Transcription factor nf e2 related factor 2. Medical search. Frequent questions

Little is known about either the basal or stimulated homeostatic mechanisms regulating nuclear tenure of Nf-e2-related factor 2 (Nrf2), a transcription factor that mediates expression of over 200 detoxification genes. (nih.gov)
The pesticide deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor Nrf2 in rat brain. (cdc.gov)
The transcription factor NF-E2-related factor 2 (Nrf2) plays a critical role in the mammalian response to chemical and oxidative stress through induction of phase II detoxification enzymes and oxidative stress response proteins. (cdc.gov)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)
Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
The nuclear factor erythroid-derived two-like 2-antioxidant response element (Nrf2-ARE) pathway and its downstream antioxidant enzyme heme oxygenase-1 (HMOX1 or HO-1) play essential roles in H2 O2 -induced oxidative damage in human melanocytes. (nih.gov)
However, the link between Nrf2 promoter polymorphisms and susceptibility to oxidative stress-related diseases such as vitiligo is unknown. (nih.gov)
OBJECTIVE- Sulforaphane is an activator of transcription factor NF-E2-related factor-2 (nrf2) that regulates gene expression through the promoter antioxidant response element (ARE). (diabetesjournals.org)
Nrf2 regulates the transcription of a battery of protective and metabolic enzymes. (diabetesjournals.org)
This also abolished the counteracting effect of sulforaphane, suggesting mediation by nrf2 and related increase of transketolase expression. (diabetesjournals.org)
CONCLUSIONS- We conclude that activation of nrf2 may prevent biochemical dysfunction and related functional responses of endothelial cells induced by hyperglycemia in which increased expression of transketolase has a pivotal role. (diabetesjournals.org)
The nuclear-factor-erythroid-2-related factor 2 (Nrf2), is a ubiquitous master transcription factor which induces the endogenous production of cytoprotective proteins/enzymes through binding to antioxidant response elements (AREs) at the DNA/gene level. (integratedhealthblog.com)
We recently used positional cloning to identify the transcription factor Nrf2 (NF-E2 related factor 2) as a susceptibility gene in a murine model of oxidant-induced acute lung injury (ALI). (elsevierpure.com)
The transcription factor NF-E2-related factor 2 (Nrf2) regulates the expression of a battery of antioxidative enzymes and Nrf2 signaling can be activated by small-molecule drugs that disrupt Keap1-mediated repression of Nrf2 signaling. (johnshopkins.edu)
The effects of physiological oxygen tension on Nuclear Factor-E2-Related Factor 2 (Nrf2)-regulated redox signaling remain poorly understood. (ox.ac.uk)
Induction of GSH-related genes xCT and GCLM were oxygen and Bach1-insensitive during long-term culture under 5% O2, providing the first evidence that genes related to GSH synthesis mediate protection afforded by Nrf2-Keap1 defense pathway in cells adapted to physiological O2 levels encountered in vivo. (ox.ac.uk)
Functional studies in non-small cell lung cancer (NSCLC) patients revealed that hyperactivation of the NF-E2-related factor 2 (Nrf2) pathway facilitates tumor growth. (oncotarget.com)
NF-E2-related factor 2 (Nrf2) is a member of the Cap'n'Collar/basic leucine zipper (CNC-bZIP) transcription factor family. (oncotarget.com)
Central to the self-protective antioxidant system is NF-E2-related aspect (Nrf2), a capncollar basic-region leucine zipper nuclear transcription aspect that mediates the principal cellular protection against the cytotoxic ramifications of oxidative tension, including pathways for xenobiotic cleansing, antioxidants, anti-inflammatory response, DNA fix, molecular chaperones, and proteasome systems. (mingsheng88.org)
In the nucleus, Nrf2 identifies and binds to a conserved antioxidant response component (ARE) and induces transcription of the battery pack of chemoprotective antoxidant genes9,10, including those encoding antioxidant proteins like heme oxygenase (HO-1)11. (mingsheng88.org)
A variety of evidence shows that GSK3 legislation of Nrf2 is normally implicated in ageing20, type 2 diabetes21, hepatotoxicity22, and neurological degeneration23C25. (mingsheng88.org)
Hardly any, nevertheless, was known about how exactly GSK3 regulates Nrf2 antioxidant response in HCV related liver organ injury. (mingsheng88.org)

