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Reverse tetracycline-controlled transactivatorCIITAProteinMHC2TATetracycline-regulatedGeneViralExpressionTranscriptionPromoterClassActivityMouseTetracyclinePromoterTranscriptionalImmunodeficiency

Reverse tetracycline-controlled transactivator2

• The aim of this work was to investigate the possibilities of recently developed reverse tetracycline-controlled transactivator rtTA2s-S2. (muni.cz)
• A potentially immunologically inert derivative of the reverse tetracycline-controlled transactivator. (nin.nl)

CIITA1

• MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses," Science , 370:241-47, 2020. (the-scientist.com)

Protein3

• Novel transcription transactivator protein. (ox.ac.uk)
• CamKII-tTA transgenic mice are viable and fertile, with expression of the tetracycline-controlled transactivator protein (tTA) directed to forebrain neurons by the forebrain-specific calcium-calmodulin-dependent kinase II (Camk2a) promoter. (mmrrc.org)
• The effector is a sequence that encodes the tetracycline transactivator protein, (or tTA). (stanford.edu)

MHC2TA1

• The MHC class II transactivator (MHC2TA) is the master controller of expression of class II genes, and methylation of the promoter of this gene has been previously been shown to alter its function. (ox.ac.uk)

Tetracycline-regulated2

• The CamKII-tTA transgene was designed by Dr. Mark Mayford (Columbia University, New York) with 8.5 kb of the mouse CaMKIIalpha promoter placed upstream of the tetracycline-regulated transactivator (tTA or "Tet-Off") gene (flanked by an artificial intron and splice sites at the 5' end and by a polyadenylation signal from SV40 at the 3' end). (mmrrc.org)
• The most commonly used systems are based on a transactivator in combination with a drug, e.g. the tetracycline-regulated system. (lu.se)

Gene2

• Results: When the transactivator expression plasmid harbouring an expression cassette of the tetracycline-responsive transactivator gene was co-transfected with a reporter gene expression plasmid, the reporter gene expression was controlled by heat treatment. (elsevierpure.com)
• Methylation of class II transactivator gene promoter IV is not associated with susceptibility to multiple sclerosis. (ox.ac.uk)

Viral1

• It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. (cancerindex.org)

Expression4

• Our results indicate that this transactivator is toxic to ES cells and raise the need for the development of other strategies for stable and inducible expression of genes in ES cells. (muni.cz)
• In this study, to combine heat-inducibility with high-level transgene expression, we developed a heat-inducible transgene expression system with transcriptional amplification mediated by a tetracycline-responsive transactivator. (elsevierpure.com)
• With this system, high levels of heat-induced transgene expression were observed compared to that from the HSP promoter alone without the transactivator. (elsevierpure.com)
• To this end, several recent studies have taken advantage of a transgenic line in which the tetracycline transactivator (tTA) was placed under control of the neuropsin (Nop) promoter to limit transgene expression within the medial EC and pre-/parasubiculum. (nih.gov)

Transcription1

• We have developed a functional "no-hybrids" screen in the fission yeast Schizosaccharomyces pombe based on the transcription transactivator activity of human p53. (ox.ac.uk)

Promoter1

• rTg4510 mice ("r" for regulatable) are produced by crossing the 4510 responder line, carrying a human MAPT P301L cDNA downstream of a tetracycline operon-responsive element (TRE), to an activator line expressing a tetracycline-controlled transactivator (tTA) under control of the CaMKIIα promoter. (alzforum.org)

Class1

• MHC class II transactivator. (invivogen.com)

Activity1

• Casein kinase-2 mediated phosphorylation increases the SUMO-dependent activity of the cytomegalovirus transactivator IE2. (ncbs.res.in)

Mouse1

• However, we found that it was not possible to establish mouse embryonic stem cell lines stably expressing this transactivator. (muni.cz)

Tetracycline3

• Tetracycline transactivator (tTA) is downstream of the CAMKIIα promoter, driving expression in excitatory neurons in the forebrain. (alzforum.org)
• The reverse tetracycline-controlled transactivator rtTA2s-S2 is toxic in mouse embryonic stem cells. (muni.cz)
• Lethality is due to overexpression of an auto-regulated tetracycline repressible transactivator (tTA) gene and occurs mostly at the pupal stage. (ncsu.edu)

Promoter2

• 11. Amelogenin Downregulates Interferon Gamma-Induced Major Histocompatibility Complex Class II Expression Through Suppression of Euchromatin Formation in the Class II Transactivator Promoter IV Region in Macrophages. (nih.gov)
• 15. IFN-gamma regulation of class II transactivator promoter IV in macrophages and microglia: involvement of the suppressors of cytokine signaling-1 protein. (nih.gov)

Transcriptional1

• One such example is the transcriptional transactivator HIV-1 Tat, which has been demonstrated to be neurotoxic. (nih.gov)

Immunodeficiency1

• Novel Mutation in the Class II Transactivator Associated with Immunodeficiency and Autoimmunity. (medlineplus.gov)