Transcription mirnas regulate micro rna that regulates. Medical search. Frequent questions

Previous findings indicate that circRNAs mainly function as microRNA (miRNA) sponges to regulate the transcription and posttranscription of miRNA-targeted genes. (hindawi.com)
Because of their unique expression profile and special functions, miRNAs have been used as molecular markers to define the direction and processes of cell differentiation by regulating one or several target genes. (researchsquare.com)
In most cases, circRNAs usually act as a competitive endogenous RNA (ceRNA) that can absorb miRNAs to regulate the expression of targeted genes [ 9 ]. (hindawi.com)
Using a combination of miRNA hairpin predictions and co-mapping with miRBase entries, we identified a highly conserved cluster of miRNA genes on the X chromosome in the tammar and a total of 94 other predicted miRNA producing genes. (biomedcentral.com)
Mapping all miRNAs to the tammar genome and comparing target genes among tammar, mouse and human, we identified 163 conserved target genes. (biomedcentral.com)
An additional nine genes were identified in tammar that do not have an orthologous miRNA target in human and likely represent novel miRNA-regulated genes in the tammar. (biomedcentral.com)
The characterization of new miRNA target genes and a unique profile for crasiRNAs has allowed for insight into multiple RNA mediated processes in the tammar, including gene regulation, species incompatibilities, centromere and chromosome function. (biomedcentral.com)
Finally, we constructed the drug, transcription factors (TFs), and microRNA network of the diagnostic genes. (nature.com)
The expression levels of most RcLOX genes could be up-regulated by aphid infestation, suggesting potential roles in aphid resistance. (bvsalud.org)
1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. (ukessays.com)
Besides cancer, some miRNAs genes cause or contribute in many inherited and genetic based diseases. (ukessays.com)
As miRNAs proposed to control the expression up to one third of all genes and possibly utilised as diagnostic and prognostic marker for many genetic based diseases. (ukessays.com)
The latest version of miRBase consists of 1881 human miRNAs, and most of them regulate more than 60% of human protein-coding genes. (biomedcentral.com)
miRNAs regulate target genes through biological processes, such as cell growth, proliferation, differentiation and apoptosis. (biomedcentral.com)
each microRNA regulates ~200 genes. (wjst.de)
The experimental knockdown of liver specific mouse microRNA shows ~300 up- and ~300 down regulated genes. (wjst.de)
Upregulated genes have in approximately 50% of cases one miRNA nucleus, downregulated ones have even less than average binding sites. (wjst.de)

miRNAs are thought to have regulatory roles through complementarity to mRNA. (wikipedia.org)
Bioinformatic predictions suggest that the human EGFR mRNA 3'-untranslated region contains three microRNA-7 (miR-7) target sites, which are not conserved across mammals. (wikipedia.org)
CircRNAs are newly discovered noncoding RNAs formed through the alternative splicing of premessenger RNA (mRNA). (hindawi.com)
These miRNAs which targeted β -catenin mRNA were confirmed by dual-luciferase reporter system and RNA-pulldown. (hindawi.com)
MicroRNAs (miRNAs) are a class of short non-coding RNAs that primarily regulate protein synthesis through reversible translational repression or mRNA degradation. (uzh.ch)
The first class of small RNAs identified were the micro RNAs (miRNAs), which are small (~22 nt) non-coding RNAs that regulate gene expression by base pairing to mRNAs where they direct either mRNA cleavage or repress translation [ 8 ]. (biomedcentral.com)
The mature miRNA is then loaded onto an Argonaute protein (Ago2 in humans) where it then interacts with and regulates the mRNA target. (biomedcentral.com)
Non-coding RNA (ncRNA) such as microRNA (miRNA) and long non-coding RNA (lncRNA) regulates the translation and/or stability of multiple mRNA targets either directly or by modulation of signal transduction pathways. (frontiersin.org)
Whereas transcription elements and epigenetic systems are in Prinaberel charge of transcriptional control, posttranscriptional legislation (splicing, mRNA editing, balance, translatability, and localization) frequently depends upon RNA-binding protein (RBP) [4]. (iassist2012.org)
Additionally, KSRP is certainly involved with different posttranscriptional procedures, such as legislation of mRNA splicing, balance, and translatability and microRNA (miRNA) maturation. (iassist2012.org)
The binding of miRNA- protein complexes to mRNA causes translation inhibition or destabilisation of target transcripts. (ukessays.com)
CircRNAs play a critical role in biological processes including transcription, mRNA splicing, RNA decay and translation [ 15 ]. (ijbs.com)
As binding of miRNAs to a target mRNA may result in an airway inflammatory disease closely correlates with either mRNA degradation or inhibition of protein immune regulation, more and more evidences suggest translation.1 More than 2000 miRNAs have been discovered in humans. (cdc.gov)

