues and organs. (medlineplus.gov)
  • Enhances transcription of genes with retinoic acid response elements (rare). (lu.se)
  • Furthermore, results obtained from mammalian two-hybrid experiments assessing various domain configurations of the respective receptors showed that full-length DAX-1 inhibited the CAR-SRC1 interaction by approximately 50%, whereas the same interaction was restored to 90% of control when the DAX-1 transcription silencing domain was deleted. (aspetjournals.org)
  • Membrane-bound HER receptors activate numerous tumor promoting signaling cascades via this mechanism, including the PI3K/AKT, Ras/Raf/Mek/Erk, PLCγ/PKC, and signal transducer and activator of transcription (STAT) pathways [1] , [2] . (plos.org)
  • One intriguing aspect of nuclear hormone receptor biology is that in addition to the known receptors there are dozens of others for which a hormone (that is, a ligand) is unknown. (the-scientist.com)
  • Steroid or nuclear hormone receptors constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. (embl.de)
  • The DNA-binding domains of nuclear receptors consist of two zinc-nucleated modules and a C-terminal extension, where residues in the first zinc module determine the specificity of the DNA recognition and residues in the second zinc module are involved in dimerisation. (embl.de)
  • However, even these patients are at risk of dying from lung cancer (both small and non-small cell types). (cancer.gov)
  • Aim: To investigate the impact of tumor-cell expression of thyroid transcription factor 1 (TTF1) on outcomes after irradiation of limited-disease small cell lung cancer (LD-SCLC). (iiarjournals.org)
  • Small cell lung cancer (SCLC) represents 10% to 25% of all lung cancer and is characterized by rapid growth, early locoregional recurrence and early distant metastases ( 1 - 3 ). (iiarjournals.org)
  • Recent studies investigated the prognostic value of thyroid transcription factor 1 (TTF1) expression in non-small cell lung cancer (NSCLC) ( 4 - 7 ). (iiarjournals.org)
  • This nuclear transcription factor plays an important role in embryologic development of the lung, as well as carcinogenesis of lung cancer. (iiarjournals.org)
  • A Systematic Review of Mesenchymal Epithelial Transition Factor (MET) and Its Impact in the Development and Treatment of Non-Small-Cell Lung Cancer. (lu.se)
  • 1, 25-Dihydroxyvitamin D3), which inhibits pro-inflammatory transcription factor NF-κB via the intracellular nuclear hormone receptor vitamin D receptor (VDR), was stably loaded into poly(ethylene glycol)-block-poly(propylene sulfide) (PEG- b -PPS) filomicelles. (frontiersin.org)
  • Stauprimide binds to NME2 and inhibits its nuclear localization, thus leading to downregulation of c-Myc. (lclabs.com)
  • Stauprimide treatment inhibits the nuclear localization of NME2 and downregulates c-Myc, enhances ESC exit from the pluripotent state and enables differentiation. (lclabs.com)
  • In this report, DAX-1, a nuclear receptor family member with corepressor properties, was identified as a potent CAR regulator. (aspetjournals.org)
  • Nuclear localized HER family receptor tyrosine kinases (RTKs) have been observed in primary tumor specimens and cancer cell lines for nearly two decades. (plos.org)
  • Brand TM, Iida M, Luthar N, Wleklinski MJ, Starr MM, Wheeler DL (2013) Mapping C-Terminal Transactivation Domains of the Nuclear HER Family Receptor Tyrosine Kinase HER3. (plos.org)
  • Yang D, Yuan J, Liu G, Ling Z, Zeng H, Chen Y, Zhang Y, She Q, Zhou X. Angiotensin Receptor Blockers and Statins Could Alleviate Atrial Fibrosis via Regulating Platelet-Derived Growth Factor/Rac1 /Nuclear Factor-Kappa B Axis. (medsci.org)
  • May be a nuclear hormone receptor coactivator. (lu.se)
  • Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
  • Zaret, K. "Using Small Molecules to Great Effect in Stem Cell Differentiation. (lclabs.com)
  • 17q12 deletion syndrome is a condition that results from the deletion of a small piece of chromosome 17 in each cell. (medlineplus.gov)
  • In addition to regulating cytoskeletal dynamics in the cytoplasm, actin modulates nuclear gene expression. (jneurosci.org)
  • In Xp11.2 translocation-associated renal cell carcinoma, tumor cells with abundant eosinophilic cytoplasm and high nuclear grade are often arranged in large nests with a delicate, intervening vascular stroma. (medscape.com)
  • Following a complex process of miRNA transcription, processing, and nuclear export, miRNAs are further processed by the RNaseIII enzyme, Dicer, and its cofactor TRBP. (biomedcentral.com)
  • Tumor cells were considered positive only if distinct nuclear staining was identified ( 5 , 8 ). (iiarjournals.org)
  • According to a previous report, the tumor samples were considered TTF1-positive if at least 5% of the tumor cells exhibited nuclear expression ( 5 ). (iiarjournals.org)
  • Within any tumor, nuclear size may vary, but uniformly, these tumors are of a high Fuhrman nuclear grade. (medscape.com)
  • Outcomes c-Fos Is normally Involved in the Nuclear Transfer of HBXIP In our prior research, we reported that HBXIP is expressed in medical breasts tumor cells highly. (techblessing.com)
  • Selective compounds have been developed that target either the extracellular ligand-binding region of the EGFR (including a number of monoclonal antibodies [MAbs], immunotoxins, and ligand-binding cytotoxic agents) or the intracellular tyrosine kinase region (including various small-molecule inhibitors). (medscape.com)
  • To accomplish this goal, various intracellular regions of HER3 were fused to the DNA binding domain of the yeast transcription factor Gal4 (Gal4DBD) and tested for their ability to transactivate Gal4 UAS-luciferase. (plos.org)
