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Transcription FactorsTranscription, GeneticPromoter Regions, GeneticDNA-Binding ProteinsSp1 Transcription FactorGene Expression RegulationMolecular Sequence DataBase SequenceTranscriptional ActivationBinding SitesTrans-ActivatorsBasic Helix-Loop-Helix Transcription FactorsRNA, MessengerProtein BindingNuclear ProteinsTranscription Factor AP-1Repressor ProteinsCell LineForkhead Transcription FactorsHomeodomain ProteinsGene Expression Regulation, DevelopmentalSignal TransductionAmino Acid SequenceDNABasic-Leucine Zipper Transcription FactorsTranscription Factor AP-2MutationCell NucleusCell DifferentiationTransfectionKruppel-Like Transcription FactorsTranscription Factors, TFIIChromatin ImmunoprecipitationGenes, ReporterYY1 Transcription FactorHeLa CellsSTAT3 Transcription FactorGATA4 Transcription FactorTranscription Factor TFIIDCells, CulturedActivating Transcription Factor 3NFATC Transcription FactorsSp3 Transcription FactorTranscription Initiation SiteNF-kappa BReverse Transcriptase Polymerase Chain ReactionZinc FingersPaired Box Transcription FactorsElectrophoretic Mobility Shift AssayActivating Transcription Factor 2Transcription Factor TFIIBEnhancer Elements, GeneticRegulatory Sequences, Nucleic AcidE2F1 Transcription FactorRNA Polymerase IIGene Expression ProfilingCloning, MolecularBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMEF2 Transcription FactorsRecombinant Fusion ProteinsPlasmidsGATA3 Transcription FactorGATA1 Transcription FactorGATA2 Transcription FactorGene ExpressionGene Expression Regulation, FungalTCF Transcription FactorsGATA Transcription FactorsMicrophthalmia-Associated Transcription FactorLuciferasesSTAT1 Transcription FactorProtein Structure, TertiaryActivating Transcription FactorsTranscription Factor RelAE2F Transcription FactorsCell Line, TumorPhosphorylationHelix-Loop-Helix MotifsChromatinSaccharomyces cerevisiaeOligonucleotide Array Sequence AnalysisSaccharomyces cerevisiae ProteinsGene Expression Regulation, PlantGATA6 Transcription FactorActivating Transcription Factor 4Models, BiologicalTranscription Factor 7-Like 1 ProteinActivating Transcription Factor 1Cyclic AMP Response Element-Binding ProteinSequence Homology, Amino AcidTranscription Factor TFIIIAProto-Oncogene ProteinsBlotting, WesternMice, KnockoutTATA BoxNFI Transcription FactorsModels, GeneticTumor Cells, CulturedDown-RegulationProto-Oncogene Proteins c-jun
ProteinsGenesMotifsEvolutionarily conservedSpeciesResiduesGenomesGene RegulationChromatinPolymerasePromoterHistoneMammalianEvolutionaryElongation factorConsensus sequenceRegulatory sequencesEukaryoticEnhancerCanonicalArabidopsisFunctionalDifferentiationDistinctEncodesPromotersRegulatesEukaryotesBacteriaTranscriptionalMotifPathwaysPathwayIsolateNucleotideRegulate geneGeneticFingerprintDomainStructuresRecognitionFamilyInitiationHighlyInteractionsSaccharomycesBinding sitesBindRegulationExpressionGeneticsHumanReference SequenceSpecific
Proteins21
  • Junk DNA" is a term that was historically used to describe portions of the DNA sequence that do not code for proteins or have any known function. (blogspot.com)
  • functional" genes encoding proteins such as late embryogenesis-associated proteins, detoxification enzymes, heat shock proteins and molecular chaperones, which directly protect plants from abiotic stress, and "regulatory" genes encoding proteins such as protein kinases and transcription factors (TFs), which have roles in the perception and transduction of stress signals. (biomedcentral.com)
  • The NAC domain was deduced from three previously characterized proteins, petunia NAM (no apical meristem), Arabidopsis thaliana ATAF1/2 ( Arabidopsis thaliana activation factor 1/2) and CUC2 (cup-shaped cotyledon) [ 13 , 14 ]. (biomedcentral.com)
  • The histone H2A.F/Z (H2AZ) variant is a functionally distinct, highly conserved histone subgroup that likely represents a separate evolutionary lineage of histone H2A proteins. (sdbonline.org)
  • It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. (nih.gov)
  • Transcription factors help to regulate gene expression-turning genes on or off and dialing up or down their level of activity-often in partnership with the proteins that they bind. (mit.edu)
  • They anchor themselves and their partner proteins to DNA at binding sites in genetic regulatory sequences, bringing together the components that are needed to make gene expression happen. (mit.edu)