MicroRNAs (miRNAs) are endogenous noncoding RNAs that act as post-transcriptional regulators of gene expression by binding to the 3′-untranslated region (UTR) of target mRNAs. (nature.com)
Circular RNAs (circRNAs) are a large group of endogenous non-coding RNAs which are key members of gene regulatory processes. (ijbs.com)
Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs with a covalently closed continuous loop that lacks 5'-3' polarity structure. (ijbs.com)
MicroRNAs (miRNAs) are small endogenous non-coding RNAs with length of about 22 nt and can regulate gene expression mainly through post-transcription [ 1 ]. (biomedcentral.com)

In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
MicroRNAs (miRNAs or miRs) are small non-coding RNAs that participate in diverse cellular processes and negatively regulate gene expression at the post-transcriptional level by binding with 3′-untranslated regions (3′-UTRs) ( 2 - 4 ). (spandidos-publications.com)
Small RNAs play important roles in many aspects of pre- and post-transcriptional gene regulation, epigenetic modifications, chromosome segregation and genome structure. (biomedcentral.com)
In addition, circRNAs can regulate gene expression at transcriptional or post-transcriptional levels by titrating microRNAs (miRNAs), regulating transcription and interfering with splicing [ 13 , 14 ]. (ijbs.com)

This review highlights the current fund of knowledge regarding the known links between miRNAs and the EndMT process, with a focus on the mechanism that regulates associated signaling pathways and discusses the potential for the EndMT as a therapeutic target to treat many diseases. (bmbreports.org)
Finally, we identified 76 therapeutic agents, 152 miRNAs targets, and 91 TFs regulatory networks. (nature.com)
Moreover, let-7 is a potential therapeutic miRNA for prevention of tumorigenesis. (biomedcentral.com)
Understanding the roles of Asthma is a worldwide problem, the prevalence of miRNAs in asthma pathogenesis may also aid to asthma ranged from 1% to 18% of the population in explore new therapeutic targets. (cdc.gov)

miRNAs are transcribed as ~70 nucleotide precursors (modelled here) and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. (wikipedia.org)
MicroRNAs are ~22-25 nucleotide non-coding RNAs. (ukessays.com)
MiRNAs are approximately 19- to 25-nucleotide estimated about 250,000 and mortality does not appear single-stranded, noncoding RNAs that exist in both to correlate well with prevalence. (cdc.gov)

While long noncoding RNAs (lncRNAs) are important i. (researchgate.net)
While long noncoding RNAs (lncRNAs) are important in cardiac development and disease, their role in physiol. (researchgate.net)
Long noncoding-RNAs (lncRNAs) are critical regulators of cardiac development as well as pathological hypertrophy and heart failure (HF). (researchgate.net)
Noncoding RNAs, including circRNAs, microRNAs, and lncRNAs, have become a significant focus of research attention due to their crucial role in regulating the progression of multiple malignancies [ 5 ], including bladder cancer, gastric cancer, nasopharyngeal carcinoma, and pancreatic cancer. (hindawi.com)
Yesterday evening I attended an excellent presentation by Nikolaus Rajewksy about microRNAs, small noncoding RNAs that are thought to have a role in posttranscriptional regulation. (wjst.de)

