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  • gene
  • Even though transcription factors ( TF s) are central players of gene regulation and have been extensively studied, their regulatory trans ‐activation domains ( tAD s) often remain unknown and a systematic functional characterization of tAD s is lacking. (embopress.org)
  • Mice lacking p63 , a single gene that encodes a group of transcription factors that either contain (TA) or lack (ΔN) a transactivation domain, fail to develop stratified epithelia as well as epithelial appendages and limbs. (pnas.org)
  • One gene that is critical for controlling epidermal morphogenesis is p63 , a transcription factor that can be expressed as isoforms that contain (TA) or lack (ΔN) a transactivation domain ( 3 ). (pnas.org)
  • The SAP domain of myocardin is not required for association with SRF, but it provides specificity to target gene activation and is required for the activation of some genes but not others ( 8 ). (pnas.org)
  • Binding
  • Interestingly, the tAD s are found at arbitrary positions within the TF sequences and can contain amino acid (e.g., glutamine) repeat regions or overlap structured domains, including helix-loop-helix domains that are typically annotated as DNA ‐binding. (embopress.org)
  • Classification based on structures of their DNA-binding domains provides cardinal insights into their modes of DNA recognition. (biomedcentral.com)
  • Mdm2 achieves this repression by binding to and blocking the N-terminal trans-activation domain of p53. (wikipedia.org)
  • central DNA-binding core domain (DBD). (wikipedia.org)
  • regulatory
  • However, activation of CBP by HIPK2 is not mediated by this phosphorylation but rather by counteracting the repressive action of the cell cycle regulatory domain 1 (CRD1) of CBP, located between amino acids 977 and 1076. (wikipedia.org)
  • shown
  • Later, the p53 N-terminal domain (p53NTD) was reported to be sufficient for inducing the transcription-independent apoptotic activity of p53 and also shown to interact with Bcl-XL. (ntu.edu.sg)