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  • Genetic
  • Finally, because one copy of the TFII-I gene is deleted in Williams-Beuren syndrome (WBS), our work implicates TLS deficiency as a potential causal factor of this human genetic disorder. (scienceopen.com)
  • When RNA Pol II stalls, or when transcription cannot properly terminate, RNA/DNA hybrids (R-loops) have extended half-lives that result in DNA double strand break (DSB) formation and genetic instability. (grantome.com)
  • interaction
  • We hypothesize that KUB5/HERA plays dual roles in the cell to: (i) regulate RNA Pol II to terminate RNA transcription via its interaction with the RNA Pol II CTD domain;and (ii) stimulate NHEJ processing of complex DSBs by Ku70 and Artemis interactions. (grantome.com)
  • general
  • Our findings extend the general principle of component sharing among divergent nuclear processes and implicate TLS deficiency as a possible contributing factor in Williams-Beuren syndrome. (scienceopen.com)
  • vivo
  • These and other results reveal an important function for OCA-B in Igh 3′ enhancer function in vivo and strongly favor an enhancer mechanism involving looping and facilitated factor recruitment rather than a tracking mechanism. (wordpress.com)
  • role
  • to define the role(s) of KUB5/HERA in regulating RNA Pol II function, RNA transcription termination, and spontaneous DSB formation and chromatid aberrations. (grantome.com)
  • Role of multifunctional transcription factor TFII-I and putative tumour suppressor DBC1 in cell cycle and DNA double strand damage repair. (jove.com)
  • promote
  • Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). (genecards.org)
  • shown
  • One of the Ets factors, TEL, was recently shown to be involved in the development of the extra-embryonic blood vessels. (ahajournals.org)
  • important
  • TLR4 ligation initiates a signalling cascade in macrophages that leads to the production of proinflammatory molecules, of which tumor necrosis factor (TNF) is one of the most important . (prolekarniky.cz)
  • cell
  • Spatiotemporally controlled delivery of soluble factors for stem cell differentiation. (jove.com)
  • development
  • Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice. (jax.org)