  • Transcription factors are a well-known family of proteins, but new research from Whitehead Institute Member Richard Young and colleagues shows that the picture we have had of them is incomplete. (mit.edu)
  • Proteins containing a region of conserved sequence, about 200 amino acids long, which encodes a particular sequence specific DNA binding domain (the T-box domain). (nih.gov)
  • These proteins are transcription factors that control developmental pathways. (nih.gov)
  • Sigma factors are a class of proteins constituting essential dissociable subunits that confer sequence-specific DNA binding properties to RNA polymerase (RNAP). (hindawi.com)
  • Using the yeast structure as a template, we have modeled the homologous domains from elongin A and CRSP70 and identified a conserved positively charged patch on the surface of all three proteins, which may be involved in conserved functional interactions with the transcriptional machinery. (embl.de)
  • Many proteins involved in eukaryotic transcription are similar in function and in sequence between organisms. (embl.de)
  • KEPE--a motif frequently superimposed on sumoylation sites in metazoan chromatin proteins and transcription factors. (ox.ac.uk)
  • As a largest plant-specific transcription factor family, NAC domain proteins play an important role in plant development and regulation of abiotic stress tolerance. (frontiersin.org)
  • We focus our attention on three families of transcription factors that are known to have roles in vertebrate chondrogenesis: Sox and the Ant- and Prd- class families of the homeodomain proteins. (europa.eu)
  • Both predicted proteins are highly conserved with other known homologous sequences, with the exception of two small domains present only in the Sof-RXR. (europa.eu)
  • The predicted structures of the Gimap proteins show common sequences and motifs, such as GTP-binding domains in the N-terminal half, but with differing C-terminal ends [ 2 , 3 ]. (hindawi.com)
  • The fact that the Gimap genes are located together in a tight cluster on RNO4 (and in conserved synteny with many other species), combined with their sequence similarities, suggests the possibility that the proteins carry out similar function. (hindawi.com)
  • Ribosome Inactivating Proteins (RIPs) are RNA N-glycosidases that depurinate a specific adenine residue in the conserved sarcin/ricin loop of the 28S rRNA. (cdc.gov)
  • All MutS proteins also contain a highly-conserved ATP-binding domain and most have weak ATPase activity. (bvsalud.org)
Genes17
  • Transcription factor II E is encoded by the GTF2E1 and GTF2E2 genes. (wikipedia.org)
  • Previous data for sequencing of 3 genes indicated that the Georgia 2007/1 isolate is closely related to isolates of genotype II, which has been identified in Mozambique, Madagascar, and Zambia. (cdc.gov)
  • Apart from identifying for any TF target genes with a conserved binding site in ten different species, also the associated gene families and Gene Ontology/InterPro annotations can be browsed. (ugent.be)
  • Our genome-wide analysis found 151 NAC transcription factor genes ( PgNAC s) in the pearl millet genome. (biomedcentral.com)
  • The pearl millet genome contains 151 NAC transcription factor genes that can be classified into 11 groups. (biomedcentral.com)
  • When transcription factors had their ARMs mutated so they couldn't bind RNA, those transcription factors were less effective in finding their target sites, remaining at those sites and regulating genes. (mit.edu)
  • We show that Stp2 physically interacts with this sequence motif, and that stp2 mutations affect the expression of genes associated with the motif. (wustl.edu)
  • Forkhead box protein M1 (FOXM1) is a key transcription factor (TF) that regulates a common set of genes related to the cell cycle in various cell types. (mdpi.com)
  • RIViT-seq technology could speed up associating transcription factors with their target genes. (doe.gov)
  • Identifying the sequences that direct the spatial and temporal expression of genes and defining their function in vivo remains a significant challenge in the annotation of vertebrate genomes. (ox.ac.uk)
  • Promoters of housekeeping genes contain built-in activating motifs for factors such as GABPA and YY1, which decrease the responsiveness of promoters to distal enhancers. (nature.com)
