Transcription of adenovirus e2 gene. Medical search. Frequent questions

Several different viral vectors have been developed for gene therapy, including ret-rovirus, adenovirus, adeno-associated virus (AAV), and herpes simplex virus (HSV). (pharmacy180.com)
Here, based on significant liver contribution to the catabolism of the branched chain amino acid leucine, we develop a liver-directed adeno-associated virus (AAV8) gene therapy for MSUD. (nature.com)
In this review article, we outline key characteristics of major gene therapy viruses-adenovirus, adeno-associated virus (AAV), and lentivirus-and summarize the mechanisms regulating important steps in the virus journey from binding at peripheral nerve terminals to nuclear delivery. (frontiersin.org)

discovered to correlate using the differential ramifications of the adenovirus E1 proteins for the manifestation of mobile MHC-class I substances (Bernards gene into hematopoietic stem cells (Hoogerbrugge shown an adenovirus vector missing binding sites for indigenous receptors blood-clotting elements and complement parts in its capsid. (scienceexhibitions.org)

It also exhaustively introduces the concrete mechanism of invading GC cells and the viral genome composition of adenovirus and herpes simplex virus type 1 (HSV-1). (frontiersin.org)
While each DNA blueprint, or gene, encodes for a different machine or structure, the genome, the collection of DNA wrapped up inside the nucleus, is much more active than a quiet library of neatly stacked blue-prints. (birmingham.ac.uk)
We are investigating the impact of specific classes of gene mutations, such as ATM, BRCA1, and MYBL2 on genome integrity. (birmingham.ac.uk)
We examine the impact that processes such as transcription and replication have on genome stability. (birmingham.ac.uk)
In Utrecht Sussenbach and Van der Vliet studied the fate of adenovirus DNA in the host cells and the mechanisms that adenoviruses use to replicate their DNA genome. (scienceexhibitions.org)
The human papillomavirus (HPV) E2 protein is a multifunctional protein essential for the control of virus gene expression, genome replication and persistence. (microbiologyresearch.org)
Furthermore, co-distribution of E2 and L1 was detected in the nuclei of upper suprabasal cells in stratified epithelia of HPV16 genome-containing primary human keratinocytes. (microbiologyresearch.org)
Viral gene transfer utilizes a genetically modified natural virus with a part of the viral genome replaced by a therapeutic gene (called transgene ) and making the virus replication deficient. (pharmacy180.com)
Adenoviruses and AAVs do not integrate their genes into the host cell genome. (pharmacy180.com)
They carry an inherent risk of mutagenesis by inserting their genome (called insertion mutagenesis) within a functional gene, which can compromise the functionality of a critical normal human protein. (pharmacy180.com)
For producing transgene-containing therapeutic adenoviruses, their genome is modified by deletion of the viral replication specific gene known as early gene 1 ( E1A ). (pharmacy180.com)
In a genome-wide screen for putative tumor suppressor genes, the EBF3 locus on the human chromosome 10q26.3 was found to be deleted or methylated in 73% of the examined cases of brain tumors. (aacrjournals.org)

Vehicle den Noordaa Clinofibrate in Amsterdam and Vehicle der Eb in Leiden utilized adenovirus and SV40 as tumor-inducing real estate agents in rodent versions. (scienceexhibitions.org)
Although very clear advances are becoming produced toward oncolytic adenoviruses you can use systemically clinical execution of systemic tumor treatment with oncolytic infections is not however being considered in the Netherlands. (scienceexhibitions.org)
Distant tumors could be reached but penetration into these tumors was limited (Idema gene (Heo (2013) Clinofibrate functional antitumor immunity of Pexa-vec administration was assessed in a rabbit VX2 tumor model and in sera from treated patients. (scienceexhibitions.org)
Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development. (uchicago.edu)
Alphavirus vectors carrying therapeutic or toxic genes used for intratumoral injections have demonstrated efficient tumor regression. (genetherapynet.com)
p53 has a unique and unequivocal tumor suppression role, which has been confirmed by the cancer susceptibility of individuals affected by Li-Fraumeni syndrome, the p53 inactivation in most sporadic human cancers, and the spontaneous tumorigenesis in mice with the p53 gene knocked out [ 11 ] . (encyclopedia.pub)
p53 supports tumor suppression through its roles as transcription factor and mitochondrial membrane permeabilization (to trigger apoptosis) and, indeed, the most investigated biological activity of p53 is its transcriptional activator role [ 17 ] . (encyclopedia.pub)
NF-κB is a transcription factor that plays a pivotal role in the highly specific pattern of gene expression observed for immune, inflammatory and acute phase response genes, including interleukin 1, interleukin 8, tumor necrosis factor and certain cell adhesion molecules. (justia.com)
Isoforms of Wilms' tumor suppressor gene (WT1) have distinct effects on mammary epithelial cells. (famri.org)

