ApoptosisTumorMonoclonal AntibodyInhibitAntibioticTherapeuticReplicationFactorsProteinsInhibitorsOxaliplatinTumorsChemotherapeuticDoxorubicinFactorTopoisomeraseProteinInhibitionNeoplasmProliferationTumoursMechanismChemotherapyCytotoxicPolymerReceptorCarcinomaGene transcriptionReverse transcriptionBreastReceptorsActivityDerivativeAnti-neoplasticDamageTreatmentsCancerActionLungPotentiallyDrugPotentialPromoterPARP
Apoptosis5
- It has antineoplastic properties, including inhibition of angiogenesis and induction of APOPTOSIS. (nih.gov)
- The biological activity of cisplatin cytotoxicity involves the binding of the drug to DNA and non-DNA targets and inhibits transcription and DNA replication that finally leads to apoptosis, necrosis, or both of them. (hindawi.com)
- Acts as an alkylating agent and a selective inhibitor of oncogenic transcription which results in DNA double-strand breaks and tumor cell apoptosis. (unboundmedicine.com)
- PTX is an anticancer agent due to its ef-ficient induction of apoptosis. (1library.net)
- However, apigenin may perform synergistically by different cell signaling pathways, including down-regulation/up-regulation of transcription factors, activate/deactivate membrane receptors, cell signaling regulatory components, and apoptosis cascades. (biomedcentral.com)
Tumor6
- Dactinomycin was formally approved for use in the United States in 1964 and continues to be a valuable agent in the therapy of solid tumors of childhood (Wilms tumor, rhabdomyosarcoma) and in choriocarcinoma in adult women. (nih.gov)
- The antineoplastic action of megestrol acetate on carcinoma of the breast is effected by modifying the action of other steroid hormones and by exerting a direct cytotoxic effect on tumor cells. (nih.gov)
- Tumor stemness in part is also the result of action of certain transcription factors like SOX2, OCT4, NANOG, MYC, among other factors [4]. (atpase-signaling.com)
- Also, gene expression signatures of phenoxbenzamine were consistent with several agents in each case that were known to suppress tumor proliferation, notably, protein kinase C inhibitors, Heat Shock Protein inhibitors, epidermal growth factor receptor inhibitors, and glycogen synthase kinase inhibitors. (fortuneonline.org)
- Vitamin E also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. (medindex.am)
- Data recorded for tumor size, percentage of tumor growth inhibition, tumor growth delay and mean survival time of EST-bearing mice demonstrated the effective role of GCar alone or combined with CPO as a promising anti-cancer agent because it reduced tumor size. (biomedcentral.com)
Monoclonal Antibody1
- A humanized monoclonal antibody directed against the CD40 receptor with potential antineoplastic activity. (blogspot.com)
Inhibit5
- These agents inhibit cell growth and proliferation. (medscape.com)
- Alkylating agents inhibit cell growth and proliferation. (medscape.com)
- These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. (bvsalud.org)
- Because it is a substrate for CYP 3A4, olaparib is susceptible to drug-drug interactions with agents that inhibit or induce hepatic CYP 3A activity. (nih.gov)
- Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES. (lookformedical.com)
Antibiotic2
- Dactinomycin is an intravenously administered, antineoplastic antibiotic that is used in the treatment of solid tumors in children and choriocarcinoma in adult women. (nih.gov)
- Antineoplastic antibiotic obtained from Streptomyces peucetius. (lookformedical.com)
Therapeutic4
- therapeutic_agents C1909 therapeutic_agents C C177537 GDC Value Terminology C129693 Gartisertib An orally available inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase, with potential antineoplastic activity. (nih.gov)
- Carnitine is studied extensively in part because of the important role it plays in fatty acid oxidation and energy production, and because it is a well-tolerated and generally safe therapeutic agent. (nih.gov)
- Plant-derived bioactive compounds are plausible novel therapeutic agents for the prevention of different types of cancers owing to a wide range of pharmacological effects [ 2 ]. (biomedcentral.com)
- Objective: Develop small molecules that can probe biological processes and serve as therapeutic agents. (ucsf.edu)
Replication5
- It inhibits DNA replication and transcription. (medscape.com)
- This may interference with DNA transcription and/or replication, which may trigger cytotoxic effects. (medscape.com)
- These crosslinks appear to impair replication and transcription of DNA. (lookformedical.com)
- DACH-Pt alkylates macromolecules and causes both inter- and intra-strand platinum-DNA crosslinks, which impede DNA replication and transcription, resulting in cell-cycle independent cytotoxicity. (blogspot.com)