MiRNAs can also control the self-renewal or proliferation of stem cells [9]. (researchsquare.com)
β -Catenin is a transcription factor that plays an important role in cell proliferation, cellular differentiation, apoptosis, and metastasis [ 10 ]. (hindawi.com)
Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. (biomedcentral.com)
MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)
As a consequence, any modulations of the target transcript expression, miRNAs can affect various signalling pathways and cellular process such as apoptosis, proliferation or differentiation. (ukessays.com)

Mature miRNA-7 is derived from three microRNA precursors in the human genome, miR-7-1, miR-7-2 and miR-7-3. (wikipedia.org)
The miR-7 gene is found in most sequenced Urbilateria species, and the sequence of its mature miRNA product is perfectly conserved from annelids to humans, indicating a strong functional conservation. (wikipedia.org)

Exosomes secreted by the umbilical cord mesenchymal stromal cells (UMSCs) and circular RNAs (circRNAs) derived from exosomes have been shown to be associated with the progression of GDM-related complications. (hindawi.com)
Studies report that circular RNAs (circRNAs) derived from exosomes may play a key role in GDM development. (hindawi.com)
Circular RNAs (circRNAs) are a form of noncoding and closed loop RNA molecules and play vital roles in the progression of various types of cancer in humans. (hindawi.com)

Here, we used RNAseq to identify a novel class of cardiac lncRNAs that are dynamically regulated by exercise. (researchgate.net)

MiRNAs that regulate components of pathways required for learning and memory further modulate the influence of epigenetics on cognition in the normal and diseased brain. (uzh.ch)

Accumulating evidence suggests that microRNAs (miRNAs) are key regulators of this network, with the capacity to target multiple messenger RNAs involved in the EndMT process as well as in the regulation of disease progression. (bmbreports.org)

This study encompasses the first analyses of the major classes of small RNAs for the newly completed tammar genome, validates preliminary annotations using deep sequencing and computational approaches, and provides a foundation for future work on tammar-specific as well as conserved, but previously unknown small RNA progenitors and targets identified herein. (biomedcentral.com)
Therefore, miRNAs could consider as cancer targets. (ukessays.com)
In this regard, computational methods are used to predict miRNAs that are most likely associated with a disease and provide experimental targets for biological experiments to save cost and time. (biomedcentral.com)
Furthermore, microRNAs are also shown to be targets for asthma therapy in the future. (cdc.gov)

miRNAs exert their effects by suppressing the translation and often inducing the degradation of their target mRNAs. (nature.com)
MiRNAs bind the 3' untranslated region (3'UTR) of target mRNAs. (ukessays.com)
Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)

Runt-related transcription factor 2 (RUNX2), a member of the RUNX family, functions as a critical regulator for osteoblast differentiation ( 14 ). (spandidos-publications.com)
Thus, as an alternative, we produced EXIQON microarray of brown and white primary murine adipocytes (prior to and following differentiation) to yield global profiles of miRNAs. (biomedcentral.com)
It has been suggested that adipogenesis is regulated by PPARβ/δ followed by PPARγ and C/EBPα promoting differentiation into mature adipocytes [ 12 ]. (biomedcentral.com)
MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)

KSRP is certainly a multifunctional, single-stranded nucleic acidity- Prinaberel (DNA- or RNA-) binding proteins. (iassist2012.org)

A large number of studies have demonstrated that the synergistic collaboration of a number of microRNAs (miRNAs), their growth factors and their downstream agents is required for the initiation and completion of pathogenesis in the liver. (wjgnet.com)
Therefore, identification of disease-related miRNAs would benefit research on pathogenesis and diagnosis. (biomedcentral.com)
MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)

This review summarizes recent data exemplifying the known roles of miRNAs in memory formation in different model organisms, and describes how neuronal plasticity regulates miRNA biogenesis, activity and degradation. (uzh.ch)