The expression of regulatory molecules, TGF-β1/2, phospho-Akt (Ser473), PPARα, sterol regulatory element-binding protein 1 (SREBP-1), fatty acid synthase (FASN), hormone-sensitive lipase (HSL), and acyl dehydrogenases was analyzed in virus-infected hepatocytes. (academic-accelerator.com)
T he immune-inflammatory dysregulation theory in schizophrenia 1 , 2 posits an imbalance of pro- and anti-inflammatory cytokines and elevated levels of inflammatory proteins (eg, C-reactive protein, S100 calcium-binding protein B [S100B], and prostaglandin E2) in subgroups of patients with schizophrenia experiencing an exacerbation of symptoms. (psychiatrist.com)
Activation of the transcription factor nuclear factor KB (NF-KB) requires the NEMO protein. (medscape.com)
Compared with individual exposures, co-exposure aerosols produced greater acellular and cellular oxidants detected by electron paramagnetic resonance (EPR) spectroscopy, and in vivo immune-spin trapping (IST), as well as synergistically increased lavage neutrophils, lavage proteins and inflammation related gene/protein expression. (cdc.gov)
E1 protein has helicase activity for replication, and E2 encodes DNA-binding protein for regulation of transcription. (medscape.com)

These studies focus on the degradation of specific disease related proteins and the general status of the UPS under conditions of an excess of aberrant or misfolded proteins. (5dok.org)
To evaluate the capacity of the UPS to degrade disease related proteins, polyglutamine (polyGln) proteins were targeted for proteasomal degradation. (5dok.org)
DNA meth-ylation represses transcription by interfering with transcription factor binding and indirectly by recruiting methyl-CpG-binding proteins and reducing chromatin remodeling activities ( 12 ). (spandidos-publications.com)
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
There are very low levels of free zinc in plasma, since it is mostly bound to proteins such as albumin, alpha-2-macroglobulin (A2M), and transferrin. (frontiersin.org)
Ageing leads to a gradual dysfunction of the proteostasis network and thus to proteome instability due to accumulation of damaged and/or misfolded proteins [ 2 ]. (hindawi.com)
Disruption of E1 and E2 allows for dysregulated downstream genes and the expression of E6 and E7 proteins, which are selectively maintained in virally induced tumors. (medscape.com)
E7 forms complexes with pRb and functionally inactivates pRb and related proteins, such as EF2, which leads to transcription growth-related proteins. (medscape.com)

A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. (nih.gov)

This has opened up the possibility to carry out systematic studies to uncover the repertoire of functionally related groups of driver genes. (biomedcentral.com)
Exploiting the aforementioned catalogs of driver genes, for example, we recently revealed the mutational landscape of chromatin regulatory factors (CRFs) in cancer [ 5 ]. (biomedcentral.com)
There are two main reasons why the catalogs of cancer drivers produced by the aforementioned projects and others need to be broken down into related sets of genes for deeper analysis. (biomedcentral.com)
Cis-acting DNA sequences which can increase transcription of genes. (lookformedical.com)
For example, clinical signs may manifest more severely in some cases where both parents are affected [3] or if two separate genetic factors are present in an individual, [4] suggesting a role for interaction among genes. (eyewiki.org)