- Platinum complexes like cisplatin and carboplatin (Fig. 13.7) exert their antitumor effects by forming DNA adducts and subsequent inhibition of DNA replication and transcription. (forwardonclimate.org)
Factors12
- However, a multitude of studies demonstrating partial progress and improvements and, finally, the new powerful possibilities of forward and reverse engineering of differentiation pathways by manipulation of transcription factors support the continued enthusiasm for differentiation therapy of leukemia in the future. (nih.gov)
- Design of DNA damaging agents that hijack transcription factors and block DNA repair. (nih.gov)
- While the precise mechanism by which megestrol produces its antineoplastic effects against endometrial carcinoma is unknown at the present time, inhibition of pituitary gonadotropin production and resultant decrease in estrogen secretion may be factors. (nih.gov)
- Finally, we observed that all four transcription factors were elevated in primary MM samples compared with normal plasma cells. (ox.ac.uk)
- We have discovered that in addition to conventional transcription factors (including AP1, octamer, and the RFX, as described in our early investigations), several proteins that bind sequence specifically with single stranded DNA (ssDNA) interact with particular elements in the c-myc promoter and its upstream regulatory region. (nih.gov)
- We have investigated the structure, function and mechanism of these factors in particular, and have aimed to elucidate the general role of conformation and topology sensitive transcription factors. (nih.gov)
- Therefore these proteins and elements also serve an important architectural role by granting position-independent access of transcription factors with promoters and with complexes that remodel and modify chromatin. (nih.gov)
- 17. Mechanism of interaction between antineoplastic agents and natural differentiation factors in the induction of human leukemic cell maturation. (nih.gov)
- The structure reveals a new architectural minor groove binding motif which stabilizes B-DNA, thereby facilitating the binding of other transcription factors in the opposing major groove. (nih.gov)
- Upstream transcription factors and microRNAs regulating DEGs were predicted. (atpase-signaling.com)
- Analysis of upstream modulators of DEGs pointed out to transcription factors that significantly overlap with GBM stem cell transcription factor. (atpase-signaling.com)
- Significance: Our study represents the response of U87 cell line to HYP, with analyses on survival, transcription factors and personalization according to GBM subtype. (atpase-signaling.com)
Proteins3
- These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. (cancerindex.org)
- Recent discoveries suggest that the critical events leading to the anti-proliferative activity of the IMiD immunomodulatory agents lenalidomide and pomalidomide in multiple myeloma (MM) cells are initiated by Cereblon-dependent ubiquitination and proteasomal degradation of substrate proteins Ikaros (IKZF1) and Aiolos (IKZF3). (ox.ac.uk)
- In general, RT-PCR is a simple, yet sensitive, tool for detecting transcription products, whereas Western blotting can be used to verify the expression of translated proteins but requires specific antibodies for each target protein. (aspetjournals.org)
Inhibitors1
Oxaliplatin2
- Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS . (bvsalud.org)
- DACH-platin, an active metabolite of the platinum-based antineoplastic agent oxaliplatin, is highly hydrophobic and toxic when administered systemically. (blogspot.com)
Tumors2
- Paclitaxel (PTX) is now considered a new type of broad-spectrum and highly efficient anticancer drug, and the efficacy of this agent on a variety of solid tumors has been noted. (1library.net)
- Cyclophosphamide (CPO) is an alkylating cytotoxic agent that has been effectively used in patients for the last century for the curing of neoplastic maladies, such as solid tumors and lymphomas, as well as non-neoplastic maladies, such as rheumatoid arthritis and systemic lupus erythrematosus [ 1 ]. (biomedcentral.com)
Chemotherapeutic6
- These agents counteract the toxic effects of the chemotherapeutic drug. (medscape.com)
- The response rates of immunochemical therapies com-bined with chemotherapeutic agents with interferon-αor interleukin-2 ranged from 2% to 39% [4,5]. (1library.net)
- We have previ-ously examined the antiproliferative effects of DAC alone, and of DAC with the various chemotherapeutic agents, on RCC cells. (1library.net)
- Briefly, our analysis proposed that the combination therapies with apigenin could suppress the unwanted toxicity of chemotherapeutic agents. (biomedcentral.com)
- The chemotherapeutic mechanism of platinum compounds is typical of DNA-binding alkylating agents. (forwardonclimate.org)
