Transcription erbb2 gene receptor erbb 2. Medical search. Frequent questions

It is also frequently called HER2 (from human epidermal growth factor receptor 2 ) or HER2/neu . (iiab.me)
HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. (iiab.me)
HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. (iiab.me)
The ErbB/HER family of receptor tyrosine kinases (RTKs) consists of four family members: the epidermal growth factor receptor (EGFR/ErbB1), HER2 (ErbB2/Neu), HER3 (ErbB3), and HER4 (ErbB4). (plos.org)
This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. (arigobio.com)
Several members of the Epidermal Growth Factor Receptor (EGFR) family, have been identified in the nucleus and nucleolus of many cancer cells, but their function in these compartments remains unexplored. (biomedcentral.com)
Activation of MAPK is initiated by one of the four ErbB receptors (ErbB1/epidermal growth factor receptor (EgfR), ErbB2-4), which leads to signaling through Raf (RAF proto-oncogene serine/threonine-protein kinase), Mek (mitogen-activated protein kinase kinase 1/2) and Erk. (biomedcentral.com)
Besides estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, novel biomarkers have shown their prognostic and predictive values, complicating our understanding towards to the heterogeneity of such cancers. (jcancer.org)
Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)
Although neither kinase-dead human epidermal growth factor receptor (HER)3 nor orphan HER2 can be activated by HER-related ligands on their own, the formation of HER2/HER3 heterodimers creates the most mitogenic and transforming receptor complex within the HER (erbB) family of transmembrane receptor tyrosine kinases. (biomedcentral.com)
The notion that breast cancer disease can be viewed as a biological process that is driven by overactive human epidermal growth factor receptor (HER)1/2 receptor tyrosine kinases (RTKs) has led to development of various anti-HER tyrosine kinase agents. (biomedcentral.com)

Activating point mutations in ErbB/Her2 receptor tyrosine kinases have an infamous role in promoting oncogenesis across several different cancers, including breast and lung. (cancer.gov)
It is used for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 (ErbB2). (hmdb.ca)
Molecular cloning of the gene showed that HER2, Neu, and ErbB-2 are all encoded by the same orthologs. (iiab.me)
[10] [11] HER2 can heterodimerise with any of the other three receptors and is considered to be the preferred dimerisation partner of the other ErbB receptors. (iiab.me)
HER2 is colocalised and most of the time, coamplified with the gene GRB7, which is a proto-oncogene associated with breast, testicular germ cell, gastric, and esophageal tumours. (iiab.me)
Inside the nucleus, HER family members (EGFR, HER2, and HER3) have been shown to function as co-transcriptional activators for various cancer-promoting genes. (plos.org)
The HER2 receptor does not bind to any known ligands, however, its dimerization arm is innately positioned in an open conformation. (plos.org)
Synthetic peptide around the C-terminus of Human HER2 / ErbB2. (arigobio.com)
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human breast cancer tissue stained with ARG66357 anti-ERBB2 / HER2 antibody [SQab1890] at 1:500 dilution. (arigobio.com)
It remains to be elucidated whether reactivation of HER3 signalling can also account for the poor efficacy of HER TKIs in treating breast carcinomas that contain low overall levels of HER2 receptors. (biomedcentral.com)
However, it appears that regardless of the mechanism that triggers the formation of oncogenic HER2/HER3 heterodimers (HER2 over-expression or overall low HER2 but high levels of the HER3 ligand heregulin), HER3 transphosphorylation is a common response of breast cancer cells upon treatment with current inhibitors of the HER receptor tyrosine kinase network. (biomedcentral.com)

Heregulins bind directly to ErbB3 and ErbB4 receptors, leading to multiple dimerization possibilities including heterodimerization with the ErbB2 receptor. (nih.gov)
We have generated ErbB3-, ErbB2- and heregulin-deficient mice to assess their roles in development and differentiation. (nih.gov)
Heterodimer activation of the ErbB2/ErbB3 oncogenic unit induces cancer cell proliferation via PI3K/AKT signaling pathways. (cancer.gov)
We focused our research on the nucleolar function that a specific member of EGFR family, the ErbB3 receptor, plays in glioblastoma, a tumor without effective therapies. (biomedcentral.com)
These results highlight the potential role for the nucleolar ErbB3 receptor, as a new target in glioblastoma. (biomedcentral.com)

Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. (neobiotechnologies.com)
The ErbB-2 proto-oncogene, also called Neu, EGFR-2 or HER-2, is a member of the transmembrane receptor tyrosine kinase family, which also includes EGF receptor and EGFR-3 (HER-3 or ErbB-3). (activemotif.com)
The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)

