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  • Clathrin
  • Furthermore, expression of activated forms of Rho1p or Pkc1p, in the absence of cell stress, is sufficient to redistribute Chs3p to the PM. In cells deficient for both the clathrin adaptor complex 1 and Chs6p, where Chs3p is transported to the PM by an alternative bypass pathway, cell wall stress did not cause mobilization of Chs3p, suggesting that Rho1p/Pkc1p regulate Chs3p exit from the trans-Golgi network. (pnas.org)
  • thus
  • Recent evidence indicates that recognition molecules, particularly neural cell adhesion molecule (NCAM), are associated with trans-Golgi-network-derived structures and thus can provide a signal for accumulation of these transport carriers at nascent synapses. (biologists.org)
  • Thus, furin processes MT3-MMP zymogen in the trans-Golgi network, where they colocalize independently of their apparent enzyme-substrate relationship. (ox.ac.uk)
  • early
  • In the presence of BFA, a mannose-6-phosphate receptor (M6PR)-enriched tubular network rapidly forms from the TGN, not from the prelysosomal compartment, and can be labeled with endocytic tracers after only 5 min of uptake at either 20 degrees C or 37 degrees C, indicating that it is also functionally an early endosome. (nih.gov)
  • Concomitant with the formation of the fused TGN-early endosome network, there is a greater than 5-fold increase in cell surface M6PRs. (nih.gov)
  • GFP-RabA1d colocalized with the trans -Golgi network marker mCherry-VTI12 and with early FM4-64-labeled endosomal compartments. (beds.ac.uk)
  • export
  • By contrast, full-length syndapin II-I had no negative effect, and instead promoted VSVG-GFP export from the Golgi. (mdc-berlin.de)