Transcription factor drosophila homologous genes. Medical search. Frequent questions

Additionally, homologous proteins were found in Drosophila melanogaster (fruit fly) and Gallus gallus (chicken). (wikipedia.org)
They have only been studied in a few model organisms, such as Drosophila melanogaster , Caenorhabditis elegans , Schmidtea mediterranea and some vertebrates. (biomedcentral.com)
In this study we investigate regulatory interactions amongst the transcription factors of Drosophila melanogaster and humans, and show that they have a similar dearth of negative autoregulation to that seen in S. cerevisiae. (ucl.ac.uk)
Drosophila melanogaster SL-2 cells were managed in Schneider's insect medium. (bio2009.org)
To understand the role of autophagy in the pathogenesis of glial tumors in vivo, an established Drosophila melanogaster model of glioma was used based on overexpression in larval glial cells of an active human EGFR and of the PI3K homolog Pi3K92E /Dp110. (sdbonline.org)
Similar secretory cells also exist in the female reproductive tract of Drosophila melanogaster, whose reproductive system is anatomically similar to human (Fig 1). (uconn.edu)
Drosophila melanogaster presents a simpler model system in which to study FGF signaling, with only three ligands and two FGF receptors (FGFRs) identified. (biologists.com)
His Cell biology research is multidisciplinary, incorporating elements of Cell cycle and Drosophila melanogaster. (research.com)

The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
Sall (Spalt-like) proteins are zinc-finger transcription factors involved in a number of biological processes. (biomedcentral.com)
The evolution of Sall proteins in bilaterians might have occurred mostly as a result of the loss of protein domains and gene duplications leading to diversification. (biomedcentral.com)
Fluorescent reporter proteins in the Drosophila model system offer a degree of specificity that allows monitoring cellular and biochemical phenomena in vivo, such as autophagy, mitophagy, and changes in the redox state of cells. (intechopen.com)
WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. (embl.de)
Members of this family include the signal-transducing G protein beta subunit, as well as other proteins that regulate signal transduction, transcription, pre-mRNA splicing, cytoskeletal organization, and vesicular fusion. (embl.de)
The 72-amino acid TEA DNA binding domains in mTEAD-2, 3, and 4 are approximately 99% homologous to the same domain in mTEAD-1, and all four proteins bind specifically to the same DNA sequences in vitro with a Kd value of 16-38 nM DNA. (embl-heidelberg.de)
HDACs form a family of enzymes that catalyze 67346-49-0 the removal of acetyl moieties from acetylated proteins including histones structural proteins or transcription factors (25 31 Together with their counterparts the histone acetyltransferases HDACs regulate the reversible acetylation of core histones and additional proteins. (bio2009.org)
In addition acetylation of transcription factors offers been shown elsewhere to impact the stability and intracellular localization of proteins or to modulate the affinity for DNA or additional proteins (34). (bio2009.org)
The initial domains of homeotic gene repression are set by the segmentation proteins, which also divide the embryo into segments. (nih.gov)

We hypothesized that p53 contributed to PC12 differentiation through the regulation of gene targets distinct from its known transcriptional targets for apoptosis or DNA repair. (biomedcentral.com)
Furthermore, we describe stimulus-specific regulation of a subset of these target genes by p53. (biomedcentral.com)
encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
All these studies have shown that spalt is activated in response to several signal transduction pathways in different tissues and developmental processes [ 11 ], and the expression patterns and functions of sall genes, together with the analysis of their regulation, indicate they cannot be universally assigned to a specific signaling pathway. (biomedcentral.com)
Caenorhabditis elegans is a powerful model for studying gene regulation, as it has a compact genome and a wealth of genomic tools. (umassmed.edu)
Genome organization involves cis and trans chromosomal interactions, both implicated in gene regulation, development, and disease. (umassmed.edu)
The aim of the present work is to review cumulative evidence regarding the participation of PI3K pathways in neuronal function, focusing on their role in neuronal metabolism and transcriptional regulation of genes involved in neuronal maintenance and plasticity or on the expression of pathological hallmarks associated with neurodegeneration. (mdpi.com)
Regulation of gene expression at the beginning of mammalian development and the TEAD family of transcription factors. (embl-heidelberg.de)
an unexpected, maladaptive up-regulation of CREG , a conserved, neuronally expressed, stress response gene and a novel repressor of PHP. (sdbonline.org)
We will further characterize the function of these genes and their regulation. (uconn.edu)