  • Human transcription factor IIIC (hTFIIIC) is a multisubunit complex that mediates transcription of class III genes through direct recognition of promoters (for tRNA and virus-associated RNA genes) or promoter-TFIIIA complexes (for the 5S RNA gene) and subsequent recruitment of TFIIIB and RNA polymerase III. (embl.de)
  • Our study contains an extensive sequencing and functional gene-annotation analysis of A. sativum L. The findings provide insights into the molecular basis of TFs, defensive genes, and a reference for future studies on the genetics and breeding of A. sativum L. (springeropen.com)
  • RNA sequencing has been used for the genome-wide quantification of absolute transcript levels, the identification of novel genes, the characterization of transcript structure (including 50 and 30 ends, introns, and exons), and the mining of molecular markers. (springeropen.com)
  • The absence of genomic resources renders the search for paralogous cuttlefish genes dependent upon the presence of highly conserved protein motifs within genes of interest, thus we used a degenerate primer strategy to isolate partial coding sequence from the conserved domains specific to these families. (europa.eu)
  • Our aim was to clone and sequence the cDNA of the BB diabetes prone (DP) and diabetes resistant (DR) alleles of all seven Gimap genes in the congenic DR. lyp rat line with 2 Mb of BB DP DNA introgressed onto the DR genetic background. (hindawi.com)
  • Widespread adoption of next-generation sequencing (NGS) technology has allowed for parallel sequencing of many genes. (medscape.com)
Motifs5
  • Seventeen other conserved motifs were found in PgNACs . (biomedcentral.com)
  • To identify these sequences, we developed an algorithm that searches for short, conserved sequence motifs in the genomes of related species. (wustl.edu)
  • The proportion of CqbZIPs was different in each subfamily, and members within the same subgroup shared conserved exon-intron structures and protein motifs. (biomedcentral.com)
  • the structure also revelas the basis of the immunocompromisednudemutation, as well as a preferential binding to non-methylated CpG motifs.AbstractFOXN1 is a member of the forkhead box (FOX) family of transcription factors, and plays an important role in thymic epithelial cell differentiation and function. (ox.ac.uk)
  • MutS has a conserved mismatch recognition domain characterized by GxFxE, or similar AMINO ACID MOTIFS that also occur in eukaryotic homologs such as MSH1, MSH6, and MSH8. (bvsalud.org)
Evolutionarily conserved2
  • Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III. (embl.de)
  • Comparison of amino acid sequences among MTGR1, MTG8, and Nervy revealed four evolutionarily conserved regions (NHR1 to NHR4). (embl-heidelberg.de)
Species8
  • A commonly discussed mechanism was variable levels of gene expression, but both Blencowe and Chris Burge,,, found that gene expression is relatively conserved among species. (uncommondescent.com)
  • Thioredoxin (Trx) is a 12 kDa protein present in all species with a well-conserved active site sequence comprising -Cys-Gly-Pro-Cys-, which catalyzes oxido-reductase reactions. (dissertations.se)
  • the majority of human transcription factors contain an ARM-like region between their DNA and protein binding regions, and these sequences were conserved across animal species. (mit.edu)
  • Domain I is conserved in evolution from yeast to human species and is homologous to the transcription factors elongin A and CRSP70. (embl.de)
  • Despite the sequence similarities, there are many factors that do not function across species. (embl.de)
  • However, the results presented here indicate that domain II is insufficient to confer species selectivity, and a primary determinant lies in a 30-amino acid highly conserved linker region connecting domain II with domain III. (embl.de)
  • Multiple MTG8-related sequences are found in several vertebrate species, from fish to mammals, albeit not in a urodele. (embl-heidelberg.de)
  • In recent years, the development of next-generation sequencing (NGS) technology has offered a significant and cost-efficient tool for the generation of transcriptomic datasets in nonmodel species using several platforms, such as Roche 454, Illumina HiSeq, and Applied Biosystems SOLiD [ 2 ]. (springeropen.com)
Residues5
