Transcription regulator myod protein. Medical search. Frequent questions

In this way, the Emc protein can have an effect on the gene expression of many genes during Drosophila development. (wikipedia.org)
This transition is caused by the Da and AS-C genes, which are transcription factors with the basic helix-loop-helix (bHLH) domains. (wikipedia.org)
Specifically, Emc proteins inactivate the Sc protein (a transcription factor) and stop transcription of genes on the X-chromosome. (wikipedia.org)
Here we reveal the expression patterns of the two MyoD genes in Oreochromis ( Alcolapia) alcalica using in situ hybridisation. (mdpi.com)
These transcription factors bind promoters and distant regulatory regions, including E-box elements, of genes whose expression is restricted to muscle cells. (unipv.it)
Separately, E2a is necessary to drive transcription of Smad2 /3 target genes, including critical regulators of dorsal cell fate and morphogenesis. (xenbase.org)
DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
With roughly 30,000 genes in mammalian genomes, fection with a vector encoding MyoD (Tapscott et al. (lu.se)
MyoD is certainly a transcription aspect needed for MuSC dedication towards the myogenic differentiation13 and lineage, and recent function confirmed that MyoD regulates a couple of genes accountable to maintain oxidative fat burning capacity in C2C12 myotubes and adult skeletal muscle tissue10. (mdm-inhibitors.com)
Maternal genes involved in dorsoventral (D/V) patterning of the Drosophila embryo interact to establish a stable nuclear concentration gradient of the Dorsal protein which acts as the morphogen along this axis. (silverchair.com)
Fasting signals are relayed by various intracellular enzymes, such as kinases, phosphatases, acetyltransferases, and deacetylases, which affect the transcriptional activity of transcription factors and transcriptional coactivators for gluconeogenic genes. (e-enm.org)
In earlier reports, PRMTs promoted active transcription of target genes by mediating asymmetric dimethylation of arginine residues on histones, resulting in increased acetylation and the subsequent activation of transcription. (e-enm.org)
We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
25 The downstream target genes of MAPK signaling cascades comprise of the differentiation related transcription aspects Jun ATF2/AP1, C/EBPB and Egr one, which are known to get necessary for myeloid differentiation. (chk1inhibitor.com)
We also identify known regulators of satellite cell function such as BMP4, CD34 and Myf6 (Mrf4) as genes whose expression is dependent on Yap activity. (kcl.ac.uk)
Finally, we confirm in myoblasts that Yap binds to Tead transcription factors and co-activates MCAT elements which are enriched in the proximal promoters of Yap-responsive genes. (kcl.ac.uk)
Locations of the candidate genes and the DME1 and DME2 myogenic transcription enhancers (92) are shown. (comprehensivephysiology.com)

