Transcription regulation e2f1 transcription factor. Medical search. Frequent questions

The first project focuses on E2F1, a regulator of genes important for cell cycle progression and apoptosis. (mdanderson.org)
And third, it blocks apoptosis by interacting with E2F1, thus silencing TP73 and Apaf1 genes. (rndsystems.com)
BRD4 methylation determines the recruitment of the transcription factor E2F1 to selected target genes which are involved in protein generation, a molecular mechanism which facilitates the balanced expression of these genes. (indiaeducationdiary.in)
Through a genome-wide expression analysis, we identified a distinct set of genes under the control of PRMT5 and E2F1, including some highly regulated genes, which influence cell migration, invasio and adherence through a PRMT5-dependent mechanism. (ox.ac.uk)
Although more highly transcribed genes acquire methylation earlier, the major transitions in the oocyte transcriptome occur well before the de novo methylation phase, indicating that transcription is generally not rate limiting in conferring permissiveness to DNA methylation. (biomedcentral.com)
The TP53 gene encodes a transcription factor that plays a pivotal role in many cellular responses through direct regulation of hundreds of target genes. (thegomap.org)
Since the mechanism of transcription of microRNA genes is similar to mRNAs, we hypothesize that in cancer cells, MTp53 alters the abundance of a subset of cellular microRNAs by regulating the activity of the above-mentioned transcription factors. (thegomap.org)
Having identified the common set of microRNAs regulated by MTp53, we will next investigate (1) whether candidate microRNAs are also regulated by other aggressive mutants of p53 (such as R175H) (2) changes in transcription and regulation of candidate microRNA genes by MTp53 and MTp53-interacting transcription factors such as E2F1, ETS1 and p63/p73. (thegomap.org)
In summary, we identified 22 co-expression modules, and the enrichment analysis results revealed that the module genes were significantly involved in the regulation of definite biotic procedures. (cellmolbiol.org)
To date, it is well known that lncRNAs participate in chromatin modifications and transcriptional and translational regulation of protein-encoding genes or regulate protein function and activity through specific binding [ 3 - 5 ]. (jcancer.org)
These results suggest that differential expression of Apaf-1 and caspase-3 genes may underlie regulation of apoptotic susceptibility during brain development, as well as after acute injury to mature brain, through the intrinsic pathway of caspase activation. (jneurosci.org)
DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
Transcription factors are proteins that regulate the transcription of genes, or the production of mRNA from DNA. (biolegend.com)
The underphosphorylated, active form of Rb interacts directly with E2F1 , leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. (biolegend.com)

Second, it appears to block cell cycle progression, possibly via a down-regulation of CDK proteins. (rndsystems.com)
Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. (nih.gov)
both E2F1 and c-Myc are stimulating factors of H19 expression, and the H19 lncRNA functions as a downstream effector of c-Myc and E2F1 in tumor development and progression [ 11 ]. (jcancer.org)
We identify an important role for DDX5 in G 1 -S-phase progression where it directly regulates DNA replication factor expression by promoting the recruitment of RNA polymerase II to E2F-regulated gene promoters. (aacrjournals.org)

We examined not just the effect of proadifen and MTX on the expression of BCRP, but we were also interested in other molecular mechanisms involved in the possible antitumour activity of proadifen alone and in combination with MTX, such as the expression of anti-apoptotic proteins, proteins involved in the regulation of BCRP and proteins involved in the reparation of chemotherapeutic drug-induced DNA damage. (spandidos-publications.com)
Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that act as key proinflammatory factors. (stria.tech)
Additionally, DBC1 knockdown eliminated the up-regulation of MMP7, EMT-related proteins, and cell cycle-related proteins as well as the enhanced proliferation and invasiveness induced by ZNF326. (cancerindex.org)

In this paper, the collaborating research teams have identified and characterized a new methylation event, catalyzed by the methyltransferase SETD6, on the transcription factor BRD4. (indiaeducationdiary.in)
E2F1 is the major target through which pRb exerts its effects and arginine methylation by PRMT5 plays a key role in dictating E2F1 activity. (ox.ac.uk)
In the female germline, DNA methylation is acquired late in oogenesis from an essentially unmethylated baseline and is established largely as a consequence of transcription events. (biomedcentral.com)
Given the predominant role of transcription, we sought to investigate whether transcription timing is rate limiting for de novo methylation and determines the asynchrony of methylation events. (biomedcentral.com)
We also identified differential enrichment of transcription factor binding motifs in CGIs acquiring methylation early or late in oocyte growth. (biomedcentral.com)
As a result, there is highly programmed methylation of a defined set of ~2000 CGIs in oocytes, mostly on account of their location within active transcription units. (biomedcentral.com)

