AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Core Binding Factor Alpha 1 SubunitCore Binding Factor Alpha 3 SubunitCore Binding Factor Alpha 2 SubunitCore Binding Factor beta SubunitTranscription FactorsCore Binding Factor alpha SubunitsTranscription, GeneticOsteoblastsOsteogenesisPromoter Regions, GeneticCell DifferentiationCleidocranial DysplasiaGene Expression RegulationGene Expression Regulation, DevelopmentalTranscriptional ActivationDNA-Binding ProteinsSignal TransductionRNA, MessengerCell LineageCell LineSp1 Transcription FactorOsteocalcinCells, CulturedMolecular Sequence DataBase SequenceMice, KnockoutCell Line, TumorBinding SitesTrans-ActivatorsNeoplasm ProteinsMice, TransgenicBasic Helix-Loop-Helix Transcription FactorsProtein BindingNuclear ProteinsMice, Inbred C57BLTranscription Factor AP-1Repressor ProteinsHomeodomain ProteinsForkhead Transcription FactorsAmino Acid SequenceDNATranscription Factor AP-2MutationBasic-Leucine Zipper Transcription FactorsCell NucleusTransfectionChromatin ImmunoprecipitationKruppel-Like Transcription FactorsTranscription Factors, TFIIGenes, ReporterHeLa CellsYY1 Transcription FactorSTAT3 Transcription FactorGATA4 Transcription FactorTranscription Factor TFIIDReverse Transcriptase Polymerase Chain ReactionActivating Transcription Factor 3NFATC Transcription FactorsElectrophoretic Mobility Shift AssayTranscription Initiation SiteSp3 Transcription FactorNF-kappa BZinc FingersPaired Box Transcription FactorsEnhancer Elements, GeneticGene Expression ProfilingActivating Transcription Factor 2Transcription Factor TFIIBRegulatory Sequences, Nucleic AcidRNA Polymerase IIE2F1 Transcription FactorRecombinant Fusion ProteinsCloning, MolecularGATA2 Transcription FactorEmbryo, MammalianPlasmidsGATA3 Transcription FactorBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsGene ExpressionCell ProliferationMEF2 Transcription FactorsGATA1 Transcription FactorGATA Transcription FactorsTCF Transcription FactorsProtein Structure, TertiaryLuciferasesGene Expression Regulation, FungalMicrophthalmia-Associated Transcription FactorSTAT1 Transcription FactorActivating Transcription FactorsSkullPhosphorylationOligonucleotide Array Sequence AnalysisChromatinProto-Oncogene ProteinsTranscription Factor RelAE2F Transcription FactorsModels, BiologicalHelix-Loop-Helix MotifsSaccharomyces cerevisiae
AML1RUNXGenesMutationsAcuteRunt domainRegulatesHematopoieticProteinGermlineProteinsBindsLeukemogenesisRegulateCBFBLeukemogenicLeukemicInhibitorEnhancerPlateletRUNX2FamilialCooperatesPathogenesisChromosome 21LeukemiaMutantRegulatorsRearrangementMacrophagesPlays a crucial roleCell differentiationRegulatoryExpressionCMMLExonFoxp3FindingsDemonstrateReceptorAdultCellsGrowthFoundEmbryonicSequencePatientsInteractionAntibodies
AML16
  • Huang G, Shigesada K, Ito K, Wee HJ, Yokomizo T, Ito Y. Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation. (medlineplus.gov)
  • Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) is a protein that in humans is encoded by the RUNX1 gene. (wikipedia.org)
  • Runt-related transcription factor 1 gene ( RUNX1 ), also known as acute myeloid leukaemia 1 protein (AML1), plays a crucial role in the pathogenesis of AML. (mdpi.com)
  • RUNX1/AML1 is one of the most frequently mutated leukaemias associated with a poor prognosis in AML. (mdpi.com)
  • According to the study, investigators identified the methyltransferase enzyme that controls the activity of the normal AML1 protein - also called RUNX1 - demonstrating its ability to regulate the function of transcription factors, proteins that control cell fate by turning genes on or off. (mskcc.org)
  • Germline mutations in the gene AML1 ( RUNX1, CBFA2 ) occur in the familial platelet disorder with predisposition for AML, an autosomal dominant disorder characterized by moderate thrombocytopenia, a defect in platelet function, and propensity to develop AML. (medscape.com)
