Transcription factor stat1. Medical search. Frequent questions

Coimmunoprecipitation analysis showed that PIAS1 was associated with Stat1 but not Stat2 or Stat3 after ligand stimulation. (nih.gov)
Furthermore, oxaliplatin decreased TLR-induced STAT1 and STAT3 expression, and NF-κB-mediated responses. (tue.nl)
STAT3 protein belongs to a group of intracellular transcription factors that mediate a variety of functions such as cellular differentiation, proliferation, and apoptosis. (biolegend.com)
Interestingly, ID-associated genes exhibit promoter-localized MER41 LTRs that harbor TF binding sites (TFBSs) for not only STAT1 but also other immune TFs such as, in particular, NFKB1 (Nuclear Factor Kappa B Subunit 1) and STAT3 (Signal Transducer And Activator Of Transcription 3). (biorxiv.org)
Combined treatment of IL-6 and TNF-α phosphorylated transcription factors STAT3 in a synergistic manner. (bvsalud.org)
STAT3, STAT1, and NF-κB physically interacted upon the cytokine stimulation. (bvsalud.org)
Notably, withaferin A inhibited STAT3 phosphorylation and abolished the STAT3, STAT1, and NF-κB interactions. (bvsalud.org)

Type I interferons (IFN-α, IFN-ß) bind to receptors, cause signaling via kinases, phosphorylate and activate the Jak kinases TYK2 and JAK1 and also STAT1 and STAT2. (wikipedia.org)
in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon-Stimulated Response Element) promoter element. (wikipedia.org)
All IFNαs and IFNβ bind to the same receptor and as a result, the cytoplasmic kinases JAK1 and TYK2 become activated and phosphorylate the STAT1 and STAT2 molecules. (cdc.gov)
Stat2, and interferon regulatory factor-9 (IRF-9) in interferon tau regulation of IRF-1. (tamu.edu)
The roles of Stat1, Stat2, and IRF-9 in IFNtau regulation of IRF-1 expression were determined using human stromal fibroblasts lacking specific IFN signaling components or complemented with specific Stat1 mutants. (tamu.edu)
In contrast, IFNtau did not affect IRF-1 expression in Stat1- and Stat2-deficient cells or in Stat1-deficient cells complemented with Stat1 Y701Q or Stat1 R602L mutants. (tamu.edu)
When binding to the receptor complex, Jak1 and Tyk2 will be activated, and leads to subsequent tyrosine phosphorylation of the IFN-λR1 (intracellular domain, Tyr406 and Tyr343, Tyr517), and activation of STAT1 and STAT2. (medchemexpress.com)
Activated STAT1 and STAT2 together with IRF-9 (p48) form a trimeric transcription factor complex (ISGF3). (medchemexpress.com)

STAT (signal transducer and activator of transcription) proteins are latent cytoplasmic transcription factors that become activated by tyrosine phosphorylation in response to cytokine stimulation. (nih.gov)
The in vivo PIAS1-Stat1 interaction requires phosphorylation of Stat1 on Tyr-701. (nih.gov)
After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. (thermofisher.com)
In addition to the known impact of phosphorylation on the transport and activity of STAT1, experimental evidence was provided demonstrating that acetylation affected the interaction of STAT1 with NF-kB p65, and subsequently modulated the expression of apoptosis-inducing NF-kB target genes. (uni-frankfurt.de)
In contrast, LPS-induced phosphorylation of IFN regulatory factor-3 and expression of IFN-beta or the type I IFN-regulated genes, CCL5 and CCL10, were unaltered in LRG47(-/-) cells. (duke.edu)
Further study demonstrated that the HBV polymerase protein inhibited the Stat1 nuclear translocation induced by IFN-alpha, but did not induce Stat1 degradation nor interfere with its phosphorylation. (edu.au)

STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. (wikipedia.org)
Interferons induce the formation of two transcriptional activators: gamma-activating factor (GAF) and interferon-stimulated gamma factor 3 (ISGF3). (wikipedia.org)
This paper identified changes in STAT1, the primary transcription factor activated by interferons. (sciencedaily.com)
STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. (thermofisher.com)
The analysis results establish the importance of interferons and the IRF-family of transcription factors, predicting that they are activated at 4 hours and maintained through 28 days in both blood and lung. (cdc.gov)

Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
Unexpectedly, infection of Stat1-deficient macrophages in vitro with promastigotes from Leishmania major and attenuated LPG1 knockout mutants (lpg2) specifically lacking lipophosphoglycan (LPG) resulted in a twofold increased intracellular growth, which was independent of IFNc and associated with a substantial increase in phagosomal pH. (wustl.edu)

These results identify PIAS1 as a specific inhibitor of Stat1-mediated gene activation and suggest that there may exist a specific PIAS inhibitor in every STAT signaling pathway. (nih.gov)
Further analysis of two overlapping deficiency lines and mutant alleles led to identification of genetic interactions between the CDK8-CycC pair and the components of the Decapentaplegic (Dpp, the Drosophila homolog of TGFβ, or Transforming Growth Factor-β) signaling pathway. (sdbonline.org)
It was observed that CDK8-CycC positively regulates transcription activated by Mad (Mothers against dpp) , the primary transcription factor downstream of the Dpp/TGFβ signaling pathway . (sdbonline.org)
This shows the importance of the IFNγ-Stat1 signaling pathway in colonic inflammation. (medindia.net)
Therefore, our study suggests that the STAT1 pathway can be manipulated to limit autoreactive T cells during autoimmunity directed against the CNS. (jci.org)
Furthermore, lithium chloride (Wnt activator) reversed the protective effect of STAT1 inhibition on VSMC calcification, while Dickkopf‑1 (Wnt inhibitor) exerted the opposite effect, suggesting that activation of the Wnt/β‑catenin signaling pathway was involved in STAT1‑mediated VSMC calcification. (spandidos-publications.com)
In conclusion, the present results indicated that exosomal STAT1 derived from HP‑treated HUVECs could promote VSMC calcification, and activation of the Wnt/β‑catenin pathway may be a potential mechanism of the VSMC calcification promoted by exosomes. (spandidos-publications.com)
It has also been demonstrated that STAT1 (Signal Transducer And Activator Of Transcription 1), a transcription factor (TF) crucially involved in the IFNγ pathway, binds consensus sequences that, in humans, are located with a high frequency in the LTRs (Long Terminal Repeats) of the MER41 family of primate-specific HERVs (Human Endogenous Retrovirus). (biorxiv.org)
However, the putative role of an IFNγ/STAT1/MER41 pathway in human cognition and/or behavior is still poorly documented. (biorxiv.org)
We tested the role of the JAK/ STAT1 signaling pathway in Leishmania pathogenesis by utilizing knockout mice lacking the signal transducer and activator of transcription 1 (Stat1) and derived macrophages. (wustl.edu)

Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. (wikipedia.org)
Signal transducer and activator of transcription 1 (STAT1) is a transcription factor that predominantly mediates signaling downstream of IFN-α, IFN-β, IFN-γ, and IFN-λ. (jci.org)
Analysis of site mutants showed that the region targeted by the polymerase protein contained the signal transducer and activator of transcription (Stat) binding site. (edu.au)
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84). (lu.se)
The present study demonstrated activation of B7-H1 by engaging signal transducer and activator of transcription (STAT)-1 signaling in MSCs. (korea.ac.kr)
Gene sequencing identified mutations in signal transducer and activator of transcription 1 ( STAT1 ), leading to defective immune responses in type 1 and type 17 helper T cells. (medscape.com)

Stimulation of TLRs (Toll-Like Receptors) by a pathogen induces activation of signal transduction cascades, which leads to translocation of nuclear factor-κB (NF-κB) to the nucleus [ 1 ], activation of interferon regulatory factors 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which cooperate to induce transcription of various cytokines such as alpha/beta interferon (IFN-α/β) to counteract infection [ 2 - 4 ]. (biomedcentral.com)
STAT1-deficient effector T cells became the target of NK cell-mediated killing, limiting their capacity to induce EAE. (jci.org)

STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. (thermofisher.com)
Our in silico findings report that there is cross-regulation between both pathways at the level of gene transcription regulation, mediated by the presence of binding sites for both factors in promoters of genes essential for these pathways. (biomedcentral.com)
In this paper we examine evidence for a direct crosstalk of the NF-κB and IRF3 signaling pathways at the lowest level, between main transcription factors and genes coding for these transcription factors. (biomedcentral.com)
We analyzed respective gene promoters' sequences using in silico methods for identification of transcription binding sites, mainly in the NF-κB- and IRF-coding genes. (biomedcentral.com)
Transcription factors are proteins that regulate the transcription of genes, or the production of mRNA from DNA. (biolegend.com)
The underphosphorylated, active form of Rb interacts directly with E2F1 , leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. (biolegend.com)
Interferon tau (IFNtau) is the pregnancy recognition signal produced by the conceptus trophectoderm and acts in a paracine manner on the ovine endometrium to increase expression of IFN-stimulated genes primarily in the stroma and deep glandular epithelium, including IFN regulatory factor-1 (IRF-1). (tamu.edu)
In addition, HBV polymerase could inhibit the transcriptional activity of other IFN-stimulated response element-driven promoters and the expression of interferon-stimulated genes (ISGs), such as Stat1 and ISG15. (edu.au)

RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding complex with CBFB. (biolegend.com)
RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. (biolegend.com)
Using mice with selective deletion of STAT1 in T cells (STAT1 CD4-Cre ), we identified a potentially novel mechanism by which STAT1 regulates neuroinflammation independently of Foxp3 + Tregs. (jci.org)
RHAMM regulates MMTV-PyMT-induced lung metastasis by connecting STING-dependent DNA damage sensing to interferon/STAT1 pro-apoptosis signaling. (medscape.com)

Biochemical and genetic analysis has demonstrated that Stat1 is essential for gene activation in response to interferon stimulation. (nih.gov)
They also expressed more Stat1, which is a transcription factor that upregulates gene expression in response to stimulation by IFNγ, a signaling molecule released in the presence of pathogens. (medindia.net)
Once the transcription factor binds to an enhancer region, this can cause stimulation or repression of gene transcription. (biolegend.com)
During Th1 differentiation, the transcription factor T-bet, which is weakly induced by TCR stimulation, is further upregulated by IFN-γ/STAT1-mediated signaling ( 13 ) and promotes the expression of IL-12Rβ2. (jci.org)