Concurrently, p62 gene expression is increased by oxidative stress through activation of the transcription factor NF-E2-related factor 2 ( 18 ). (spandidos-publications.com)
encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. (nih.gov)
UBE2D2 is a member of the E2 ubiquitin-conjugating enzyme family and cloning of the human gene was first described by Jensen et al. (ubiquigent.com)
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria. (lookformedical.com)
BRCA2 gene promoter has bi-directional activity, expressing BRCA2 and a novel C4-type zinc finger containing transcription factor ZAR2. (biomedcentral.com)
20) gene [9] and Transforming growth factor-β-induced and clusterin [10] . (eyewiki.org)
Both GATA-1 and NF-E2 bound upstream of the miR-199b gene locus and activated its transcription. (molcells.org)
The up-regulation of miR-199b-5p during erythroid differentiation was dependent on the binding of GATA-1 and NF-E2 to its gene locus, which activated its transcription and maintained its high expression level in mature erythroid cells. (molcells.org)
In 2000, the International Incontinentia Pigmenti Consortium reported that incontinentia pigmenti is caused by a genomic rearrangement of the gene for NEMO, or nuclear factor kappa B essential modulator (IKBKG-IKK gamma). (medscape.com)
[ 2 ] The defect in the X chromosome is proximal to the gene for factor VIII at Xq28. (medscape.com)

The results of the present study revealed that ketamine treatment induced NF‑κB p65 translocation to nuclei and activated COX‑2 expression and prostaglandin (PGE)2 production in bladder tissue, whereas COX‑2 inhibitor suppressed the inflammatory effect. (spandidos-publications.com)
11 , 12 A case has been made for adjunctive treatment of symptoms of schizophrenia using anti-inflammatory drugs, such as cyclooxygenase (COX) inhibitors, since these medications shift the immune responsivity from predominantly type-2 to type-1 and inhibit prostaglandin E2 synthesis. (psychiatrist.com)

These measurements were compared with filtration efficiencies, airflow resistances, and fit factors measured on manikin headforms and humans. (cdc.gov)
For other human tumour virus- primate species are related to the hu- tween data in humans and in experi- es, the use of humanized severe man tumour viruses, the incidence of mental animals is not obvious. (who.int)

Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway. (wisc.edu)
1 , 3 Diabetes mellitus may down-regulate a redox sensitive transcription factor, NF-E2-related factor 2 activity via extracellular signal-related kinase, resulting in impairment of the sevoflurane postconditioning effect because this pathway has been proved to be induced by the oxidative stress in the diabetic heart. (asahq.org)
The water extract was the most effective in counteracting lipopolysaccharide-induced neuroinflammation in microglial BV-2 cells by strongly reducing the expression of proinflammatory mediators through the modulation of the TLR4/NF- κ B pathway. (hindawi.com)

Although studies have identified several miRNAs that regulate erythroid commitment and differentiation, we do not understand the mechanism by which the crucial erythroid transcription factors, GATA-1and NF-E2 directly regulate and control differentiation via miRNA pathways. (molcells.org)
NF-KB is important in immune, inflammatory, and apoptotic pathways. (medscape.com)

E6 promotes cell growth by inactivation of the p53-related effects, which control cellular proliferation and apoptosis. (medscape.com)

In particular, the methanol extract was the most effective in protecting neuron-like SH-SY5Y cells against H 2 O 2 -induced oxidative stress by upregulating endogenous antioxidant enzymes such as thioredoxin reductase, heme oxygenase 1, NADPH quinone oxidoreductase, and glutathione reductase. (hindawi.com)

The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION. (lookformedical.com)

These results indicate that inhibition of GPR39-1b induces Sucrase a decrease in anxiety-related behaviors and disturbs appetite. (nartsignaling.com)

The present study investigated the methylation of CpG sites in the cyclooxygenase (COX)‑2 promoter via nuclear factor (NF)‑κB transcriptional regulation and elucidated its effect on the COX‑2 transcriptional expression in a ketamine‑induced ulcerative cystitis (KIC) animal model. (spandidos-publications.com)
Moreover, DNA hypomethylation of the COX‑2 promoter region located from ‑1,522 to ‑829 bp might contribute to transcriptional regulation of COX‑2 expression and induce a pro‑inflammatory response in KIC. (spandidos-publications.com)

Extensive research within the past two decades has shown that curcumin mediates its anti-inflammatory effects through the downregulation of inflammatory transcription factors (such as nuclear factor kappaB), enzymes (such as cyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as tumor necrosis factor, interleukin 1 and interleukin 6). (integratedhealthblog.com)

PDT has been reported to be effective for treating aggressive colon cancer showing a high level of the vascular endothelial growth factor, which promotes tumor growth through angiogenesis ( 5 ). (spandidos-publications.com)