Receptor tyrosine-protein kinase erbB-2 , also known as CD340 (cluster of differentiation 340), proto-oncogene Neu , Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (iiab.me)
ERBB2 , a known proto-oncogene , is located at the long arm of human chromosome 17 (17q12). (iiab.me)

c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary. (neobiotechnologies.com)
HER-2 is over-expressed in approximately 7-34% of patients with gastric cancer [20] [21] and in 30% of salivary duct carcinomas. (iiab.me)
ErbB-2 overexpression is also observed in ovarian, gastric, salivary and non-small cell lung carcinomas. (activemotif.com)

CTC expressed PTCH, EGFR and ErbB2 protein and RNA. (hdac-inhibitors.com)
Like the CTCs, LNCaP C4 2B cells also express PTCH, EGFR and ErbB2 RNA. (hdac-inhibitors.com)
The development of LNCaP C4 2B cells in androgen no cost medium was appreciably reduced by therapy using the Hedgehog pathway inhibi tor cyclopamine, the EGFR inhibitor gefitinib and also the EGFR and ErbB2 inhibitor lapatinib. (hdac-inhibitors.com)

However, the regions of each receptor that confer transcriptional potential remain poorly defined. (plos.org)
To understand how the B 1 and B 2 regions influenced the transcriptional functions of nuclear HER3, we performed cyclin D1 promoter-luciferase assays in which HER3 deleted of the B 1 and B 2 regions was severely hindered in regulating this promoter. (plos.org)
While the classical membrane-bound functions of HER family RTKs have been extensively studied, accumulating data suggest that these receptors can be found in the cell's nucleus where they can function as co-transcriptional activators [4] , [5] . (plos.org)
We have identified anti-cancer effects of Huaier, and its unique characteristics of 1) no side effects or toxicity, 2) in dose dependent manner, 3) causing specific cancer cell death with simultaneous tissue regeneration, 4) miRNA-mediated transcriptional control on the rescue of multiple signal transduction, by dependent on individual genomic potential. (fortunejournals.com)
The mitogen-activated protein kinase (MAPK)/Erk pathway plays a central role in cell communication: it orchestrates signaling from external receptors to internal transcriptional machinery, which leads to changes in phenotype [ 6 , 7 ]. (biomedcentral.com)
A total of 7 possible genetic alterations and epigenetic changes in CAFs are discussed, including gene differential expression, karyotype analysis, gene copy number variation, loss of heterozygosis, allelic imbalance, microsatellite instability, post‑transcriptional control and DNA methylation. (spandidos-publications.com)
Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)

Back to 1970s, breast cancer was divided into two subtypes according to the status of estrogen receptor (ER). (jcancer.org)
Although the lack of estrogen receptor β (ERβ) is a risk factor for the development of inflammatory bowel disease (IBD) and psychiatric disorders, the underlying cellular and molecular mechanisms are not fully understood. (biomedcentral.com)

lacks kinase domain), and erbB-4. (iiab.me)

Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with HER-2 Mouse Monoclonal Antibody (ERBB2/3078). (neobiotechnologies.com)
SDS-PAGE Analysis Purified HER-2 Mouse Monoclonal Antibody (ERBB2/3078). (neobiotechnologies.com)
Analysis of Protein Array containing more than 19,000 full-length human proteins using HER-2 Mouse Monoclonal Antibody (ERBB2/3078). (neobiotechnologies.com)
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. (neobiotechnologies.com)
The Y877 kit contains phospho-ErbB-2 antibody that recognizes ErbB-2 only when phosphorylated at Tyr877, while the Y1248 kit provides a phospho-antibody that recognizes ErbB-2 only when phosphorylated at Tyr1248. (activemotif.com)
Each kit contains a total-ErbB-2 antibody that recognizes ErbB-2 regardless of its phosphorylation state. (activemotif.com)
The FACE ErbB-2 (Y877) Kit contains a phospho-ErbB-2 antibody that was raised in rabbit against a synthetic phospho-peptide corresponding to residues surrounding phosphorylated Tyr877 of human ErbB-2 and recognizes ErbB-2 only when phosphorylated at Tyr877. (activemotif.com)
The total-ErbB-2 antibody supplied in the FACE ErbB-2 Kits recognizes ErbB-2 protein regardless of its phosphorylation site. (activemotif.com)
Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
For continuous use, store undiluted antibody at 2-8°C for up to a week. (arigobio.com)

Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. (neobiotechnologies.com)
This process leads to the activation of each receptors' tyrosine kinase and the subsequent phosphorylation of tyrosine residues located on their C-terminal tails. (plos.org)

Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways. (iiab.me)
Membrane-bound HER receptors activate numerous tumor promoting signaling cascades via this mechanism, including the PI3K/AKT, Ras/Raf/Mek/Erk, PLCγ/PKC, and signal transducer and activator of transcription (STAT) pathways [1] , [2] . (plos.org)
This Part 2 post is concerned with anti-cancer drug and other interventions that simultaneously address multiple growth pathways. (anti-agingfirewalls.com)
We find that U87 mg electrotaxis is abolished under pharmacological inhibition of PI3Kγ, mTOR, AKT and ErbB2 signaling, whereas DAOY cell electrotaxis was not attenuated by these or other pathways evaluated. (nature.com)
However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. (arigobio.com)
Tumor suppressors, oncogenes and alternatively deregulated upstream signalling pathways can directly influence the RNA polymerase I activity inducing hyper activation of rRNA transcription in cancer cells. (biomedcentral.com)
Generally, these receptors explain their function on the cell membrane where, after the binding with growth factors or neuregulin undergo to homo or hetero oligomerization with the activation of the intrinsic tyrosine kinase activity and the subsequent recruitment of proteins involved in the cytoplasmic signalling pathways. (biomedcentral.com)
In addition, the ErbB receptors integrate a diverse array of signals, both at the cell surface level and through cross-talk with other pathways, such as the phosphoinositide 3-kinase (Pi3k) pathway [ 11 ]. (biomedcentral.com)
In contrast, we observed excellent discrimination amongst the nor mal subjects along with the androgen independent patient groups for ErbB2, PTCH and DD3PCA3, constant with the Hedgehog and ErbB pathways contributing to AIPC. (hdac-inhibitors.com)
As we now have been unable to create proliferating cultures of CTC for inhibitor and biochemical scientific studies, to additional investigate the purpose of the Hedgehog and ErbB pathways in AIPC we have now utilized the androgen independent prostate cancer cell line LNCaP C4 2B. (hdac-inhibitors.com)
To determine the importance of the Hedgehog and ErbB pathways to AIPC cell growth we handled LNCaP C4 2B cells with unique inhibitors to cyclopamine which blocks Hedgehog signalling, gefitinib and lapatinib, both singularly or in combination. (hdac-inhibitors.com)

Phosphorylated tyrosine residues recruit various intracellular adaptor and effector molecules that result in the propagation of growth promoting signal transduction cascades [1] , [2] . (plos.org)
Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). (arigobio.com)

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. (neobiotechnologies.com)

Methods: The clinical significance and immunological function of CDH5 in pan-cancers were comprehensively analyzed based on the correlations between CDH5 and clinicopathologic features, prognosis values, tumor mutation burden (TMB), microsatellite instability (MSI), immune cells infiltration and immune response genes using 33 datasets from The Cancer Genome Atlas (TCGA). (bvsalud.org)
Amplification, also known as the over-expression of the ERBB2 gene, occurs in approximately 15-30% of breast cancers . (iiab.me)
This family of RTKs has been highly implicated in the formation and progression of various cancers via aberrant overexpression, kinase activation, and mutation [1] , [2] . (plos.org)
Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. (arigobio.com)
Sustaining proliferative signaling' further differentiates cancers with positive hormone receptors. (jcancer.org)

A comprehensive "proteogenomic" analysis of the proteins, genes, and RNA transcription involved in pediatric brain tumors has yielded a more complete understanding of these tumors, which are the leading cause of cancer-related deaths in children. (cancer.gov)
Protein glycosylation, the enzymatic process that attaches glycans or sugar molecules to proteins, plays a crucial role in cancer development processes, such as cell-cell adhesion, cell growth, ligand-receptor binding, and tumor metastasis. (cancer.gov)
By contrast, the 10 downregulated genes were primarily associated with epithelial membrane proteins ( 11 ). (spandidos-publications.com)

Also, the growth-inhibitory effects of HER1/2 tyrosine kinase inhibitors (TKIs) were previously found to be attenuated in the presence of heregulin, which is a high-affinity combinatorial ligand for HER3. (biomedcentral.com)

Formation of Neu/ErbB2-induced mammary tumors is unaffected by loss of ErbB4. (rochester.edu)
To gain insights into the impact of hypomyelination on excitatory and inhibitory neuronal network function in A1, we took advantage of mice in which ErbB receptor signaling in oligodendrocytes has been eliminated by expression of a dominant-negative ErbB4 in cells of the oligodendrocyte lineage under the control of the CNPase promoter (CNP-DN-ErbB4, 15 ). (biorxiv.org)