RUNX7
  • It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). (wikipedia.org)
  • In fact, the RUNX family is often referred to as α-subunits, together with binding of a common β-subunit CBFβ, RUNX can behave as heterodimeric transcription factors collectively called the core binding factors (CBFs). (wikipedia.org)
  • Nusslein-Volhard and Wieschaus discovered the transcription factor RUNX in a screen that was conducted to identify mutations that affect segment number and polarity in Drosophila. (wikipedia.org)
  • Runt-related transcription factor 2 (RUNX2) belongs to the RUNX family (including RUNX1-3) and has been recognized as a key modulator and master transcription factor for osteogenesis, as well as prostate and skeletal development ( 4 - 7 ). (spandidos-publications.com)
  • RUNX3 protein is a transcription factor, containing a highly conserved DNA binding domain which binds to a DNA core motif of 5′ pyGpyGGT 3′ designated as a "runt domain, RD" which shares a sequence similarity with D. melanogaster RUNX. (hindawi.com)
  • These findings suggest that Runx1 regulates growth and survival of myeloid cells and provide a novel insight into the role of Runx family gene translocations in leukemogenesis. (monocyte.eu)
  • Here, we show that loss of Runx/Cbfβ transcription factors complexes during DC development leads to loss of CD103 + CD11b + cDC2s and alters characteristics of CD103 − CD11b + cDCs in the intestine, which was accompanied with impaired differentiation of Rorγt + Th17 cells and type 3 Rorγt + regulatory T cells. (life-science-alliance.org)
Genes15
  • Like other transcription factors, the RUNX1 protein attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
  • The RUNX1 protein turns on (activates) genes that help control the development of blood cells (hematopoiesis). (medlineplus.gov)
  • These events are dependent on the proper levels of transcription and translation of certain genes. (cancerquest.org)
  • Transcription factors are proteins that regulate the transcription of genes, or the production of mRNA from DNA. (biolegend.com)
  • The underphosphorylated, active form of Rb interacts directly with E2F1 , leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. (biolegend.com)
  • Figure 1A: Genomic rearrangement involving USP16 and RUNX1 genes in a CMML. (atlasgeneticsoncology.org)
  • Arrowheads point to USP16 and RUNX1 genes targeted by transition profiles located in these respective regions. (atlasgeneticsoncology.org)
  • Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes. (atlasgeneticsoncology.org)
  • The spectrum of genes harboring germline variants in pediatric MDS has also recently begun to expand beyond transcription factors, including ANKRD26 17 and SRP72 18 . (nature.com)
  • Co-expression of two mutant genes increased myeloid stem cells in animal model, suggesting that cooperation of RUNX1 and ASXL1 mutations played a critical role in leukemia transformation. (biomedcentral.com)
  • In this study, we show that increased expression of Runt related transcription factor 1 (RUNX1) maintains undifferentiated state of CSC-like SP cells through upregulation of inhibitors of DNA binding/differentiation genes (ID1 and ID3) in late cisplatin-paclitaxel resistant cells. (techscience.com)
  • The protein-protein interaction network analysis of 397 upregulated genes in RUNX1-high samples of TCGA data show significant enrichment of pathways known to negatively regulate CSC differentiation. (techscience.com)
  • Immunity genes are activated in the Drosophila fat body by Rel and GATA transcription factors. (sdbonline.org)
  • Thus RUNX1/ETO contributes to increased expression of miR451 target genes and interferes with normal gene expression during differentiation. (uni-frankfurt.de)
  • The runx1 and c-fms genes showed an identical pattern of expression in mature macrophages. (monocyte.eu)
Mutations14
