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  • subset
  • However, acidic activators interact directly with a similar subset of chromatin-associated activities, including yeast NuA4, SAGA, and SWI/SNF as well as their human counterparts ( 15 , 23 , 27 , 43 , 67 ). (asm.org)
  • The apparent absence in vitro of distinct interaction preferences among this subset of coactivators is consistent with in vivo studies suggesting that a variety of natural and chimeric activators are able to recruit overlapping sets of coactivators ( 7 , 12 , 49 , 53 , 56 , 58 , 66 ). (asm.org)
  • Activation
  • We show that PHO5 activation is highly dependent on both coactivators at intermediate phosphate concentrations, conditions that reduce the nuclear concentration of the Pho4 transactivator and severely diminish its association with PHO5 in the absence of Gcn5 or SWI/SNF. (asm.org)
  • directly
  • We have previously shown that Rap1 directly binds to the TFIID complex through interaction with its TATA-binding protein-associated factor (Taf) subunits Taf4, -5, and -12. (pubmedcentralcanada.ca)
  • TFIID, a complex composed of TATA-binding protein (TBP) and 14 evolutionarily conserved Taf subunits ( 4 , - 6 ), is an attractive candidate target for transactivator regulatory interactions within the PIC, both because TFIID promoter binding appears to be rate-limiting in vivo ( 7 ) and because transactivators have been shown to bind directly to TFIID subunits ( 8 , 9 ). (pubmedcentralcanada.ca)