ERBB is abbreviated from erythroblastic oncogene B, a gene isolated from avian genome. (iiab.me)
ErbB-2 was named for its similarity to ErbB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR. (iiab.me)

Although, ErbB-2 does not have any known high-affinity ligands, its kinase activity can be activated without ligand by either overexpression or heteroassociation with other members of the ErbB family. (activemotif.com)
Amplification of the ErbB-2 gene and overexpression of its product has been detected in almost 40% of primary human breast tumors, which correlates with poor prognosis in node positive breast cancer. (activemotif.com)

Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1, St7, and Prim2. (rochester.edu)

The ErbB inhibitors gefitinib and lapat inib also inhibited EGF induced autophophor ylation of your EGFR in LNCaP C4 2B cells. (hdac-inhibitors.com)
To be able to set up no matter whether the mixed results of Hedgehog and ErbB inhibitors were synergistic the isobo logram and combination index was calculated in accordance on the Chou and Talalay median impact principal. (hdac-inhibitors.com)

In a recent publication in the journal Clinical Chemistry, CPTAC investigators from Fred Hutchinson Cancer Research Center described a robust technique for evaluating biomarker expression of key receptors in patients with breast cancer bone metastasis using non-decalcified bone biopsies in immuno. (cancer.gov)

Nuclear localized HER family receptor tyrosine kinases (RTKs) have been observed in primary tumor specimens and cancer cell lines for nearly two decades. (plos.org)

Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. (wikipedia.org)

Recognizes a protein of 185kDa, which is identified as c-erbB-2/HER-2/neu. (neobiotechnologies.com)

1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al. (wikipedia.org)
Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. (neobiotechnologies.com)
These data demonstrate the ability of pCALM1 to conduct restricted neuronal gene expression, illustrating the feasibility of ultra-miniature promoters for targeting brain-cell subtypes. (bvsalud.org)
In summary, signaling through the ErbB family of receptors promotes cell proliferation and opposes apoptosis, and therefore must be tightly regulated to prevent uncontrolled cell growth from occurring. (iiab.me)
Classically, HER family members function from the cell surface, where binding to cognate ligands can induce receptor homo- or hetero-dimerization with other HER family receptors [3] . (plos.org)
Gene expression The affect of DADS therapy on cytokine induced metalloproteinase gene expression was assessed from the SW1353 cell line by TaqMan qRT PCR. (hdac-inhibitors.com)
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. (univ-amu.fr)

Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. (neobiotechnologies.com)

The current study aimed to map the putative transactivation domains (TADs) of the HER3 receptor. (plos.org)
To accomplish this goal, various intracellular regions of HER3 were fused to the DNA binding domain of the yeast transcription factor Gal4 (Gal4DBD) and tested for their ability to transactivate Gal4 UAS-luciferase. (plos.org)
Brand TM, Iida M, Luthar N, Wleklinski MJ, Starr MM, Wheeler DL (2013) Mapping C-Terminal Transactivation Domains of the Nuclear HER Family Receptor Tyrosine Kinase HER3. (plos.org)

Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. (neobiotechnologies.com)
Here, we report the development of an extremely short promoter that enables selective gene expression in neurons, but not glial cells, in the brain. (bvsalud.org)
The promoter sequence originates from the human CALM1 gene and is only 120 bp in size. (bvsalud.org)
The activity of this enzyme is under the control of two main factors, UBF and SL1 both components of the complex that stabilizes RNA Pol I on rDNA promoter [ 1 , 2 ]. (biomedcentral.com)

ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene. (wikipedia.org)

The ErbB family consists of four plasma membrane-bound receptor tyrosine kinases. (iiab.me)

Because of this, ErbB-2 is one of the major drug targets for breast cancer and other cancer treatments. (activemotif.com)
in one study, 31 genes in breast CAFs, which were identified using Affymetrix Human Genome U133 Plus 2.0 and an empirical Bayesian model, were different from those in NFs ( 11 ). (spandidos-publications.com)
These results are consistent with another study concerning the gene expression profiling of breast CAFs, which were detected using a complementary DNA microarray ( 15 ). (spandidos-publications.com)

Targeted molecular therapy, like therapy with monoclonal antibodies, gene therapy, and other therapies, has limited or nonexistent side effects on normal cells of the body, unlike present modalities such as surgery, chemotherapy, and radiotherapy. (medscape.com)
A very large number of gene mutations may be involved in a single cancer - 50 or more - making the molecular dynamics of cancer cells different in important respects from those of normal cells. (anti-agingfirewalls.com)