2) lilli mutation strongly suppresses the rough eye phenotype of ectopically expressed phyllopod (Tang, 2001), and (3) lilli was identified in a screen for genes that enhance the embryonic lethal phenotype of dpp alleles (Su, 2001). (sdbonline.org)
These mutant phenotypes correlate with markedly reduced expression of the early zygotic genes serendipity alpha , fushi tarazu and huckebein , which are essential for cellularization and embryonic patterning (Tang, 2001). (sdbonline.org)
In Drosophila , the homeotic genes specify cell identities at both embryonic and adult stages. (nih.gov)
In Drosophila , a pool of SGG isoenzymes encoded by a single gene is necessary to establish cell fate and polarity within embryonic segments [ 8 ] as well as for development of the nervous system [ 9 ]. (biomedcentral.com)

One of the important groups of conserved developmental genes are the homeotic genes. (nih.gov)
The homeotic genes are expressed in precise spatial patterns that are crucial for the proper determination of cell fate. (nih.gov)
The changes provide powerful assays for identifying the trans -acting factors that regulate the homeotic genes and the cis -acting sequences through which they act. (nih.gov)
Assays in transgenes in Drosophila previously identified cis -acting transcriptional regulatory elements from homeotic genes. (nih.gov)
We used a large number of existing chromosomal aberrations in the Scr homeotic gene to investigate the functions of the cis -acting elements within the endogenous gene. (nih.gov)

How Gene Expression (mRNA and protein synthesis) is spatially controlled in embryos. (albertkharris.com)
Names are often "whimsical" - mutants with no hearts might be called "Heartless", but the name "Tinman" (from The Wizard of Oz) was chosen for one of the best-characterized genes that can be mutated to produce embryos that fail to develop a heart. (albertkharris.com)
In mouse development, transcription is first detected in late 1-cell embryos, but translation of newly synthesized transcripts does not begin until the 2-cell stage. (embl-heidelberg.de)
The most effective enhancer in cleavage stage mouse embryos depends on DNA binding sites for TEF-1, the prototype for a family of transcription factors that share the same TEA DNA binding domain. (embl-heidelberg.de)
UV-binding factors found in 12-h-old zebrafish embryos may be involved in processing developmental stage-specific DNA structures similar to UV-damage DNA. (ncl.edu.tw)

Members of the DTX (Deltex) family act as Notch signaling modifiers and may also regulate transcription through interactions with specific transcription factors. (nih.gov)
MicroRNAs are small, non-coding RNA molecules that can complementarily bind to the mRNA 3'-UTR region to regulate the gene expression by transcriptional repression or induction of mRNA degradation. (gene-quantification.com)
Increasing evidence suggests a new mechanism by which miRNAs may regulate target gene expression by binding in promoter and amino acid coding regions. (gene-quantification.com)

His work in Control of chromosome duplication, Origin recognition complex, Saccharomyces cerevisiae, Gene conversion and Meiosis is related to Genetics. (research.com)
His Origin recognition complex study incorporates themes from General transcription factor, Pre-replication complex, Control of chromosome duplication, Licensing factor and E-box. (research.com)
Polyploid, Eukaryotic DNA replication, Replication factor C, DNA replication factor CDT1 and Control of chromosome duplication are the core of his Genetics study. (research.com)
The enhancer is not only able to activate transcription of the Scr promoter that is 35 kb distant but can also activate transcription of the Scr promoter on the homologous chromosome. (nih.gov)
When not physically linked, the elements interact with elements on the homologous chromosome and cause derepression of its wild-type Scr gene. (nih.gov)
Genomic and cDNA sequence alignments as well as chromosome localization using nullisomic-tetrasomic lines provided strong evidence for three expressed gene copies located on homoeolog chromosomes for TaSK1 as well as for TaSK2 . (biomedcentral.com)