  • The crystal structures of the conserved ETS domain of SAP-1 bound to DNA sequences from the E74 and c-fos promoters reveal that a set of conserved residues contact a GGA core DNA sequence. (rcsb.org)
  • Discrimination for sequences outside this core is mediated by DNA contacts from conserved and nonconserved protein residues and sequence-dependent DNA structural properties characteristic of A-form DNA structure. (rcsb.org)
  • A conserved charged stretch in the linker region (residues 89-95, DPTLPR) mediated the interaction with RNA polymerase II. (embl.de)
  • FOXN1 recognizes a DNA sequence that is different from the common consensus binding sequence of FH domains, although key binding residues are identical. (ox.ac.uk)
  • Here, we present the structure of FOXN1 in complex with DNA at 1.6 Å resolution, in which the DNA sequence is recognised by a mixture of direct and water-mediated contacts provided by residues in an a-helix inserted in the DNA major groove (the recognition helix). (ox.ac.uk)
Genomes2
  • So far, the genomes of quinoa and 3 other Amaranthaceae crops ( Spinacia oleracea , Beta vulgaris , and Amaranthus hypochondriacus ) have been fully sequenced. (biomedcentral.com)
  • Both genomes have been completely sequenced [ 17 , 18 ] and serve as the reference sequences for the major monocot and dicot plant lineages. (biomedcentral.com)
Gene Regulation2
  • A Collection of Conserved Non-Coding Sequences to Study Gene Regulation in Flowering Plants' (Van de Velde et al. (ugent.be)
  • This rethinking of how transcription factors work may lead to a better understanding of gene regulation, and may provide new targets for RNA-based therapeutics. (mit.edu)
Chromatin1
  • These results describe a novel pathway for regulating transcription using variant histones to modulate chromatin structure (Santisteban, 2000). (sdbonline.org)
Polymerase10
  • Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. (wikipedia.org)
  • Noteworthy, was our demonstration that although termination of DNA replication did not require specific DNA sequences, some DNA sequences did promote pausing of DNA replication forks in vivo (and DNA polymerase in vitro), and some sequences, such as thosewithin the termination region for SV40 DNA replication, did promote formation of catenated intertwines during separation of sibling chromosomes. (nih.gov)
  • Within the RNAP holoenzyme, sigma factors provide promoter recognition specificity to the polymerase and contribute to DNA strand separation, then they dissociate from RNAP core enzyme and transcription initiation follows [ 1 ]. (hindawi.com)
  • We have previously solved the structures of domains II and III, which stimulate arrested polymerase II elongation complexes in order to resume transcription. (embl.de)
  • Domain I also interacts with the transcriptionally active RNA polymerase II holoenzyme and therefore, may have a function unrelated to the previously described transcription elongation activity of TFIIS. (embl.de)
  • The RPB9 subunit of RNA polymerase II regulates transcription elongation activity and is required for the action of the transcription elongation factor, TFIIS. (embl.de)
  • The individual zinc ribbon domains, in isolation or in combination, could not stimulate transcription by a polymerase lacking RPB9, pol IIDelta9. (embl.de)
  • For example, transcript elongation factor TFIIS is highly conserved among eukaryotes, and yet the TFIIS protein from Saccharomyces cerevisiae cannot function with mammalian RNA polymerase II and vice versa. (embl.de)
  • Relative levels of gene expression throughout development were determined by quantitative polymerase chain reaction (PCR) analysis and in cases where sufficient specific gene sequence was acquired, ribonucleic acid (RNA) probes were generated to evaluate the spatial expression patterns during the period of organogenesis. (europa.eu)
  • Throat and nasal swab specimens were collected from outpatients (with influenza-like illness) and inpatients (with severe acute respiratory illness) and tested for influenza viruses using real-time reverse transcription polymerase chain reaction. (who.int)
Promoter7
  • Here we show that the maize dominant Barren inflorescence3 ( Bif3 ) mutant harbors a tandem duplicated copy of the ZmWUS1 gene, ZmWUS1-B , whose novel promoter enhances transcription in a ring-like pattern. (nature.com)