Early support for the role of emc came from the mouse Inhibitor of differentiation (Id) gene, which negatively regulates myogenesis by forming a heterodimer with the MyoD protein and therefore inhibiting its abilities as a transcription factor. (wikipedia.org)
The basic helix-loop-helix transcription factor NeuroD (Neurod1) has been implicated in neuronal fate determination, differentiation and survival. (biologists.com)
Skeletal muscle differentiation is triggered by a unique family of myogenic basic helix-loop-helix transcription factors, including MyoD, MRF-4, Myf-5, and Myogenin. (unipv.it)
Alter J, Bengal E. (2011) Stress-Induced C/EBP Homology Protein (CHOP) Represses MyoD Transcription to Delay Myoblast Differentiation . (technion.ac.il)
Ostrovsky O., Bengal, E .*, and Aronheim, A.* (2002) Induction of Terminal Differentiation by the c-Jun Dimerization Protein JDP2 in C2 Myoblasts and Rhabdomyosarcoma Cells . (technion.ac.il)
Tamir, Y., and Bengal E . (2000) Phosphoinositide 3-kinase induces the transcriptional activity of MEF2 proteins during muscle differentiation . (technion.ac.il)
Zetser, A., Gredinger, E., and Bengal, E. (1999) p38 mitogen-activated protein kinase promotes skeletal muscle differentiation: participation of the MEF2C transcription factor . (technion.ac.il)
Tamir, Y., and Bengal, E. (1998) p53 protein is activated during muscle differentiation and participates with MyoD in the transcription of muscle creatine kinase gene . (technion.ac.il)
The transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is expressed in Pax7 + satellite cells of healthy muscle and is downregulated during myoblast differentiation. (biomedcentral.com)
Persistent expression of C/EBPβ upregulates Pax7, inhibits MyoD, and blocks myogenic differentiation. (biomedcentral.com)
CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that regulate cellular growth and differentiation, metabolism, and inflammation [ 18 ]. (biomedcentral.com)
When overexpressed in the murine myoblast cell line C2C12 or in primary myoblasts, C/EBPβ reduced MyoD and other myogenic protein levels during differentiation, in addition to reducing myoblast fusion. (biomedcentral.com)
Recently, several chromatin-related proteins have been shown to regulate ESC pluripotency and/or differentiation, yet the role of the major heterochromatin proteins in pluripotency is unknown. (biomedcentral.com)
Here we identify Heterochromatin Protein 1β (HP1β) as an essential protein for proper differentiation, and, unexpectedly, for the maintenance of pluripotency in ESCs. (biomedcentral.com)
Abstract Metabolic reprogramming can be an energetic regulator of stem cell fate options, and effective stem cell differentiation in various compartments needs the induction of oxidative phosphorylation. (mdm-inhibitors.com)
This MyoD recruitment was additional increased with the induction of differentiation in myogenically transformed IMR90 fibroblasts (Fig.?2g), suggesting that MyoD regulation of is conserved between mouse and individual species. (mdm-inhibitors.com)
Subsequent scientific studies in quite a few selleckchem VER 155008 AML cell lines uncovered that HPK1 signaling can offer a dual function, each as a regulator of AML cell differentiation/cell cycle and like a mediator of resistance to vitamin D derivatives. (chk1inhibitor.com)
Constitutive expression of Yap maintains Pax7 + and MyoD + satellite cells and satellite cell-derived myoblasts, promotes proliferation but prevents differentiation. (kcl.ac.uk)
Preincubation of skeletal myoblasts with IGF-1 blocked MSTN-induced Smad3 activation, promoting myod expression and myoblast differentiation. (unab.cl)

Feeding with amino acids can stimulate protein synthesis in all tissues, especially in skeletal muscle as reviewed by Davis et al. (nature.com)
Studies previously conducted show that HS negatively affects the skeletal muscle growth and development by changing its effects on myogenic regulatory factors, insulin growth factor-1, and heat-shock proteins. (frontiersin.org)
Here, we show that the transcription factor zinc finger E-box-binding homeobox 2 (Zeb2, Sip-1, Zfhx1b) is present in skeletal muscle tissues. (unipv.it)
We therefore propose that Zeb2 is a novel myogenic regulator and a possible target for improving skeletal muscle regeneration. (unipv.it)
Keren, A., Tamir , Y., and Bengal, E . (2006) The p38 MAPK signaling pathway: A major regulator of skeletal muscle development . (technion.ac.il)
Myostatin, a member of the transforming growth factor-β superfamily, is a negative regulator of skeletal muscle growth in vertebrates that exerts its inhibitory function by activating Smad transcription factors. (unab.cl)
DUX4‐fl transcription factor misexpression in skeletal muscle leads to disrupted RNA splicing, nonsense mediated decay (NMD), and protein degradation, possibly causing damaged associated molecular pattern (DAMP) release, which may elicit an immune response to targeted damaged muscles. (comprehensivephysiology.com)

2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)
Likewise, ChIP-seq evaluation using myogenic transformation of individual IMR90 fibroblasts towards the myogenic lineage with the induction of ectopic MyoD appearance demonstrated the recruitment of MyoD towards the promoter (Fig.?2g). (mdm-inhibitors.com)
Focusing on transdifferentiation of primary human skin fibroblasts by forced expression of myogenic transcription factor MyoD, we performed quantitative analyses of gene expression and chromatin accessibility profiles of transdifferentiated cells compared to fibroblasts and myoblasts. (duke.edu)

E2a Regulates Samd2/3 Positioning at lefty and Represses lefty Transcription (A) qRT-PCR showing upregulation of lefty in E2a -depleted embryos and downregulation of gsc and xbra . (xenbase.org)
The variant histone H2A.Z regulates gene transcription, and deletion of the gene encoding H2A.Z strongly increases the requirement for SNF/SWI and SAGA. (sdbonline.org)

g MyoD ChIP-seq sign peaks and distribution in the promoter in IMR90-derived myoblasts and myotubes. (mdm-inhibitors.com)
We also demonstrate that the transcriptional regulator PRDM16 (PRD1-BF1-RIZ1 homologous domain containing 16) controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells. (bioseek.eu)
Stimulation of skeletal myoblasts with MSTN resulted in a transient increase in the pSmad3:Smad3 ratio and Smad-dependent transcription. (unab.cl)