  • Translocations and other types of mutations involving the RUNX1 gene have been associated with different types of leukemia and related blood disorders, including acute lymphoblastic leukemia (ALL), chronic myelomonocytic leukemia (CMML), familial platelet disorder with predisposition to acute myeloid leukemia, and myelodysplastic syndromes (MDS). (medlineplus.gov)
  • The RUNX1 gene mutations associated with these diseases are somatic mutations and are not inherited. (medlineplus.gov)
  • Mutations in RUNX1 are implicated in cases of breast cancer. (wikipedia.org)
  • Mice embryos with homozygous mutations on RUNX1 died at about 12.5 days. (wikipedia.org)
  • Previously, we observed that transcription factor RUNX1 mutations ( RUNX1 -MT) coexisted with ASXL1 -MT in CMML and at myeloid blast phase of chronic myeloid leukemia. (biomedcentral.com)
  • The contribution of RUNX1 mutations in the pathogenesis of myeloid transformation in ASXL1 -mutated leukemia, however, remains unclear. (biomedcentral.com)
  • At 9 months post-BMT, mice harboring combined RUNX1 and ASXL1 mutations developed disease characterized by marked splenomegaly, hepatomegaly, and leukocytosis with a shorter latency. (biomedcentral.com)
  • Mice transduced with both ASXL1 and RUNX1 mutations enhanced inhibitor of DNA binding 1 (ID1) expression in the spleen, liver, and bone marrow cells. (biomedcentral.com)
  • Bone marrow samples from CMML showed that ID1 overexpressed in coexisted mutations of RUNX1 and ASXL1 compared to normal control and either RUNX1 -MT or ASXL1 -MT samples. (biomedcentral.com)
  • We also investigated the extent to which ASH1L pathogenic mutations alter the expression of the transcription factor FOXP1 and its transcriptional regulator RUNX1 in human neurons. (sc.edu)
  • Somatic RUNX1 mutations are found in approximately 10% of patients with de novo acute myeloid leukemia (AML), but are more common in secondary forms of myelodysplastic syndrome (MDS) or AML. (molcells.org)
  • How these RUNX1 mutations contribute to the pathobiology of secondary MDS/AML is still unknown. (molcells.org)
  • This mini-review focusses on the role of RUNX1 mutations as the most common secondary leukemogenic hit in MDS/AML evolving from severe congenital neutropenia (SCN). (molcells.org)
  • Why secondary RUNX1 mutations are associated with sMDS/AML and how they contribute to the pathogenesis of these conditions remains largely unclear. (molcells.org)
Acute7
  • Surprisingly, both acute and chronic mechanical pain was largely unaffected in these Runx1 mutants. (jneurosci.org)
  • A rearrangement (translocation) of genetic material involving the RUNX1 gene is found in approximately 7 percent of individuals with a form of blood cancer known as acute myeloid leukemia (AML). (medlineplus.gov)
  • Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells. (medlineplus.gov)
  • Oncogenic transcription factors such as the leukemic fusion protein RUNX1/ETO, which drives t(8;21) acute myeloid leukemia (AML), constitute cancer-specific but highly challenging therapeutic targets. (prinsesmaximacentrum.nl)
  • RUNX1 was first identified as a RUNX1-ETO fusion protein in acute myeloid leukemia (AML) and is frequently mutated in AML and myelodysplastic syndrome due to chromosomal translocation. (biolegend.com)
  • T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy that is commonly characterised by overexpression of oncogenic factors, such as LIM-only 2 (LMO2). (bham.ac.uk)
  • Furthermore, we observed that inhibition of RUNX1/ETO in Kasumi1 cells and in RUNX1/ETO positive primary acute myeloid leukemia patient samples leads to up-regulation of miR144/451. (uni-frankfurt.de)
Runt domain5
  • We then found that VGLUT3-persistent neurons express the runt domain transcription factor Runx1. (jneurosci.org)
  • As a transcription factor (TF), its DNA binding ability is encoded by the runt domain (residues 50 - 177), which is homologous to the p53 family. (wikipedia.org)