Here, we focus on trans interactions in Drosophila, where homologous chromosomes are paired in somatic cells from embryogenesis through adulthood. (umassmed.edu)

We show that regulatory interactions between pairs of homologous genes within the same cell can lead to under-dominance - mutations which result in stronger autoregulation, and decrease noise in homozygotes, paradoxically can cause increased noise in heterozygotes. (ucl.ac.uk)
Mutations in the GLA Gene and LysoGb3: Is It Really Anderson-Fabry Disease? (mdpi.com)
In humans, mutations affecting the genes of this family are associated with specific diseases. (sdbonline.org)
Heterozygous null mutations in each autism gene are demonstrated to have normal baseline neurotransmission and PHP. (sdbonline.org)
A subsequent electrophysiology-based genetic screen identifies the first known heterozygous mutations that commonly genetically interact with multiple ASD gene orthologs, causing PHP to fail. (sdbonline.org)
We are investigating the impact of specific classes of gene mutations, such as ATM, BRCA1, and MYBL2 on genome integrity. (birmingham.ac.uk)
By analyzing lethal mutations in the fruit fly Drosophila Hadorn accumulated evidence that genes control development to a large extent and that they determine the body plan in great detail. (balzan.org)
Gain-of-function mutations in the STAT3 gene have been reported to cause multi-organ early onset auto-immune diseases. (statpathway.com)

Using a genome-wide chromatin immunoprecipitation cloning technique, we identified and validated 14 novel p53-regulated genes following NGF treatment. (biomedcentral.com)
Using genome and transcriptome mining, we confirmed the presence of sall genes in a range of additional animal taxa, for which their presence had not yet been described. (biomedcentral.com)
Nautilus shows a compact, minimalist genome with few encoding genes and slow evolutionary rates in both non-coding and coding regions among known cephalopods. (nature.com)
While each DNA blueprint, or gene, encodes for a different machine or structure, the genome, the collection of DNA wrapped up inside the nucleus, is much more active than a quiet library of neatly stacked blue-prints. (birmingham.ac.uk)
We examine the impact that processes such as transcription and replication have on genome stability. (birmingham.ac.uk)
All of his Genetics and Genome, Gene, DNA re-replication, Aurora B kinase and Polyploid investigations are sub-components of the entire Genetics study. (research.com)
The Drosophila genome is about one twentieth the size of the human genome. (nih.gov)
In contrast to the human genome that contains two genes, plant GSKs are encoded by a multigene family. (biomedcentral.com)
A Whole Genome Assembler for Drosophila. (auth.gr)
In participating UK research institutions, investigators can publish open access in Genome Research, Genes & Development, RNA, and Learning & Memory without article publication charges and all staff can read the entire renowned Cold Spring Harbor journal collection. (cshlpress.com)

Ligands of the transforming growth factor-β (TGFβ) superfamily of growth factors initiate signal transduction through a bewildering complexity of ligand-receptor interactions. (nature.com)
The interactions of the three HH factors are complicated. (regenmedres-journal.org)
The transcriptional silencers are clustered in the two regions whose interactions are required for the maintenance of silencing in the endogenous genes. (nih.gov)
The large majority of the early embryologists thought that the genes played only a minor role in development, for example by determining eye color, and that development is rather controlled by tissue interactions. (balzan.org)

More than 30 mammalian genes comprise the TGFβ superfamily of growth factors. (nature.com)