- Platinum-based antineoplastic drugs (informally called platins) are chemotherapeutic agents used to treat cancer. (forwardonclimate.org)
Doxorubicin1
- Doxorubicin is an anthracycline antineoplastic that causes DNA strand breakage through effects on topoisomerase II and direct intercalation into DNA, which causes DNA polymerase inhibition. (medscape.com)
Factor6
- LRRN1 knockdown also resulted in upregulation of JUN, a subunit of the transcription factor AP-1 (activator protein-1). (cancerindex.org)
- Differentiation of naïve T cells to TH17 cells in vitro requires COX-upregulation, prostaglandin production and induction of the RORγt transcription factor. (nih.gov)
- After binding to the EGF receptor, the agent is internalized by the cell, where the diphtheria toxin moiety exerts its cytotoxic effect, inhibiting protein synthesis through ADP-ribosylation of elongation factor 2. (blogspot.com)
- Background/Aim: We performed a retrospective study too clarify whether the presence or absence of driver genes affects the relationship between thyroid transcription factor-1 (TTF-1) expression and response to pemetrexed (PEM) in non-squamous non-small cell lung cancer (non-sq-NSCLC) patients. (cancerdiagnosisprognosis.org)
- Thyroid transcription factor-1 (TTF-1) is expressed in thyroid follicle, parathyroid gland, alveolar epithelium, and diencephalon, and participates in the differentiation, development, and functional maintenance of these organs ( EMBO J 8(9) (1989)">1 - Mol Cell Biol 14(9) (1994)">3 ). (cancerdiagnosisprognosis.org)
- TLRs often act through MyD88-dependent pathway with early activation of NF-kB, an important transcription factor that is responsible for the expression of proinflammatory molecules, such as TNF-α, IL-6, IL-8, and others. (biomedcentral.com)
Topoisomerase1
- Distamycin inhibits the transcription and increases the activity of the topoisomerase II. (wikipedia.org)
Protein5
- Interferes with DNA transcription, ultimately disrupting protein synthesis and causing cell death. (unboundmedicine.com)
- A recombinant fusion protein derived from the melanoma antigen MAGE-3 with potential immunostimulating and antineoplastic activities. (blogspot.com)
- An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. (blogspot.com)
- The expression level of BRCA2 is presumably regulated through various mechanisms including transcription, subcellular localization, binding to partners, and protein modification and stabilization. (biomedcentral.com)
- Analysis of qPCR mRNA gene and protein expression revealed that GCar alone or combined with CPO were promising anticancer agents. (biomedcentral.com)
Inhibition1
- The actinomycins are chromopeptides which bind to double-helical DNA and interrupt RNA transcription, causing cell arrest and inhibition of cell division. (nih.gov)
Neoplasm1
- Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures. (lookformedical.com)
Proliferation1
- DSS1 knockdown suppresses the proliferation of drug-resistant MDA-MB-231 breast cancer cells, particularly effectively in combination with DNA-damaging agents. (biomedcentral.com)
Tumours2
- Derivates from distamycin are used as alkylating antineoplastic agents to combat tumours. (wikipedia.org)
- In addition, cancer treatment with microbial agents or their products has the potential to shrink tumours. (nature.com)
Mechanism1
- synergistic mechanism of both agents against RCC cells. (1library.net)
Chemotherapy2
- Chemotherapy with dactinomycin in combination with other agents is associated with serum enzyme elevations in a high, but variable proportion of patients depending upon the dose, other agents used as well as the frequency of monitoring and criteria used to define elevations. (nih.gov)
- Most commonly used chemotherapy agents are mitomycin and gemcitabine. (medscape.com)
Cytotoxic1
- 3. Gold Nanorods are Selective Cytotoxic Agents. (nih.gov)
Polymer2
- progression_or_recurrence_anatomic_site C C177537 GDC Value Terminology C128030 Evexomostat A synthetic copolymer-drug conjugate of a fumagillin-derived methionine aminopeptidase 2 (MetAP2) inhibitor conjugated to the bio-compatible polymer poly(N-(hydroxypropyl)methacrylamide) (HPMA), with potential antineoplastic activity. (nih.gov)
- A low molecular weight polymer-conjugated platinum complex with potential antineoplastic activity. (blogspot.com)
Receptor1
- disease_type C2991 disease_type D C177537 GDC Value Terminology C105615 ALK Inhibitor RO5424802 An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. (nih.gov)
Carcinoma1
- Olaparib is a small molecule inhibitor of poly ADP-ribose polymerase and is used as an antineoplastic agent in the therapy of refractory and advanced ovarian carcinoma. (nih.gov)
Gene transcription2