  • The runt domain of RUNX1 binds to the core consensus sequence TGTGGNNN (where NNN can represent either TTT or TCA). (wikipedia.org)
  • RUNX1 can bind DNA as a monomer, but its DNA binding affinity is enhanced by 10 fold if it heterodimerises with the core binding factor β (CBFβ), also via the runt domain. (wikipedia.org)
  • RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding complex with CBFB. (biolegend.com)
Regulates5
  • RUNX1 is a transcription factor that regulates the differentiation of hematopoietic stem cells into mature blood cells. (wikipedia.org)
  • RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. (biolegend.com)
  • Abstract: A network of lineage-specific transcription factors and microRNAs tightly regulates differentiation of hematopoietic stem cells along the distinct lineages. (uni-frankfurt.de)
  • In this report, we demonstrate that Runx1 precisely regulates c-fms (CSF-1 receptor) gene expression. (monocyte.eu)
  • A multisubunit enzyme complex that regulates GENETIC TRANSCRIPTION by deacetylating the HISTONE residues of NUCLEOSOMES. (bvsalud.org)
Hematopoietic3
  • RUNX1-deficient mice fail to generate hematopoietic stem cells. (biolegend.com)
  • We found that the hematopoietic master regulator RUNX1 controls the expression of certain microRNAs, of importance during erythroid/megakaryocytic differentiation. (uni-frankfurt.de)
  • These altered proteins acquire new dimerization properties that result in the assembly of inappropriate multimeric transcription complexes that deregulate hematopoietic programs and induce leukemogenesis. (lincoln.ac.uk)
Protein17
  • The RUNX1 gene provides instructions for making a protein called runt-related transcription factor 1 (RUNX1). (medlineplus.gov)
  • This protein interacts with another protein called core binding factor beta or CBFβ (produced from the CBFB gene), which helps RUNX1 bind to DNA and prevents it from being broken down. (medlineplus.gov)
  • The full-length RUNX1 protein is encoded by 12 exons. (wikipedia.org)
  • These domains are necessary for RUNX1 to mediate DNA binding and protein-protein interactions respectively. (wikipedia.org)
  • The protein RUNX1 is composed of 453 amino acids. (wikipedia.org)
  • Although the protein encoded by runt was demonstrated to exhibit nuclear translocation, it was not yet established that this protein is a transcription factor. (wikipedia.org)
  • Soon after the discovery of the drosophila runt protein and the human RUNX1 protein, RUNX1's function was discovered. (wikipedia.org)
  • Runx1 was purified as a sequence-specific DNA-binding protein that regulated the disease specificity of the Moloney murine Leukemia virus. (wikipedia.org)
  • The encoded protein contains two different binding sites that are known to bind DNA and function as a regulator of gene transcription. (biolegend.com)
  • STAT3 protein belongs to a group of intracellular transcription factors that mediate a variety of functions such as cellular differentiation, proliferation, and apoptosis. (biolegend.com)
  • A key feature of LMO2 is its function as part of a multi-protein complex, where it directly interacts with transcription factors that are essential during normal haematopoietic development, such as TAL1, GATA, LDB1 and E proteins. (bham.ac.uk)
  • Augmentations in foxp3 protein expression and decreases in runx1 and foxp3 mRNA occurred concurrently with expression of miR-210 following dermal TDI exposure. (cdc.gov)
  • Moreover, the RUNX1 mutant protein was more stable than WT and increased HIF1-α and its target ID1 gene expression in ASXL1 mutant cells. (biomedcentral.com)
  • Intriguingly RUNX1 inhibition not only induces CSC differentiation but also downregulates anti-apoptotic protein BCL2 in both SP and NSP cells and potentiates cytotoxic effects of Cisplatin-Paclitaxel in chemoresistant EOC cells. (techscience.com)
