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Leucine ZippersTranscription FactorsTranscription, GeneticBasic-Leucine Zipper Transcription FactorsMolecular Sequence DataAmino Acid SequenceBase SequenceDNA-Binding ProteinsPromoter Regions, GeneticGene Expression RegulationG-Box Binding FactorsTranscriptional ActivationBinding SitesProtein BindingBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsTrans-ActivatorsRNA, MessengerNuclear ProteinsCell LineDNAMutationDimerizationRepressor ProteinsRecombinant Fusion ProteinsSequence Homology, Amino AcidSp1 Transcription FactorProto-Oncogene Proteins c-junCloning, MolecularTransfectionProtein Structure, TertiaryHelix-Loop-Helix MotifsCell NucleusPlasmidsTranscription Factor AP-1HeLa CellsSaccharomyces cerevisiae ProteinsSignal TransductionSequence AlignmentDNA, ComplementaryTranscription Initiation SiteActivating Transcription FactorsFungal ProteinsGenes, ReporterCells, CulturedCCAAT-Enhancer-Binding ProteinsHomeodomain ProteinsActivating Transcription Factor 2Cyclic AMP Response Element-Binding ProteinGene Expression Regulation, DevelopmentalActivating Transcription Factor 3Activating Transcription Factor 4Mutagenesis, Site-DirectedOncogene Protein p65(gag-jun)Saccharomyces cerevisiaeEscherichia coliProto-Oncogene Proteins c-fosGene ExpressionRegulatory Sequences, Nucleic AcidBasic Helix-Loop-Helix Transcription FactorsRecombinant ProteinsRNA Polymerase IITwo-Hybrid System TechniquesReverse Transcriptase Polymerase Chain ReactionMicrophthalmia-Associated Transcription FactorCell DifferentiationSTAT3 Transcription FactorPlant ProteinsElectrophoretic Mobility Shift AssayEnhancer Elements, GeneticZinc FingersPhosphorylationRestriction MappingGene Expression Regulation, FungalCarrier ProteinsUpstream Stimulatory FactorsGene Expression Regulation, PlantChromatin ImmunoprecipitationMacromolecular SubstancesAmino Acid MotifsBlotting, NorthernTranscription Factors, TFIIBacterial ProteinsSequence Homology, Nucleic AcidTranscription Factor TFIIDTumor Cells, CulturedDNA-Directed RNA PolymerasesLeucyl AminopeptidaseConserved SequenceCOS CellsLuciferasesKineticsReverse TranscriptionGene Expression Regulation, BacterialProtein BiosynthesisBlotting, WesternOligodeoxyribonucleotidesProto-Oncogene Proteins c-mycConsensus SequenceModels, MolecularProtein Conformation
Neural retina leucine zipperHomeodomain-leucine zipperProteinProteinsEukaryoticGeneHELIX-LOOP-HFactorsBHLHBZIP transcription factor familyKinaseArabidopsisPoorlyGenesFamilyMetabolismRegulationMRNADomainReplicationApoptosisCellsPlantsRetina leucine zipperBasicProteinsRegulatorEukaryoticNeuralResiduesHomeoboxSignaling pathwayPREDICTEDDifferentiationInducing transcription factorDownstreamVariantsGene transcriptionDomainsActivateHuman
Neural retina leucine zipper1
  • To describe the clinical phenotype and genetic basis of non-syndromic retinitis pigmentosa (RP) in one family and two sporadic cases with biallelic mutations in the transcription factor neural retina leucine zipper ( NRL) . (molvis.org)
Homeodomain-leucine zipper1
  • Homeodomain-leucine zipper transcription factors (HDZip TFs) are known as modulators of morphogenesis in response to environmental stimuli and plant development programs. (agrisera.com)
Protein12
  • Examples include Microphthalmia-associated transcription factor and Sterol regulatory element binding protein (SREBP). (wikipedia.org)
  • Activated and released IRE1α acts as an RNase to initiate transcription of XBP1 mRNA and it becomes a transcriptional activator for unfolded protein response (UPR) gene targets, such as BiP and calreticulin ( 10 ). (spandidos-publications.com)
  • String-based protein-protein interaction analysis suggested that bZIP53, a transcription factor might be involved in the activation of transcription of ELO / KCS genes. (nature.com)
  • The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. (cancerindex.org)
  • A basic Leucine Zipper (bZIP) transcription factor protein is the candidate gene for bc-u. bZIP protein gene Phvul.005G124100 carries a unique non-synonymous mutation at codon 14 in the first exon (Pv05: 36,114,516 bases), resulting in a premature termination codon that causes a nonfunctional protein. (usda.gov)
  • MAX dimerization (MXD) protein 3 (MXD3) is a member of the MXD family of basic-helix-loop-helix-leucine-zipper (bHLHZ) transcription factors that plays pivotal roles in cell cycle progression and cell proliferation. (researchgate.net)
  • Sterol regulatory element binding protein (SREBP)-1 is a transcription factor with important roles in the control of fatty acid metabolism and adipogenesis. (diabetesjournals.org)