The expression of 10 adipogenesis-regulated miRNAs were studied using real-time qPCR and then we selected 5 miRNAs, that showed robust expression, were profiled in subcutaneous adipose tissue obtained from 20 humans with a range of body mass indices (BMI, range = 21-48, and all samples have U133+2 Affymetrix profiles provided). (biomedcentral.com)
He mentioned 3 classes known so far in humans: oncomiRNA, miRNA 375 myotrophin, and miRNA 122 acting on cholesterol (quite interesting as being described recently in the NEJM . (wjst.de)

In addition, Kayed et al ( 15 ) demonstrated that RUNX2 was overexpressed in PC and could be regulated by certain cytokines, including transforming growth factor β1 and bone morphogenetic protein 2. (spandidos-publications.com)
Studies in the past decade have demonstrated the essential roles of several AJC protein, including underlying actinomyosin components, actin isoforms, and intracellular signal transducer and activator of transcription (STAT) transcription factors, and nuclear factor-κB (NF-κB) in the maintenance and remission of IBD progression ( 5 ). (frontiersin.org)
Uncoupling Protein 1 (UCP-1) in the inner membrane of brown-fat mitochondria uncouples electron transport from ATP production, allowing energy dissipation, thus helping to regulate body temperature [ 3 ]. (biomedcentral.com)
This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)
A gene is a segment of DNA that provides the code to construct a protein or RNA molecule. (msdmanuals.com)

miRNAs are thought to exert a profound effect on almost every aspect of liver biology and pathology. (wjgnet.com)

As a result, it adversely regulates the appearance of immune system modulatory cytokines like TNF-and type I interferons [7, 11]. (iassist2012.org)
Zhang et al cytokines, mediators and signals and closely related to demonstrated that microRNA let-7i was upregulated immune regulation. (cdc.gov)

Previous studies have demonstrated that microRNAs (miRs) serve important roles in the progression of human cancer types, including pancreatic cancer (PC), a highly lethal malignancy. (spandidos-publications.com)

MicroRNAs (miRNAs) regulate many physiological processes including body growth. (nature.com)

High-throughput RNA sequencing and bioinformatics analysis have led to the identification of several novel circRNAs that exhibit biological characteristics and regulatory functions [ 6 , 9 ]. (hindawi.com)
Small RNAs have proven to be essential regulatory molecules encoded within eukaryotic genomes. (biomedcentral.com)

Previous studies have confirmed that miRNAs play an important role in gene regulation in CD44 + CD24 -/low breast cancer stem cells (BCSCs). (researchsquare.com)
These short RNAs participate in a diverse array of cellular processes including gene regulation, chromatin dynamics and genome defense. (biomedcentral.com)
We also discuss several crucial mechanisms of miRNAs, their relationships with transcription factors and the target gene-mediated hormone signaling interactions in the regulation of root growth and development. (chinaagrisci.com)
DC demonstrated that miRNAs participate in airway maturation, while downregulation of let-7i significantly inflammatory regulation in asthma. (cdc.gov)

A number of studies have demonstrated that altered expression of miRs serves critical roles in human cancers by directly regulating cell behaviors ( 5 - 7 ). (spandidos-publications.com)

Using bioinformatics, a luciferase reporter assay and western blot analyses, the current study identified that runt‑related transcription factor 2 (RUNX2) was a target of miR‑205 in PC and overexpression of miR‑205 suppressed the expression of RUNX2. (spandidos-publications.com)
Here we generate a UAS-miRNA library of Drosophila stocks and perform a genetic screen to identify miRNAs whose overexpression in the IPCs inhibits body growth in Drosophila . (nature.com)
The overexpression of many miRNAs in the IPCs alters wing length, both positively and negatively. (nature.com)

Recent studies, including our previous findings, have demonstrated that miRNAs play an important role in regulating biological functions [6-8]. (researchsquare.com)

MiRNAs can act by translational control of transcription factors or via direct action on the chromatin, and thereby contribute to the non-genetic control of gene-environment interactions. (uzh.ch)
If I understood that correctly, miRNA are the feedback mechanism on RNA level (with transcription factors at the DNA level). (wjst.de)

