AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
LIM-Homeodomain ProteinsHomeodomain ProteinsTranscription FactorsNerve Tissue ProteinsLIM Domain ProteinsTranscription, GeneticGene Expression Regulation, DevelopmentalDNA-Binding ProteinsGenes, HomeoboxMolecular Sequence DataPromoter Regions, GeneticBase SequenceAmino Acid SequenceBinding SitesRepressor ProteinsGene Expression RegulationIn Situ HybridizationTrans-ActivatorsRecombinant Fusion ProteinsNuclear ProteinsProtein BindingTranscriptional ActivationCell DifferentiationAntennapedia Homeodomain ProteinSp1 Transcription FactorLim KinasesDNAWingBasic Helix-Loop-Helix Transcription FactorsMotor NeuronsRNA, MessengerPaired Box Transcription FactorsMutationCell LineDrosophila ProteinsInterneuronsSignal TransductionCell NucleusTransfectionEnhancer Elements, GeneticSequence Homology, Amino AcidGenes, ReporterDrosophilaProtein Structure, TertiaryTranscription Factor AP-1Octamer Transcription Factor-1Forkhead Transcription FactorsCloning, MolecularZinc FingersRegulatory Sequences, Nucleic AcidHeLa CellsChromatin ImmunoprecipitationTwo-Hybrid System TechniquesCells, CulturedBasic-Leucine Zipper Transcription FactorsElectrophoretic Mobility Shift AssayConsensus SequenceEmbryo, NonmammalianSequence AlignmentConserved SequenceTranscription Factor AP-2Reverse Transcriptase Polymerase Chain ReactionGene ExpressionKruppel-Like Transcription FactorsPhenotypeOtx Transcription FactorsMSX1 Transcription FactorProto-Oncogene ProteinsPOU Domain FactorsTranscription Factors, TFIIGATA4 Transcription FactorBody PatterningPlasmidsGoosecoid ProteinGene Expression Regulation, FungalLuciferasesDNA, ComplementaryTranscription Factor Pit-1YY1 Transcription FactorXenopus ProteinsSTAT3 Transcription FactorModels, BiologicalTranscription Factor TFIIDGene Expression ProfilingHelix-Loop-Helix MotifsGene Expression Regulation, PlantTATA BoxZebrafish ProteinsHost Cell Factor C1Activating Transcription Factor 3NFATC Transcription FactorsEye ProteinsFushi Tarazu Transcription FactorsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsMice, KnockoutSp3 Transcription FactorDrosophila melanogasterTranscription Initiation SiteNF-kappa B
TranscriptionalGenesHumansMiceHomeobox proteinsLHX4RegulateProto-OncogeneDomain proteinsEukaryoticInterneuronsGeneticIsl1KinaseBindChromatinDrosophilaTumorVertebrateHighly conservedMetabolismRegulatorsSynergisticallyPituitaryDifferentiationCysteine-rich proteinDevelopmentalFamilyPathwaysEncodes a proteinGene expressionSuperfamilyEffectorsEntry representsBindsCellsAntennapediaNucleicEnhancerInteractAmyloidZinc fingerElegansPromotersRibosomeHuman
Transcriptional14
  • The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of the pituitary gland. (wikipedia.org)
  • Mammalian LH-2, a transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types. (embl.de)
  • The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. (nih.gov)
  • It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. (nih.gov)
  • Our findings establish Sox17 as a tissue -specific modifier of Wnt responses and point to a novel paradigm where genomic specificity of Wnt/β-catenin transcription is determined through functional interactions between lineage-specific Sox TFs and β-catenin/Tcf transcriptional complexes. (xenbase.org)
  • see RTKRas/MAP kinase signaling ), LIN-12 (see LIN-12/Notch signaling in C. elegans ), and WNT (see Wnt signaling ), as well as the functions of the SynMuv and mediator proteins (see Transcriptional regulation ). (wormbook.org)
  • The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in epigenetics and chromatin-mediated transcriptional regulation. (embl-heidelberg.de)
  • The function of this domain is not yet known but in analogy with the LIM domain it could be involved in protein-protein interaction and be important for the assembly or activity of multicomponent complexes involved in transcriptional activation or repression. (embl-heidelberg.de)
  • A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
  • Furthermore, Smad proteins, transcriptional effectors of TGF-β signaling, are co-expressed and physically interact in the basal ganglia with Dlx homeodomain transcription factors, which are critical regulators of the differentiation, migration and survival of telencephalic GABAergic neurons. (biomedcentral.com)
  • By screening for proteins that colocalize with NHR-67 punctae, we identified new regulators of uterine cell fate maintenance: homologs of the transcriptional co-repressor Groucho (UNC-37 and LSY-22), as well as the TCF/LEF homolog POP-1. (elifesciences.org)
  • This valuable data study presents convincing data that expression of the C. elegans transcription factor NHR-67 is sufficient to drive an invasive fate, and that the alternative proliferative fate is associated with NHR-67 transcriptional down-regulation. (elifesciences.org)
  • In this study, we identified a pair of highly-related basic helix-loop-helix (bHLH) transcription factors, Nhlh1 and Nhlh2, as such a transcriptional program. (biorxiv.org)
