Tax modulates cellular processes by protein-protein interaction (binding with proteins), transcriptional activation (promoting the production of proteins) and transcriptional repression (inhibiting the production of proteins). (wikipedia.org)
Oncogenic transformation of CD4 + T cells by human T-cell lymphotropic virus type 1 (HTLV-1) is understood as the initial step to adult T-cell leukemia/lymphoma, a process that is mainly initiated by perturbation of cellular signaling by the viral Tax oncoprotein, a potent transcriptional regulator. (ashpublications.org)
Nuclear factor-κB signals were important for Tax-mediated transcriptional regulation of Fascin in T cells. (ashpublications.org)
HTLV-1 Taxes is certainly a transcriptional transactivator of pathogen replication and induces the appearance of a Spectinomycin HCl number of mobile genes by activation from the NF-B and CREB/ATF pathways (Matsuoka and Jeang 2011). (biotech2012.org)
HTLV-1 Tax1
Interesting, HTLV-1 Tax viral gene is known to dampen innate antiviral signaling pathways to avoid host detection and elimination, through SOCS1 and Aryl Hydrocarbon Receptor Interacting Protein (AIP). (wikipedia.org)
Oncoprotein2
Here we report that a direct link can exist between a single viral oncoprotein and Fascin expression, as the viral oncoprotein Tax was sufficient to induce high levels of Fascin. (ashpublications.org)
1 The virus transforms CD4 + T lymphocytes to permanent growth, a process that is mainly mediated by the viral Tax oncoprotein. (ashpublications.org)
Transcription3
Tax acts as a transactivator, causing the transcription (production of mRNA from genetic code) of viral proteins in the long terminal repeat that are essential for replication. (wikipedia.org)
2 , 3 Tax activates viral transcription through the HTLV-1 long terminal repeat and induces cellular genes through signaling pathways, including nuclear factor-κB (NF-κB), serum response factor/activator protein 1, and cyclic-AMP response element-binding protein (CREB). (ashpublications.org)
De novo infections requires appearance of Taxes since transcription from the sense-strand Rabbit Polyclonal to CBLN2 from the provirus which is in charge of the generation from the viral genome and viral proteins. (biotech2012.org)
CREB1
3 , 4 Activation of CREB by Tax is involved in immortalization of primary human T cells. (ashpublications.org)
Proteins1
Ex vivo, Taxes proteins is portrayed in peripheral bloodstream. (biotech2012.org)
Pathogenesis2
This suggests that Fascin up-regulation by Tax contributes to the development of HTLV-1-associated pathogenesis. (ashpublications.org)
Molecular pathogenesis of Taxes The gene encodes a 353-amino acidity, 40-kDa protein, Taxes, which has a central function in HTLV-1 biology (Bangham 2018). (biotech2012.org)
Protein2
A Tax Gene Product (Tax) is a nuclear protein that has a molecular weight of about 37,000 to 40,000 daltons. (wikipedia.org)
The tax protein produced from HTLV-1 and HTLV-2 have been most extensively studied. (wikipedia.org)
Cellular1
Cellular processes that Tax dysregulates to produce cancerous cells include the cell cycle and the maintenance of genomic integrity. (wikipedia.org)
Cells3
Tax also causes aneuploidy (abnormal chromosome numbers), which is a possible cause of transformation (normal cells becoming cancer cells). (wikipedia.org)
Although Tax from HTLV-1 and HTLV-2 can cause cells to become cancerous experimentally, Tax produced by HTLV-2 is less oncogenic than that from HTLV-1 and therefore is thought to be the reason that HTLV-2 is not associated with ATL. (wikipedia.org)
Taxes has been thoroughly studied since it induces the appearance of many web host mobile genes and therefore plays a part in dysfunction in immune system cells of HAM/TSP sufferers. (biotech2012.org)
Protein12
and tax, which encodes a transactivator protein of 40,000 daltons (p40x). (cdc.gov)
A Tax Gene Product (Tax) is a nuclear protein that has a molecular weight of about 37,000 to 40,000 daltons. (wikipedia.org)
The tax protein produced from HTLV-1 and HTLV-2 have been most extensively studied. (wikipedia.org)
Tax modulates cellular processes by protein-protein interaction (binding with proteins), transcriptional activation (promoting the production of proteins) and transcriptional repression (inhibiting the production of proteins). (wikipedia.org)
Interesting, HTLV-1 Tax viral gene is known to dampen innate antiviral signaling pathways to avoid host detection and elimination, through SOCS1 and Aryl Hydrocarbon Receptor Interacting Protein (AIP). (wikipedia.org)
7. Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein. (nih.gov)
10. Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications. (nih.gov)
20. Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades. (nih.gov)
[ 1 ] Leukemia is preceded by oligoclonal expansions arising from a polyclonal background of activated HTLV-1-infected T cells as a result of the expression of the viral transactivator protein Tax, which activates various cellular genes [ 2 , 3 ] and creates an autocrine loop involving IL-2, IL-15 and their cognate receptors. (medscape.com)
HBZ protein suppresses transcription of the tax gene through blocking the LTR recruitment of not only ATF/CREB factors but also CBP/p300. (biomedcentral.com)
Cellular thermal shift assay and pulldown assays provided evidence for a direct interaction between vioE and the viral transactivator protein, Tax. (bvsalud.org)
TAT is the most characterized fragment of the HIV transactivator protein (TAT). (mobitec.com)
Viral3
Tax acts as a transactivator, causing the transcription (production of mRNA from genetic code) of viral proteins in the long terminal repeat that are essential for replication. (wikipedia.org)
On the other hand, results were totally different when analyzing sense and antisense transcription from viral constructs containing both LTRs: Tax did not activate antisense transcription from the 3′ LTR in this case [ 14 ]. (biomedcentral.com)
Taken together, all these observations suggest that Tax could indirectly keep antisense transcription to low levels through its stimulation of sense transcription and viral production. (biomedcentral.com)
which is where the name Tax comes from (transactivator from the X-gene region). (wikipedia.org)
A promoter assay using 5'-serially deleted eNOS promoters revealed that Tax-responsive element site, located at −962 to −873 of the eNOS promoter, was responsible for aphidicolin-stimulated eNOS gene expression. (biomolther.org)
Interaction1
15. HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity. (nih.gov)
Infection1
In HTLV-1-infected rabbits, entry into the chronic stage of infection coincides with the loss of Tax and Gag production, while HBZ expression is maintained at a steady state [ 16 ]. (biomedcentral.com)
Molecular1
11. Studies of the immortalizing activity of HTLV type 1 Tax, using an infectious molecular clone and transgenic mice. (nih.gov)
Include1
All prices are net in Euro and do not include applicable taxes, shipping & handling , or other charges (e.g., customs duties). (mobitec.com)
Virus4
Tax is produced by members of the retroviral family primate T-lymphotropic virus, which are classified as Deltaretroviruses. (wikipedia.org)
HTLV-1 causes an aggressive form of leukaemia: adult T cell leukaemia (ATL), and Tax has largely been implicated in the oncogenic potential of this virus. (wikipedia.org)
5. Differences in the ability of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 tax to inhibit p53 function. (nih.gov)
6. Analysis of p53 inactivation in a human T-cell leukemia virus type 1 Tax transgenic mouse model. (nih.gov)
Checkout1
Tax calculation will be finalised during checkout. (springer.com)