• Extensive evidence has revealed that the core clock machinery involves "clock genes" and "clock proteins" functioning as molecular cogs. (bioone.org)
  • E. coli inhibits the expression of trp operon genes (stops transcription). (ittutoria.net)
  • Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). (qedbio.com)
  • Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. (lookformedical.com)
  • Genes that encode highly conserved TRANSCRIPTION FACTORS that control positional identity of cells (BODY PATTERNING) and MORPHOGENESIS throughout development. (lookformedical.com)
  • The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)
  • It promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. It also acts as a transcription repressor of E2F1 target genes. (nih.gov)
  • Some other genes are also regulated, including those for immunoglobulin light and heavy chains (Oct-2) [ ( PUBMED:1967834 ) ( PUBMED:1967821 ) ], and trophic hormone genes, such as those for prolactin and growth hormone (Pit-1). (embl.de)
  • This study shows that the nucleosome remodeller dMi-2 is recruited to ecdysone-regulated genes to limit transcription. (sdbonline.org)
  • Site-specific iterations of biological clues or cumulative issues Compared at other models in the F2 Mechanisms of Inorganic and Organometallic thrive for using the solution of the processes of these cells and network or cycle proteins and Modelling interactions about sufficient capsids and genes of PPT sites. (scoutconnection.com)
  • The top highly abundant rhizospheric soil non-redundant ARGs that are prevalent in bacterial human pathogens or colonizers (commensal) included mtrA , soxR, vanRO , golS , rbpA , kdpE , rpoB2 , arr-1 , efrA and ileS genes. (springeropen.com)
  • In this way, regulation of the transcription of all of the structural genes encoding the enzymes that catalyze the many steps in a single biochemical pathway can be controlled simultaneously, because they will either all be needed at the same time, or none will be needed. (pressbooks.pub)
  • Reprime la TRANSCRIPCIÓN GENÉTICA de los GENES diana y desempeña una función fundamental en la ODONTOGÉNESIS. (bvsalud.org)
  • It represses GENETIC TRANSCRIPTION of target GENES and plays a critical role in ODONTOGENESIS. (bvsalud.org)
  • also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). (cancerindex.org)
  • We report that haploinsufficiency for the forkhead transcription factor Foxo1 reverses beta cell failure in Irs2(-/-) mice through partial restoration of beta cell proliferation and increased expression of the pancreatic transcription factor pancreas/duodenum homeobox gene-1 (Pdx1). (nih.gov)
  • Antennapedia homeodomain protein is a homeobox protein involved in limb patterning in ARTHROPODS. (lookformedical.com)
  • Homeobox proteins as sequence-specific transcription factors. (embl.de)
  • The download Hanging Sam: A Military Biography of General of Insulin like Growth Factor Binding Proteins( IGFBPs) phase 50 response pathway good research with reviewed N cell and C formation enzymes binding for conjugating Insulin like Growth Factors I and II( IGF I and IGF II). (evakoch.com)
  • Background GATA1 encodes a protein, GATA1, which belongs to the GATA family of transcription factors. (qedbio.com)
  • The effects of DNA methylation and the histone code are due, at least in part, to modification-specific recruitment of factors, such as heterochromatin-associated proteins (HP1) and methyl-binding domain proteins, which establish and maintain higher order of chromatin structure. (aacrjournals.org)
  • MLX belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. (prosci-inc.com)
  • These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. (prosci-inc.com)
  • MLX may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4.The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. (prosci-inc.com)
  • FoxO transcription factors and contrive stall homeostasis: insights from the hematopoietic syshoot. (upb.ro)
  • POU proteins are eukaryotic transcription factors containing a bipartite DNA binding domain referred to as the POU domain. (embl.de)
  • The acronym POU (pronounced 'pow') is derived from the names of three mammalian transcription factors, the pituitary-specific Pit-1, the octamer-binding proteins Oct-1 and Oct-2, and the neural Unc-86 from Caenorhabditis elegans. (embl.de)
  • POU-domain transcription factors: pou-er-ful developmental regulators. (embl.de)
  • This study examined the roles of hormone-dependent transcription factors (Nuclear Receptors), in accessory gland development, function and male fertility of a genetically tractable insect model, Drosophila melanogaster. (sdbonline.org)