Furthermore, these findings may have important implications in other oxidative stress related illnesses. (elsevierpure.com)

Then, I collect a list of downstream targets of the all driver transcription factors (TFs), and identify which of them exhibit a differential expression upon alterations of driver transcription factors. (biomedcentral.com)

The anti-inflammatory effect of curcumin is most likely mediated through its ability to inhibit cyclooxygenase-2 (COX-2), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS). (integratedhealthblog.com)

To treat patients with colorectal cancer, an approach that selectively targets cancer cells without damaging normal cells and which minimizes the risk of perforating the intestinal barrier is needed ( 2 ). (spandidos-publications.com)
Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
Through a screening system using these two phenotypes in HEK293 cells and evaluation using alveolar epithelial type 2 (AT2) cells differentiated from patient-derived induced pluripotent stem cells (iPSCs), we identified Cryptotanshinone (CPT) as a potential therapeutic agent for ILD. (bvsalud.org)
When the cells are in the dividing state (S/G 2 ), the forward activity of the promoter is 5-8 folds higher than the reverse activity. (biomedcentral.com)
Furthermore, the increase of miR-199b-5p in erythroid cells occurred in a GATA-1- and NF-E2-dependent manner during erythrocyte maturation. (molcells.org)
[ 6 ] NF-KB protects cells from apoptosis in response to tumor necrosis factor-alpha (TNF-alpha). (medscape.com)

COX-2, LOX, and iNOS are important enzymes that mediate inflammatory processes. (integratedhealthblog.com)
Improper upregulation of COX-2 and/or iNOS has been associated with the pathophysiology of certain types of human cancer as well as inflammatory disorders. (integratedhealthblog.com)
The pro-inflammatory miRNA-9 was found to be increased in sputum samples from patients with neutrophilic asthma, which is often resistant to corticosteroid therapy, compared with eosinophilic asthma [ 2 ] . (encyclopedia.pub)
Aldo-keto reductase family 1 member B10 (AKR1B10) is an inflammatory regulator and is closely related to the prognosis of patients with GC. (portlandpress.com)

Ketamine treatment increased the binding of NF‑κB and permissive histone H3 lysine‑4 (H3K4)m3, but caused a decrease in the repressive histone H3K27m3 and H3K36m3 on the COX‑2 promoter ranging from ‑1,522 to ‑1,331 bp as determined by a chromatin immunoprecipitation assay. (spandidos-publications.com)
Moreover, in the ketamine group, the level of Ten‑Eleven‑Translocation methylcytosine dioxygenase for demethylation as determined by reverse transcription‑quantitative PCR assay was increased in comparison with the control group, but that was not the case for the level of DNA methyltransferases for methylation. (spandidos-publications.com)
E2-Ubiquitin Thioester Loading Assay: The activity of GST-UBE2D2 was validated by loading E1 UBE1 activated ubiquitin onto the active cysteine of the GST-UBE2D2 E2 enzyme via a transthiolation reaction. (ubiquigent.com)

2 We also have to keep in mind that 5-hydroxydecanonate is not a selective inhibitor of mitochondrial adenosine triphosphate sensitive K + channels anymore because it is a substrate for the enzyme acyl-CoA synthethase in the electron transport chain of mitochondria, 4 and it is capable of playing a role as an inhibitor of sarcolemmal adenosine triphosphate sensitive K + channels. (asahq.org)
Chiang MH, Chen LF, Chen H (2008) Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation. (ubiquigent.com)

AntagomiRNA-mediated inhibition of miRNA-9 increased both PP2A activity and GR nuclear translocation in macrophages, and restored steroid sensitivity in isolated macrophages and in several mouse models of steroid-resistant AHR [ 2 ] . (encyclopedia.pub)

[2] In large cohorts of people with Fuchs' dystrophy, approximately two out of three people harbor this genetic variant, an expanded trinucleotide repeat. (eyewiki.org)
The most prevalent genetic risk factor for Fuchs' dystrophy is the CTG18.1 trinucleotide repeat expansion in TCF4 . (eyewiki.org)