The levels of each of these proneural proteins is likely to be regulated by the Notch signaling pathway, as the lack of Notch causes an excess of neural cells while "constitutive Notch signaling. (wikipedia.org)
This pathway can be potentiated by R-spondins, a family of proteins that bind RNF43/ZNRF3 E3 ubiquitin ligases and LGR4/5 receptors to prevent Frizzled degradation. (xenbase.org)
Ciechanover, A., Breitschopf, K., Abu Hatoum, O., and Bengal E. (1999) Degradation of MyoD by the ubiquitin pathway: regulation by specific DNA-binding and identification of a novel site for ubiquitination . (technion.ac.il)
The Nodal signaling pathway has many biological functions that all converge on the transcription factors Smad2 /3. (xenbase.org)
These results describe a novel pathway for regulating transcription using variant histones to modulate chromatin structure (Santisteban, 2000). (sdbonline.org)
Interestingly, recent reports suggest that PRMTs function as regulators of fuel metabolism through interaction with a number of transcriptional regulators in the pathway. (e-enm.org)

This protein belongs to the rel proto-oncogene and NF-KB transcriptional factor family and acts by controlling zygotic gene expression. (silverchair.com)
Quantitative analyses revealed a continuum of changes in chromatin accessibility induced by MyoD, and a strong correlation between chromatin-remodeling deficiencies and incomplete gene expression reprogramming. (duke.edu)
Moreover, MSTN inhibited myod gene expression and myoblast fusion in an Activin receptor-like kinase/Smad3-dependent manner. (unab.cl)

These characteristics correlate with a distinct nuclear architecture, epigenetic signatures enriched for active chromatin marks and hyperdynamic binding of structural chromatin proteins. (biomedcentral.com)
Molecular analysis suggested that Esc2p contributed to silencing in a manner similar to Sir1p and probably helped recruit or stabilize the other Sir proteins, while Htz1p present at HMR assembled a specialized chromatin structure necessary for silencing (Dhillon, 2000). (sdbonline.org)
CCCTC-binding factor (CTCF) is a conserved transcription factor that performs diverse roles in transcriptional regulation and chromatin architecture. (preprints.org)

Our group has shown that Pbx and Meis homeodomain transcription factors are critical regulators of heart development in zebrafish. (seattlechildrens.org)

Post-translational modification of proteins at lysine residues by reversible acetylation is catalyzed by the opposing activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs), which act on both histone and non-histone substrates despite their names. (biomedcentral.com)

It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes. (archivesofmedicalscience.com)

The gene extramachrochaetae (emc) is a Drosophila melanogaster gene that codes for the Emc protein, which has a wide variety of developmental roles. (wikipedia.org)

The interaction between Da or AS-C proteins with Emc to form dimers renders them inactive as transcription factors. (wikipedia.org)
Finally, the expression patterns of three neuronal type-specific transcription factors, unc-3, unc-4 and unc-30 , were altered. (biologists.com)
We are using zebrafish and mouse models to study the functions of factors such as Pbx homeodomain transcription factors and how they control muscle fiber-type development. (seattlechildrens.org)
Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)
Transcription factors are divided into two groups. (intechopen.com)
First, the general TFs (GTFs), including preinitiation complex components TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and THIIH, are the primary protein factors that are required for the initiation of transcription from the TATA box (or TATA element), then elongation is executed by RNA polymerase II (RNA pol II) [ 1 ]. (intechopen.com)

We report our analysis of MyoD1 and MyoD2 protein sequences from 54 teleost species, and show that O. alcalica , along with some other teleosts, include a polyserine repeat between the amino terminal transactivation domains (TAD) and the cysteine-histidine rich region (H/C) in MyoD1. (mdpi.com)
The evolutionary history of MyoD1 and MyoD2 is compared to the presence of this polyserine region using phylogenetics, and its functional relevance is tested using overexpression in a heterologous system to investigate subcellular localisation, stability, and activity of MyoD proteins that include and do not include the polyserine region. (mdpi.com)

