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Transcription Factor TFIIIARNA, Ribosomal, 5STranscription FactorsXenopus laevisRNA, RibosomalTranscription, GeneticZinc FingersXenopusDNA-Binding ProteinsMolecular Sequence DataBase SequenceDNA, RibosomalDeoxyribonuclease IBinding SitesProtein BindingPromoter Regions, GeneticDNAAmino Acid SequenceSp1 Transcription FactorGene Expression RegulationRNA Polymerase IIIOocytesNucleic Acid ConformationGenesTranscriptional ActivationTrans-ActivatorsCloning, MolecularRNA, MessengerBasic Helix-Loop-Helix Transcription FactorsNuclear ProteinsTranscription Factor AP-1ZincRepressor ProteinsCell LineForkhead Transcription FactorsHomeodomain ProteinsGene Expression Regulation, DevelopmentalSignal TransductionMutationBasic-Leucine Zipper Transcription FactorsTranscription Factor AP-2KineticsCell NucleusCell DifferentiationTransfectionKruppel-Like Transcription FactorsTranscription Factors, TFIIChromatin ImmunoprecipitationGenes, ReporterHeLa CellsYY1 Transcription FactorSTAT3 Transcription FactorGATA4 Transcription FactorTranscription Factor TFIIDCells, CulturedRegulatory Sequences, Nucleic AcidActivating Transcription Factor 3NFATC Transcription FactorsSp3 Transcription FactorTranscription Initiation SiteNF-kappa BReverse Transcriptase Polymerase Chain ReactionPaired Box Transcription FactorsPlasmidsElectrophoretic Mobility Shift AssayActivating Transcription Factor 2Transcription Factor TFIIBEnhancer Elements, GeneticRecombinant Fusion ProteinsE2F1 Transcription FactorRNA Polymerase IIGene Expression ProfilingTranscription Factor TFIIABasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMEF2 Transcription FactorsGATA3 Transcription FactorGATA1 Transcription FactorGATA2 Transcription FactorGene ExpressionGene Expression Regulation, Fungal
ProteinsInteractsZinc fingerInteractionBoundGene transcriptionInitiationRRNARegionXenopusRibosomalProteinZinc fingersComplexesGeneralRecognitionStructureAlternativeActivationRoleExpression
Proteins1
  • Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev". Proceedings of the National Academy of Sciences of the United States of America. (wikipedia.org)
Interacts2
  • Gene-specific factor TFIIIA interacts with DNA and acts as an adaptor for TFIIIC-promoter interactions. (bvsalud.org)
  • A nucleation site, most likely at or near the ICR, is proposed to exist through which TFIIIA specifically interacts and orients the binding of additional protein molecules in a cooperative and highly ordered manner to the flanking DNA sequences on either side of the ICR. (xenbase.org)
Zinc finger2
  • The TFIIIA in Xenopus was the first zinc finger protein discovered. (wikipedia.org)
  • To obtain structural information, we synthesized single and double zinc finger peptides from the yeast transcription activator ADR1, and assessed the metal-binding and DNA-binding properties of these peptides, as well as the solution structure of the metal-stabilized domains, with the use of a variety of spectroscopic techniques. (embl.de)
Interaction1
  • The interaction of Xenopus transcription factor IIIA (TFIIIA) with the intragenic control region (ICR) of the 5 S RNA gene was studied by footprinting techniques under conditions which elicited a unique DNase I digestion pattern. (xenbase.org)
Bound1
  • Here, we use cryoelectron microscopy (cryo-EM) to visualize the S. cerevisiae complex of TFIIIA and TFIIIC bound to the promoter. (bvsalud.org)
Gene transcription1
  • The APP effect near the ICR may play a role in the initiation and stabilization of 5 S RNA gene transcription. (xenbase.org)
Initiation1
  • Our findings provide new insights into the transcription initiation complex assembly on the 5S rRNA promoter and allow us to directly compare Pol III and Pol II transcription adaptations. (bvsalud.org)
RRNA1
Region1
  • Xenopus transcription factor IIIA binds to the flanking regions of the 5 S RNA gene intragenic control region in a unique and highly ordered state. (xenbase.org)
Xenopus7
  • The TFIIIA in Xenopus was the first zinc finger protein discovered. (wikipedia.org)
  • 2. Interaction of the RNA binding fingers of Xenopus transcription factor IIIA with specific regions of 5 S ribosomal RNA. (nih.gov)
  • 4. Dissection of the DNA-binding domain of Xenopus laevis TFIIIA. (nih.gov)
  • 5. Studies on interaction of different zinc-finger domains of Xenopus laevis TFIIIA with eukaryotic 5S rRNAs. (nih.gov)
  • 8. Genetic analysis of Xenopus transcription factor IIIA. (nih.gov)
  • 10. Transcription factor IIIA induced bending of the Xenopus somatic 5S gene promoter. (nih.gov)
  • 17. Differential binding of oocyte-type and somatic-type 5S rRNA to TFIIIA and ribosomal protein L5 in Xenopus oocytes: specialization for storage versus mobilization. (nih.gov)
Ribosomal3
  • 1. Identification of a minimal domain of 5 S ribosomal RNA sufficient for high affinity interactions with the RNA-specific zinc fingers of transcription factor IIIA. (nih.gov)
  • It is a zinc finger ( ZINC FINGERS ) protein and is required for transcription of 5S ribosomal genes. (nih.gov)
  • Identification and characterization of transcription factor IIIA and ribosomal protein L5 from Arabidopsis thaliana. (igred.fr)
Protein4
  • Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene. (wikipedia.org)
  • 6. Protein and DNA requirements for the transcription factor IIIA-induced distortion of the 5 S rRNA gene promoter. (nih.gov)
  • Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. (utsouthwestern.edu)
  • A20 is a cytoplasmic zinc finger protein that inhibits nuclear factor kappa-B activity and tumor necrosis factor (TNF)-mediated programmed cell death. (biomedcentral.com)
Zinc fingers5
  • Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex. (nih.gov)
  • 3. The role of the central zinc fingers of transcription factor IIIA in binding to 5 S RNA. (nih.gov)
  • 7. Solution structure of the first three zinc fingers of TFIIIA bound to the cognate DNA sequence: determinants of affinity and sequence specificity. (nih.gov)
  • 11. Importance of minor groove binding zinc fingers within the transcription factor IIIA-DNA complex. (nih.gov)
  • 12. Relative contributions of the zinc fingers of transcription factor IIIA to the energetics of DNA binding. (nih.gov)
Complexes1
  • Quantitative DNase I footprinting analysis of specific complexes between a 5 S RNA gene fragment and N-terminal fragments of TFIIIA containing three, four or five zinc-finger domains. (nih.gov)
General1
Recognition1
Structure1
  • To obtain structural information, we synthesized single and double zinc finger peptides from the yeast transcription activator ADR1, and assessed the metal-binding and DNA-binding properties of these peptides, as well as the solution structure of the metal-stabilized domains, with the use of a variety of spectroscopic techniques. (embl.de)
Alternative1
  • Transcript levels, alternative splicing and proteolytic cleavage of TFIIIA control 5S rRNA accumulation during Arabidopsis thaliana development. (igred.fr)
Activation1
  • Stress-induced activation of heterochromatic transcription. (igred.fr)
Role1
  • A role for MED14 and UVH6 in heterochromatin transcription upon destabilization of silencing. (igred.fr)
Expression1