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  • E2F1
  • Analysis of ChIP-seq data from a panel of cell cycle transcription factors (E2F1, E2F4, E2F6, and GABPA) from the Encyclopedia of DNA Elements and ChIP-seq data for the DREAM complex finds that a set of core cell cycle genes regulated in both U2OS and HeLa cells are bound by multiple cell cycle transcription factors. (nih.gov)
  • Unlike E2F1 , E2F2 and E2F3 , which exhibit a cyclin A binding domain at their N-terminus, E2F4 has a truncated N-terminus and therefore does not harbor this domain (Beijersbergen et al. (atlasgeneticsoncology.org)
  • Schematic diagram of the amino acid sequences of E2F family members (N-terminus to the left, C-terminus to the right) highlighting the relative locations of functional domains within each member: Homo sapiens E2F1 mRNA or E2F1 protein sequences from NCBI protein and nucleotide database. (wikipedia.org)
  • E2F1-6 have DP1,2 heterodimerization domain which allows them to bind to DP1 or DP2, proteins distantly related to E2F. (wikipedia.org)
  • This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. (wikipedia.org)
  • specificity
  • Recently, mitochondrial transcription specificity factors (TFB1M and TFB2M), which markedly enhance mtDNA transcription in the presence of Tfam and mitochondrial RNA polymerase, have been identified in mammalian cells. (asm.org)
  • In Saccharomyces cerevisiae , transcription is directed by a 145-kDa core polymerase and a 43-kDa specificity factor, also known as sc-mtTFB. (asm.org)
  • A vertebrate polymerase and a specificity factor have been characterized biochemically in Xenopus laevis ( 4 ), and a cDNA that encodes human mitochondrial RNA polymerase has been isolated ( 31 ). (asm.org)
  • Most recently, two isoforms of a human mitochondrial transcription specificity factor, termed TFB1M and TFB2M (also known as h-mtTFB), have also been identified ( 9 , 20 ). (asm.org)
  • biochemical
  • Given the structural and biochemical diversity observed for trxG genes ( F rancis and K ingston 2001 ), two operational criteria are widely used to define members of this group ( S hearn 1989 ). (genetics.org)
  • complexes
  • Model of active and complexes with E2F and an 'L-X-C-X-E' peptide (Protein Data Bank (PDB) codes: 2QDJ, 1GUX, 1N4M and 2AZE). (nih.gov)
  • Even though cyclin D levels in proliferating cells are sustained as long as the growth factors are present, a key player for G1/S transition is active cyclin D-Cdk4/6 complexes. (wikipedia.org)
  • progression
  • Rb is an important regulator of genes responsible for progression through the cell cycle, in particular through G1/S phase. (wikipedia.org)
  • Role of mitogen signaling in cell cycle progression The ERK pathway plays an important role of integrating external signals from the presence of mitogens such as epidermal growth factor (EGF) into signaling events promoting cell growth and proliferation in many mammalian cell types. (wikipedia.org)
  • genomic
  • However, these statistical associations only provide evidence for genomic regions likely to harbor a causal gene(s) and do not directly identify such genes. (diabetesjournals.org)
  • nuclear
  • Moreover, ectopic expression of PGC-1α is sufficient to induce the coordinate expression of all three nucleus-encoded mitochondrial transcription factors along with nuclear and mitochondrial respiratory subunits. (asm.org)
  • The biogenesis of mitochondria requires the expression of a large number of genes encoded by both nuclear and mitochondrial genetic systems ( 10 ). (asm.org)
  • However, because the protein coding capacity of mitochondrial DNA (mtDNA) is limited to 13 respiratory subunits, nuclear genes must provide the vast majority of products required for mitochondrial oxidative functions and biosynthetic capacity. (asm.org)
  • In addition, nuclear genes must play a predominant role in controlling mitochondrial transcription, translation, and DNA replication. (asm.org)
  • loci
  • Expedient identification of genes mediating the effects of genome-wide association study-identified loci will enable mechanism-of-action studies and accelerate understanding of human disease processes under genetic influence. (diabetesjournals.org)
  • A major limitation to identification of the genes through which these loci cause disease has been the dearth of large-scale cohorts in which both gene expression and genotype data have been measured in the same individuals ( 5 ). (diabetesjournals.org)
  • are subsequently maintained by the antagonistic activities of two families of trans -regulator genes, the Polycomb and trithorax group loci (PcG and trxG, respectively). (genetics.org)
  • cell
  • In contrast to findings in other cell types, growth factor- or balloon injury-induced downregulation of the cell cycle inhibitor p27 Kip1 was not affected by rapamycin treatment. (ahajournals.org)
  • Increased sensitivity to taxanes, but not to DNA crosslinking platinum agents, was also characteristic of NCI60 cancer cell lines with a high YY1/E2F signature. (unt.edu)
  • To further determine the effects of LXR ligands and identify their potential mechanisms of action in breast cancer cells, we carried out microarray analysis of gene expression in four breast cancer cell lines following treatments with the synthetic LXR ligand GW3965. (diva-portal.org)
  • We observed cell line-specific transcriptional responses as well as a set of common responsive genes. (diva-portal.org)
  • This results in 2140 transcripts mapping to 1871 unique cell cycle-regulated genes that show periodic oscillations across multiple synchronous cell cycles. (nih.gov)
  • FOXM1 is bound to cell cycle-regulated genes with peak expression in both S phase and G2/M phases. (nih.gov)
  • These data identify the cell cycle-regulated genes in a second cancer-derived cell line and provide a comprehensive picture of the transcriptional regulatory systems controlling periodic gene expression in the human cell division cycle. (nih.gov)
  • Periodic expression of well-characterized cell cycle genes. (nih.gov)
  • Periodically expressed genes in the U2OS cell cycle. (nih.gov)
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. (genecards.org)
  • The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. (genecards.org)
  • Once the cells reach a critical cell size (and if no mating partner is present in yeast) and if growth factors and mitogens (for multicellular organism) or nutrients (for unicellular organism) are present, cells enter the cell cycle. (wikipedia.org)
  • E2F family members play a major role during the G1/S transition in mammalian and plant cell cycle (see KEGG cell cycle pathway). (wikipedia.org)
  • The signal starts when a signaling molecule binds to the receptor on the cell surface and ends when the DNA in the nucleus expresses a protein and produces some change in the cell, such as cell division. (wikipedia.org)
  • Apart from EGFR, other cell surface receptors that can activate this pathway via GRB2 include Trk A/B, Fibroblast growth factor receptor (FGFR) and PDGFR. (wikipedia.org)
  • WWC2 alias, BOMB, was researched in a grant suggesting that BOMB, along with two other genes (APOL6 and APOL1) promoted cell death in p53-null HCT116 cells. (wikipedia.org)
  • microarray
  • Clustering of microarray data for these genes revealed that high YY1/E2F3 activity positively correlates with survival of patients treated with the microtubule stabilizing drug paclitaxel. (unt.edu)