• In silico analyses demonstrated that genes altered during recovery from infection were transcriptionally regulated by conserved transcription factors, including GATA/ELT-2, FOXO/DAF-16, and Nrf/SKN-1. (duke.edu)
  • As major regulators of gene expression , transcription factors play a role in all cell processes. (conservapedia.com)
  • We report here on overlapping and nonoverlapping expression patterns of transcription factors in these cells and thus provide novel insights into the dynamic networks of transcriptional regulators in embryonic and adult stem cells. (mendeley.com)
  • Beside the core Oct4-Sox2-Nanog circuitry, accumulating regulators, including transcription factors, epigenetic modifiers, microRNA and signaling molecules have also been found to play important roles in preserving pluripotency. (mdpi.com)
  • MicroRNAs (miRNAs) and transcription factors are master regulators of the cellular system. (intechopen.com)
  • Transcription factors, the key regulators of plant growth and development, are the targets of the miRNAs families. (intechopen.com)
  • Transcription factors are also regulated by cofactors, forming complexes that can activate or inhibit transcriptional activity. (qiagen.com)
  • Cellular functions regulated by FOXO transcription factors. (hindawi.com)
  • Insulin resistance and type 2 diabetes are associated with low levels of high-density lipoprotein-cholesterol (HDL-C). The insulin-repressible FoxO transcription factors are potential mediators of insulin's effect on HDL-C. FoxOs mediate a substantial portion of insulin-regulated transcription, and poor FoxO repression is thought to contribute to the excessive glucose production in diabetes. (jci.org)
  • Authoritative and cutting-edge FOXO Transcription Factors: Methods and Protocols aims to ensure successful results in the further study of this vital field. (springer.com)
  • Our results suggest that ARFs can activate or repress transcription by binding to AuxREs directly and that selected ARFs, when overexpressed, may potentiate activation further by associating with an endogenous transcription factor(s) (e.g., an ARF) that is bound to AuxREs. (pnas.org)
  • Its gene resides at the mi locus in mice, and its protumorogenic targets include factors involved in cell death, DNA replication , repair, mitosis, microRNA production, membrane trafficking, mitochondrial metabolism, and much more. (wikipedia.org)
  • distant structural relatives of the conserved cyclin core or "box" can also function as general transcription factors (like TFIIB) or survive embedded in the chain of the tumor suppressor, retinoblastoma protein. (curehunter.com)
  • FOXA1 Promotes Tumor Progression in Prostate Cancer via the Insulin-Like Growth Factor Binding Protein 3 Pathway. (psu.edu)
  • Without the correct complement of transcription factors, cells undergo an "identity crisis" and fail to execute their correct developmental programs. (washington.edu)
  • These prebound transcription factors facilitate activated transcription when auxin levels are elevated or when ARF activators are overexpressed in transfected protoplasts. (pnas.org)
  • They can act as activators or repressors , respectively increasing or decreasing the transcription of a target gene . (conservapedia.com)
  • A palindromic TGTCTC AuxRE was used as bait in a yeast one-hybrid system to isolate a transcription factor, referred to as auxin-response factor 1 (ARF1) ( 2 ). (pnas.org)
  • They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. (nih.gov)
  • To identify additional factors necessary for the inhibition of the Cdk1/Cdc28 kinase in G1, we isolated mutants that can replicate DNA in the absence of Cdc4 function. (mendeley.com)
  • These results suggest a new function for the USFs in the regulation of activity-dependent transcription in neurons. (jneurosci.org)
  • The best understood of these genes encode transcription factors, such as GATA-2, RUNX1, ETV6, and C/EBPα, which establish and maintain genetic networks governing the genesis and function of blood stem and progenitor cells. (jci.org)
  • therefore, a better understanding of factors that drive SAN development and function is crucial to generation of potential therapies, such as biological pacemakers, for sinus arrhythmias. (jci.org)
  • RNA-sequencing (RNA-seq) analyses of FACS-purified cells from ISL1-deficient SANs revealed that a number of genes critical for SAN function, including those encoding transcription factors and ion channels, were downstream of ISL1. (jci.org)
  • Fusing combinations of these elements, derived from different kingdoms, has resulted in production of diverse hybrid factors having defined DNA-binding specificity and transcriptional activation function for the target organism in question. (genetics.org)
  • Thus, it is concluded that ref1 possesses transcription repressor activity in addition to its function as a transcriptional auxiliary protein. (labome.org)
  • Overall, this study suggests that specific alternate transcripts of "activator" E2F, dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor. (sdbonline.org)
