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  • chromatin
  • This decreased binding allows chromatin expansion, permitting genetic transcription to take place. (wikipedia.org)
  • It is a mistake to regard HDACs solely in the context of regulating gene transcription by modifying histones and chromatin structure, although that appears to be the predominant function. (wikipedia.org)
  • Genetic studies of the LAT-DNA have identified a portion known as a chromatin insulator which forms a boundary between activated LAT-DNA and the inactive lytic viral DNA. (wikipedia.org)
  • The TIM protein in these complexes mediate the accumulation of the dimeric PER-TIM protein complex and their subsequent importation into the nucleus, where the PER protein in these complexes then mediates the release of CYC-CLK from the chromatin, repressing CYC-CLK dependent transcription. (wikipedia.org)
  • inducible
  • Tetracycline-Controlled Transcriptional Activation is a method of inducible gene expression where transcription is reversibly turned on or off in the presence of the antibiotic tetracycline or one of its derivatives (e.g. doxycycline). (wikipedia.org)
  • repress
  • In B. subtilis, DnaA has previously been shown to repress its own transcription and has also been implicated in directing part of the transcriptional response to replication stress. (mit.edu)
  • cell's
  • The steps contributing to the production of primary transcripts involve a series of molecular interactions that initiate transcription of DNA within a cell's nucleus. (wikipedia.org)
  • To initiate the transcription process in a cell's nucleus, DNA double helices are unwound and hydrogen bonds connecting compatible nucleic acids of DNA are broken to produce two unconnected single DNA strands. (wikipedia.org)
  • loci
  • Evidence from various studies has shown that genetic susceptibility to T2DM is polygenic [ 5 , 6 ], and Genome Wide Association Studies (GWAS) have reported more than 20 genetic loci associated with the risk of T2DM [ 7 , 8 ]. (hindawi.com)
  • Complex haploinsufficiency, which occurs when a strain containing two heterozygous mutations at distinct loci shows a phenotype that is distinct from either of the corresponding single heterozygous mutants, is an expedient approach to genetic interactions analysis in diploid organisms. (g3journal.org)
  • introns
  • must be replaced by that of a transcription unit containing regions which will be lost from the mature messenger - which I suggest we call introns (for intragenic regions) - alternating with regions which will be expressed - exons. (wikipedia.org)
  • However, different types of introns were identified through the examination of intron structure by DNA sequence analysis, together with genetic and biochemical analysis of RNA splicing reactions. (wikipedia.org)
  • Following transcription into RNA, group I and group II introns also make extensive internal interactions that allow them to fold into a specific, complex three-dimensional architecture. (wikipedia.org)
  • interaction
  • Because of the largely diploid nature of the human fungal pathogen Candida albicans , genetic interaction analysis has been limited to a small number of large-scale screens and a handful for gene-by-gene studies. (g3journal.org)
  • Here, we describe the construction of a barcoded-library of 133 heterozygous TF deletion mutants and deletion cassettes for designed to facilitate complex haploinsufficiency-based genetic interaction studies of the TF networks in C. albicans . (g3journal.org)
  • The genetic interaction networks at each stage of biofilm formation are significantly different indicating that the network is not static but dynamic. (g3journal.org)
  • One area of C. albicans genetic analysis that has not been extensively developed compared to other systems is genetic interaction analysis. (g3journal.org)
  • metabolic
  • Classical examples of biocomplexity include the behavior of molecular motors during DNA transcription, genetic and metabolic networks within cells, the interacting filaments of the cytoskeleton, which allow the cell to move, the differentiation, organization and movement of cells during embryonic development, the function of the networks of neurons which compose the brain and the schooling of fish or birds. (wikipedia.org)
  • protein
  • It has been suggested that transcription factor 7-like 2 protein (TCF7L2) plays an important role in glucose metabolism by regulating the production level of glucagon-like peptide-1, a hormone which modifies glucose-dependent insulin secretion. (semanticscholar.org)
  • Regulation thus occurs primarily through the negative feedback by the PER-TIM protein complex in the transcription-translation feedback loop described above. (wikipedia.org)
  • factor
  • Transcription factor 7-like 2 gene ( TCF7L2 ) and peroxisome proliferator-activated receptors- γ 2 ( PPAR- γ 2 ) have a profound effect on the incidence of type 2 diabetes mellitus (T2DM) and had previously been found to be associated with T2DM risk in various ppopulations. (hindawi.com)
  • The cyc gene is located on the left arm of chromosome 3 and codes for a transcription factor containing a basic helix-loop-helix (bHLH) domain and a PAS domain. (wikipedia.org)
  • NFE2L1 is a cap 'n' collar, basic-leucine zipper (bZIP) transcription factor. (wikipedia.org)
  • translation
  • This cycle is called the transcription-translation feedback loop as demonstrated in this video by the Howard Hughes Medical Institution. (wikipedia.org)
  • CK1ε and CK1δ are essential in the genetic transcription-translation (and post-translation) feedback loops that generate circadian rhythm in mammals. (wikipedia.org)