Cancer genetics, DNA damage response, apoptosis, cell cycle My current research is focused on two transcription factors that respond to DNA damage and play important roles in regulating tumor development. (mdanderson.org)
STAT3 protein belongs to a group of intracellular transcription factors that mediate a variety of functions such as cellular differentiation, proliferation, and apoptosis. (biolegend.com)

E2F1 is one of the transcription factors that cells enter the S phase and plays a key role in cell cycle. (hindawi.com)
Studies have found that E2F1 is highly expressed in a variety of tumor tissues and cells and plays a role of oncogenic gene [ 10 - 13 ]. (hindawi.com)
Previous studies have confirmed that miRNAs play an important role in gene regulation in CD44 + CD24 -/low breast cancer stem cells (BCSCs). (researchsquare.com)
In cancer cells, the MTp53 protein influences the transcriptome by interacting with several transcription factors including E2F1, ETS1 and the p53 family members, p63 and p73. (thegomap.org)
To test the hypothesis that mutations in p53 can regulate transcription of microRNAs in cancer cells, we decided to use stable cell lines expressing MTp53 in p53-null H1299 lung cancer cells. (thegomap.org)
Our findings suggest that the increased invasiveness of MTp53 cells could be partly mediated by increased levels of oncogenic microRNAs and down-regulation of tumor suppressor microRNAs. (thegomap.org)
Because miR-155 is expressed at reasonably high levels only in immune cells, we hypothesize that regulation of miR-155 by mutant p53 may have a functional effect only in immune cells. (thegomap.org)
Luminal-like breast tumor cells express estrogen receptor alpha (ER-alpha) , a member of the nuclear receptor family of ligand-activated transcription factors that controls their proliferation, survival, and functional status. (unica.it)
To identify the molecular determinants of this hormone-re- sponsive tumor phenotype , a comprehensive genome- wide analysis was performed in estrogen stimulated MCF-7 and ZR-75.1 cells by integrating time-course mRNA expression profiling with global mapping of genomic ER-alpha binding sites by chromatin immunopre- cipitation coupled to massively parallel sequencing , mi- croRNA expression profiling, and in silico analysis of transcription units and receptor binding regions iden- tified. (unica.it)
We applied an assay that measures the stability of maintenance of an episomal plasmid in human tissue culture cells to screen for new DNA replication factors. (aacrjournals.org)
Espanel X, Le Cam L, North S, Sardet C, Brun G, Gillet G. Regulation of E2F-1 gene expression in avian cells. (u-bordeaux.fr)
The TME consists of various cellular components, including immune cells, stromal cells, and extracellular matrix, along with soluble factors and signaling molecules. (biomedcentral.com)
The capability of these cells to differentiate depends on the stem cell type, the regulation of gene expression by various transcription factors and interaction with the stem cell niche 1,4 . (biolegend.com)
RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. (biolegend.com)
Via dephosphorylation, calcineurin is the enzyme responsible for activating nuclear factor of activated T-cells (NF-AT), a T cell transcriptional regulatory factor. (medindex.am)

Moreover, our studies demonstrate that E2F1 recruits chromatin-modifying enzymes to sites of damage to facilitate access to the DNA repair machinery. (mdanderson.org)
These findings indicate that E2F1 stimulates DNA repair through a non-transcriptional mechanism that functions in the context of chromatin. (mdanderson.org)
Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. (nih.gov)

North S, Moenner M, Bikfalvi A. Recent developments in the regulation of the angiogenic switch by cellular stress factors in tumors. (u-bordeaux.fr)

Can we direct specific cellular factors to regulate this process? (indiaeducationdiary.in)
Finally, non-coding RNAs (ncRNAs) and transcription factors that regulate the module are predicted based on hypergeometric testing. (cellmolbiol.org)
In conclusion, we recognized the ncRNA pivot (including miR-193b-3p, CRNDE, etc.) and TF pivot (including E2F1, E2F4, etc.) that significantly regulate dysfunction modules. (cellmolbiol.org)