The histone H2A.F/Z (H2AZ) variant is a functionally distinct, highly conserved histone subgroup that likely represents a separate evolutionary lineage of histone H2A proteins. (sdbonline.org)

The Emc protein has a helix-loop-helix protein domain without the basic region, making it unable to bind to DNA and act as a transcription factor. (wikipedia.org)

Her laboratory, located in the Duke Center for Genomic and Computational Biology, develops computational methods and high-throughput experimental techniques to quantitatively characterize protein-DNA interactions and their role in gene regulation. (duke.edu)

Protein arginine methyltransferases (PRMTs) comprise a group of enzymes that catalyze the transfer of methyl groups to the amino acid arginine or the arginine residues of proteins in eukaryotic species. (e-enm.org)
While all three types of PRMTs are capable of catalyzing monomethylation of arginine residues, type I PRMTs can transfer a second methyl group to the monomethylated nitrogen atom of the guanidino group of monomethyl arginine, resulting in the formation of proteins containing one or more asymmetric dimethylarginine residues. (e-enm.org)
Type II PRMTs transfer a methyl group to the unmodified nitrogen atom of the guanidine group of monomethyl arginine to form proteins with symmetric dimethylarginine residues. (e-enm.org)

It does, however, have the ability to bind other basic helix-loop-helix domain-containing proteins, such as the products of the achaete-scute complex (ac-s), to form dimers that inactivate the target protein, which is usually a transcription factor. (wikipedia.org)

The Emc protein itself is a Class V HLH protein due to its lack of the basic region and consequential inability to bind DNA. (wikipedia.org)
It codes for a 'b-HLH' DNA-bind-ing protein which can dimerize and bind to DNA in vitro and to polytene chromosomes in vivo. (silverchair.com)

The MyoD gene was duplicated during the teleost whole genome duplication and, while a second MyoD gene ( MyoD2 ) was subsequently lost from the genomes of some lineages (including zebrafish), many fish lineages (including Alcolapia species) have retained both MyoD paralogues. (mdpi.com)

Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases dependent on nicotine adenine dinucleotide (NAD) and are found in organisms ranging from bacteria to humans. (biomedcentral.com)

The two DUX4‐fl isoforms produce the same protein sequence and differ only in the splicing of the 3′UTR. (comprehensivephysiology.com)

Didier Trono s'est beaucoup intéressé aux interactions entre les virus et leurs hôtes, ce qui l'a conduit à étudier la biologie de pathogènes comme le VIH et le virus de l''hépatite B, et à créer des outils de transfert génétique dérivés du VIH aujourd'hui utilisés avec succès en thérapie génique. (epfl.ch)
Also, other DUX4‐fl protein interactions may affect muscle function. (comprehensivephysiology.com)

G protein subunit gamma 2 [Sourc. (gsea-msigdb.org)

Brix domain-containing proteins, such as Peter Pan (PPan), are essential for eukaryotic ribosome biogenesis. (silverchair.com)

These observations suggest that Rspo2 is a context-specific regulator of TCF3 phosphorylation and Wnt signaling. (xenbase.org)

In the ventral part of the embryo, dorsal specifically activates transcription of the gene twist and ventrally and laterally dorsal represses the expression of zerkn üllt , a gene involved in the formation of dorsal derivatives. (silverchair.com)

Nucleosomes impose a block to transcription that can be overcome in vivo by remodeling complexes such as SNF/SWI and histone modification complexes such as SAGA. (sdbonline.org)
PRMT5, a predominant type II PRMT in mammals, represses transcription by promoting symmetric dimethylation of arginine 8 on histone H3 (H3R8) and symmetric dimethylation of arginine 3 on histone H4 (H4R3) [ 6 ]. (e-enm.org)

FSH (80 ng/mL) facilitated the effects of P4 biosynthesis and secretion, ATP production, mtDNA copy numbers, cell proliferation and the MFN2 transcription of granulosa cells from F5 (F5G) in vitro. (bvsalud.org)
In keeping with ChIP-seq data, Isolated from MyoD KO mice41 MuSCs,42 showed decreased mRNA amounts when cultured for 3 times in vitro (Fig.?2h). (mdm-inhibitors.com)