The involvement of Dicer in miRNA processing suggests a relationship with the phenomenon of RNA interference. (wikipedia.org)

MicroRNAs (miRNAs) have become a hot topic in cancer research, but the underlying mechanism of its involvement in cancer remains unclear. (researchsquare.com)
The understanding of miRNA has increased over the past 10 years, and particularly the involvement of miRNAs in cancer. (ukessays.com)
This review provides multiple perspectives on the involvement of miRNAs in regulating root growth and development in plants. (chinaagrisci.com)

Following a complex process of miRNA transcription, processing, and nuclear export, miRNAs are further processed by the RNaseIII enzyme, Dicer, and its cofactor TRBP. (biomedcentral.com)

Right here, KSRP binds towards the terminal loop of the mark miRNA precursors and thus promotes their maturation. (iassist2012.org)

This miRNA has been predicted or experimentally confirmed in a wide range of species. (wikipedia.org)
the obtained data are then combined with experimentally validated (or known) miRNA-disease networks. (biomedcentral.com)

Abnormal changes in miRNAs have been discovered in breast cancer, and miRNAs have been demonstrated to be associated with the tumorigenesis and progression of breast cancer [8, 10]. (researchsquare.com)
BACKGROUND: Human hydroxysteroid dehydrogenase-like 2 (HSDL2), which regulates cancer progression, is involved in lipid metabolism. (bvsalud.org)
However, the role of HSDL2 in cholangiocarcinoma (CCA) and the mechanism by which it regulates CCA progression by modulating ferroptosis are unclear. (bvsalud.org)

Dorsoventral (DV) patterning of the Drosophila embryo is initiated by a broad Dorsal (Dl) nuclear gradient, which is regulated by a conserved signaling pathway that includes the Toll receptor and Pelle kinase. (sdbonline.org)

Insulin/IGF signalling is the primary regulator of animal body growth, but the extent to which miRNAs act in insulin-producing cells (IPCs) is unclear. (nature.com)

In January 2021, Diagenode launched a new small RNA-sequencing solution, D-Plex Small RNA DNBSEQ Kit, compatible with MGI's DNBSEQ sequencers. (mordorintelligence.com)

Circulating extracellular RNAs (ex-RNAs) are an emerging class of biomarkers with target-organ epigenetic effects. (researchgate.net)
Since the insulin and growth phenotypes are rescued by expression of sNPFR1, we propose that the conserved miR-9a/miR-9 regulates body growth by modulating insulin signalling through its conserved sNPFR1/NPY2R target in both Drosophila and mammals. (nature.com)
Here, we report that Drosha, one of the most important components of the miRNA processing machinery, is a c-Myc target gene. (johnshopkins.edu)

Another class of important small RNAs is the piRNAs. (biomedcentral.com)
Thus, it is highly important to understand the molecular basis of miRNA control of EndMT. (bmbreports.org)
The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)

Extracellular small non-coding RNAs (exRNAs) have been associated with cardiac inflammation and fibrosis and we hypothesized that they are associated with post-MI LVRm phenotypes. (researchgate.net)
The kit incorporates unique D-Plex technology for library preparation enabling high performance with ultralow RNA inputs and providing diverse small RNA transcript detection. (mordorintelligence.com)
As part of the genome sequencing initiative for the tammar, we have explored the evolution of each of the major classes of mammalian small RNAs in an Australian marsupial for the first time, including the first genome-scale analysis of the newest class of small RNAs, centromere repeat associated short interacting RNAs (crasiRNAs). (biomedcentral.com)
Using next generation sequencing, we have characterized the major classes of small RNAs, micro (mi) RNAs, piwi interacting (pi) RNAs, and the centromere repeat associated short interacting (crasi) RNAs in the tammar. (biomedcentral.com)
We examined each of these small RNA classes with respect to the newly assembled tammar wallaby genome for gene and repeat features, salient features that define their canonical sequences, and the constitution of both highly conserved and species-specific members. (biomedcentral.com)
A survey of the tammar gonadal piRNAs shows that these small RNAs are enriched in retroelements and carry members from both marsupial and tammar-specific repeat classes. (biomedcentral.com)
Each class of small RNAs is synthesized by a distinct mechanism and each has discrete biological functions. (biomedcentral.com)