Variability of the promoter region of CCR5 gene might be the reason for differing CCR5 expression levels. (biomedcentral.com)
Mechanistically, FSH, via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter, thus preventing FoxO1 from repressing SREBP-2 gene transcription. (nature.com)
OBJECTIVE- Sulforaphane is an activator of transcription factor NF-E2-related factor-2 (nrf2) that regulates gene expression through the promoter antioxidant response element (ARE). (diabetesjournals.org)
EBF3 bound directly to p21 cip1/waf1 promoter and regulated transcription from both p21 cip1/waf1 and p27 kip1 promoters in reporter assays. (aacrjournals.org)

Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy. (docksci.com)
The Human Papillomavirus (HPV) E2 protein, which inhibits the E6 and E7 viral oncogenes, is believed to have antioncogenic properties. (docksci.com)
This work pinpoints E2 as a key protein in the initiation of HPV-induced cervical cancer and identiﬁes the SAC as a target for oncogenic pathogens. (docksci.com)
Here, we show for the first time to our knowledge that HPV16 E2 directly associates with the major capsid protein L1, independently of other viral or cellular proteins. (microbiologyresearch.org)
Upon co-expression in keratinocytes, L1 reduces nucleolar association of E2 protein, and when co-expressed with E1 and E2, L1 is partially recruited to viral replication factories. (microbiologyresearch.org)
Characterization of the human papillomavirus E2 protein: evidence of trans-activation and trans-repression in cervical keratinocytes. (microbiologyresearch.org)
Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
Genes Dev 2007, 21:379-84) that can express the BrafV600E mutant protein following Cre-mediated recombination. (refine.bio)
The protein plays a role in regulating DNA topology and activation of RIBOSOMAL RNA transcription. (childrensmercy.org)

Developed in the United Kingdom by Oxford University and British-Swedish company AstraZeneca, using as a vector the modified chimpanzee adenovirus ChAdOx1. (wikipedia.org)
As a result the vector exhibited reduced capability to bind human being erythrocytes strongly decreased hepatic tropism and improved bioavailability upon systemic delivery to mice (Schagen (2014) who proven the potential of utilizing T-cell-derived Jurkat cells to provide oncolytic adenovirus towards the primary and infiltrative areas of intracranial glioma in mice therefore opening potential for potential autologous T-cell-mediated oncolytic pathogen delivery. (scienceexhibitions.org)
Subgroup B and F fiber chimeras eliminate normal adenovirus type 5 vector transduction in vitro and in vivo. (cornell.edu)
The adenovirus vector infects epithelial cells expressing the coxsackievirus and adenovirus receptor (CAR). (bvsalud.org)

In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)
Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). (bvsalud.org)
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. (lookformedical.com)
The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)

Gene therapy is a method for the treatment or prevention of disease that uses genes to provide the patient's somatic cells with the genetic information necessary to produce specific therapeutic proteins needed to correct or to modulate a disease. (pharmacy180.com)
The promise of gene therapy is to overcome limitations associated with the administration of therapeutic proteins, including low bio-availability, inadequate pharmacokinetic profiles, and high manufacturing cost. (pharmacy180.com)
Removing these structural genes and inserting therapeutic genes in their place make muLV-based vectors. (pharmacy180.com)
As an autosomal recessive monogenic disease, MSUD represents an ideal target for liver-directed gene therapy since clinical OLT data suggests that incomplete restoration of liver BCKD enzyme activity (representing 9-13% of body BCKD activity 10 ) is fully therapeutic. (nature.com)
This constitutes a strong rationale for testing liver gene transfer as a therapeutic option for MSUD. (nature.com)
Additionally, we describe how neuropathology can negatively influence these pathways, and conclude by discussing opportunities to optimize the intramuscular administration route to maximize gene delivery and thus therapeutic potential. (frontiersin.org)

Upon infection, human adenovirus (HAdV) must block interferon signaling and activate the expression of its early genes to reprogram the cellular environment to support virus replication. (bepress.com)
E1A binds and appropriates components of the cellular transcriptional machinery to modulate cellular gene transcription and activate viral early genes transcription. (bepress.com)