  • In this study, by characterization of the dominant maize mutant Barren inflorescence3 ( Bif3 ) we identified a tandem-duplicated copy of ZmWUS1 whose expression is dramatically enhanced by the insertion of a short stretch of chimeric proximal promoter sequence. (nature.com)
  • In addition, we validated our strategy by reproducing the previously reported interaction between a MYB-CC (PHR1) TF, a central regulator of phosphate starvation responses, with a conserved promoter fragment (IPS1 element) containing its cognate binding sequence. (upm.es)
  • Besides the vegetative sigma factor, which recognizes the "standard" promoter, many bacteria possess alternative sigma factors that confer altered promoter specificity upon RNAP [ 2 ]. (hindawi.com)
  • Here we design a high-throughput reporter assay called enhancer × promoter self-transcribing active regulatory region sequencing (ExP STARR-seq) and applied it to examine the combinatorial compatibilities of 1,000 enhancer and 1,000 promoter sequences in human K562 cells. (nature.com)
  • Together, this systematic assessment of enhancer-promoter compatibility suggests a multiplicative model tuned by enhancer and promoter class to control gene transcription in the human genome. (nature.com)
  • 8. Tran L S P,Nakashima K,Sakuma Y,et al.Isolation and functional analysis of Arabidopsis stress-inducible NAC transcription factors that bind to a drought-responsive cis-element in the early responsive to dehydration stress 1 promoter[J].The Plant Cell,2004,16(9):2481-2498. (nefu.edu.cn)
Histone7
  • Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)
  • Nucleosomes impose a block to transcription that can be overcome in vivo by remodeling complexes such as SNF/SWI and histone modification complexes such as SAGA. (sdbonline.org)
  • The variant histone H2A.Z regulates gene transcription, and deletion of the gene encoding H2A.Z strongly increases the requirement for SNF/SWI and SAGA. (sdbonline.org)
  • The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. (sdbonline.org)
  • CBP/p300 can also be important for transcription, but the recruitment of CBP/p300 and their associated histone acetylation marks do not absolutely correlate with a requirement for gene activation. (aging-us.com)
  • Relevant to the role of CBP/p300 as HATs, hyperacetylation of histone N-terminal tail lysines correlates strongly with active transcription [ 2 ]. (aging-us.com)
  • In baker's yeast, however, histone mutations can be easily made and numerous studies show that histone PTMs might not be as essential as their correlative behavior with transcription would suggest [ 9 - 14 ]. (aging-us.com)
Mammalian2
  • 2) What are the requirements for DNA replication and transcription at the beginning of mammalian development? (nih.gov)
  • Domain III has previously been shown to be readily exchanged between mammalian and yeast factors. (embl.de)
Evolutionary2
  • This thesis work focuses on understanding evolutionary aspects to explain mechanisms from two different biological systems of study: speciation of a fungal pathogen and evolution of transcription factor binding sites. (imsc.res.in)
  • In this study, we made use of extreme evolutionary sequence conservation as a filter to identify putative gene regulatory elements, and characterized the in vivo enhancer activity of a large group of non-coding elements in the human genome that are conserved in human-pufferfish, Takifugu (Fugu) rubripes, or ultraconserved in human-mouse-rat. (ox.ac.uk)
Elongation factor2
  • Translation elongation factor P (EF-P) is critical for virulence in bacteria. (cipsm.de)
  • TFIIS is a transcription elongation factor that consists of three domains. (embl.de)
Consensus sequence2
  • MOTIVATION: We noted that the sumoylation site in C/EBP homologues is conserved beyond the canonical consensus sequence for sumoylation. (ox.ac.uk)
  • FOXN1 belongs to a subset of the FOX family that recognize an alternate consensus sequence (GACGC), which is different from the more widely-recognized canonical sequence consensus RYAAAYA. (ox.ac.uk)
Regulatory sequences1
  • Completing the annotation of a genome sequence requires identifying the regulatory sequences that control gene expression. (wustl.edu)
Eukaryotic1
  • EF-P is present in all bacteria and orthologous to archaeal and eukaryotic initiation factor 5A, yet the biological function has so far remained enigmatic. (cipsm.de)