  • We avoid most of this complexity in this demonstration workflow in order to examine transcription factor binding sites in a small set of seven broadly co-expressed Saccharomyces cerevisiae genes of related function. (bioconductor.org)
  • Many genetic disorders in the brain and other organ systems have been linked to defective transcription factor function. (washington.edu)
  • Until now, no one had looked at whether there was any variability in the targets of transcription factors from one person to the next. (redorbit.com)
  • Classifying transcription factor targets and discovering relevant biological features. (openwetware.org)
  • The team mapped every binding region for these two factors inside the genomes of 10 individuals. (redorbit.com)
  • It is known that CNTF indirectly turns on the transcription factor STAT3, so the researchers wanted to determine if STAT3 is behind CNTF's protective powers. (newswise.com)
  • Researchers led by Mustafa Khammash have developed a new method that uses blue light to control the transcription of DNA into RNA in single cells. (phys.org)
  • In a series of experiments, the researchers demonstrated that a transcription factor known as TCF1 (for T cell factor-1) is essential for the creation and persistence of disease-fighting antibodies in the bloodstream. (genome.gov)
  • In the current issue of Proceedings of the National Academy of Sciences , researchers from Nationwide Children's Hospital describe a new paradigm for treating transcription factor-driven cancers. (nationwidechildrens.org)
  • Understanding how such signalling molecules interact with bHLH-PAS transcription factors should inform future drug development for a variety of unmet human conditions including cancer. (wellcome.ac.uk)
  • This is accomplished by the upregulation of a vast array of regeneration-associated genes (RAGs) including the rapid induction of transcription factors and enhanced synthesis of adhesion molecules, cytoskeletal elements, growth factors, cytokines, neuropeptides, and other molecules involved in regeneration. (frontiersin.org)
  • These molecules are composed of programmable DNA-binding ligands flexibly tethered to a small molecule that engages the transcription elongation machinery. (curefa.org)
  • Furthermore, the modular design of Syn-TEF1 defines a general framework for developing a class of molecules that license transcription elongation at targeted genomic loci. (curefa.org)
  • The activity of transcription factors determines what a cell is doing at any given moment," says Kasowski, who was a medical student at Yale when she received her HHMI medical research fellowship. (redorbit.com)
  • As a result, it alters the structure of the transcription factor itself and controls its activity. (mpg.de)
  • Neighbouring DNA segments have a significant impact on transcription factor shape, thus modulating the activity of the gene. (mpg.de)
  • In addition, adjacent DNA segments influence the activity of the bound transcription factors. (mpg.de)
  • Scientists had previously assumed that these segments exert an effect by inhibiting the binding of transcription factors, thus impeding the activity of neighbouring genes," Meijsing says. (mpg.de)
  • Reduced FoxO1 activity is therefore an important factor in the development of pulmonary hypertension. (eurekalert.org)
  • In further experiments it was found that certain growth factors and chemical messengers are responsible for reduced FoxO1 activity. (eurekalert.org)
  • The study, in Proceedings of the National Academy of Sciences, found that broad differences in the gene activity of humans and of chimpanzees, affecting nearly 1,000 genes, appear to be linked to the action of about 90 transcription factors. (innovations-report.com)
  • The analysis revealed a broad pattern of activity in 90 transcription factors that paralleled the activity of about 1,000 genes in humans and chimps. (innovations-report.com)
  • Investigating the regulatory mechanisms that control the transcription of these genes in neurons may provide important insights into activity-dependent neural development and synaptic plasticity. (jneurosci.org)
  • However, activation of CREB alone is not sufficient to mediate the activity-dependent transcription of BDNF exon III. (jneurosci.org)
  • By limiting activity to targeted loci, Syn-TEFs convert constituent modules from broad-spectrum inhibitors of transcription into gene-specific stimulators. (curefa.org)
  • We demonstrate that the activity of CRISPR-based transcription factors (crisprTFs) can be tuned by directing multiple crisprTFs to different positions in natural promoters and by arraying multiple crisprTF-binding sites in the context of synthetic promoters in yeast and human cells. (harvard.edu)
  • Consistent with the predicted loss of ETS transcription factor binding, we observed that recurrent hotspot mutations resulted in decreased luciferase activity in reporter assays. (aacrjournals.org)
  • A large family of structurally-related transcription factors that were originally discovered based upon their close sequence homology to an HMG-box domain found in SEX-DETERMINING REGION Y PROTEIN. (harvard.edu)