This phenotype is associated with interaction of E2 with the Mitotic Checkpoint Complex (MCC) proteins Cdc20, MAD2 and BUBR1. (docksci.com)
While BUBR1 silencing rescues the mitotic phenotype induced by E2, p53 silencing or presence of E6/E7 (inactivating p53 and increasing BUBR1 levels respectively) both amplify it. (docksci.com)
Primary bovine intervertebral disc cells transduced with adenovirus overexpressing 12 BMPs and Sox9 maintain appropriate phenotype. (uchicago.edu)
BCKDHA gene transfer rescued the lethal phenotype. (nature.com)

Light regulation of plant gene expression by an upstream enhancer-like element. (wikidata.org)
Tissue-specific and light-regulated expression of a pea nuclear gene encoding the small subunit of ribulose-1,5-bisphosphate carboxylase. (wikidata.org)
Using cell-based assays, we show that co-expression of L1 and E2 results in enhanced transcription and virus origin-dependent DNA replication. (microbiologyresearch.org)
The expression of Recombinant adenovirus IkappaBalphaM in human hepatocarcinoma HepG2 and it's inhibitive effect to the activity of NF-kappaB]. (uchicago.edu)
This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
This class of noncoding RNAs is small, single stranded, and 19-25 nucleotide long that act as negative regulators involved in posttranscriptional silencing of the gene expression [ 5 ]. (hindawi.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
Thus, the duration of gene expression is much longer with retroviruses (weeks to months) as compared to adenoviruses and AAVs (days to weeks). (pharmacy180.com)
Genes introduced into cells using adenoviral vectors are maintained extrachromosomally in the nucleus and provides transient transgene expression. (pharmacy180.com)
RESULTS- Activation of nrf2 by sulforaphane induced nuclear translocation of nrf2 and increased ARE-linked gene expression, for example, three- to fivefold increased expression of transketolase and glutathione reductase. (diabetesjournals.org)
Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)
Application of replication-deficient vectors leads to short-term expression, which makes these vectors highly attractive for cancer gene therapy. (genetherapynet.com)
IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression. (harvard.edu)
The expression of cyclin-dependent kinase inhibitors was profoundly affected with early activation and then repression of p21 cip1/waf1 and persistent activation of both p27 kip1 and p57 kip2 , whereas genes involved in cell survival and proliferation were suppressed. (aacrjournals.org)
CreERT2 expression occurs only in tissues where the Cdx2 gene is expressed, which is almost exclusively in adult mouse cecum and colon epithelium. (refine.bio)
Gene expression profiling in pulmonary hypertension. (famri.org)
BACKGROUND: Small, non-coding microRNAs, usually of 20-25 nucleotides, are known to regulate the post-transcriptional gene expression, which has a significant role in human biological processes, including immune-biogenesis, homeostasis and infection control as differential expression of such miRNAs is responsible for fine-tuning the organismic development. (bvsalud.org)

Characterization of adenovirus-mediated gene transfer in rabbit flexor tendons. (uchicago.edu)

These findings indicate miR-34a along with its putative target genes could play a role in RCC tumorigenesis and progression. (hindawi.com)
the regulatory regions of target genes. (scirp.org)

In addition, transcription prediction showed that mutation of these 6 SNPs might alternate the binding of particular transcription factors. (biomedcentral.com)
These studies identified the role of the human transcription factors NF-I and NF-III/OCT1 in orchestrating the initiation complex involved in adenovirus type 5 DNA replication illustrating the interplay between cellular and viral processes involved with adenovirus replication [evaluated in (Hoeben and Uil 2013 The observations that some infections could change cells were interesting and stimulated research to Clinofibrate acquire insights in the procedures involved in mobile transformation. (scienceexhibitions.org)
Genes that encode highly conserved TRANSCRIPTION FACTORS that control positional identity of cells (BODY PATTERNING) and MORPHOGENESIS throughout development. (lookformedical.com)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. (lookformedical.com)
In common with other transcription factors, p53 is composed of three distinct domains, which are responsible for oligomerization, transcriptional activation and sequence-specific DNA-binding [ 22 ] [ 23 ] . (encyclopedia.pub)
These proteins are transcription factors that control developmental pathways. (nih.gov)
Hepatocyte nuclear factors are a family of evolutionarily conserved transcription factors that are preferentially expressed in HEPATOCYTES. (umassmed.edu)
this family of proteins is hereafter called EBF) are a group of DNA-binding transcription factors with the basic helix-loop-helix (bHLH) domain. (aacrjournals.org)
A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG. (ucdenver.edu)