Enhancer4
  • In vivo enhancer analysis of human conserved non-coding sequences. (ox.ac.uk)
  • We tested 167 of these extremely conserved sequences in a transgenic mouse enhancer assay. (ox.ac.uk)
  • The testing of the top predictions in transgenic mice resulted in a threefold enrichment for sequences with forebrain enhancer activity. (ox.ac.uk)
  • Fig. 5: P2 promoters contain built-in enhancer sequences. (nature.com)
Canonical1
  • Comparisons with other FOX family structures reveal that the canonical and alternate DNA sequences are bound in two distinct modes, with partially different registers for the protein DNA contacts. (ox.ac.uk)
Arabidopsis6
  • The NAC [NAM (No Apical Meristem), ATAF1 ( Arabidopsis thaliana Activation Factor 1), and CUC2 (Cup-shaped Cotyledon)] transcription factor family is one of the largest transcription factor families in plants. (biomedcentral.com)
  • His Transcription factor research includes elements of Arabidopsis, Mutant, Regulation of gene expression, Transcription and Plant defense against herbivory. (research.com)
  • His primary scientific interests are in Genetics, Gene, Arabidopsis, Transcription factor and WRKY protein domain. (research.com)
  • His primary areas of investigation include Arabidopsis, Transcription factor, Cell biology, WRKY protein domain and Gene. (research.com)
  • His scientific interests lie mostly in Transcription factor, WRKY protein domain, Arabidopsis, Cell biology and Immune system. (research.com)
  • The NAC domain transcription factors in Arabidopsis function in plant development, senescence, and stress regulation. (frontiersin.org)
Functional2
  • Among these are traits that depend on functional meristems, populations of stem cells maintained by the CLAVATA-WUSCHEL (CLV-WUS) negative feedback-loop that controls the expression of the WUS homeobox transcription factor. (nature.com)
  • The most NH2-terminal of these is proportionately more conserved among the human polypeptides, presumably due to specific structural/functional constraints. (embl-heidelberg.de)
Differentiation8
  • We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
  • The basic helix-loop-helix transcription factor NeuroD (Neurod1) has been implicated in neuronal fate determination, differentiation and survival. (biologists.com)
  • Here, we show that loss of Runx/Cbfβ transcription factors complexes during DC development leads to loss of CD103 + CD11b + cDC2s and alters characteristics of CD103 − CD11b + cDCs in the intestine, which was accompanied with impaired differentiation of Rorγt + Th17 cells and type 3 Rorγt + regulatory T cells. (life-science-alliance.org)
  • 13. Endo H,Yamaguchi M,Tamura T,et al.Multiple classes of transcription factors regulate the expression of VASCULAR-RELATED NAC-DOMAIN7,a master switch of xylem vessel differentiation[J].Plant and Cell Physiology,2015,56(2):242-254. (nefu.edu.cn)
  • Ectopic expression of AML1-MTG8 in L-G murine myeloid progenitor cells inhibits differentiation to mature neutrophils and induces cell proliferation in response to granulocyte colony-stimulating factor (G-CSF). (embl-heidelberg.de)
  • Use of this method to target doublesex (a gene involved in sex differentiation) or fork head (which encodes a salivary gland transcription factor) resulted in reduced target gene expression and/or protein immunofluorescence signal, as measured by quantitative Real-Time PCR (qRT-PCR) or fluorescence confocal microscopy, respectively. (cdc.gov)
  • First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)
  • Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
Distinct3
  • Consequent to this rapid evolution, recently reported strains are indicating cross identification within the previously defined four distinct geographical clades.We propose a rapid and specific colony PCR-based clade identification system (CLaID) that uses unique DNA sequence junctions conserved in clade-specific manner for the classification of newly found strains of C.auris. (imsc.res.in)
  • 3. Olsen A N,Ernst H A,LEGGIO L L,et al.NAC transcription factors:structurally distinct,functionally diverse[J].Trends in Plant Science,2005,10(2):79-87. (nefu.edu.cn)
  • Comparison of the three predicted human MTG8-related polypeptides to their Drosophila counterpart (nervy) highlights four separate regions of sequence conservation that may correspond to distinct domains. (embl-heidelberg.de)