  • A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS . (nih.gov)
Genes17
  • Rhombotin 1 (RBTN1 or TTG-1) and rhombotin-2 (RBTN2 or TTG-2) are proteins of about 160 amino acids whose genes are disrupted by chromosomal translocations in T-cell leukemia. (embl.de)
  • Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. (nih.gov)
  • Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. (lookformedical.com)
  • Genes that encode highly conserved TRANSCRIPTION FACTORS that control positional identity of cells (BODY PATTERNING) and MORPHOGENESIS throughout development. (lookformedical.com)
  • The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)
  • Our results show that podocyte expression of some genes is combinatorially regulated by two transcription factors interacting synergistically with a common enhancer. (ox.ac.uk)
  • LIM-homeodomain transcription factors regulate many aspects of development and mutations in the genes that encode these regulatory proteins are associated with several diseases. (endocrine-abstracts.org)
  • Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
  • The absence of genomic resources renders the search for paralogous cuttlefish genes dependent upon the presence of highly conserved protein motifs within genes of interest, thus we used a degenerate primer strategy to isolate partial coding sequence from the conserved domains specific to these families. (europa.eu)
  • Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)
  • We also show that Dlx and Smad proteins localize to promoters/enhancers of a number of common telencephalic genes in vivo and that Smad proteins co-activate transcription with Dlx family members, except with certain mutated human DLX proteins identified in autistic individuals. (biomedcentral.com)
  • Based on previous phylogenetic analyses in arabidopsis ( Arabidopsis thaliana ), our results showed that some tomato SL-ZH ( S. lycopersicum zinc-finger homeodomain) genes cluster into the same neighbor-joining (NJ) branch as arabidopsis, indicating that these genes may share similar structures and functions in these plants. (ashs.org)
  • Plant growth is systematically regulated by a system of specialized genes that encode various proteins, with certain genes being capable of influencing vegetative growth and stress tolerance, including cold, drought, and salinity. (ashs.org)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). (bvsalud.org)
  • So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikidoc.org)
  • Exploiting the aforementioned catalogs of driver genes, for example, we recently revealed the mutational landscape of chromatin regulatory factors (CRFs) in cancer [ 5 ]. (biomedcentral.com)
Humans2
  • LIM/homeobox protein Lhx4 is a protein that in humans is encoded by the LHX4 gene. (wikipedia.org)
  • In humans and mice, hotspots are specified by PRDM9, a meiosis-specific PRDM family protein (Baudat et al. (springer.com)
Mice1
  • One pathway, which has been extensively studied in yeast, is mainly guided by chromatin structure and the other, analyzed in detail in mice, is driven by the sequence-specific DNA-binding PR domain-containing protein 9 (PRDM9). (springer.com)
Homeobox proteins3
  • Vertebrate homeobox proteins lim-1, lim-2 (lim-5) and lim3. (embl.de)
  • Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)
  • A hallmark of events observed during segmentation was the induction of multiple transcription factors, including a large group of homeobox proteins in pace with decay of a large fraction of maternal transcripts. (biomedcentral.com)
LHX41
  • We tested the hypothesis that a variant of the LIM homeodomain gene LHX4 is responsible for the dwarfism phenotype. (nih.gov)
Regulate3
  • However, how transcription codes regulate axon pathfinding remains poorly understood. (biologists.com)
  • Signaling mechanisms mediated by the Transforming Growth Factor-β (TGF-β) superfamily regulate a variety of developmental processes. (biomedcentral.com)
  • Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. (bvsalud.org)
Proto-Oncogene1
Domain proteins1
  • It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions. (nih.gov)
Eukaryotic1
  • DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. (nih.gov)
Interneurons4
Genetic2
  • Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
  • Several other genetic backgrounds result in enlargement of the haltere significantly beyond the normal range of haploinsufficient phenotypes, suggesting genetic variation in cofactors that mediate homeotic protein function. (lookformedical.com)
Isl15
  • LIM domains coordinate one or more zinc atoms, and are named after the three proteins (LIN-11, Isl1 and MEC-3) in which they were first found. (embl.de)
  • Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons. (nih.gov)
  • Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. (ox.ac.uk)
  • We have recently shown that the LIM homeodomain transcription factor islet 1 (Isl1) marks a subset of cardiac progenitors. (ox.ac.uk)