Disruption of p53 activity through direct mutation or regulatory dysfunction is a demonstrated causal factor in a large proportion of human malignancies [ 2 ]. (biomedcentral.com)
As a transcription factor, many of the functional cellular roles of the p53 protein are elicited through direct DNA binding to sequence-specific cis-regulatory elements [ 3 ] leading to the transactivation or transrepression of target genes. (biomedcentral.com)
However, identification of regulatory elements has been limited, as DNA-binding motifs are known for only 71 of the estimated 763 sequence-specific transcription factors (TFs). (umassmed.edu)
Motif enrichment in promoters of functionally related genes is consistent with known biology, and also identifies putative regulatory roles for unstudied TFs. (umassmed.edu)
Regulatory networks have evolved to allow gene expression to rapidly track changes in the environment as well as to buffer perturbations and maintain cellular homeostasis in the absence of change. (ucl.ac.uk)
Our work offers a simple and general explanation for a previously unexplained difference between the regulatory architectures of E. coli and yeast, Drosophila and humans. (ucl.ac.uk)
Importantly, multiple genomic innovations including gene losses, independent contraction and expansion of specific gene families and their associated regulatory networks likely moulded the evolution of the nautilus pinhole eye. (nature.com)
The Hh gene family encodes a secreted protein that plays a critical regulatory role in the process of embryogenesis and environmental stabilization in adult tissues of invertebrates and vertebrates [ 44 ]. (regenmedres-journal.org)
In the fly, signals are regulated by a single Hh gene, while in mammals, Sonic (SHH), Indian (IHH), and Desert (DHH) hedgehog play different regulatory roles [ 37 , 148 ]. (regenmedres-journal.org)
While these transgenic assays have been important in defining the structure of the cis -regulatory elements and identifying trans -acting factors that bind to them, their functions within the context of the endogenous genes remain poorly understood. (nih.gov)

Bok (Bcl-2 related ovarian killer) is a protein-coding gene of the Bcl-2 family that is found in many invertebrates and vertebrates. (wikipedia.org)
The Bok gene is activated and produces protein in different tissues. (wikipedia.org)
Our analysis of the protein domains shows that the characteristic arrangement of the multiple zinc-finger domains is conserved in bilaterians and may represent the ancient arrangement of this family of transcription factors. (biomedcentral.com)
The lilli gene encodes a nuclear protein related to the AF4/FMR2 family. (sdbonline.org)
The SHH pathway should be off at most of the time, by the inhibition of specific factors such as Patched 1 (PTC1), Protein Kinase A (PKA), Casein Kinase1 (CK1), and Glycogen Synthase Kinase 3 beta (GSK3b), and only valid at precise time points [ 98 ]. (regenmedres-journal.org)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
The Cell cycle study combines topics in areas such as Ploidy, Mitosis, Drosophila Protein and Cell fate determination. (research.com)

However, despite its smaller size, most developmental genes and at least half of the disease- and cancer-causing genes in humans are conserved in Drosophila , making Drosophila an excellent model system for the study of human development and disease. (nih.gov)

These gene sequences are conservative through evolution (for example have homologous sequences in flies and in vertebrates) although they don't necessarily have the same function. (albertkharris.com)

The human BOK promoter is activated by the overexpression of members of the E2F hand transcription factor family. (wikipedia.org)
Following relatively long initiation and promoter clearance, RNA polymerase II can pause and then rapidly elongate following recruitment of positive elongation factors. (sdbonline.org)
The transcriptional activation from CACNA1F the p21 gene by these inhibitors is normally marketed by chromatin redecorating pursuing acetylation of histones H3 and H4 in the p21 promoter area (32 54 This activation of p21 takes place within a p53-unbiased fashion and for that reason HDAC inhibitors are appealing realtors for cancers therapy being that they are operative in cells with mutated p53 genes a hallmark of several tumors. (bio2009.org)
The promoter from the individual p21 gene harbors six conserved GC containers binding sites for the transcription aspect Sp1. (bio2009.org)
In addition to its function as a transcriptional activator Sp1 offers been recently shown to act as a repressor by recruiting HDAC1 to the growth-regulated murine thymidine kinase gene (TK) promoter (11). (bio2009.org)

Furthermore, these FGF ligands are not regulated solely by differential expression, but the sequences of these linked genes have evolved to serve different functions. (biologists.com)

The most salient differentiation-relevant target genes included wnt7b involved in dendritic extension and the tfcp2l4/grhl3 grainyhead homolog implicated in ectodermal development. (biomedcentral.com)
Interestingly, the resulting hyperplastic glia express high levels of key components of the lysosomal-autophagic compartment, including vacuolar-type H(+)-ATPase (V-ATPase) subunits and ref(2)P (refractory to Sigma P), the Drosophila homolog of SQSTM1/p62. (sdbonline.org)