  • The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. (thermofisher.com)
  • Electrophoretic mobility shift analysis using nuclear extracts obtained from RAW264 cells and from the promonocytic cell line U-937 revealed the formation of at least three distinct protein-DNA complexes at each of these sites, one of which was found to contain the transcription factor Sp1. (uni-frankfurt.de)
  • Furthermore, the leukemogenic RUNX1/ETO fusion protein transcriptionally represses the miR144/451 pre-microRNA. (uni-frankfurt.de)
Germline6
  • The break/fusion was not present in the germline since we did not find the USP16-RUNX1 transcript in buccal smear cells of the patient. (atlasgeneticsoncology.org)
  • Monoallelic germline pathogenic variants in RUNX1 cause autosomal dominant familial platelet disorder with predisposition to myeloid malignancy (FPDMM). (eviq.org.au)
  • Refer to the evidence section for information about the selection of appropriate samples for testing RUNX1 germline pathogenic variants. (eviq.org.au)
  • Individuals with a monoallelic RUNX1 germline pathogenic variant should be informed of the risk of platelet dysfunction, particularly during pregnancy and major surgery. (eviq.org.au)
  • Monoallelic RUNX1 germline pathogenic variants cause autosomal dominant FPDMM which typically presents with mild-to-moderate thrombocytopenia with normal-sized platelets, a functional platelet defect leading to prolonged bleeding and an increased risk of MDS and AL (more commonly AML, followed by T-ALL). (eviq.org.au)
  • TAp63a, a homolog of the p53 tumor suppressor, is a quality control factor in the female germline. (uni-frankfurt.de)
Proteins6
  • Together, these proteins form one version of a complex known as core binding factor (CBF). (medlineplus.gov)
  • The transcription of RUNX1 is regulated by 2 enhancers (regulatory element 1 and regulatory element 2), and these tissue specific enhancers enable the binding of lymphoid or erythroid regulatory proteins, therefore the gene activity of RUNX1 is highly active in the haematopoietic system. (wikipedia.org)
  • However, multiple ATG codons through exons 5 to 7 of the fused RUNX1 sequence could be used as new start codons and generate truncated RUNX1 proteins. (atlasgeneticsoncology.org)
  • ChIP-sequencing analysis, using antibodies recognising PRMT5, LMO2 and RUNX1, showed overlapping peaks in T-ALL, confirming a functional relationship between these proteins. (bham.ac.uk)
  • Recurring chromosomal translocations observed in human leukemia often result in the expression of fusion proteins that are DNA-binding transcription factors. (lincoln.ac.uk)
  • Here, we show that the 8th zinc finger motif of MDS1/EVI1 is an oligomerization domain involved not only in interaction of AME with itself but also in interactions with the parental proteins, RUNX1 and MDS1/EVI1, from which AME is generated. (lincoln.ac.uk)
Binds1
  • Once the transcription factor binds to an enhancer region, this can cause stimulation or repression of gene transcription. (biolegend.com)
Leukemogenesis2
  • RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis. (medlineplus.gov)
  • Transcription factor RUNX1 plays important roles in hematopoiesis and leukemogenesis. (bvsalud.org)
Regulate3
  • Altogether, this study defines the repertoire of transcription factors that regulate developmental myofiber growth and the role of Gsk3/Deaf1/glycolysis in this process. (sdbonline.org)
  • Subsequent results confirmed that RUNX1, as an independent prognostic factor for LGG, may target interferon-gamma receptor 2 (IFNGR2) to regulate glioma cell proliferation, invasion, and migration. (bjbms.org)
  • We found that in vitro, this interaction alters the ability of RUNX1 to bind to DNA and to regulate a reporter gene, whereas in vivo, the expression of the isolated 8th zinc finger motif of EVI1 is sufficient to block the granulocyte colony-stimulating factor-induced differentiation of 32Dcl3 cells, leading to cell death. (lincoln.ac.uk)