  • Chronic ER stress promotes apoptosis, at least in part through the UPR-induced transcription factor C/EBP homologous protein (CHOP). (jci.org)
  • HD-Zip protein usually contain two highly conserved domains: homeodomain (HD) and leucine zipper (LZ) [ 1 ]. (biomedcentral.com)
  • The leucine zipper domain forms a dimer that is essential for HD-Zip protein recognition of DNA [ 3 ]. (biomedcentral.com)
  • MYC associated factor X (MAX) is a gene that encodes a protein belongs to the basic helix-loop-helix leucine zipper (bHLHZ) transcription factor family. (mycancergenome.org)
  • A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. (bvsalud.org)
Proteins5
Eukaryotic4
Gene4
  • c-maf is a transcription factor for IL-10 gene expression in LPS-activated macrophages. (thermofisher.com)
  • This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. (cancerindex.org)
  • MLX may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4.The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. (prosci-inc.com)
  • We show with chromosome conformation capture and gene-expression analysis that the rs17713054-affected enhancer upregulates the interacting gene, leucine zipper transcription factor like 1 (LZTFL1). (cdc.gov)
HELIX-LOOP-H1
Factors20
  • Basic helix-loop-helix leucine zipper transcription factors are, as their name indicates, transcription factors containing both Basic helix-loop-helix and leucine zipper motifs. (wikipedia.org)
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
  • This graph shows the total number of publications written about "Basic Helix-Loop-Helix Leucine Zipper Transcription Factors" by people in UAMS Profiles by year, and whether "Basic Helix-Loop-Helix Leucine Zipper Transcription Factors" was a major or minor topic of these publications. (uams.edu)
  • Below are the most recent publications written about "Basic Helix-Loop-Helix Leucine Zipper Transcription Factors" by people in Profiles over the past ten years. (uams.edu)
  • Among all JA downstream transcription factors, MYC2 is considered as the fatal point of the entire JA signaling pathway ( Kazan and Manners, 2013 ). (frontiersin.org)
  • The basic leucine zipper (bZIP) transcription factor (TF) is one of the largest families of transcription factors (TFs). (biomedcentral.com)
  • Important regulatory factors, TFs bind to the promoter regions of target genes and activate or inhibit their transcription. (biomedcentral.com)
  • c-maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. (thermofisher.com)
  • MLX belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. (prosci-inc.com)
  • Subsequently, as a Research Fellow at the Laboratory of Metabolism, NCI, Bethesda he examined the role of basic leucine zipper transcription factors in lipoatrophic diabetes, carcinogenesis and addiction. (nih.gov)
  • Given that transcription factors act as central regulators of a diversity of developmental and physiological processes, such differences may partly account for the evolutionary distance between these entirely different life forms. (biomedcentral.com)
  • A variety of prominent transcription factor families are present in all four species, including Myb, basic helix-loop-helix, basic leucine zipper, C2H2 zinc finger and homeodomain transcription factors. (biomedcentral.com)
  • As well as several small families, the large families of AP2/EREBP, NAC and WRKY transcription factors, consisting of 144, 109 and 72 members, respectively, are found exclusively in plants. (biomedcentral.com)
  • Exon shuffling has led to transcription factors unique to plants that contain both homeodomains and leucine zippers. (biomedcentral.com)
  • In particular, the existence of a great variety of transcription factors that are unique to distinct kingdoms, such as the large plant-specific AP2/EREBP and WRKY families and the animal-specific nuclear hormone receptors, reflects the need for specific solutions that meet the regulatory challenges connected with entirely different developmental programs and life styles. (biomedcentral.com)
  • Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. (biomedcentral.com)
  • HD-Zips (Homeodomain-Leucine Zippers) are a class of plant-specific transcription factors that play multiple roles in plant growth and development. (biomedcentral.com)
  • These 23 PpHDZ transcription factors all contained a homeomorphism box domain and a leucine zipper domain, were divided into 4 subfamilies(I-IV) according to the evolutionary analysis, and their promoters contained many different cis-acting elements. (biomedcentral.com)