Typically, these transcription factors are involved in the promotion of S-phase, so there might be a connection between Bok expression and cell cycle progression. (wikipedia.org)
However, the expression pattern of the Bok gene varies among species. (wikipedia.org)
runx1 expression in the lateral plate mesoderm co-localizes with the hematopoietic transcription factor scl , and expression of runx1 is markedly reduced in the zebrafish mutants spadetail and cloche . (biologists.com)
Less is known regarding its critical role in neuronal physiology, neuronal metabolism, tissue homeostasis, and the control of gene expression in the central nervous system in healthy and diseased states. (mdpi.com)
Thus, the onset of zygotic gene expression (ZGE) is regulated at the level of both transcription and translation. (embl-heidelberg.de)
In the vertebrate CNS, HB9/MNR2 transcription factors are specifically expressed in all somatic motoneurons and are necessary to distinguish motoneurons from interneurons, in part by repressing interneuron-specific gene expression. (jneurosci.org)
Almost half of the genes expressed in adults showed reduced expression, supporting a broad role for the three tested genes in steady-state transcript abundance. (sdbonline.org)
Expression profiles following lilliputian and Suppressor of Triplolethal RNAi were nearly identical raising the possibility that they are obligatory co-factors. (sdbonline.org)
Genes showing reduced expression due to these RNAi treatments were short and enriched for genes encoding metabolic or enzymatic functions. (sdbonline.org)
Hundreds of genes were observed with sex-biased differential expression following treatment. (sdbonline.org)
DHH/PTC1 signaling triggers differentiation of Leydig cells by up-regulating Steroidogenic Factor 1 and expression of cytochrome P450 Side-Chain Cleavage enzyme located outside testicular cord [ 145 ]. (regenmedres-journal.org)
To find out irrespective of whether these probable explanations may very well be excluded, the expression of Tat induced IDO by MoDCs was analyzed by culturing cells inside a transwell co culture technique that allowed factor diffusion involving the upper and decrease chambers. (statpathway.com)
Genes whose expression levels rise and fall similarly in a large set of samples, may be considered coexpressed. (mdpi.com)
The expression of distorted DNA-binding factors was studied in developing zebrafish using UV-damaged DNA as the binding target. (ncl.edu.tw)
CYTOMER® : A database on gene expression sources. (auth.gr)
Interpreting Clusters of Gene Expression Profiles in Terms of Metabolic Pathways. (auth.gr)

Additional screens for MMTV provirus entry sites in tumors revealed several other upregulated genes that are associated with other gene development pathways such as INT2, INT3, and INT4 [4,5,6]. (chemdiv.com)

Activation of p53 efficiently counteracts deacetylase-mediated repression and induces cell cycle arrest by activating the p21 gene. (bio2009.org)
Characterization of the chromosomal rearrangements shown in Figure 1 also revealed that two genetic elements (proximal and distal MES [maintenance elements for silencing]), about 70 kb apart in the Scr gene, must be in cis to maintain proper repression. (nih.gov)

Here, we identify and characterize the single Drosophila ortholog of the HB9/MNR2 gene family. (jneurosci.org)

E2F composite units in promoters of cell cycle genes. (auth.gr)

On the basis of recent vertebrate studies, the HB9/MNR2 gene family is a prime candidate for a general determinant of somatic motoneuron cell type. (jneurosci.org)
Together, vertebrate HB9/MNR2 transcription factors are expressed in all somatic motoneurons and excluded from interneurons. (jneurosci.org)
Thus, vertebrate HB9/MNR2 genes are expressed specifically in somatic motoneurons and are essential for distinguishing motoneuron/interneuron cell types. (jneurosci.org)
Drosophila HB9 differs from its vertebrate orthologs in several ways: it is not expressed in all somatic motoneurons, it is expressed in a subset of interneurons, and it is required for the proper development of both interneurons and motoneurons. (jneurosci.org)

Simultaneous work in the field of developmental biology and work with Drosophila has established the INT1 gene is a homologue of the Drosophila segment polarity gene [2]. (chemdiv.com)

The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)

Shimmi, O., Umulis, D., Othmer, H. & O'Connor, M. B. Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo. (nature.com)