  • Inherent in this technically accurate paradox is that while the former supports the well-established link between microbial pathogens and infectious diseases, the latter infers that disease susceptibility can be modified by extramicrobial factors [ 1 - 3 ]. (hindawi.com)
  • Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. (embl.de)
  • The PAH2 domain of the scaffold protein SIN3A interacts with the specific Sin3 Interaction Domain (SID) of several transcription factors, such as MAD1, bringing chromatin-modifying proteins such as histone deacetylases, and it targets chromatin for specific modifications. (bvsalud.org)
  • Her research showed that atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) became abnormally high in people with hypertrophy, and that an increase in REST could halt the rise of the other proteins. (wikipedia.org)
  • Examination of the structure resulted in the identification of several structural features and specific amino acid residues that may be involved in conserved protein-protein interactions mediated by the POZ domains as well as those that may contribute to the specificity of these interactions. (embl.de)
  • Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. (cusabio.com)
  • MORF4L1 may also participate in the formation of NuA4 related complexes which lack the HTATIP/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. (novusbio.com)
  • In principle, development of small molecule inhibitors of interactions of specific transcriptional activators (or repressors) with DNA or with the basal transcription machinery could provide highly selective regulators of gene expression and thus highly selective therapeutic agents (e.g., antiviral agents based on disabling essential viral gene expression). (mtu.edu)
  • Previously, we have established that blocking the PAH2-mediated Sin3A interaction with SID-containing proteins using SID peptides or small molecule inhibitors (SMI) increased RARß expression and induced retinoic acid metabolism in breast cancer cells, both in in vitro and in vivo models. (bvsalud.org)
  • We have previously shown that a synthetic peptide (CKS-17) homologous to retroviral envelope protein suppresses the accumulation of superantigen staphylococcal enterotoxin-induced TNF-alpha mRNA in human PBMC and in highly purified human monocytes. (duke.edu)
  • The present study was designed to examine the underlying mechanism(s) by which CKS-17 down-regulates the TNF-alpha mRNA expression using a human acute monocytic leukemia cell line THP-1 stimulated with the superantigen staphylococcal enterotoxin E. A cyclooxygenase inhibitor indomethacin does not reverse the inhibition of TNF-alpha mRNA expression by CKS-17, suggesting that prostaglandins are not responsible for the suppressive action of CKS-17. (duke.edu)
  • Nuclear run-on transcription assays further reveal that CKS-17 suppresses the TNF-alpha mRNA transcription rate. (duke.edu)
  • Taken together, these results suggest that the synthetic retroviral peptide CKS-17 down-regulates TNF-alpha mRNA expression through inhibition of transcriptional activation of the TNF-alpha gene, which requires de novo synthesis of a transcriptional repressor protein(s). (duke.edu)
  • interaction( Hh) is a bound transfer that is very proteins in modifications resulting past plasma mRNA, fibril-associated information DNA, isoform kinase and activity( characterised in Hui and Angers, 2011). (evakoch.com)
  • MDM2 is a multidomain protein that functions as an E3 ubiquitin ligase, transcription repressor, mRNA-binding protein, translation factor, and molecular chaperone. (ed.ac.uk)
  • Translation is the process of producing a protein using an mRNA sequence. (ittutoria.net)
  • Immunocytochemistry demonstrated that the decrease in ER-β mRNA was translated into depletion of receptor protein content in hyper-osmotic animals. (jneurosci.org)
  • It was Besides referred that the suitable types of pyrimidines of rodents at such and bulk Advances( PPT as the protein of chloride, rice, the receptor of copy after coding the vector) mRNA gene analysis combining the polymorphism authors at older promoters( 8, 10, 11). (scoutconnection.com)
  • Our multi-disciplinary research program aims to understand the molecular architecture and recognition features of the early events in transcription initiation, and to use these insights to develop inhibitors of transcriptional assembly. (mtu.edu)
  • Insect hormones such as ecdysteroids and juvenoids play a key role in accessory gland development and protein synthesis but little is known about underlying molecular players and their mechanism of action. (sdbonline.org)
  • This protein is the full-length p52 subunit and partial p100 subunit. (abcam.com)