We have discovered that E2F1 localizes to sites of both DNA double-strand breaks and UV-induced DNA damage and that this involves the phosphorylation of E2F1 by the ATM or ATR kinases. (mdanderson.org)
The physiological relevance of E2F1 in the DNA damage response is now being explored using a novel knock-in mouse model we developed that blocks E2F1 phosphorylation by ATM/ATR. (mdanderson.org)
We also observed that down-regulation of the phosphorylation of retinoblastoma protein (pRB) by this compound was associated with enhanced binding of pRB and the transcription factor E2F-1. (dsmc.or.kr)

Key factors of the pentose phosphate pathway and linoleic acid metabolism, G6PD and CYP2C8/9/18/19, respectively, are related to the survival of PC patients according to our tissue microarray. (aging-us.com)
The pRb-E2F pathway is a critical point of regulation in the cell cycle and loss of control of the pathway is a hallmark of cancer. (ox.ac.uk)
Our results suggest a causal relationship between PRMT5 and E2F1 in driving the malignant phenotype and thereby highlight an important pathway for therapeutic intervention. (ox.ac.uk)
We have developed a model of insulin signalling in rodent adipocytes that includes both transcriptional feedback through the Forkhead box type O (FOXO) transcription factor, and interaction with oxidative stress, in addition to the core pathway. (biomedcentral.com)
Here we demonstrate that, during brain maturation, the potential of the intrinsic apoptotic pathway is progressively reduced and that such repression is associated with downregulation of apoptotic protease-activating factor-1 (Apaf-1) and caspase-3 gene expression. (jneurosci.org)

BRD4 has a fundamental role in the regulation of gene expression and thus became a promising epigenetic therapeutic candidate to target diverse pathologies. (indiaeducationdiary.in)
e.g. inflammation, genotoxicity, and This chapter focuses on issues as- ellers, growth factors, growth factor epigenetic alterations) and can have sociated with the understanding and receptors, signal transducers, and both genetic and epigenetic origins. (who.int)

Here, we explored the mechanistic role of RIP140 in breast cancer and its involvement in estrogen receptor α (ERα) transcriptional regulation of gene expression. (aacrjournals.org)

MicroRNAs are an abundant class of small non-coding RNAs that play key roles in gene regulation. (thegomap.org)
MicroRNAs are also integral components of this gene regulation net- work because miR-107, miR-424, miR-570, miR-618, and miR-760 are regulated by 17beta-estradiol along with other microRNAs that can target a significant number of transcripts belonging to one or more estrogen-respon- sive gene clusters. (unica.it)
SncRNAs are less than 200 nt in length, consisting of microRNAs (miRNAs), Piwi-interacting RNAs (piRNAs), endogenous small interfering RNAs (endo-siRNAs or esiRNAs) and transcription initiation RNAs (tiRNAs) [ 6 ]. (ijbs.com)

Alterations in this balance under pathological conditions are generally mediated through up-regulation of pro-angiogenic and/or downregulation of anti-angiogenic factors, leading to growth of new and abnormal blood vessels. (bvsalud.org)
The underlying mechanism lies in that miR-20b-5p overall enhanced both CCND1 and E2F1 targets via bidirectional regulation probably involving direct downregulation and indirect upregulation. (researchsquare.com)
S transition in the cell cycle, upregulated expression of tumor-promoting microenvironmental factors, and profound dysregulation of metabolic pathways (e.g., increased aerobic glycolysis, downregulation of pathways that metabolize drugs and xenobiotics). (biomedcentral.com)

So far, the studies which explore the relationship between the E2F1 polymorphisms and ovarian cancer susceptibility are rare. (hindawi.com)

Desogestrel binds intracellular progesterone receptors in progesterone responsive tissue and the resultant complex interacts with DNA and results in either gene transcription or gene repression. (medindex.am)

Therefore, it is of great significance to explore the mechanism of tumorigenesis in breast cancer and further identify key regulatory factors. (researchsquare.com)

The encoded protein contains two different binding sites that are known to bind DNA and function as a regulator of gene transcription. (biolegend.com)