CBFB1
  • There is a deficit of expression of Runx1, Tal1, Lyl1 and Cbfb in adult endothelial cells compared to their embryonic counterparts. (biorxiv.org)
Leukemogenic1
  • To evaluate the leukemogenic role of RUNX1-MT in ASXL1 -mutated cells, we co-expressed RUNX1 -MT (R135T) and ASXL1 -MT (R693X) in different cell lines and performed immunoblot, co-immunoprecipitation, gene expression microarray, quantitative RT-PCR, cell proliferation, differentiation, and clonogenic assays for in vitro functional analyses. (biomedcentral.com)
Leukemic2
  • This strategy identified Cyclin D2 (CCND2) as a crucial transmitter of RUNX1/ETO-driven leukemic propagation. (prinsesmaximacentrum.nl)
  • RUNX1 was found to be rearranged in the leukemic cell DNAs from t(8;21)(q22;q22) AML patients. (wikipedia.org)
Inhibitor1
  • A single injection of a RUNX1 inhibitor (Ro5-3335) led to significant reductions in lesion size. (aao.org)
Enhancer2
  • Deformed epidermal autoregulatory factor-1 (DEAF-1) is a transcription factor that was originally shown to bind the autoregulatory enhancer of the Deformed ( Dfd ) Hox gene, which is activated in embryonic head segments of Drosophila (Gross, 1996). (sdbonline.org)
  • Runx1 controlled expression by binding to multiple sites within the mouse c-fms gene, allowing interaction between promoter and downstream enhancer elements. (monocyte.eu)
Platelet1
  • Impaired differentiation of megakaryocytes and decreased circulating platelet count were observed in the absence of RUNX1. (biolegend.com)
RUNX23
  • purified Runx2, the homolog of Runx1. (wikipedia.org)
  • the binding affinity of RUNX1 and RUNX2 was significantly increased by association with CBFβ. (wikipedia.org)
  • Runt‑related transcription factor 2 (RUNX2), a pivotal transcription factor in mammary gland and bone development, has also been related to metastatic cancer and BCSCs. (spandidos-publications.com)
Familial1
  • Several factors have been implicated in the causation of AML, including antecedent hematologic disorders, familial syndromes, environmental exposures, and drug exposures. (medscape.com)
Cooperates1
Pathogenesis2
  • Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. (medlineplus.gov)
  • The present study demonstrated the biological and functional evidence for the critical role of RUNX1 -MT in ASXL1 -mutated leukemia in the pathogenesis of myeloid malignancies. (biomedcentral.com)
Chromosome 212
  • The translocation, written as t(8;21), combines genetic information from chromosome 21 and chromosome 8, fusing the RUNX1 gene on chromosome 21 with a gene on chromosome 8 called RUNX1T1 (also known as ETO ). (medlineplus.gov)
  • In humans, the gene RUNX1 is 260 kilobases (kb) in length, and is located on chromosome 21 (21q22.12). (wikipedia.org)
Leukemia5
  • Our data demonstrate that RUNX1/ETO maintains leukemia by promoting cell cycle progression and identifies G1 CCND-CDK complexes as promising therapeutic targets for treatment of RUNX1/ETO-driven AML. (prinsesmaximacentrum.nl)
  • Chromosomal translocations involving the RUNX1 gene are associated with several types of leukemia including M2 AML. (wikipedia.org)
  • These findings revealed that RUNX1 acts as a tumor suppressor for myeloid leukemia and is crucial for the development and terminal differentiation of several blood cell lineages 2,3 . (biolegend.com)
  • Gene translocations that repress the function of the Runx1 transcription factor play a critical role in the development of myeloid leukemia. (monocyte.eu)
  • RUNX1-positive leukemia cells in preclinical models. (lu.se)
Mutant6
  • We analysed RUNX1 mutant AML patients compared to non-mutant patients using an integrated multi-omics, multi-database analysis of exome, and transcriptomics data. (mdpi.com)