  • The amino-terminal sequence of β-galactosidase, the α-peptide involved in α-complementation, participates in a subunit interface. (wikidoc.org)
  • Thompson, M. (2009) Polybromo-1: the chromatin targeting subunit of the PBAF complex. (mtu.edu)
  • Notably, SAP30 formed a homodimer with 1 subunit binding to SIN3A and another subunit recruiting MLL1 through specific Phe186/200 residues within its transactivation domain. (bvsalud.org)
  • In chapter 2, by using CRISPR/Cas9 gene editing, genetic analysis and biochemical assays, I identified the differential pairings of typical NLR receptor SOC3 with atypical NLR proteins CHS1 or TN2 to guard the homeostasis of the E3 ligase SAUL1. (ubc.ca)
  • We later identified PIAS (protein inhibitor of activated STAT)xalpha as a DJ-1-binding protein, and found that DJ-1 restored androgen receptor (AR) transcription activity that was repressed by PIASxalpha. (nih.gov)
  • Subsequently, by using independent RNAi/ dominant negative forms, it was shown that Ecdysone Receptor (EcR) is essential for male fertility due to its requirement in the normal development of accessory glands in Drosophila: EcR depleted glands fail to make seminal proteins and have dying cells. (sdbonline.org)
  • Immunogen Peptide sequence that includes phosphorylation site of Serine 310 (K-A-S(p)-G-K) derived from human GATA1 and conjugated to KLH. (qedbio.com)
  • Different dimer combinations act as transcriptional activators or repressors, respectively. (abcam.com)
  • The inhibitory effect of CKS-17 is, however, significantly blocked by a protein synthesis inhibitor cycloheximide, indicating that CKS-17 requires de novo protein synthesis to induce the suppressive activity. (duke.edu)
  • Our findings revise theories of labour division between the major RNA polymerases, and identify nucleolar Pol II as a major factor in protein synthesis and nuclear organization, with potential implications for health and disease. (nature.com)
  • Ribosomes create peptide bonds between amino acids and form a peptide sequence. (ittutoria.net)
  • Plant intracellular nucleotide binding and leucine-rich repeat proteins (NB-LRR, NLRs) function as immune receptors to detect microbial pathogens directly or indirectly. (ubc.ca)
  • These receptors bind various cargo proteins via their luminal Vps10p domains and have been shown to mediate a variety of intracellular sorting and trafficking functions. (biomedcentral.com)
  • These data indicate that the α- and γ-secretase cleavages of the mammalian Vps10p sorting receptors occur in a fashion analogous to other known γ-secretase substrates, and could possibly regulate the biological functions of these proteins. (biomedcentral.com)
  • In the ATP-bound form, it has a low affinity for substrate proteins. (cusabio.com)
  • However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. (cusabio.com)
  • Antibody is purified by peptide affinity chromatography method. (prosci-inc.com)
  • The final product is generated by affinity chromatography using a Rb-derived peptide that is phosphorylated at serine 249 and threonine 252. (abcam.cn)
  • NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. (abcam.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
  • A human dwarfism mutation that affects positive control in the related POU domain protein Pit-1 maps to the same region of the HTH motif as do positive control mutations in lambda repressor. (embl.de)
  • Interestingly, functionally redundant SNIPER1 and SNIPER2 can control the protein levels of diverse sNLRs and the interactions between SNIPER1 and sNLRs appear to be through the common nucleotide-binding (NB) domains of sNLRs. (ubc.ca)
  • This binding of Nutlin-3 has two consequences: (i) antagonistic effects through competitive disruption of the MDM2-p53 complex and (ii) agonist effects that allosterically stabilize MDM2 protein-protein interactions that increase p53 ubiquitination as well as nucleophosmin deoligomerization. (ed.ac.uk)
  • In fact, biological outcomes are often due to physical interactions between proteins that are so highly selective that seemingly minor chemical modifications (i.e. methylation, acetylation or phosphorylation) can completely abolish biomolecular recognition processes and redirect signaling pathways. (mtu.edu)
  • This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. (novusbio.com)
  • These models are the Mechanisms of Inorganic of using C31 cells in Eukaryotic sites for diameter and transfection of same p+2K+1× as they have solid importance on the nucleoside of regression conserved to irreversible data. (scoutconnection.com)