  • HD-Zip transcription factors belong to the Homeodomain (HD) transcription factor superfamily and are only found in plants. (biomedcentral.com)
  • OBJECTIVE: Fruit set is triggered after ovule fertilization, as a consequence of the downregulation of ovary growth repressors, such as the tomato transcription factors Auxin/indole-3-acetic acid 9 (IAA9) and Agamous-like 6 (AGL6). (bvsalud.org)
BHLH1
  • Here, TcMYC2a was identified to contain a basic helix-loop-helix (bHLH)-leucine zipper domain, a bHLH-MYC_N domain, and a BIF/ACT-like domain. (frontiersin.org)
BZIP transcription factor family2
  • Conclusions: In summary, this genome-wide identification, characterization and expression analysis of legume bZIP genes provides valuable information for understanding the molecular functions and evolution of the legume bZIP transcription factor family, and highlights potential legume bZIP genes involved in regulating tissue development and abiotic stress responses. (datadryad.org)
  • Genome-wide identification and expression analysis of the bZIP transcription factor family genes in response to abiotic stress in Nicotiana tabacum L. (biomedcentral.com)
Kinase1
  • inositol-requiring enzyme 1 (IRE1α), PRKR-like ER kinase (PERK) and activating transcription factor-6 (ATF-6). (spandidos-publications.com)
Arabidopsis2
Poorly1
Genes2
  • they can combine with the promoter regions of key genes in signaling pathways to regulate their transcription levels and, in turn, plant resistance to stress. (biomedcentral.com)
  • An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (umassmed.edu)
Family2
  • MafF is a member of the basic leucine zipper (bZIP) transcription factor Maf family and is commonly downregulated in multiple cancers. (techscience.com)
  • Except for the conserved DNA-binding domains, however, there are no significant similarities between members of the same transcription factor family from different kingdoms. (biomedcentral.com)
Metabolism1
  • As a unique transcription factor in plants, HD-Zip plays an important regulatory role in plant growth and development, environmental response, cell cycle and cell metabolism [ 9 ]. (biomedcentral.com)
Regulation1
MRNA1
  • Pan troglodytes basic leucine zipper ATF-like transcription factor 2 (BATF2), transcript variant X1, mRNA. (genscript.com)
Domain4
  • The leucine-zipper domain is involved in the interaction with LRPICD. (thermofisher.com)
  • It contains one DNA binding motif (aa 41-59) with an adjacent leucine-zipper (aa 63-84), but lacks a transactivation domain. (rndsystems.com)
  • We then found that VGLUT3-persistent neurons express the runt domain transcription factor Runx1. (jneurosci.org)
  • and domain shuffling, leading to new combinations of common transcription factor domains. (biomedcentral.com)
Replication1
  • G-quadruplex (G4) DNA, an alternate structure formed by Hoogsteen hydrogen bonds between guanines in G-rich sequences, threatens genomic stability by perturbing normal DNA transactions including replication, repair, and transcription. (nih.gov)
Apoptosis1
  • Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress conditions and plays an important role in inducing cancer cell apoptosis. (hindawi.com)
Cells2
  • It is expressed in Th1 cells and conventional dendritic cells (CD11c + ), and serves to downregulate AP-1 mediated transcription. (rndsystems.com)
  • Calycosin dose- and time-dependently inhibited proliferation, migration, and invasion by T47D and MCF-7 breast cancer cells by downregulating basic leucine zipper ATF-like transcription factor expression. (news-medical.net)
Plants1
  • Although some functions of HD-Zip transcription factor have been reported in several plants, it has not been comprehensively studied in peach, especially during adventitious root formation of peach cuttings. (biomedcentral.com)
Retina leucine zipper2
  • Bioinformatic analysis was performed to identify novel noncoding transcripts and assess their regulation by rod differentiation factor neural retina leucine zipper (NRL). (nih.gov)
  • The basic motif-leucine zipper transcription factor NRL (neural retina leucine zipper) is essential for rod photoreceptor specification in the mammalian retina. (thomassci.com)
Basic15
Proteins8
  • All HD-ZIP superclass proteins possess HD and leucine-zipper (LZ) domains. (frontiersin.org)
  • A number of eukaryotic proteins, which probably are sequence specific DNA- binding proteins that act as transcription factors, share a conserved domain of 40 to 50 amino acid residues. (embl.de)