We studied the transcriptional role of p53 during nerve growth factor-induced differentiation of the PC12 line into neuron-like cells. (biomedcentral.com)
With the powerful genetic tools available in Drosophila, we have identified multiple candidate genes required for secretory cells differentiation and for regulating ovulation and sperm function. (uconn.edu)
Fibroblast growth factor (FGF) signaling controls a vast array of biological processes including cell differentiation and migration, wound healing and malignancy. (biologists.com)
We demonstrate that the Drosophila FGFs have different activities and that cell migration and differentiation have different ligand requirements. (biologists.com)

Although the imaginal leg enhancer can activate transcription in all three pairs of legs, it is normally silenced in the second and third pairs of legs. (nih.gov)
Imaginal discs are the primordia of the Drosophila larva, which during metamorphosis give rise to the various parts of the adult fruit fly. (balzan.org)

Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)

These results suggest that transcriptional elongation control is especially important for rapidly expressed genes to support digestion and metabolism, many of which have sex-biased function. (sdbonline.org)

Glioblastoma (GBM), a very aggressive and incurable tumor, often results from constitutive activation of EGFR (epidermal growth factor receptor) and of phosphoinositide 3-kinase (PI3K). (sdbonline.org)

Recently, we identified and characterized a unique diffuse large B-cell lymphoma risk-related gene named BAL (B aggressive lymphoma). (nih.gov)
Thus, Drosophila HB9 is required in a subset of motoneurons and interneurons for establishing proper axon projections but does not have a general role in distinguishing motoneuron and interneuron cell types. (jneurosci.org)
effects the main target for p53-induced cell cycle arrest seems to be the p21 gene. (bio2009.org)
We recently defined the secretory cell lineage at the single cell resolution and discovered that gland formation utilizes a conserved genetic program including the Notch signaling pathway, NR5A family member Hr39 (homologous to Lrh-1 in mammals), and Runt-domain transcription factor Lozenge [4] (See the video below). (uconn.edu)
NR5A Nuclear Receptor Hr39 Controls Three-Cell Secretory Unit Formation in Drosophila Female Reproductive Glands. (uconn.edu)
Most Fibroblast growth factors (FGFs) have N-terminal signal peptides and are secreted from cells, allowing binding to and activation of their cell surface receptors (FGFRs). (biologists.com)
His primary scientific interests are in Genetics, Cell biology, Gene, Sister chromatids and Cell cycle. (research.com)
The various areas that Terry L. Orr-Weaver examines in his Cell cycle study include Transcription factor and DNA replication. (research.com)
The scientist's investigation covers issues in Genetics, Cell biology, Sister chromatids, DNA replication and Gene. (research.com)
The genes encode homeodomain-containing transcription factors that control cell fates by regulating the transcription of downstream target genes. (nih.gov)
The trans -acting factors are also conserved between Drosophila and human and have important functions, not only in development but also in stem-cell maintenance and cancer. (nih.gov)

Here we analyze the specificity of FGFR [Heartless (Htl) and Breathless (Btl)]activation by each of the FGF ligands [Pyramus (Pyr), Thisbe (Ths) and Branchless (Bnl)] in Drosophila . (biologists.com)

The gene, and its paralogues, have become a well-studied model for the family, and hence much of what is known about the T-box family is derived from the murine Brachyury gene. (embl-heidelberg.de)
Therefore, Drosophila becomes a valuable model for understanding the basic biology of oviduct secretory cells and their contribution to cancer formation [8]. (uconn.edu)
Therefore, I switched to Drosophila for my doctoral thesis, a model organism which can be manipulated much more easily. (balzan.org)

Multiple elongation complexes exist, but the role of specific components in adult Drosophila is underexplored. (sdbonline.org)

Although BBAP has a unique N terminus, the C-terminal region is highly homologous to that of DTX family members. (nih.gov)
These genes were uncovered on the basis of similarity to the DNA binding domain [ ( PUBMED:9504043 ) ] of Mus musculus (Mouse) Brachyury (T) gene product, which similarity is the defining feature of the family. (embl-heidelberg.de)