Encodes1
  • This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. (nih.gov)
Promoters1
  • As a proof of concept, in silico analyses of several Brassicaceae LIP1 promoters identified a highly conserved sequence (LIP1 element) that is sufficient to drive strong expression of a reporter gene in planta. (upm.es)
Regulates1
Eukaryotes1
  • The basic leucine zipper (bZIP) transcription factor represents exclusively in eukaryotes and can be related to many biological processes. (biomedcentral.com)
Bacteria1
  • Based on the results of the spectrum diagram and sequencing, the isolated bacteria were identified as Pseudomonas oleovorans and were positive to reactions of ADH, MTE, CIT, MLT, ONPG, and ACE. (bvsalud.org)
Transcriptional1
  • His study explores the link between Transcription factor and topics such as Transcription that cross with problems in Reprogramming, Transcriptional Networks and Reporter gene. (research.com)
Motif1
  • This revealed significant enrichment of the motif using different Gene Ontology terms (e.g. 'transcription') that pertain to the nucleus. (ox.ac.uk)
Pathways2
  • In garlic, the next-generation sequencing analysis based on RNA from renewal buds resulted in de novo assembly of 128,000 unigenes that were annotated and analyzed with respect to Gene Ontology (GO) and metabolic pathways [ 28 ]. (springeropen.com)
  • Our results indicated that CmNAC1 is a critical factor in ABA signaling pathways and it can be utilized in transgenic breeding to improve the abiotic stress tolerance of crops. (frontiersin.org)
Pathway1
  • 10. Robertson M.Two transcription factors are negative regulators of gibberellin response in the HvSPY-signaling pathway in barley aleurone[J].Plant Physiology,2004,136(1):2747-2761. (nefu.edu.cn)
Isolate2
  • We report the complete genomic coding sequence of the Georgia 2007/1 isolate and comparison with other isolates. (cdc.gov)
  • Phylogeny based on concatenated sequences of 125 conserved ORFs showed that this isolate clustered most closely with the Mkuzi 1979 isolate. (cdc.gov)
Nucleotide3
  • Transcription factors (TFs), which bind to specific nucleotide sequences, have been shown to play important roles in the regulatory networks of numerous developmental processes in plants. (ashs.org)
  • Over 932 Mb of end sequence was analyzed for repeats, simple sequence repeats, miRNA and single nucleotide variations, providing the most extensive analysis of Oryza sequence to date. (biomedcentral.com)
  • Here we report the construction of 12 BAC/BES framework physical maps derived from these libraries and an analysis of the BESs in terms of transposable element, simple sequence repeat (SSR), microRNA (miRNA), and single nucleotide variation (SNV) content. (biomedcentral.com)
Regulate gene1
Genetic1
  • e.g. inflammation, genotoxicity, and This chapter focuses on issues as- ellers, growth factors, growth factor epigenetic alterations) and can have sociated with the understanding and receptors, signal transducers, and both genetic and epigenetic origins. (who.int)
Fingerprint1
  • We describe the establishment and analysis of a genus-wide comparative framework composed of 12 bacterial artificial chromosome fingerprint and end-sequenced physical maps representing the 10 genome types of Oryza aligned to the O. sativa ssp. (biomedcentral.com)
Domain8
  • WUS is a homeodomain transcription factor (TF) produced in the organizing center (OC) domain of apical meristems and is transported via plasmodesmata into the apical domain (called central zone, CZ) to promote proliferation of stem cells 3 . (nature.com)
  • The reason that researchers had not recognized transcription factors' RNA binding region as such is because it is not a typical RNA binding domain. (mit.edu)
  • Following an initial cleavage by alpha-secretase, the resulting transmembrane domain of Notch is cleaved by gamma-secretase to release the intracellular transcription factor. (nih.gov)
  • Structure of a conserved domain common to the transcription factors TFIIS, elongin A, and CRSP70. (embl.de)
  • Imre E. Somssich focuses on Genetics, WRKY protein domain, Transcription factor, W-box and Gene. (research.com)
  • 5. Ernst H A,Olsen A N,Skriver K,et al.Structure of the conserved domain of ANAC,a member of the NAC family of transcription factors[J].EMBO Reports,2004,5(3):297-303. (nefu.edu.cn)