  • Scholars@Duke publication: Transcriptional down-regulation of tumor necrosis factor-alpha gene expression by a synthetic peptide homologous to retroviral envelope protein. (duke.edu)
  • Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MLX. (prosci-inc.com)
  • Synthetic peptide corresponding to Human Rb (phospho S249 + T252). (abcam.cn)
  • Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)
  • Using iterative database searches, a statistically significant sequence similarity was detected between the POZ (poxvirus and zinc finger) domains found in a variety of proteins involved in animal transcription regulation, cytoskeleton organization, and development, and the tetramerization domain of animal potassium channels. (embl.de)
  • In addition to the binding of DJBP to the COOH-terminal region of DJ-1, DJBP was also found to bind in vitro and in vivo to the DNA-binding domain of the AR in a testosterone-dependent manner and to be colocalized with DJ-1 or AR in the nucleus. (nih.gov)
  • This causes a conformation in the repressor that allows it to bind to the operator. (ittutoria.net)
  • If tryptophan is not present, the repressor will be in an inactive conformation and can't bind to the operator. (ittutoria.net)
  • Proteins which bind to DNA. (lookformedical.com)
  • The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
  • Chandrasekaran, R., and Thompson, M. (2007) Polybromo-1-bromodomains bind histone H3 at specific acetyl-lysine positions. (mtu.edu)
  • Polybromo-1 bromodomains bind histone H3 at specific acetyl-lysine positions. (mtu.edu)
  • J Immunol 151, no. 5 (September 1, 1993): 2733-41. (duke.edu)
  • 1993 Sep 1;151(5):2733-41. (duke.edu)
  • 1993 Sep 1;151(5):2733-2741. (duke.edu)
  • Two isoforms of the EWS protein are produced by differential splicing. (medindex.am)
  • This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. (prosci-inc.com)
  • Using human breast cancer cells transfected with MAD1 SID or treated with the MAD SID peptide, we observed a dissociation of MAD1, RARα and RARß from Sin3A in a coimmunoprecipitation assay. (bvsalud.org)
  • Pharmacologic inhibition of the retinol-induced interaction of retinol-binding protein 4 (RBP4) with transthyretin (TTR) in the serum may decrease the uptake of serum retinol to the retina and reduce formation of lipofuscin bisretinoids. (arvojournals.org)
  • A surface-exposed groove lined with conserved amino acids is formed at the dimer interface, suggesting a peptide-binding site. (embl.de)
  • Trp repressor Trp high (trp), repression occurs in na Leadereo attenuator trpE, trpD, trpC and trpB. (ittutoria.net)
  • Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation. (tcd.ie)
  • For several substrates the liberated cytoplasmic domain has been shown to translocate to the nucleus where it is involved in nuclear signaling (Notch ErbB4, Delta-1 Jagged, APLP1/2). (biomedcentral.com)
  • Proteins found in the nucleus of a cell. (lookformedical.com)
  • Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (lookformedical.com)
  • The NuA4 complex interacts with MYC and the adenovirus E1A protein. (novusbio.com)
  • The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. (abcam.cn)
  • A homeodomain protein that interacts with TATA-BOX BINDING PROTEIN. (bvsalud.org)
  • The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. (genetex.com)
  • Ubiquitous nuclear and cytoplasmic RNA Binding Protein EWS belongs to the TET family of RNP proteins, contains an RNA recognition motif and a RANBP2-type zinc finger, and may function as a repressor. (medindex.am)
  • Zinc-finger domain of monoamine-oxidase A repressor R1 [Interproscan]. (ntu.edu.sg)
  • The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. (cancerindex.org)
  • The HPV E7 peptide contains the LxCxE motif, shared by other Rb-binding viral and cellular proteins. (nih.gov)
  • Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
  • She completed her doctoral research on the transcriptional repressor REST (Repressor Element 1-Silencing Transcription factor) at the University of Leeds. (wikipedia.org)
  • NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. (abcam.com)
  • Pharmacological disruption of the Notch transcription factor complex. (harvard.edu)
  • Biological Function Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. (qedbio.com)
  • Peptide chain release factor class I [Interproscan]. (ntu.edu.sg)
  • much 75 cytosol of pairing substrates are in 1500 220 KDa proteins with IGFBP3 and ALS. (evakoch.com)
  • All identified γ-secretase substrates are type I transmembrane proteins [ 29 ] and contain a putative stop transfer sequence immediately following the transmembrane region [ 30 ]. (biomedcentral.com)
  • A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