  • Additionally, we find that Bmp signaling in Isl1-expressing progenitors is required for expression of T-box transcription factors Tbx2 and Tbx3 in heart and limb. (ox.ac.uk)
Kinase1
  • PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
Bind7
  • Some LIM domains bind protein partners via tyrosine-containing motifs. (embl.de)
  • They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl.de)
  • Proteins which bind to DNA. (lookformedical.com)
  • The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
  • In similarity to the RING finger and the LIM domain, the PHD finger is thought to bind two zinc ions. (embl-heidelberg.de)
  • Transcription factors (TFs), which bind to specific nucleotide sequences, have been shown to play important roles in the regulatory networks of numerous developmental processes in plants. (ashs.org)
  • In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. (bvsalud.org)
Chromatin2
  • The PHD finger and the bromodomain are small protein domains that occur in many proteins associated with phenomena related to chromatin. (embl-heidelberg.de)
  • DSB sites are preferentially located within chromatin loops, while several proteins that are required for DSB formation (Rec114, Mei4, and Mer2) localize on the chromosome axis (Blat et al. (springer.com)
Drosophila7
Tumor5
  • We will discuss three key proteins that function as tumor suppressors implicated in the development of pediatric (and some adult) cancers: pRB, p53, and PTEN. (medscape.com)
  • RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
  • Using immunohistochemistry, we observed HOXD9 protein expression in human brain tumor tissues, including astrocytomas and glioblastomas. (123dok.net)
  • [ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
  • Here, I focus on driver transcription factors and their connection to tumorigensis in several tumor types through the alteration of the expression of their targets. (biomedcentral.com)
Vertebrate5
  • Vertebrate insulin gene enhancer binding protein isl-1. (embl.de)
  • Vertebrate protein kinases LIMK-1 and LIMK-2. (embl.de)
  • Vertebrate paxillin, a cytoskeletal focal adhesion protein. (embl.de)
  • Transcription factor codes play an essential role in neuronal specification and axonal guidance in both vertebrate and invertebrate organisms. (biologists.com)
  • We focus our attention on three families of transcription factors that are known to have roles in vertebrate chondrogenesis: Sox and the Ant- and Prd- class families of the homeodomain proteins. (europa.eu)
Highly conserved1
  • Both predicted proteins are highly conserved with other known homologous sequences, with the exception of two small domains present only in the Sof-RXR. (europa.eu)
Metabolism2
  • We further provide evidence to support the hypothesis that transcription factors (TFs) required to drive induction, differentiation, and maintenance of midbrain dopaminergic neural progenitor cells which give rise to terminally differentiated SNpc neurons are uniquely involved in both developmental patterning and metabolism, a dual function unlike other TFs that program neurons in other brain regions. (frontiersin.org)
  • They play important roles in liver-specific transcription and are critical for CELL DIFFERENTIATION and METABOLISM. (umassmed.edu)
Regulators3
  • LIM domains are found in many key regulators of developmental pathways. (embl.de)
  • 15. Denaxa M , Sharpe PT, Pachnis V. (2009) The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition. (fleming.gr)
  • PRDM9 is a member of the PRDM family of transcription regulators, but unlike other family members, it contains a Krüppel-associated box (KRAB)-related domain that is predicted to be a potential protein interaction domain. (springer.com)
Synergistically1
  • In some cases, Sox17 and β-catenin synergistically activate transcription apparently independent of Tcfs, whereas on other enhancers, Sox17 represses β-catenin/Tcf-mediated transcription to spatially restrict gene expression domains. (xenbase.org)
Pituitary2
  • LHX3 is a LIM homeodomain transcription factor necessary for proper development of the pituitary and central nervous system. (endocrine-abstracts.org)
  • The LHX3 LIM-homeodomain protein is critical for pituitary gland organogenesis and some nervous s. (endocrine-abstracts.org)
Differentiation3
  • a protein required for the differentiation of the set of six touch receptor neurons in this nematode. (embl.de)
  • Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. (ox.ac.uk)
  • Here we show that components of both bone morphogenetic protein/growth differentiation factor and TGF-β/activin/Nodal branches of TGF-β superfamily signaling are expressed in the developing subpallium. (biomedcentral.com)
Cysteine-rich protein1
  • Mammalian and avian cysteine-rich protein (CRP), a 192 amino-acid protein of unknown function. (embl.de)
Developmental2
Family5
  • This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. (wikipedia.org)