  • POLR3C plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.POLR3C acts as nuclear and cytosolic DNA sensor involved in innate immune response. (thermofisher.com)
  • We have used block-substitution mutagenesis and in vitro transcription assays to identify cis-acting DNA sequence elements important for initiation and 3'-end formation of a U1 small nuclear RNA (snRNA) in the parasitic nematode Ascaris lumbricoides. (cshl.edu)
  • Deletion of DAX-1's C-terminal transcription silencing domain restored CAR1 transactivation activity in reporter assays to approximately 90% of control, demonstrating its critical function in mediating the CAR repression activities. (aspetjournals.org)
  • Thus, herein we provide first evidence that neuronal motility not only depends on cytoplasmic actin dynamics but also on the availability of actin to modulate nuclear functions such as gene transcription. (jneurosci.org)
  • To investigate whether the administration of renin-angiotensin system (RAS) inhibitors and statins could alleviate atrial fibrosis via platelet-derived growth factor (PDGF)/Rac1 /nuclear factor-kappa B (NF-κB) axis. (medsci.org)
  • In 2000, the International Incontinentia Pigmenti Consortium reported that incontinentia pigmenti is caused by a genomic rearrangement of the gene for NEMO, or nuclear factor kappa B essential modulator (IKBKG-IKK gamma). (medscape.com)
  • These calpains work as a heterodimer, comprising a big (80 kDa) and a little (28 kDa) subunit (1,4,5). (exposed-skin-care.net)
  • Also, CAPN3 does not have a little subunit and most likely features being a homodimer (14C18). (exposed-skin-care.net)
  • In addition to regulation of cytoplasmic cytoskeletal dynamics, a little appreciated property of actin signaling is modulation of gene expression so far only reported for non-neuronal cells. (jneurosci.org)
  • Next, we identified full-length nuclear HER3 association and regulation of a 122 bp region of the cyclin D1 promoter. (plos.org)
  • Daix (France), Long Island City (New York, United States), March 29, 2023 - Inventiva (Euronext Paris and Nasdaq: IVA) (the "Company"), a clinical-stage biopharmaceutical company focused on the development of oral small molecule therapies for the treatment of patients with non-alcoholic steatohepatitis ("NASH") and other diseases with significant unmet medical needs, today reported its full-year results for 2022. (globenewswire.com)
  • Daix (France), Long Island City (New York, United States), November 21, 2023 - Inventiva (Euronext Paris and Nasdaq: IVA) (the "Company"), a clinical-stage biopharmaceutical company focused on the development of oral small molecule therapies for the treatment of patients with non-alcoholic steatohepatitis ("NASH") and other diseases with significant unmet medical needs, today reported financial information for the nine months ended September 30, 2023. (wate.com)
  • The Role of MB0, MBI and MBII in Interaction and Dynamics of the Master Regulatory Transcription Factor c-Myc. (lu.se)
  • Changing the conditions for the transcription reactions allowed the identification of a processing pathway for the small ribosomal RNA species, and an RNA species from the region surrounding the origin of light-strand replication with novel electrophoretic properties. (caltech.edu)
  • Stauprimide interacts with NME2, a c-Myc-activating transcription factor that is highly expressed in ESCs. (lclabs.com)
  • Translocation carcinoma is a renal cell carcinoma (RCC) subtype that harbors a translocation involving a member of the microphthalmia transcription factor gene family. (medscape.com)
  • The company leverages a chemical biology approach and its proprietary discovery platform for building a pipeline of small molecule inhibitors to numerous NAD+ utilizing enzymes includes monoPARPs, which have applications across multiple therapeutic areas. (cbinsights.com)
  • Small duplications, substitutions, and small mutations have also been reported. (medscape.com)
  • Subsequently, truncation and mutation of a vimentin promoter demonstrated that HDAC1‑induced vimentin expression was dependent on a nuclear factor κ‑light‑chain‑enhancer of activated B cells (NF‑κB) binding site in the vimentin promoter sequence. (spandidos-publications.com)
  • Immunohistochemical analyses for vimentin and nuclear ß-catenin were performed to highlight the occurrence of the EMT phenomenon in association to Al bioaccumulation. (bvsalud.org)
  • Al-positive samples showed a significant increase in both the number of vimentin-positive and nuclear ß-catenin-positive cancer cells compared to Al-negative samples. (bvsalud.org)
  • Published Date : 12 2022 Source : Small. (cdc.gov)
  • Transcription of a nematode U1 small nuclear RNA in vitro. (cshl.edu)
  • This cylinder-to-micelle transition was characterized in vitro by cryogenic transmission electron microscopy (CryoTEM) and small angle X-ray scattering (SAXS). (frontiersin.org)
  • We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
  • As the material increased in purity, there are more high-aspect-ratio particulates and a corresponding distinct increase in cytotoxicity, nuclear factor-B transcription, and inflammasome activation. (cdc.gov)
  • Lnc408 can recruit transcript factor SP3 to CBY1 promoter to serve as an inhibitor in CBY1 transcription in BCSCs. (nature.com)
  • It is expressed in Th1 cells and conventional dendritic cells (CD11c + ), and serves to downregulate AP-1 mediated transcription. (rndsystems.com)
  • ACVR2 small interfering RNA reversed these effects in complemented cells. (nih.gov)
  • A small molecule primes embryonic stem cells for differentiation. (lclabs.com)
  • Vascular complications of diabetes: Studies on NFAT (Nuclear Factor of Activated T-cells) as a novel target for the treatment of atherosclersis and vascular dysfunction in diabetes. (lu.se)