  • The solution structure of the Oct-1 POUs domain has been determined by multidimensional nuclear magnetic resonance spectroscopy and consists of four alpha helices surrounding a conserved hydrophobic core. (embl.de)
  • Protein kinase A anchor protein, nuclear localisation signal domain [Interproscan]. (ntu.edu.sg)
  • We show that Foxo1 acts as a repressor of Foxa2-dependent (Hnf-3beta-dependent) expression from the Pdx1 promoter. (nih.gov)
  • Most resulting proteins lead in techniques with IGFBPs, which plan methylated to modulate the CLASP of acts in the mode, react salt of IGFs to trim members for mice, promote cornea like supplements of IGFs, and be as encoding mitochondria here of IGFs. (evakoch.com)
  • The TRpR gene is upstream from the promoter and acts as a repressor of the Trp operon. (ittutoria.net)
  • Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones. (novusbio.com)
  • SUSA2 encodes an F-box protein Actin-Related Protein 8 (ARP8) and SUSA3 encodes the chaperone protein HSP90.3. (ubc.ca)
  • Central to the epigenetic control of gene expression is the histone code through which input signals can be translated into a heritable pattern of gene expression defining cellular output states ( Fig. 1 ). (aacrjournals.org)
  • Whereas regulating gene expression in multicellular organisms allows for cellular differentiation, in single-celled organisms like prokaryotes, it primarily ensures that a cell's resources are not wasted making proteins that the cell does not need at that time. (pressbooks.pub)
  • however, gene expression in eukaryotes is more complicated because of the temporal and spatial separation between the processes of transcription and translation. (pressbooks.pub)
  • Storage This antibody is stable for at least one (1) year at -20°C. (qedbio.com)
  • MLX antibody can be used for detection of MLX by ELISA at 1:1562500. (prosci-inc.com)
  • MLX antibody can be used for detection of MLX by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000. (prosci-inc.com)
  • The antibody has been negatively preadsorbed using a non-phosphopeptide corresponding to the site of phosphorylation to remove antibody that is reactive with non-phosphorylated Rb protein. (abcam.cn)
  • snc1 harbors a gain-of-function mutation in the TNL SNC1 (Suppressor of npr1, Constitutive 1) and exhibits autoimmune phenotype. (ubc.ca)
  • To further characterize the function of DJ-1, we cloned cDNA encoding a novel DJ-1-binding protein, DJBP, by a yeast two-hybrid system. (nih.gov)
  • These results suggest that AR is positively regulated by DJ-1, which antagonizes the function of negative regulators, including DJBP. (nih.gov)
  • Several other genetic backgrounds result in enlargement of the haltere significantly beyond the normal range of haploinsufficient phenotypes, suggesting genetic variation in cofactors that mediate homeotic protein function. (lookformedical.com)
  • The Ataxin-2 protein is required for miRNA function and synapse-specific, long-term olfactory habituation. (tcd.ie)
  • Voltage-dependent, ion-selective channels such as Na+, Ca2+ and K+ channel proteins function as tetrameric assemblies of identical or similar subunits. (embl.de)
  • protein_coding" "Cz03g33270.t1","No alias","Chromochloris zofingiensis","Domain of unknown function DUF155 [Interproscan]. (ntu.edu.sg)
  • Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. (cusabio.com)
  • The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. (academicinfluence.com)
  • CO-utilizing microorganisms include aerobic bacteria, phototrophic purple nonsulfur bacteria, acetogens, methanogens, and hydrogenogenic bacteria and archaea, as well as sulfate-reducing prokaryotes (SRP) [ 1 , 2 ]. (hindawi.com)
  • In bacteria and archaea , structural proteins with related functions are usually encoded together within the genome in a block called an operon and are transcribed together under the control of a single promoter , resulting in the formation of a polycistronic transcript ( Figure 12.30 ). (pressbooks.pub)
  • A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington's disease. (tcd.ie)
  • A genome-wide resource for the analysis of protein localisation in Drosophila. (tcd.ie)
  • We have investigated and provide evidence for γ-secretase cleavage of this family of proteins. (biomedcentral.com)
  • Following ectodomain shedding, γ-secretase cleavage liberates both the cytoplasmic fragment and a small secreted peptide. (biomedcentral.com)
  • US Patent #6,348,317 - Fluorescent and DNA cleavage properties of peptide/dye conjugates. (mtu.edu)
  • Many BTB proteins are transcriptional regulators that are thought to act through the control of chromatin structure. (embl.de)