Approximately 70 years ago, several DNA viruses such as adenovirus, human Epstein-Barr virus, polyoma and SV40 were found to be able to cause tumors in humans and rodents [ 1 ] . (encyclopedia.pub)

Graham and Vehicle der Eb proven that human being cells too could possibly be changed by nude adenovirus DNA utilizing their Clinofibrate calcium mineral phosphate co-precipitation way of the effective transfer of nude DNA into Clinofibrate focus on cells (Graham and vehicle der Eb 1973 Subsequently these methods were used to review the variations in oncogenic potential from the adenovirus types 5 and 12. (scienceexhibitions.org)
Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus. (microbiologyresearch.org)

Adusumilli PS, Chan MK, Hezel M, Yu Z, Stiles BM, Chou TC, Rusch VW, Fong Y. Radiation-induced cellular DNA damage repair response enhances viral gene therapy efficacy in the treatment of malignant pleural mesothelioma. (famri.org)

The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
Taken together, our findings suggest that the interaction between E2 and L1 is important for the regulation of E2 function during the late events of the HPV life cycle. (microbiologyresearch.org)

The BCKD enzyme is a multimeric enzyme complex with four components, branched-chain keto acid decarboxylase alpha and beta subunits (E1 α and E1 β ), dihydrolipoyl transacylase (E2) subunit, and dihydrolipoamide dehydrogenase (E3) subunit. (nature.com)

Their sequences contain a 180 nucleotide sequence designated the homeobox, so called because mutations of these genes often results in homeotic transformations, in which one body structure replaces another. (lookformedical.com)

The human CCR5 gene located on 3p21.31, is composed of four exons and two introns. (biomedcentral.com)
The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes. (microbiologyresearch.org)
A novel interaction between the human papillomavirus type 16 E2 and E1^E4 proteins leads to stabilization of E2. (microbiologyresearch.org)
It also gives the homologous human gene IDs we used for enrichment testing, which were 1-to-1 best homologs according to build 68 of NCBI's Homologene. (refine.bio)
A second supplementary sheet shows the data we enrichment tested after collapsing to distinct human homologs, joins of the results of tests with GSE4045 data and of tests with TCGA data to the mouse genes, and the intersections of selected genes in those data set with our gene selections in mouse. (refine.bio)

To identify potential viral pathogens, we performed reverse transcription PCR (RT-PCR) to detect a panel of viruses, including canine distemper virus, canine parvovirus, canine coronavirus, and canine adenovirus. (cdc.gov)
Adenoviruses are nonenveloped DNA viruses carrying linear double-stranded DNA of about 35 kb length. (pharmacy180.com)
Administration of gene therapy viruses into skeletal muscle, where distal terminals of motor and sensory neurons reside, has been shown to result in extensive transduction of cells within the spinal cord, brainstem, and sensory ganglia. (frontiersin.org)
Gene therapy viruses are non-replicating, but still hijack host cell machinery to express transgenes of interest in the nucleus. (frontiersin.org)

The Braf(CA) (Braf-Cre-activated) allele mice carry a gene-targeted allele of Braf, where Braf sequences from exons 15-18 are present in the normal mouse Braf intron 14, followed by a mutated exon 15 (carrying the V600E mutation). (refine.bio)

Defective retroviral vectors are devoid of the genes encoding viral pro-teins but retain the ability to infect cells and insert their genes into the chromosomes of the target cells. (pharmacy180.com)
Their special ability to infect and integrate into nondividing cells has application for the construction of lentiviral vectors for gene deliv-ery into nondividing, terminally differentiated cells such as neuronal tissue, hematopoietic cells, and myofibers. (pharmacy180.com)
Adenoviral vectors are based on natural adenoviruses of serotypes 2 and 5. (pharmacy180.com)
In these first generation adenoviral-vectors, additional partial dele-tions of E1B and E3 genes can be made to create more space for transgene insertion. (pharmacy180.com)
Alphaviruses are of interest to gene therapy researchers, in particular the Ross River virus, Sindbis virus, Semliki Forest virus, and Venezuelan Equine Encephalitis virus have all been used to develop viral vectors for gene delivery. (genetherapynet.com)
The stable integration of viral genes is mediated by the retroviral interiors of these vectors. (genetherapynet.com)

Moreover, blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor ( FSHR ) gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding. (nature.com)
We propose that antiplatelet agents targeting thromboxane A2 receptor signaling such as low-dose aspirin merit consideration for chemoprophylaxis when administering the adenovirus based COVID-19 vaccines to young adults at risk of thrombosis provided there are no contraindications. (bvsalud.org)