  • The expression of RUNX1 mutant in ASXL1 -mutated myeloid cells augmented proliferation, blocked differentiation, and increased self-renewal activity. (biomedcentral.com)
  • Besides, we also found that the expression levels of RUNX1 and IFNGR2 were significantly reduced, and their correlation was enhanced in the IDH-mutant subtype. (bjbms.org)
  • Patients with a high expression of RUNX1 and/or IFNGR2 (HH/H) in the IDH-mutant subtype showed poorer prognosis and significantly increased infiltration of M2 macrophages. (bjbms.org)
  • This finding implied the possible key role of RUNX1 in the differentiation of IDH mutant subtypes as well as in the formation of tumor microenvironment (TME) infiltration signatures by monitoring IFNGR2. (bjbms.org)
  • Here, we will discuss the current insights and ideas regarding mutant RUNX1 in the context of malignant transformation of iBMFs, taking SCN as the leading example. (molcells.org)
Regulators2
  • This screen identifies new regulators of myofiber atrophy and hypertrophy, including the transcription factor Deaf1 . (sdbonline.org)
  • Runt-related transcription factors (RUNXs), RUNX1-3, are the master regulators of development and differentiation and are all important to the development of immune cells. (bjbms.org)
Rearrangement1
Macrophages1
  • Runx1 expression was repressed in CSF-1 stimulated, proliferating bone marrow-derived macrophages (BMM) and significantly increased in quiescent, CSF-1 starved cells. (monocyte.eu)
Plays a crucial role1
  • RUNX1 plays a crucial role in adult (definitive) haematopoiesis during embryonic development. (wikipedia.org)
Cell differentiation1
Regulatory3
  • RUNX1 is also required for the differentiation of CD8+, Th17, and regulatory T cells. (biolegend.com)
  • The identification of dimethylated arginine RUNX1 indicates a possible regulatory function for PRMT5, which may be related to their interaction with the LMO2 complex. (bham.ac.uk)
  • Altogether, our data reveal new regulatory roles by RUNX1 to modulate CSC differentiation via ID1 and ID3 and to promote chemoresistance through BCL2 upregulation. (techscience.com)
Expression9
  • Analyses of mice with a conditional knock-out of Runx1 in VGLUT3 lineage neurons demonstrate that Runx1 is pivotal to the development of VGLUT3-persistent neurons, such as the expression of VGLUT3 and TH and the formation of the longitudinal lanceolate endings. (jneurosci.org)
  • Furthermore, Runx1 is required to establish mechanosensitivity in C-LTMRs, by controlling the expression of the mechanically gated ion channel Piezo2. (jneurosci.org)
  • The capability of these cells to differentiate depends on the stem cell type, the regulation of gene expression by various transcription factors and interaction with the stem cell niche 1,4 . (biolegend.com)
  • Although transcriptional similarities have been found between embryonic and adult endothelial cells, we found some key differences in term of transcription factors expression. (biorxiv.org)
  • Higher RUNX1 expression was found to correlate with decreased median overall survival and disease-free survival in The Cancer Genome Atlas (TCGA) data set of high grade serous ovarian cancer (HGSOC) patients. (techscience.com)
  • They found that DEL-1 interacted with a molecule on the T cell surface which induced a transcription factor called RUNX1 that promotes the expression and stability of FOXP3, a "master regulator" of Tregs. (upenn.edu)
  • Expression of a reporter gene linked to the −101HCK promoter region was up-regulated by Sp1, but not by other members of the Sp1 family of transcription factors, in Drosophila Schneider cells. (uni-frankfurt.de)
  • The RAW264.7 and Mono-Mac-6, macrophage-like cell lines expressed low levels of Runx1 and both showed growth arrest and cell death with ectopic expression of Runx1. (monocyte.eu)