In the skin, NF-KB regulates cell growth in the stratified epithelium and apoptosis. (medscape.com)

2005). This complex has been shown to mediate activation of NFκB and promote degradation of phosphorylated IκBα. (ubiquigent.com)

In the present study, we identified miR-199b-5p as a positive erythroid regulator, that was regulated by the key erythroid transcription factors GATA-1 and NF-E2. (molcells.org)

The present findings revealed that there was a hypomethylation pattern of the COX‑2 promoter in association with the level of COX‑2 transcription in KIC. (spandidos-publications.com)

Zinc's functions can be classified as catalytic, structural, and regulatory ( 2 ). (frontiersin.org)

Extensive research over the past 30 years indicates that these molecules can provide positive benefits against a wide range of health issues related to cell function, lungs, liver, nervous system, joint function, metabolism, and cardiovascular system. (integratedhealthblog.com)

Taken together, our results establish a functional link among the erythroid transcription factors GATA-1/NF-E2, miR-199b-5p and c-Kit, and provide new insights into the coupling of transcription and post-transcription regulation in erythroid differentiation. (molcells.org)

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. (lookformedical.com)

Here, we focus on emerging insights and methodologies from studies in fetal sheep that have begun to define cellular and vascular factors that contribute to white matter injury. (nartsignaling.com)
Recent advances include spatially defined Tanespimycin manufacturer measurements of cerebral blood flow in utero, the definition of cellular maturational factors that define the topography of injury and the application of high-field magnetic resonance imaging to define novel neuroimaging signatures for specific types of chronic white matter injury. (nartsignaling.com)
In addition, the subcellular distribution of mitochondria can affect the cellular transcriptome and transcription rates. (hindawi.com)

Cardiac, pulmonary, and central nervous system (CNS) complications can occur during the course of infection ( 1 , 2 ). (cdc.gov)
Fatality rates among patients with untreated typhus are ≈4% ( 3 , 4 ) among patients with R. typhi infection and 13%-30% ( 2 ) among those with R. prowazekii infection. (cdc.gov)

Here, I focus on driver transcription factors and their connection to tumorigensis in several tumor types through the alteration of the expression of their targets. (biomedcentral.com)

Environmental risk factors include smoking and body mass index. (eyewiki.org)

Jensen JP, Bates PW, Yang M, Vierstra RD, Weissman AM (1995) Identification of a family of closely related human ubiquitin conjugating enzymes. (ubiquigent.com)

Overexpression of p62 is likely related to tumorigenesis and has been observed in many types of tumors ( 13 , 21 - 23 ), such as chemotherapy-resistant epithelial cell carcinoma ( 24 ). (spandidos-publications.com)

Non-small cell lung cancer (NSCLC) accounts for 85% to 90% of total pulmonary malignancies [ 1 ], and it is the most lethal cancer worldwide [ 2 ]. (oncotarget.com)

Results: Macrophage polarization was the main immune infiltration pattern in GC, and the state of macrophage polarization was closely related to the pathological grading of GC and the clinical stage of patients. (portlandpress.com)

Oxidative stress is believed to be a principal factor in the development of many chronic neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's and Amyotrophic Lateral Sclerosis. (wisc.edu)

Anatomy17

Organisms8

Diseases1

Chemicals and Drugs136

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes68

Disciplines and Occupations1

Information Science3

NRF225

Protein5

Proteins8

Basic leucine zipper1

Genes5

Gene11

Prostaglandin2

Humans2

Pathway3

Pathways2

Inactivation1

Endogenous1

Biosynthesis1

Induces1

Transcriptional2

Mediates1

Tumor growth1

Oxidative stress-related1

Downstream1

Inhibit1

Cells6

Inflammatory4

Assay3

Enzyme2

Nuclear translocation1

Genetic2

Regulates1

Activation1

Regulator1

Promoter1

Regulatory1

Metabolism1

Differentiation1

Bound1

Cellular3

Infection2

Expression1

Risk Factors1

Enzymes1

Epithelial1

Lung cancer1

Closely related1

Chronic1