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  • induces
  • Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis. (semanticscholar.org)
  • The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner. (moffitt.org)
  • novel
  • Here, we report on the identification of a novel E2F target gene, ATAD2 , the predicted protein product of which contains both a bromodomain and an ATPase domain. (aacrjournals.org)
  • human
  • Human E2F6 full-length ORF ( AAH08348, 1 a.a. - 281 a.a.) recombinant protein with GST-tag at N-terminal. (abnova.com)
  • The data presented here imply that the p45 SKP2 -CUL‐1-p19 SKP1 complex may be a human representative of an SCF‐type E3 ubiquitin protein ligase. (embopress.org)
  • activity
  • Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus. (semanticscholar.org)
  • vascular
  • Thymoquinone inhibited vascular endothelial growth factor-induced extracellular signal-regulated kinase activation but showed no inhibitory effects on vascular endothelial growth factor receptor 2 activation. (aacrjournals.org)
  • AKT signaling stimulates the production of hypoxia-inducible factortranscription factors and thereby mediates secretion of vascular endothelial growth factor (VEGF) and other growth factors, which are important proangiogenic factors ( 21 , 22 ). (aacrjournals.org)
  • Initiation
  • The active ULK and Beclin-1 complexes re-localize to the site of autophagosome initiation, the phagophore, where they both contribute to the activation of downstream autophagy components. (antibodies-online.com)
  • links
  • We suggest that ATAD2 links the E2F and MYC pathways and contributes to the development of aggressive cancer through the enhancement of MYC-dependent transcription. (aacrjournals.org)
  • role
  • EGR-1/Bax pathway plays a role in vitamin E δ-tocotrienol-induced apoptosis in pancreatic cancer cells. (nih.gov)
  • Atg13
  • ULK ist zusammen mit Atg13, Atg101 und FIP200 Teil eines Proteinkomplexes welcher Beclin-1 phosphoryliert und somit aktiviert. (antikoerper-online.de)