Reverse transcription2
- most used reverse transcription (RT)-polymerase chain reaction (PCR) or Northern blotting (Beaulieu et al. (aspetjournals.org)
- China, HFRS is caused mainly by 2 serotypes of hantavi- quences amplified by reverse transcription PCR is presented rus: Hantaan virus (HTNV) and Seoul virus (SEOV) ( 4 ). (cdc.gov)
Breast1
- Because DSS1, a mammalian component of the transcription/RNA export complex, is known to stabilize BRCA2, we investigated how the expression of DSS1 is associated with clinical parameters in breast cancers. (biomedcentral.com)
Receptors1
- Bacterial products that have potential antineoplastic or immunostimulatory properties include bacterial toxins, microbial ligands of pattern recognition receptors, as well as bacterial metabolites, including butyrate, polyamines and pyridoxine. (nature.com)
Activity7
- Cell cycle-specific with activity in the S-phase as single agent and has for many years been combined with biochemical modulator leucovorin. (medscape.com)
- Therefore FUSE melting is likely to be coupled with ongoing c-myc promoter activity since transcription is the major source of torsional stress in vivo . (nih.gov)
- Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (lookformedical.com)
- An organoplatinum compound that possesses antineoplastic activity. (lookformedical.com)
- A triazene derivative with antineoplastic activity. (blogspot.com)
- Polymeric micellar nanoparticles containing diaminocyclohexane platinum (DACH-platin or DACH-Pt) with potential antineoplastic activity. (blogspot.com)
- This agent is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production. (medindex.am)
Derivative1
- More recently, we have been studying some diimine Pt(II) and Pd(II) complexes of dithiocarbamate derivative as potential anticancer agents [ 31 ]. (hindawi.com)
Anti-neoplastic2
- Resistance to anti-neoplastic agents is the major cause of therapy failure, leading to disease recurrence and metastasis. (nih.gov)
- Hypericin (HYP), an active compound from H. perforatum, exhibits both pro-apoptotic and anti-angiogenic effects, thus it might serve as a potentially effective anti-neoplastic agent [8]. (atpase-signaling.com)
Damage1
- These evidences suggest that several pathological agents, able to induce liver damage, can stimulate an inflammatory and hyperproliferative response in hepatocytes by activating and/or inhibiting several cell molecular pathways. (biomedcentral.com)
Treatments2
- A substantial proportion of the cancer morbidity could be prevented through early detection and treatments, which renders the quest for highly effective antineoplastic agents [ 6 ]. (hindawi.com)
- Thus, future antineoplastic treatments could combine the modulation of the microbiome and its products with immunotherapeutics and more conventional approaches that directly target malignant cells. (nature.com)
Cancer3
- Due to its high response rate and low incidence of serious side effects, PEM has become one of the essential antineoplastic agents for non-sq-NSCLC in routine clinical practice ( J Thorac Oncol 8(10) (2013)">7 - J Cancer Res Ther 16(4) (2020)">15 ). (cancerdiagnosisprognosis.org)
- In preclinical models, defined strains of live microbial agents may be used to stimulate immunosurveillance against cancers, either alone or in combination with cancer therapeutics. (nature.com)
- The results revealed that GCar could serve as an apoptotic stimulator agent, presenting a novel and potentially curative approach for cancer treatment, inducing fewer side effects than those of the commercially used anti-cancer drugs, such as CPO. (biomedcentral.com)
Action2
- The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS. (lookformedical.com)
- 2005) Enhancement of antineoplastic action of 5-aza-2'-deoxycytidine by zebularine on L1210 leukemia. (jenabioscience.com)
Lung1
- The basis of the group's work in this area is the hypothesis that cyclooxygenase (COX)-derived eicosanoids (Figure 1) are important modulators of the lung immune response to environmental agents (Figure 2). (nih.gov)
Potentially1
- In many instances, it is difficult to attribute the liver test abnormalities to dactinomycin, because of the exposure to other potentially hepatotoxic agents. (nih.gov)
Drug1
- Megestrol acetate is a synthetic, antineoplastic and progestational drug. (nih.gov)
Potential1
- A particular feature of the CLUE platform is the identification of potential molecular targets for agents that perturb gene expression. (fortuneonline.org)
Promoter1
- FUSE, FBP and FIR comprise elements of a system regulating the transition from transcription initiation through promoter escape--the point at which unencumbered transcription elongation occurs and the promoter is again available for reinitiation. (nih.gov)