Thus, SMADs both transmit the signal into the nucleus and execute the downstream effects by directly regulating target-gene transcription. (nature.com)

IHH is a core factor in the morphogenesis of vertebrate skeleton. (regenmedres-journal.org)

Nucleotide excision repair in yeast is mediated by sequential assembly of repair factors and not by a pre-assembled repairosome. (ncl.edu.tw)

This study identified a set of common phenotypic modifiers that interact with five independent autism gene orthologs [RIMS1 ( Rim ), CHD8 ( Kismet ), CHD2 ( Chd1 ), WDFY3 ( Blue cheese ), ASH1L ( ASH1 )] causing a common failure of presynaptic homeostatic plasticity (PHP) in Drosophila. (sdbonline.org)

Theoretical work and empirical investigation in Escherichia coli have shown that negative autoregulation confers both rapid response times and reduced intrinsic noise, which is reflected in the fact that almost half of Escherichia coli transcription factors are negatively autoregulated. (ucl.ac.uk)

We recently discovered new ways the BRCA1 gene functions which could help expand our understanding of the development of ovarian and breast cancers. (birmingham.ac.uk)

However, negative autoregulation is rare amongst the transcription factors of Saccharomyces cerevisiae. (ucl.ac.uk)

Mice contain at least four, and perhaps five, genes with the same TEA DNA binding domain (mTEAD genes). (embl-heidelberg.de)
We will then determine the function of their homologous genes in mice. (uconn.edu)

metabolic response, or gene or gene variant to the members of one species. (lookformedical.com)

Drosophila HB9 is detected in a subset of motoneurons with ventral muscle targets and in a small group of interneurons, including the well characterized serotonergic interneurons. (jneurosci.org)

The function of the non-mutant form of that gene is construction of the heart. (albertkharris.com)
Transcriptional elongation is a generic function, but is also regulated to allow rapid transcription responses. (sdbonline.org)

In his research, Computational biology is intimately related to RAD52 Gene, which falls under the overarching field of Gene conversion. (research.com)

Since mTEAD-2 is the only one expressed during the first 7 days of mouse development, it is most likely responsible for the TEAD transcription factor activity that first appears at the beginning of ZGE. (embl-heidelberg.de)
Likewise the p21 67346-49-0 gene could be turned on by transforming development aspect β Ca2+ lovastatin or nerve development aspect (16). (bio2009.org)

Blobe, G. C., Schiemann, W. P. & Lodish, H. F. Role of transforming growth factor β in human disease. (nature.com)
Translocations between MLL (a human trithorax -related gene) and AF4 or AF5q31 are involved in acute lymphoblastic leukemia (Wittwer, 2001, Tang, 2001 and Su, 2001). (sdbonline.org)
To address this issue, we present miRWalk, a comprehensive database on miRNAs, which hosts predicted as well as validated miRNA binding sites, information on all known genes of human, mouse and rat. (gene-quantification.com)
All mRNAs, mitochondrial genes and 10 kb upstream flanking regions of all known genes of human, mouse and rat were analyzed by using a newly developed algorithm named 'miRWalk' as well as with eight already established programs for putative miRNA binding sites. (gene-quantification.com)

Anatomy19

Organisms13

Chemicals and Drugs104

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes95

Disciplines and Occupations3

Information Science4

Melanogaster8

Proteins11

Regulation10

Embryonic4

Homeotic5

Embryos5

Regulate3

Chromosome6

Chromosomes1

Mutations8

Genome10

Interactions4

Mammalian genes1

Regulatory10

Protein7

Humans1

Vertebrates1

Promoter5

Sequences1

Homolog2

Expression16

Tumors1

Repression2

Characterize1

Promoters1

Somatic4

Homologue1

Thioredoxin1

Embryo1

Differentiation4

Imaginal2

Leucine zipper1

Metabolism1

Kinase1

Cell11

Specificity1

Model3

Adult1

Family2

Target-gene1

Vertebrate1

Yeast1

Interact1

Coli1

Ovarian1

Saccharomyces1

Mice2

Metabolic1

Subset1

Function2

Biology1

Development2

Human4