At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
Microfluidic-based analyses of single-cell dynamics in response to dynamic biochemical signals are emerging as pivotal approaches for investigating the effects of extracellular microenvironmental biochemical factors on cellular structure, function, and behavior. (bvsalud.org)
Our results also suggest that regulation of let-7 by mutant p53 plays an important role in driving cellular proliferation and increasing cell migration and invasion. (thegomap.org)
E2F transcription factors are a family of master regulators that coordinate gene expression during cellular proliferation and diverse cell fates. (ox.ac.uk)

This review expounds the up- or down-regulation of lncRNAs in OSCC and the molecular mechanisms by which lncRNAs perform their function in the malignant cell. (biomedcentral.com)
Based on biological analysis, miR-20b-5p was hypothesized to be a key factor due to the malignant behavior of BCSCs. (researchsquare.com)

Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
Most significantly, a coincidence was apparent between the expression of PRMT5 and E2F1 in human tumours, and elevated levels of PRMT5 and E2F1 correlated with poor prognosis disease. (ox.ac.uk)
Finally, we manually assembled a proposed regulation network model of subcutaneous preadipocyte differentiation base on the expression data, and suggested that E2F1 may serve as an important link between the processes of duck subcutaneous preadipocyte proliferation and differentiation. (biomedcentral.com)
Our results shed light on a new transcription-based mechanism that mediates the inflammatory effect of PAD4 and establish the interplay between citrullination and acetylation in the control of E2F-1 as a regulatory interface for driving inflammatory gene expression. (ox.ac.uk)
Loss of Ecd led to marked down-regulation of E2F target gene expression. (unmc.edu)
Intervertebral disc degeneration Protein interaction network Enrichment Co-expression analysis Regulatory factors. (cellmolbiol.org)
The expression of distorted DNA-binding factors was studied in developing zebrafish using UV-damaged DNA as the binding target. (ncl.edu.tw)
Dedieu S, Canron X, Rezvani HR, Bouchecareilh M, Mazurier F, Sinisi R, Zanda M, Moenner M, Bikfalvi A, North S. The cytoprotective drug amifostine modifies both expression and activity of the pro-angiogenic factor VEGF-A. BMC Med. (u-bordeaux.fr)
RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding complex with CBFB. (biolegend.com)

The main reason is that the regulation mechanism of the tumor cell cycle is damaged, which leads to uncontrolled cell growth. (hindawi.com)
Regulation of MCL1 through the AR signaling axis is indirectly mediated via a cell cycle-dependent mechanism. (oncotarget.com)

Normal oral keratinocytes are prolonged by adverse factors, resulting in intracellular microenvironment imbalance and genetic alterations. (biomedcentral.com)

Here we have explored the functional role of the PRMT5-E2F1 axis and highlight its influence on different aspects of cancer cell biology including viability, migration, invasion and adherence. (ox.ac.uk)
Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1. (ox.ac.uk)

As a transcription factor, Pax6 acts at the molecular level in the signaling and formation of the central nervous system 11 . (biolegend.com)

MiR-20b-5p directly targeted both CCND1 and E2F1 in a dual luciferase assay, while antagomir-20b-5p downregulated the protein levels of CCND1 and E2F1. (researchsquare.com)
1) The regulation of these protein levels is vital for the understanding of the cell cycle control and its dysregulation. (ukessays.com)

Role of mammalian Ecdysoneless in cell cycle regulation. (unmc.edu)

Pax6 is a transcription factor present during embryonic development. (biolegend.com)

Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nucleotides that function as regulatory factors in many human diseases, including cancer. (jcancer.org)

Understanding factors required for DNA replication will enrich our knowledge of this important process and potentially identify vulnerabilities that can be exploited in cancer therapy. (aacrjournals.org)
Transcription factors have an important role in the ability of a cell to self-renew and also differentiate into most cell types, also known as pluripotency 1 . (biolegend.com)

Once the transcription factor binds to an enhancer region, this can cause stimulation or repression of gene transcription. (biolegend.com)

1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)

Karagianni P, Moulos P, Schmidt D, Odom DT, Talianidis I. (2020) Bookmarking by Non-pioneer Transcription Factors during Liver Development Establishes Competence for Future Gene Activation. (forth.gr)

also bHLHE76) is a 110 kDa member of the bHLH/PAS transcription factor family. (rndsystems.com)

However, our understanding of the regulatory mechanisms of AR-V7-driven transcription is limited. (cancerindex.org)

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