Expression of STAT1 can be induced with diallyl disulfide, a compound in garlic. (wikipedia.org)
In mechanistic details, the researchers found that intrinsic IFN-γ-STAT1 signaling in B cells in the germinal center of lung-draining lymph nodes promoted expression of the T-bet transcription factor, and T-bet was necessary for differentiation into pre-memory B cells that express the surface marker CXCR3. (eurekalert.org)
In astrocytes the OGD enhanced the nuclear translocation of hypoxia-inducible factor 1 (HIF-1), the major transcription factor regulating EPO expression. (jneurosci.org)
Stage identity and developmental progression in insects is controlled by sequential expression of temporal-specific transcription factors. (elifesciences.org)
DRAM2 overexpression also increased proteins CDK4, CyclinD3, and decreased p27 expression, all of which are cell cycle-related factors. (cancerindex.org)
Im Rahmen dieser Arbeit konnte gezeigt werden, daß durch Acetylierung des Transkriptionsfaktors Stat1 dessen Interaktion mit NF-KB p65 verstärkt, und somit die subzelluläre Lokalisation und die DNA-Bindung von NF-KB sowie letztendlich die NF-KB kontrollierte Expression von Apoptose-induzierenden Zielgenen beeinflußt wurde. (uni-frankfurt.de)
NF-κB also controls expression of the downstream IFN auto-amplification loop through STAT1, IRF-1, −5, and −7 transcription factors. (biomedcentral.com)
Mice lacking Stat1 expression differentiated fewer inflammatory macrophages from their monocyte lineage, and additionally developed less severe inflammation of their colons than control mice," study first author Yusuke Nakanishi says. (medindia.net)
The capability of these cells to differentiate depends on the stem cell type, the regulation of gene expression by various transcription factors and interaction with the stem cell niche 1,4 . (biolegend.com)
Exosomes derived from HP‑HUVECs promoted the calcification of VSMCs, as assessed by Alizarin Red S staining, alkaline phosphatase activity assays, Ca content measurements and the increased expression of runt‑related transcription factor 2 and osteopontin. (spandidos-publications.com)
Inhibition of STAT1 expression in VSMCs using fludarabine or knockdown of STAT1 expression using small interfering RNA alleviated the calcification of VSMCs. (spandidos-publications.com)
In summary, these results indicate that HBV polymerase is a general inhibitor of IFN signalling and can inhibit IFN-inducible MyD88 expression by inhibiting the activity of the MyD88 promoter through blocking the nuclear translocation of Stat1. (edu.au)
The new Mechanistic Network Analysis in IPA was used to computationally construct a plausible hypothesis that TRIM24 inactivation may lead to activation of IRF7 and STAT1 and other upstream regulators to drive the gene expression profile after the first exposure. (cdc.gov)

Specifically STAT1 can be activated by several ligands such as Interferon alpha (IFNα), Interferon gamma (IFNγ), Epidermal Growth Factor (EGF), Platelet Derived Growth Factor (PDGF), Interleukin 6 (IL-6), or IL-27. (wikipedia.org)

STAT1α, the full-length version of the protein, is the main active isoform, responsible for most of the known functions of STAT1. (wikipedia.org)
STAT1ß, which lacks a portion of the C-terminus of the protein, is less-studied, but has variously been reported to negatively regulate activation of STAT1 or to mediate IFN-γ-dependent anti-tumor and anti-infection activities. (wikipedia.org)
2 related patients had a homozygous missense STAT1 mutation which caused impaired splicing, therefore a defect in mature protein. (wikipedia.org)
Binding to dsRNA by these proteins may result in initiation of helicase activity, concomitant with a conformational change that leads to recruiting additional cellular factors, including the recently identified IPS-1/MAVS protein ( 5 , 6 ). (cdc.gov)
The encoded protein contains two different binding sites that are known to bind DNA and function as a regulator of gene transcription. (biolegend.com)
Protein and mRNA levels were measured by western blot analysis and reverse transcription‑quantitative PCR (RT‑qPCR). (spandidos-publications.com)
Effects of EGCG on nuclear factor kappa B (NFκB) and activator protein-1 (AP-1) transcriptional activity were assessed by reporter gene assay. (molvis.org)
Treatment of HCEpiC with 1 ng/ml IL-1β for 18 h significantly increased release of the cytokines/chemokines granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemotactic protein-1 (MCP-1), while hyperosmolarity-induced release of IL-6 and MCP-1. (molvis.org)

PIAS1, but not other PIAS proteins, blocked the DNA binding activity of Stat1 and inhibited Stat1-mediated gene activation in response to interferon. (nih.gov)

Effector CD4 + T cell subsets have been defined based on their secretion of cytokines, as well as based on transcription factors and cytokines required for their development and maintenance. (jci.org)

All STAT molecules are phosphorylated by receptor associated kinases, that causes activation, dimerization by forming homo- or heterodimers and finally translocate to nucleus to work as transcription factors. (wikipedia.org)
This allows STAT1 to enter the nucleus. (wikipedia.org)
Activated IRF3, together with NF-κB and AP-1, accumulate in the nucleus, bind to the IFNβ promoter, and stimulate transcription. (cdc.gov)

Specific immune cells known as macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin-10 (IL-10). (medindia.net)