  • It is a member of a large family of transcription factors which recognize DNA sequences through the conserved Forkhead (FH) domain. (ox.ac.uk)
  • Transactivation assay in yeast cells revealed that CmNAC1 functions as a transcription activator, and its transactivation domain is located in the C-terminus. (frontiersin.org)
Structures1
  • Transcription factors do not contain such structures, and so standard searches for RNA binding domains had not identified them in transcription factors. (mit.edu)
Recognition1
  • We identify a single alternate rotamer within the recognition helix itself as an important determinant of DNA specificity, and indicate sequence features in the recognition helix that could be used to predict the specificity of other FOX family members. (ox.ac.uk)
Family2
  • The encoding sequence of TaNAC1 contained five typical NAC conserved domains and belonged to ATAF sub-type NAC family. (nefu.edu.cn)
  • CREB binding protein (CBP, CREBBP) and its paralog p300 (EP300) constitute the KAT3 family of HATs in mammals, which has mostly unique sequence identity compared to other HAT families. (aging-us.com)
Initiation1
  • The transcription initiation TFIID complex is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). (embl-heidelberg.de)
Highly1
  • Because recombinant antibody production involves sequencing the antibody light and heavy chains, it is a highly controlled and reliable process. (cellsignal.com)
Interactions1
  • The number, position and interactions between cis-elements and transcription factors (TFs) determine the expression pattern of a gene. (upm.es)
Saccharomyces1
Binding sites5
Bind3
Regulation2
  • The regulation of WUS transcription is crucial for meristem homeostasis, whereby high WUS expression leads to enlarged meristems and low expression leads to the formation of small meristems 3 , 14 . (nature.com)
  • We will focus particularly on the roles of a tumor suppressor, neurofibromin 2 (NF2), whose expression is not only dependent on compartment-specific transcription factors, but is also subject to regulation by a Hippo-Yap feedback signaling circuit. (molcells.org)
Expression7
  • The expression of 36 randomly selected PgNAC s were examined by quantitative reverse transcription-PCR. (biomedcentral.com)
  • Finally, the expression patterns of three neuronal type-specific transcription factors, unc-3, unc-4 and unc-30 , were altered. (biologists.com)
  • Our data suggest that cnd-1 may specify the identity of ventral cord motor neurons both by maintaining the mitotic competence of their precursors and by modulating the expression of neuronal type-specific determination factors. (biologists.com)
  • Here we report that 45% of these sequences functioned reproducibly as tissue-specific enhancers of gene expression at embryonic day 11.5. (ox.ac.uk)
  • We identified sequence signatures enriched in a subset of these elements that targeted forebrain expression, and used these features to rank all approximately 3,100 non-coding elements in the human genome that are conserved between human and Fugu. (ox.ac.uk)
  • As a transcription factor whose expression is increased by DNA damage, p53 blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
  • The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
Genetics1
  • His Transcription factor study introduces a deeper knowledge of Genetics. (research.com)
Human3
  • Young, Oksuz and Henninger got their biggest clue that researchers might be overlooking something from the human immunodeficiency virus (HIV), which produces a transcription factor-like protein called Tat. (mit.edu)
  • The researchers wondered if Tat might be more similar to human transcription factors than anyone had realized. (mit.edu)
  • The AML1-CBFbeta transcription factor complex is essential for the definitive hematopoiesis of all lineages and is the most frequent target of chromosomal rearrangements in human leukemia. (embl-heidelberg.de)
Reference Sequence1
  • Our strategy is to develop bacterial artificial chromosome (BAC)-end sequence (BES) physical frameworks of the ten genome types of Oryza and align them to the reference sequence. (biomedcentral.com)
Specific1
  • NAC-type transcription factor is one of the plant-specific gene families, which plays key roles in regulating the development and response to environmental stress in plants. (nefu.edu.cn)