  • We show that expression of the cardiac transcription factor Nkx2.5 marks a mesodermal population outside of the cardiac crescent in the extraembryonic and lateral plate mesoderm, with characteristics of hemogenic angioblasts. (elifesciences.org)
CMML1
Exon2
Foxp31
  • Confirmed (foxp3) and predicted (runx1t1, runx3, smad4, and stat6) miR-210 transcription factor targets were identified using computational algorithms. (cdc.gov)
Findings1
  • Skin findings, including eczema and psoriasis, have been reported in up to 50% of individuals with RUNX1-FPDMM and can be treated topically. (eviq.org.au)
Demonstrate1
  • Here, we demonstrate that Runx1 indeed coordinates C-LTMR development. (jneurosci.org)
Receptor2
  • HER2/neu (also called ERB B2 ) is the gene that encodes the human epidermal growth factor receptor type 2. (cancerquest.org)
  • This receptor is found in moderate levels on some normal cells and as the gene's name implies, it is involved in cellular responses to growth factors. (cancerquest.org)
Adult1
  • The RUNX1 transcription factor is essential for adult haematopoiesis. (bham.ac.uk)
Cells4
  • This was confirmed by nested PCR amplification of reverse-transcribed RNA from the patients BM cells, which detected a 245 bp-long USP16-RUNX1 transcript. (atlasgeneticsoncology.org)
  • Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor. (umassmed.edu)
  • Multiple sclerosis and T1D have distinct target organs, genetic risk factors, onset ages, and female to male ratios, but target organ-specific T cells as initiators unite these diseases. (frontiersin.org)
  • Extra-cardiac Nkx2.5 lineage progenitors migrate into the embryo and contribute to clusters of CD41 + /CD45 + and RUNX1 + cells in the endocardium, the aorta-gonad-mesonephros region of the dorsal aorta and liver. (elifesciences.org)
Growth5
  • In the animation below, these signals would be represented by the the 'X' shaped growth factor and the foot in the video portion. (cancerquest.org)
  • This growth can occur in the absence of normal pro-growth signals such as those provided by growth factors. (cancerquest.org)
  • As shown below, binding of the growth factor can lead to cell division. (cancerquest.org)
  • Although these results were observed in preclinical models, study authors hope to continue this research, including whether such drugs could be delivered topically versus via injection, and how RUNX1 and vascular endothelial growth factor (VEGF) interplay in angiogenesis. (aoa.org)
  • 1,100 muscle-targeted RNAi interventions to comprehensively assess the function of 447 transcription factors in the developmental growth of body wall skeletal muscles in Drosophila. (sdbonline.org)
Found2
  • Among these, RUNX1 was identified and found to be dimethylated at arginine R244. (bham.ac.uk)
  • Published online in the journal Diabetes , the Massachusetts Eye and Ear Infirmary study identifies a particular transcription factor commonly found in abnormal retinal blood vessels that can be inhibited to achieve a 50% reduction in retinopathy. (aoa.org)
Embryonic1
  • Pax6 is a transcription factor present during embryonic development. (biolegend.com)
Sequence1
  • Sequence analysis showed that the result of the inversion/fusion generated a chimeric USP16-RUNX1 transcript. (atlasgeneticsoncology.org)
Patients3
  • Per the report, researchers studied PDR patients' fibrovascular membrane tissue and identified the presence of the transcription factor RUNX1 expressed in response to high glucose. (aoa.org)
  • There is significant clinical heterogeneity in patients with RUNX1-FPDMM. (eviq.org.au)
  • However, most patients who present with de novo AML have no identifiable risk factor. (medscape.com)
Interaction2
  • Our project shows the interaction of the LMO2 multiprotein complex with both PRMT5 and RUNX1. (bham.ac.uk)
  • Because the 8th zinc finger motif is also present in the oncoprotein EVI1, we have evaluated the effects of the interaction between RUNX1 and EVI1 in vitro and in vivo. (lincoln.ac.uk)
Antibodies1