Transcobalamin I migrates electrophoretically as a beta-globulin, while transcobalamins II and III migrate as alpha-globulins. (nih.gov)
Although approximately 90% of plasma vitamin B 12 circulates bound to transcobalamins I and III, only transcobalamin II is capable of transporting vitamin B 12 into cells. (mhmedical.com)
Carrier proteins2
Transcobalamins are carrier proteins which bind cobalamin (B12). (wikipedia.org)
Once bound to IF, vitamin B12 travels up to the ileum where IF is removed and B12 binds with carrier proteins called transcobalamins and this complex is taken up by the liver and bone marrow, among other tissues. (wikidoc.org)
Bound1
Vitamin B12 in plasma is bound to transcobalamins I and II. (msdmanuals.com)
Plasma5
1: Folia Haematol Int Mag Klin Morphol Blutforsch 1986;113(6):766-75 Plasma transcobalamins in haematological disorders. (drlauda.at)
Plasma UBBC-B12 and transcobalamins were measured in 112 patients suffering from different haematological disorders. (drlauda.at)
Plasma UBBC-B12 and transcobalamins were significantly higher than normal in untreated chronic myeloid leukaemia, acute promyelocytic leukaemia, nutritional megaloblastic anaemia and in refractory anaemias with hypercellular marrow. (drlauda.at)
Chronic myeloid leukaemia patients during blast crisis and acute myeloid leukaemia patients except those suffering from acute promyelocytic leukaemia showed varying pattern of plasma transcobalamins depending on type of blast crisis or FAB subtype of AML. (drlauda.at)
The significance of these changes in plasma transcobalamins have been discussed along with the experience of other workers in this field. (drlauda.at)
Proteins2
Transcobalamins are carrier proteins which bind cobalamin (B12). (wikipedia.org)
Once in the bloodstream, B12 binds to proteins called transcobalamins. (biolev.com)
Vitamin1
Vitamin B12 in plasma is bound to transcobalamins I and II. (msdmanuals.com)