Loading...
  • Human Genome
  • In its infancy, the field was mainly restricted to observations of familial clustering of drug reactions, but the combination of the Human Genome [ 7 , 8 ] and HapMap [ 9 , 10 ] projects has transformed the field to include both the area of pharmacogenomics and a wider spectrum of genetic characteristics beyond single nucleotide polymorphisms (SNPs) in the genome. (pubmedcentralcanada.ca)
  • Between 2,000 and 3,000 transcription factor proteins are encoded by the human genome, potentially creating more than 4 million potential protein pairings. (ucsd.edu)
  • Regulation
  • Robust regulation of Tfh cell response and subsequent antibody maturation are critical for infection clearance ( 2 , 3 ), whereas aberrancy in controlling Tfh immune response is implicated in progression of autoimmune diseases such as systemic lupus erythematosus (SLE), arthritis, and type I/II diabetes ( 4 - 10 ). (frontiersin.org)
  • Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase. (springer.com)
  • Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. (springer.com)
  • The ubiquitin- proteasome system (UPS) is responsible for the degradation of most cellular proteins and thereby plays indispensible roles in intracellular protein quality control and the regulation of virtually all cellular functions. (grantome.com)
  • The availability of this large combinatorial network of transcription factors will provide scientists with many opportunities to study gene regulation, tissue differentiation and evolution in mammals," said Ideker, professor in the Department of Medicine and at UCSD's Jacobs School of Engineering. (ucsd.edu)
  • secretion
  • Diminished constitutive IFNβ secretion (left) results in decreased expression of ISGF3 subunit proteins, altering the balance of signaling (e.g., between ISGF3 and STAT4) and culminating in susceptibility to infection and cancer, inefficient hematopoietic stem cell (HSC) mobilization, and increased bone resorption. (nih.gov)
  • Nitric Oxide Sy
  • Heat shock protein 90 contributes to cutaneous vasodilation through activating nitric oxide synthase in young male adults exercising in the heat. (nih.gov)
  • Abstract
  • Popular Abstract in Swedish Förekomsten av fetma ökar lavinartat över hela världen, Sverige inte undantaget, och detta är en stor bidragande orsak till att antalet fall av typ 2 diabetes tilltar på ett liknande sätt. (dissertations.se)
  • significantly
  • In fact, for some diseases, such as type 2 diabetes mellitus (T2D), pharmacologic treatment of at-risk individuals even before manifestation of disease symptoms can significantly reduce disease risk [ 1 , 2 , 3 , 4 , 5 ]. (pubmedcentralcanada.ca)
  • Functional
  • This protein family shows low sequence similarity to other protein families, which is why structural information for the functional domains of these proteins is crucial to understand their biochemical features. (sigmaaldrich.com)
  • The description of the WRKY transcription factor family in Brachypodium that we report here provides a framework for functional genomics studies in an important model system. (biomedcentral.com)
  • Diabetes
  • Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Tunisian Arab subjects. (semanticscholar.org)
  • A variety of treatment modalities exist for individuals with type 2 diabetes mellitus (T2D). (pubmedcentralcanada.ca)
  • Background: Gene-diet interactions have been reported to contribute to the development of type 2 diabetes (T2D). (ox.ac.uk)
  • Både fetma och typ 2 diabetes är sjukdomar med ett komplicerat mönster av samverkande genetiska och miljömässiga faktorer. (dissertations.se)
  • Type 2 diabetes mellitus (T2DM), characterized by a complex, multifactorial, and chronic condition that often necessitates the use of various medications to achieve normal blood glucose, is a complex endocrine and metabolic disorder with dire consequences for human health and well-being. (biomedcentral.com)
  • However, few studies have investigated this possibility for variants associated with type 2 diabetes or obesity, and these show little consensus. (beds.ac.uk)
  • There was no indication that the effects of common type 2 diabetes variants on fasting glucose varied with age during adulthood or over time. (beds.ac.uk)
  • activator
  • On the other hand, Tfh generation is negatively regulated at specific steps of Tfh generation by specific cytokine (IL-2, IL-7), surface receptor (PD-1, CTLA-4), transcription factors B lymphocyte maturation protein 1, signal transducer and activator of transcription 5, T-bet, KLF-2 signaling, and repressor miR 146a. (frontiersin.org)
  • inducible
  • In a healthy organism, low amounts of IFNβ are constitutively secreted, which maintains appropriate expression of IFN-inducible signaling intermediaries, including the transcription factors STAT1, STAT2, IRF5, IRF7, and IRF9 (center) . (nih.gov)
  • Nucleotide
  • We analysed exonic single nucleotide polymorphisms (SNPs) in a large cohort (Oxford: n = 1,893) and prospectively tested 2 additional European sample sets (Leuven: n = 688, Vienna: n = 1,628). (nih.gov)
  • type
  • As hypothesized, the two factors showed a correlating pattern in wild type as well as in mutated individuals in our cohort and HD-6 exhibited the same dependence on the LRP6 genotype which was seen for HD-5 in ileal CD (Figure 5A). (nih.gov)
  • Further the EBF proteins contain an IPT/TIG domain and an atypical helix-loop-helix domain with a novel type of dimerization motif. (sigmaaldrich.com)
  • COL1A1 (Collagen, type I, alpha 1) is the gene that codes for the major component in type I collagen, the major protein component of connective tissues (e.g. bone. (nephrologynews.com)
  • Human papillomavirus type 16 E6 protein transcriptionally modulates fibronectin gene expression by i. (biomedsearch.com)
  • pathogenesis
  • Although DRC is not a common heart disease but understanding its pathogenesis will shed lights on many common forms of heart disease, especially those with increased production of abnormal proteins in cardiomyocytes. (grantome.com)
  • DRM or DRC is characterized by aberrant protein aggregation in muscle cells and this aggregation appears to play a central role in DRC pathogenesis. (grantome.com)
  • Previous studies have elucidated how DNA methylation interacted with various factors in T2DM pathogenesis. (biomedcentral.com)
  • infection
  • The TBEVHostDB could potentially be used for assessment of risk factors for severe forms of tick-borne encephalitis and for the design of personalized pharmacological strategies for the treatment of TBEV infection. (biomedcentral.com)
  • interaction
  • The influence of genotype on these traits may also vary over time through interaction with factors such as age, developmental stage or time-dependent environmental factors. (beds.ac.uk)
  • specific
  • The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. (nih.gov)
  • Many different functions have been identified for these proteins in animals, including the control of cell proliferation and development of specific cell lineages. (uni-bielefeld.de)
  • In a significant leap forward in the understanding of how specific types of tissue are determined to develop in mammals, an international team of scientists has succeeded in mapping the entire network of DNA-binding transcription factors and their interactions. (ucsd.edu)
  • Fibrosis
  • LMO7 Is a Negative Feedback Regulator of Transforming Growth Factor β Signaling and Fibrosis. (nih.gov)
  • cell
  • This global network, indicating which factors can combine to determine cell fate, will be published in the March 5 issue of the journal Cell . (ucsd.edu)