Desogestrel binds intracellular progesterone receptors in progesterone responsive tissue and the resultant complex interacts with DNA and results in either gene transcription or gene repression. (medindex.am)

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)

During the initial phase of infection, these processes are orchestrated by the first HAdV gene expressed during infection, early region 1A (E1A). (bepress.com)

Furthermore, the use of whole alphaviruses for gene therapy is of limited efficacy both because several internal alphaviral proteins are involved in the induction of apoptosis upon infection and also because the alphaviral capsid mediates only the transient introduction of mRNA into host cells. (genetherapynet.com)

Furthermore, we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX) mice, in which a normal level of estrogen (E2) was maintained by exogenous supplementation. (nature.com)

RNA interference-mediated gene silencing of vascular endothelial growth factor in colon cancer cells. (uchicago.edu)
Pharmacological disruption of the Notch transcription factor complex. (harvard.edu)
En el CITOPLASMA, las proteínas B I-kappa se unen al factor de transcripción NF-KAPPA B. La estimulación celular causa su disociación y traslocación del NF-kappa B activo al núcleo. (bvsalud.org)
In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. (bvsalud.org)

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. (wikidata.org)
This shed light on the viral and cellular proteins that are involved in adenovirus replication. (scienceexhibitions.org)
E2 is expressed throughout the differentiation-dependent virus life cycle and is functionally regulated by association with multiple viral and cellular proteins. (microbiologyresearch.org)
In addition, the subcellular distribution of mitochondria can affect the cellular transcriptome and transcription rates. (hindawi.com)

Virus-mediated gene therapy has the potential to deliver exogenous genetic material into specific cell types to promote survival and counteract disease. (frontiersin.org)

Nrf2 regulates the transcription of a battery of protective and metabolic enzymes. (diabetesjournals.org)
Several major species of E2 enzymes have been characterized in mammalian cells, plants, and yeast. (justia.com)

Alphaviral envelope pseudotypes of retroviruses or lentiviruses are able to integrate the genes that they carry into the expansive range of potential host cells that are recognized and infected by the alphaviral envelope proteins E2 and E1. (genetherapynet.com)

Here we show efficacy of gene therapy for MSUD demonstrating its potential for clinical translation. (nature.com)

This can be recapitulated in vitro by treating MSCs with inflammatory cytokines TNF α and IFN γ , which induce indoleamine 2,3-dioxygenase (IDO) and TNF-stimulated gene-6 (TSG-6). (biomedcentral.com)

Light-stimulated transcription of genes for two chloroplast polypeptides in isolated pea leaf nuclei. (wikidata.org)

There are limitations to the use of alphaviruses in the field of gene therapy due to their lack of targeting, however, through the introduction of variable antibody domains in a non-conserved loop in the structure of E2, specific populations of cells have been targeted. (genetherapynet.com)
Immediately prior to ovulation, the combination of E2 and FSH leads to the production of luteinizing-hormone (LH) receptors on the granulosa cells surrounding the lead follicle. (medscape.com)

In a rat model Idema (2011) demonstrated that distribution of adenovirus particles delivered via CED is at least partially volume dependent when the virus was infused in white matter tracts but not in the gray matter. (scienceexhibitions.org)

We have mapped the L1 binding region within E2 and show that the α -2 helices within the E2 DNA-binding domain mediate L1 interaction. (microbiologyresearch.org)

Immunoglobulin gene transcription is activated by downstream sequence elements. (wikidata.org)

They play important roles in liver-specific transcription and are critical for CELL DIFFERENTIATION and METABOLISM. (umassmed.edu)

Another clinical trial in which an oncolytic adenovirus was equipped with (Li. (scienceexhibitions.org)
With thousands of clinical trials to date, gene therapy is a flourishing strategy with great promise for the treatment of diseases impacting the nervous system. (frontiersin.org)

Potential use of Sox9 gene therapy for intervertebral degenerative disc disease. (uchicago.edu)

A fifth group of mice had the floxed Cdx2 alleles, but no CDX2P-CreERT2 gene. (refine.bio)

Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. (bvsalud.org)

Gene therapy approaches are utilized for treating genetic and acquired diseases. (pharmacy180.com)
This route is minimally invasive and therefore clinically relevant for gene therapy targeting to peripheral nerve soma. (frontiersin.org)

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. (wikidata.org)

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