Since the EGFR signalling promotes proliferation in tumor the EGFR receptors often represent a marker of resistance with poor prognosis. (biomedcentral.com)

also called Asp2, memapsin 2), is the enzyme responsible for initiating Aβ generation. (jneurosci.org)

Persons with the most common pediatric brain malignancy, medulloblastoma, fare only slightly better than average, with a 71.9% 5-year survival, though the most common adult brain tumor, glioblastoma multiforme (GBM), incurs a mere 5.1% 5-year survival rate 2 . (nature.com)

The FACE ErbB-2 (Y1248) and ErbB-2 (Y877) Kits were used to assay the levels of total and phosphorylated ErbB-2 contained within untreated or EGF treated A-431 cells. (activemotif.com)
The goal of gene therapy is to introduce new genetic material into cancer cells that selectively kills them without causing toxicity to the surrounding cells. (medscape.com)
This task can be accomplished by replacing tumor suppressor genes that have been lost or mutated, selectively inserting genes that produce cytotoxic substances, or modifying the immune system to destroy the tumor cells. (medscape.com)
Importantly, the growth of LNCaP C4 2B cells is just not impacted by withdrawal of androgens, confirming the androgen independence of these cells and these cells express androgen receptor and PSA. (hdac-inhibitors.com)
In addi tion, LNCaP C4 2B cells express a promiscuous kind in the androgen receptor, possessing the most AR frequent sub stitution, which can be repeatedly observed in prostate cancer selleck chemical tissue specimens of individuals with AIPC. (hdac-inhibitors.com)
Singularly, SPDEF, a transcription factor associated with mucus metaplasia, was rarely detected in mucus cells in IPF. (bmj.com)
Mucus cells lining abnormal airways from patients with IPF expressed MUC5B and SOX2 but lacked SAM pointed domain containing ETS transcription factor (SPDEF) and forkhead box A3(FOXA3). (bmj.com)
Genes to Cells. (elsevierpure.com)

Its symptoms are typically treated with levodopa or dopamine receptor agonists, but its action lacks specificity due to the wide distribution of dopamine receptors in the central nervous system and periphery. (bvsalud.org)

The prostaglandin-endoperoxide synthase 2 gene (PTGS2), which encodes cyclooxygenase-2, was found to upregulate the expression of TGF-β2 ( 14 ). (spandidos-publications.com)

Gene expression profiling of ErbB receptor and ligand-dependent transcription. (rochester.edu)
Furthermore, diverse structural alterations have been identified that cause ligand-independent firing of this receptor, doing so in the absence of receptor over-expression. (iiab.me)
CAFs are different from NFs, and their unique phenotypes and functions are partly determined by differences in gene expression. (spandidos-publications.com)

Genetic mutation promotes biological evolution and results in biodiversity ( 2 , 3 ). (spandidos-publications.com)

The progress in cancer research has been processed by the discovery of molecules, genes, and mechanisms to cause carcinogenesis. (fortunejournals.com)
Genes mainly involved in coding adhesion molecules and growth factors have also been found to be upregulated in other types of CAFs, including colon ( 12 ) and pancreatic ( 13 ). (spandidos-publications.com)

Familial AD (FAD) cases are caused by autosomal dominant mutations in the genes for amyloid precursor protein (APP) and the presenilins (PS1 and PS2) ( Sisodia and St George-Hyslop, 2002 ). (jneurosci.org)

Genetic alterations include genetic mutation, gene copy number variation (CNV), loss of heterozygosity (LOH), allelic imbalance (AI) and microsatellite instability (MSI). (spandidos-publications.com)

Anatomy16

Organisms9

Diseases2

Chemicals and Drugs123

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes80

Disciplines and Occupations1

Information Science3

Epidermal12

HER211

ErbB35

Transmembrane3

Proto-oncogene2

Carcinomas3

EgfR and ErbB23

Transcriptional7

Estrogen receptor2

Kinase domain1

Antibody10

Phosphorylation2

Pathways11

Tyrosine residues2

Protein tyrosi1

Cancers5

Proteins3

HER11

ErbB42

Oncogene2

Overexpression2

Tumor genes1

Inhibitors2

Metastasis1

RTKs1

Binds1

Recognizes1

Cell7

Neuregulins1

HER33

Promoter4

Inhibitor1

Family consists1

Breast3

Molecular2

Proliferation1

Enzyme1

Glioblastoma1

Cells8

Lacks1

Encodes1

Expression3

Promotes1

Molecules2

Mutations1

Microsatellite instability1