It also examines the relevance of miRNAs for memory impairment in human, using recent clinical observations related to neurodevelopmental and neurodegenerative diseases, and discusses the potential mechanisms by which these miRNAs may contribute to memory disorders. (uzh.ch)
The test uses nanoparticles to capture tumor-specific microRNAs (miRNAs) in human serum. (mordorintelligence.com)
In conclusion, we provide a preliminary analysis of miRNAs associated with primary cell in vitro adipogenesis and demonstrate that the inflammation-associated miRNA, mir-21 is up-regulated in subcutaneous adipose tissue in human obesity. (biomedcentral.com)
Approximately 30-60 % of the human genome, regulated by miRNAs. (ukessays.com)

The expression levels of RNA of hsa_circ_0046060, mmu_circ_0002819, and miR-338-3p were determined by quantitative real-time polymerase chain reaction (RT-qPCR). (hindawi.com)
However, to the best of our knowledge, the miRs that regulate RUNX2 expression in tumors are unknown. (spandidos-publications.com)
showed significant upregulation of miR-301a in the heart of diabetic ventricles to regulate expression of voltage-gated potassium channel (Kv4.2) by direct interaction with 3′UTR in the diabetes mouse (db/db) model ( 9 ). (frontiersin.org)
The c-Myc oncogenic transcription factor is known to regulate microRNA (miRNA) expression at the transcriptional level. (johnshopkins.edu)
Both in vitro andin vivo microRNA processing assays demonstrated that c-Myc promotes miRNA processing by upregulating the Drosha expression level. (johnshopkins.edu)
Overall, our study reveals a previously unrecognised function of c-Myc in miRNA processing and provides valuable insight into a new aspect of how c-Myc regulates microRNA expression. (johnshopkins.edu)

I am molecular and cellular biologist with expertise in virus and microRNAs. (researchgate.net)

The Dl and Twist proteins appear to make synergistic contact with the basal transcription complex, so that snail is activated throughout the presumptive mesoderm in response to both peak and high levels of the Dl gradient. (sdbonline.org)

This method not only depends on known miRNA-diseases associations but also accurately measures miRNA and disease similarity and resolves the problem of overestimation. (biomedcentral.com)

Chances are that KSRP modulates cytokine creation also via its capability to promote the maturation of a particular subset of miRNAs [12]. (iassist2012.org)

Computational methods help select potential disease-related miRNAs to improve the efficiency of biological experiments. (biomedcentral.com)

Biological experiments have confirmed the association between miRNAs and various diseases. (biomedcentral.com)
FCMDAP also exhibits satisfactory performance in predicting diseases without any related miRNAs and miRNAs without any related diseases. (biomedcentral.com)

Anatomy8

Organisms9

Chemicals and Drugs95

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes74

Disciplines and Occupations1

Information Science3

Genes17

MRNA13

Endogenous4

Post-transcriptional4

Therapeutic4

Nucleotide3

Noncoding RNAs5

Proliferation5

Mature miRNA2

Circular RNAs3

LncRNAs1

Pathways1

Regulators1

Targets4

MRNAs3

Differentiation4

Single stranded1

Pathogenesis3

Biogenesis1

Humans2

Protein6

Exert1

Cytokines2

Roles in the progression1

Physiological1

Regulatory2

Regulation4

Cancers1

Overexpression3

Role in regulating1

Factors2

Interference1

Involvement3

Dicer1

Precursors1

Experimentally2

Progression3

Pathway1

Unclear1

20211

Target3

Important3

Small7

Human4

Expression6

Molecular1

Proteins1

Similarity1

Maturation1

Methods1

Diseases2