  • The Bcl-2 homology 3 (BH3) domain is crucial for the death-inducing and dimerization properties of pro-apoptotic members of the Bcl-2 protein family, including Bak, Bax, and Bad. (lookformedical.com)
  • Four members of the mouse Dlx protein family (Dlx1, 2, 5 and 6), part of the Antennapedia class of non-Hox homeodomain transcription factors, are expressed in the embryonic subpallium (Panganiban and Rubenstein 2002 ). (biomedcentral.com)
  • Members of the zinc-finger homeodomain (ZF-HD) family play a key role in the control of plant growth and development, which are involved in plant responses to stress. (ashs.org)
  • Hepatocyte nuclear factors are a family of evolutionarily conserved transcription factors that are preferentially expressed in HEPATOCYTES. (umassmed.edu)
Pathways3
  • We have gained crucial insights into molecular factors and pathways of the cells generating either the supporting gonadal cells or germ cells of both sexes. (lidsen.com)
  • In that regard, recent studies in non-neural cells have suggested the existence of functional interactions between Dlx proteins and Smad transcription factors, which are critical mediators of transforming growth factor-β (TGF-β) superfamily signaling pathways (Chiba et al. (biomedcentral.com)
  • These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR , where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA . (nih.gov)
Encodes a protein1
  • This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)
Gene expression1
Superfamily1
  • Together, these results suggest that TGF-β superfamily signaling plays a role in telencephalic GABAergic neuron development through functional interactions with Dlx transcription factors. (biomedcentral.com)
Effectors1
  • Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers. (xenbase.org)
Entry represents1
  • This entry represents LIM-type zinc finger (Znf) domains. (embl.de)
Binds1
  • Isl-1 binds to one of the two cis-acting protein-binding domains of the insulin gene. (embl.de)
Cells7
  • a protein required for the asymmetric division of vulval blast cells. (embl.de)
  • In addition, entinostat, a HDAC inhibitor targeting SALL4, could suppress the proliferation, migration, and invasion of gastric cancer cells via regulating expression of EMT-associated proteins. (bvsalud.org)
  • The anchor cell induces nearby epidermal precursor cells to generate vulval cells via an epidermal growth factor (EGF) signaling pathway. (wormbook.org)
  • Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)
  • Transcription of nhr-67 is downregulated following post-translational degradation of its direct upstream regulator, HLH-2 (E/Daughterless) in VU cells. (elifesciences.org)
  • In the nuclei of VU cells, residual NHR-67 protein is compartmentalized into discrete punctae that are dynamic over the cell cycle and exhibit liquid-like properties. (elifesciences.org)
  • Cytokinesis in animal cells relies on a centralspindlin complex consisting of male germ cell RacGap (MgcRacGAP) and mitotic kinesin-like protein 1 (MKLP1). (shengsci.com)
Antennapedia2
Nucleic1
  • Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (lookformedical.com)
Enhancer1
  • Within this enhancer, we identified a cis-acting element composed of two adjacent DNA-binding sites (FLAT-E and forkhead) bound by transcription factors Lmx1b and FoxC. (ox.ac.uk)
Interact3
  • Zyxin is a low-abundance adhesion plaque protein which has been shown to interact with CRP. (embl.de)
  • However, the molecular mechanisms by which Otx and other transcription factors (TFs) interact with the genome to direct head formation are largely unknown. (xenbase.org)
  • In addition, we identified proteins that interact with the KRAB domain of PRDM9 in yeast two-hybrid assay screens, particularly CXXC1, a member of the COMPASS complex. (springer.com)
Amyloid2
  • Aβ1-40 mediated aggregation of proteins and metabolites unveils the relevance of amyloid cross-seeding in amyloidogenesis. (shengsci.com)
  • Here, we show that amyloid fibrils of Aβ1-40 peptide can effectively initiate amyloid formation in different globular proteins and metabolites, converti. (shengsci.com)
Zinc finger1
  • these include the LIM domain protein LIN-11 , the Pax2/5/8 protein EGL-38 , the zinc finger protein LIN-29 , and the Nkx6.1/6.2 protein COG-1. (wormbook.org)
Elegans2
  • C. elegans homeobox protein ceh-14. (embl.de)
  • C. elegans homeobox protein unc-97. (embl.de)
Promoters1
  • Indeed, in the absence of PRDM9, meiotic DSBs occur at transcription regulatory regions, such as promoters and enhancers (Brick et al. (springer.com)
Ribosome2
  • Identification, characterization and structure analysis of a type I ribosome-inactivating protein from Sapium sebiferum (Euphorbiaceae). (shengsci.com)
  • Ribosome-inactivating proteins (RIPs) are N-glycosidases (EC3.2.2.22) that universally inactivate the ribosome, thereby inhibiting protein biosynthesis. (shengsci.com)
Human1
  • PR domain-containing protein 9 (PRDM9) is a major regulator of the localization of meiotic recombination hotspots in the human and mouse genomes. (springer.com)