STAT1 has a key role in many gene expressions that cause survival of the cell, viability or pathogen response. (wikipedia.org)
In humans STAT1 has been particularly under strong purifying selection when populations shifted from hunting and gathering to farming, because this went along with a change in the pathogen spectrum. (wikipedia.org)
Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. (thermofisher.com)

There are two possible transcripts (due to alternative splicing) that encode 2 isoforms of STAT1. (wikipedia.org)
Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described. (thermofisher.com)

The researchers found that mice whose B cells lacked STAT1 also failed to accumulate flu-specific BRMs after influenza infection. (eurekalert.org)
Elimination of NK cells restored EAE susceptibility in STAT1 CD4-Cre mice. (jci.org)

STAT molecules form dimers and bind to ISGF3G/IRF-9, which is Interferon stimulated gene factor 3 complex with Interferon regulatory Factor 9. (wikipedia.org)

A natural heterozygous germline STAT1 mutation associated with susceptibility to mycobacterial but not viral disease was found in two unrelated patients with unexplained mycobacterial disease. (wikipedia.org)

The very first reported case of STAT1 deficiency in human was an autosomal dominant mutation and patients were showing propensity to mycobacterial infections. (wikipedia.org)

STAT1 loss of function, therefore STAT1 deficiency can have many variants. (wikipedia.org)
First there can be autosomal recessive partial or even complete deficiency of STAT1. (wikipedia.org)
Scientists now claim that recessive STAT1 deficiency is a new form of primary immunodeficiency and whenever a patient suffers sudden, severe and unexpected bacterial and viral infections, should be considered as potentially STAT1 deficient. (wikipedia.org)

Once activated, p38 phosphorylates a number of targets, including the nuclear transcription factors ATF2 and Max. (rndsystems.com)
Once activated, p38 alpha phosphorylates a number of targets, including the cytoplasmic kinases MNK 4 and PRAK5 and the nuclear transcription factors ATF2 1 and STAT1. (rndsystems.com)

Mutations in the STAT1 molecule can be gain of function (GOF) or loss of function (LOF). (wikipedia.org)

Our results suggest a role of acidic pH in the control ofintracellular Leishmania growth early during infection and identify for the first time an unexpected role of Stat1 in natural anti-microbial resistance independent from its function as IFNc-induced signal transducer. (wustl.edu)
Several host factors are important in defending against infection by candidal organisms. (medscape.com)

Within the scope of this work, it could be shown that regulated nucleo-cytoplasmic transport of a subfamily of homeobox transcription factors controlled their intra- and intercellular transport, and thereby influencing also their transcriptional activity. (uni-frankfurt.de)

STAT1 plays a major role in normal immune responses, particularly to viral, mycobacterial and fungal pathogens. (sciencedaily.com)

The transcription factor STAT1 plays a critical role in modulating the differentiation of CD4 + T cells producing IL-17 and GM-CSF, which promote the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). The protective role of STAT1 in MS and EAE has been largely attributed to its ability to limit pathogenic Th cells and promote Tregs. (jci.org)

Analysis of Stat1 (pY701) in human peripheral blood monocytes. (bdbiosciences.com)

The NF-κB and IRF transcription factor families are major players in inflammation and antiviral response and act as two major effectors of the innate immune response (IIR). (biomedcentral.com)

This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human STAT1. (thermofisher.com)
Besides estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, novel biomarkers have shown their prognostic and predictive values, complicating our understanding towards to the heterogeneity of such cancers. (jcancer.org)

Transcription factors have an important role in the ability of a cell to self-renew and also differentiate into most cell types, also known as pluripotency 1 . (biolegend.com)
This novel Stat1 function may have important implications to studies of other pathogens, as the acidic phagolysosomal pH plays an important role in antigen processing and the uncoating process of many viruses. (wustl.edu)

The first wave had the highest number of registered cases and COVID-19 mortality.Conclusion Tumor stage or melanoma treatments are non-significant prognostic factors for COVID-19 mortality. (unav.edu)

Anatomy17

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Stat37

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STAT1

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