  • Studies in cyanobacteria, however, changed our view of the clock mechanism, since it was found by Kondo and colleagues that these single-cell organisms could maintain accurate 24-hour timing in the absence of transcription, i.e. there was no requirement for a transcription-translation autoregulatory feedback loop for rhythms. (wikipedia.org)
  • involves
  • Within the last decade, studies have revealed that abortive initiation involves DNA scrunching, in which RNA polymerase remains stationary while it unwinds and pulls downstream DNA into the transcription complex to pass the nucleotides through the polymerase active site, thereby transcribing the DNA without moving. (wikipedia.org)
  • Initiation
  • After each nucleotide-addition step in initial transcription, RNA polymerase, stochastically, can proceed on the pathway toward promoter escape (productive initiation) or can release the RNA product and revert to the RNA polymerase-promoter open complex (abortive initiation). (wikipedia.org)
  • It had been observed that RNA polymerase did not escape from the promoter during transcription initiation, so it was unknown how the enzyme could read the DNA strand to transcribe it without moving downstream. (wikipedia.org)
  • Arabidopsis
  • The first successful example of TF-based genetic engineering for increased NUE is the improvement of Arabidopsis growth under nitrogen-limited conditions, which was achieved using the maize TF gene Dof1 . (springer.com)
  • In this chapter, we summarize the concept underlying TF-based genetic engineering of NUE and provide a list of TFs shown to be potentially useful for genetically modifying NUE in the model plant Arabidopsis and several crop species. (springer.com)
  • regulation
  • It is involved in controlling both the sleep-wake cycle and circadian regulation of gene expression by promoting transcription in a negative feedback mechanism. (wikipedia.org)
  • extent
  • have now used a technique called global run-on sequencing to measure the extent of transcription in many different types of leukemia cells. (elifesciences.org)
  • To determine the extent of genetic variations and the nature of swine HEV infections in U.S. pigs, we developed a universal reverse transcription-PCR (RT-PCR) assay that is capable of detecting genetically divergent strains of HEV. (pubmedcentralcanada.ca)
  • activation
  • Arrhenius graphs for both these rates are given, and the activation energies mtieasured are 11,000 calories per mole for decay and 22,000 calories per mole for transcription. (sciencemag.org)
  • cell
  • TRANSCRIPTION - The cell makes a copy of the gene whose message is to be interpreted. (thehumangenome.co.uk)
  • Moreover, this clock was reconstructed in a test tube (i.e., in the absence of any cell components), proving that accurate 24-hour clocks can be formed without the need for genetic feedback circuits. (wikipedia.org)
  • yield
  • A primary transcript is the single-stranded ribonucleic acid (RNA) product synthesized by transcription of DNA, and processed to yield various mature RNA products such as mRNAs, tRNAs, and rRNAs. (wikipedia.org)
  • Research
  • This discovery of endogenous R-loops, in conjunction with rapid advances in genetic sequencing technologies, inspired a blossoming of R-loop research in the early 2000s that continues to this day. (wikipedia.org)
  • allows
  • Enclosed within the envelope is a capsid surrounding single stranded RNA, integrase, protease, and reverse transcriptase, an enzyme that allows for the reversal of genetic transcription. (wikipedia.org)
  • cancer
  • In November 1993, the National Forum on Breast Cancer issued a recommendation to develop a policy with respect to genetic screening and to consider whether there should be legislated protection for women in such areas as privacy, insurance and misuse of data. (docplayer.net)
  • Objectives The objective of this study was to assess current knowledge, perceptions, attitudes and practices of women with a family history of breast or ovarian cancer regarding issues that pertain to breast cancer genetic testing and insurance. (docplayer.net)
  • 6 Family Members with Breast or Ovarian Cancer Breast Cancer Genetic Testing and Insurance Most first degree relatives with breast or ovarian cancer were sisters or mothers of the participant. (docplayer.net)
  • There has been a body of work discussing the view that cancer arises from genetic instability. (biomedcentral.com)
  • multiple
  • The key of our method is the systematic purification of several tagged components of the protein complex in multiple genetic deletion strains, which serve to compromise the integrity of the complex. (embopress.org)
  • code
  • An example is the N-glycosylation site motif: Asn, followed by anything but Pro, followed by either Ser or Thr, followed by anything but Pro where the three-letter abbreviations are the conventional designations for amino acids (see genetic code). (wikipedia.org)
  • elements
  • In early work (1980's), he discovered mobile genetic elements in Haloarchaea, while a graduate student with H. Gobind Khorana (Nobel Laureate) and Uttam L. RajBhandary. (wikipedia.org)
  • suggest
  • Expression analyses of the c.[124A;125_130delallele suggest that MC1R transcription may be regulated epigenetically in rabbits with the Japanese brindling phenotype. (biomedcentral.com)
  • However contrary to the animal model claims, human genetic data might suggest that the effect may be indirect Uteroglobin knockout mice on the inbred 129 strain appear to have healthy phenotype (no glomerulopathy development), but show physiological differences in their responses to respiratory challenges. (wikipedia.org)
  • effect
  • Segregation in F 1 and F 2 families confirmed the order of dominance already determined by classical genetic experiments with a possible dose effect evident comparing e J / e J and e J / e animals. (biomedcentral.com)