  • The hairy-related proteins (hairy, E(spl), deadpan) also repress transcription although they can bind DNA. (embl.de)
  • Mouse helix-loop-helix proteins MATH-1 and MATH-2 which activate E box- dependent transcription in collaboration with E47. (embl.de)
  • This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. (caslab.com)
  • The number of proteins that constitute functional transcription factors may therefore be higher than that reported in this paper. (biomedcentral.com)
  • p40 has no apparent similarity to gag proteins, but contains a leucine zipper region which may be responsible for the occurrence of p40 multimers. (nih.gov)
  • Another type of DNA segment, the so-called Alu sequence, also inserts in new positions in human chromo- somes, but Alu segments do not appear to encode en- zymes or other proteins that are expected to be required for their own transposition. (nih.gov)
Regulator2
  • family of transcription regulator in plant stress are largely unclear. (alliedacademies.org)
  • The well-conserved transcriptional regulator Signal Transducer and Activator of Transcription (STAT) promotes cell migration, but its signaling is modulated by downstream targets Apontic (APT) and Slow Border Cells (SLBO). (sdbonline.org)
Eukaryotic1
  • We believe that an approach, such as the one shown here, could help to understand the one regulation of transcription in eukaryotic cells. (hindawi.com)
Neural1
  • SOX9 is a transcription factor essential for multipotent neural stem cell (NSC) formation and maintenance. (thomassci.com)
Residues1
  • Leucine zippers differ from other 2-helix coiled coils only in that their d-residues are almost invariably Leu. (proteopedia.org)
Homeobox1
  • The researchers identified semidominant alleles (variants of DNA sequences) for a class of III home-odomain-leucine zipper transcription factor, HOMEOBOX DOMAIN-2 (HB-2) on wheat A and D subgenomes, which generate more flower-bearding spikelets. (foodnavigator.com)
Signaling pathway1
  • 1) The transcription factor TFAP4 is a new limiting component of the WNT signaling pathway. (nih.gov)
PREDICTED1
  • PREDICTED: activating transcription factor 6 beta-like[Saccoglossus kowalevskii]. (bioinformatics.org)
Differentiation1
  • AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. (nih.gov)
Inducing transcription factor6
  • Melanocyte inducing transcription factor helps control the development and function of pigment-producing cells called melanocytes. (medlineplus.gov)
  • Additionally, melanocyte inducing transcription factor regulates the development of specialized cells in the eye called retinal pigment epithelial cells. (medlineplus.gov)
  • Some research indicates that melanocyte inducing transcription factor also regulates the development of cells that break down and remove bone (osteoclasts) and cells that play a role in allergic reactions (mast cells). (medlineplus.gov)
  • The structure of melanocyte inducing transcription factor includes three critically important regions. (medlineplus.gov)
  • Dimers incorporating the abnormal melanocyte inducing transcription factor cannot be transported into the cell nucleus to bind with DNA. (medlineplus.gov)
  • Some MITF gene variants change the amino acids used to make melanocyte inducing transcription factor, which alters the helix-loop-helix or leucine-zipper motif. (medlineplus.gov)
Downstream2
  • Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. (nih.gov)
  • We have stimulated isolated double positive T cells (DPs) with anti-CD3 to mimic positive selection and compared basal and stimulated transcription across the four genotypes to discover the downstream targets of Sap1a involved in positive selection. (gsea-msigdb.org)
Variants1
  • To unravel the molecular basis of such coupled preferences, we determined two high-resolution structures of the transcription factor MafB as a homodimer and as a heterodimer with c-Fos bound to variants of the Maf-recognition element. (rcsb.org)
Gene transcription1
  • The said phenomena are indicative of a sophisticated machinery involved in the regulation of gene transcription: highly connected TFs are also regulated by others, which may (or may not) be highly connected. (hindawi.com)
Domains1
  • and domain shuffling, leading to new combinations of common transcription factor domains. (biomedcentral.com)
Activate1
  • Our data provide a concept for transcription factor design to selectively activate dimer-specific pathways and binding repertoires. (rcsb.org)
Human1
  • Human transcription factor AP-4. (embl.de)