OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Malonyl Coenzyme AAcyl-Carrier Protein S-MalonyltransferaseMalonatesFatty Acid Synthase, Type IIAcyltransferasesCoenzyme AAcyl-Carrier Protein S-AcetyltransferaseLysophospholipaseCoenzymesAcyl Carrier ProteinFatty Acid Synthases3-Oxoacyl-(Acyl-Carrier-Protein) ReductaseAcetyl Coenzyme AKetone Oxidoreductases3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)Multienzyme ComplexesFatty AcidsCoenzyme A Ligases1-Acylglycerophosphocholine O-Acyltransferase3-Oxoacyl-(Acyl-Carrier-Protein) SynthaseBarth SyndromeAcyl Coenzyme AAcylationSubstrate SpecificityKineticsCarboxy-LyasesAcetyltransferasesPlatelet Activating FactorUbiquinonePantetheineEscherichia coliMolecular Sequence DataApium graveolensCarnitine O-PalmitoyltransferaseAmino Acid SequencePalmitoyl Coenzyme ACloning, MolecularLysophosphatidylcholinesArachidonic AcidPhospholipases APhospholipases A2CobamidesMaple Syrup Urine DiseaseCoenzyme A-TransferasesCardiolipinsHydroxymethylglutaryl CoA ReductasesAcetyl-CoA CarboxylasePeptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine AmidasePhenylmethylsulfonyl FluorideCarnitinePhospholipidsPolyketide Synthases
MCATFattyMalonateBiosynthesisGenerateRole
MCAT3
  • Malonyl-CoA is utilised in fatty acid biosynthesis by the enzyme malonyl coenzyme A:acyl carrier protein transacylase (MCAT). (wikipedia.org)
  • MCAT serves to transfer malonate from malonyl-CoA to the terminal thiol of holo-acyl carrier protein (ACP). (wikipedia.org)
  • 18 genes belonged to the acetyl-CoA carboxylase (ACC), malonyl-CoA:ACP transacylase (MCAT), ß-ketoacyl-ACP synthase (KAS), and fatty acyl-ACP thioesterase (FAT) gene families involved in fatty acid biosynthesis, and 16 genes belonged to the glycerol-3-phosphate acyltransferase (GPAT), diacylglycerol acyltransferase 3 (DGAT3), phospholipid:diacylglycerol acyltransferase (PDAT), FAD2, and lysophosphatidic acid acyltransferase (LPAAT) gene families playing important roles in triacylglycerol synthesis. (bvsalud.org)
Fatty3
  • Malonyl-CoA provides 2-carbon units to fatty acids and commits them to fatty acid chain synthesis. (wikipedia.org)
  • Malonyl-CoA is formed in the first step of mitochondrial fatty acid synthesis (mtFASII) from malonic acid by malonyl-CoA synthetase (ACSF3). (wikipedia.org)
  • Malonyl-CoA inhibits fatty acids from associating with carnitine by regulating the enzyme carnitine acyltransferase, thereby preventing them from entering the mitochondria, where fatty acid oxidation and degradation occur. (wikipedia.org)
Malonate2
  • MCAT serves to transfer malonate from malonyl-CoA to the terminal thiol of holo-acyl carrier protein (ACP). (wikipedia.org)
  • This enzyme catalyzes the transacylation of malonate from MALONYL CoA to activated holo-ACP, to generate malonyl-(acyl-carrier protein), which is an elongation substrate in FATTY ACIDS biosynthesis. (bvsalud.org)
Biosynthesis2
  • Malonyl-CoA is utilised in fatty acid biosynthesis by the enzyme malonyl coenzyme A:acyl carrier protein transacylase (MCAT). (wikipedia.org)
  • Conclusion: We speculated that the non-acyl coenzyme A pathway played a significant role in DAG biosynthesis. (bvsalud.org)
Generate1
  • In CMAMMA due to ACSF3, malonyl-CoA synthetase is decreased, which can generate malonyl-CoA from malonic acid, which can then be converted to acetyl-CoA by malonyl-CoA decarboxylase. (wikipedia.org)
Role1
  • Malonyl-CoA plays a special role in the mitochondrial clearance of toxic malonic acid in the metabolic disorder combined malonic and methylmalonic aciduria (CMAMMA). (wikipedia.org)