Transcription factor complexes have varied effects on cell fate and behavior, but how this diversification of function occurs is largely unknown. (xenbase.org)
C) Distribution of key transcription factor binding sites near the lefty locus. (xenbase.org)
Furthermore, we identify the transcription factor Gli1, expressed in medial IZ cells, as an antagonist of E(Spl) and Gsk3β/PKA, and demonstrate that the neurogenesis-promoting activity of Gli1 accounts for the reduced sensitivity of medial IZ progenitors to neurogenesis inhibitors and their increased propensity to differentiate. (biologists.com)
Our approach for analyzing, on a genome-wide scale, the efficiency of cellular transdifferentiation driven by a transcription factor master regulator can be applied to any transdifferentiation system, and we expect it to be particularly useful for studying systems with low conversion efficiency. (duke.edu)

Dipeptidyl peptidase (DPP) 9, DPP8, DPP4 and fibroblast activation protein (FAP) are the four enzymatically active members of the S9b protease family. (preprints.org)

In particular, ESRR alpha (ESRRa) and ESRR gamma (ESRRg) are key metabolic regulators of energy homeostasis and abnormal functions of these proteins are linked to metabolic syndromes including diabetes and fatty liver disease 5 . (nature.com)

Molecular mechanisms of the initiation of transcription from TATA box have been well known as the most essential nuclear events in mammalian cells. (intechopen.com)

Other E-box binding zinc finger proteins target the same DNA response elements, however, their function in muscle development and regeneration is still unknown. (unipv.it)
Our approach is to manipulate fiber-type regulators that function early in development in dmd zebrafish embryos. (seattlechildrens.org)
Type II PRMTs (PRMT5, PRMT7, and PRMT9) are less well characterized and may function as transcriptional repressors, although some reports suggest that they can function as activators of transcription. (e-enm.org)

All superior and inferior rectus muscles from both globes were examined for BrdU incorporation, MyoD expression, neonatal and developmental myosin heavy chain (MyHC) isoform expression, and myofiber cross-sectional area alterations. (arvojournals.org)

We recognize Fam3a, a cytokine-like protein, as a significant Stat3 downstream effector in muscle tissue stem cells. (mdm-inhibitors.com)

Protein arginine methyltransferases (PRMTs) were recently added to the list of enzymes that are critical for regulating transcription in hepatic gluconeogenesis. (e-enm.org)

Mutants of Sir1p were generated that are recruited to the silencer but are unable to silence, and these mutants were used to identify four proteins, Sir3p, Sir4p, Esc2p, and Htz1p, that when overexpressed, restored silencing. (sdbonline.org)

Meanwhile, we observed that change fold of MFN2 transcription, ATP production, mtDNA copy numbers and cell proliferation rate in F5G after treatment with FSH were greater than those in SYFG. (bvsalud.org)

HS causes poor meat quality by impairing protein synthesis and augmenting undesirable fat in meat. (frontiersin.org)

DUX4 protein sequences beginning at the ATG start codon, with the stop codon indicated, and the 3′UTRs shown in orange. (comprehensivephysiology.com)

The Brassica family contains several economically important crops, including rapeseed (Brassica napus, 2n = 38, AACC), the second largest source of seed oil and protein meal worldwide. (preprints.org)

Furthermore, we systematically characterized mitochondria during disease progression starting before the onset of muscle damage, noting additional changes in mitochondrial DNA copy number and regulators of mitochondrial size. (frontiersin.org)
We expect that this project will identify genetic and epigenetic regulators of muscle fiber-type identities that confer susceptibility or resistance to muscular dystrophy. (seattlechildrens.org)
In the resected muscle and in the passively stretched antagonist muscle, there was a dramatic increase in the number of myofibers positive for neonatal MyHC and in the number of BrdU- and MyoD-positive satellite cells. (arvojournals.org)

Anatomy5

Organisms2

Chemicals and Drugs22

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes30

Information Science3

Genes17

Differentiation19

Skeletal muscle7

Fibroblasts3

Regulates2

Myoblasts3

Pathway6

Gene expression3

Chromatin3

Critical regulators1

Acetylation1

Regulate1

Drosophila1

Factors6

MyoD12

Lineage1

Helix-loop-helix pr1

Regulation1

Residues3

Basic helix1

Bind2

Genomes1

Deacetylases1

Isoforms1

Interactions2

Subunit1

Eukaryotic1

Phosphorylation1

Dorsal1

Histone2

Vitro2

Factor4

Fibroblast1

Metabolic1

Mammalian1

Function3

Developmental1

Stat31

Enzymes1

Mutants1

Cell proliferation1

Synthesis1

Sequences1

Family1

Muscle3